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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ERN2
Full Name:
Serine/threonine-protein kinase/endoribonuclease IRE2
Alias:
Endoplasmic reticulum-to-nucleus signaling 2;Inositol-requiring protein 2;Ire1-beta
Type:
Mass (Da):
102466
Number AA:
926
UniProt ID:
Q76MJ5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
S
A
V
R
G
S
R
P
W
P
R
L
G
Site 2
S54
D
G
S
L
H
A
L
S
K
Q
T
G
D
L
K
Site 3
T63
Q
T
G
D
L
K
W
T
L
R
D
D
P
V
I
Site 4
S89
L
S
D
P
A
D
G
S
L
Y
I
L
G
T
Q
Site 5
Y91
D
P
A
D
G
S
L
Y
I
L
G
T
Q
K
Q
Site 6
T95
G
S
L
Y
I
L
G
T
Q
K
Q
Q
G
L
M
Site 7
S115
I
P
E
L
V
H
A
S
P
C
R
S
S
D
G
Site 8
S119
V
H
A
S
P
C
R
S
S
D
G
V
F
Y
T
Site 9
S120
H
A
S
P
C
R
S
S
D
G
V
F
Y
T
G
Site 10
T126
S
S
D
G
V
F
Y
T
G
R
K
Q
D
A
W
Site 11
S140
W
F
V
V
D
P
E
S
G
E
T
Q
M
T
L
Site 12
T146
E
S
G
E
T
Q
M
T
L
T
T
E
G
P
S
Site 13
T148
G
E
T
Q
M
T
L
T
T
E
G
P
S
T
P
Site 14
T149
E
T
Q
M
T
L
T
T
E
G
P
S
T
P
R
Site 15
S153
T
L
T
T
E
G
P
S
T
P
R
L
Y
I
G
Site 16
T154
L
T
T
E
G
P
S
T
P
R
L
Y
I
G
R
Site 17
Y158
G
P
S
T
P
R
L
Y
I
G
R
T
Q
Y
T
Site 18
Y164
L
Y
I
G
R
T
Q
Y
T
V
T
M
H
D
P
Site 19
T165
Y
I
G
R
T
Q
Y
T
V
T
M
H
D
P
R
Site 20
T180
A
P
A
L
R
W
N
T
T
Y
R
R
Y
S
A
Site 21
T181
P
A
L
R
W
N
T
T
Y
R
R
Y
S
A
P
Site 22
Y182
A
L
R
W
N
T
T
Y
R
R
Y
S
A
P
P
Site 23
Y185
W
N
T
T
Y
R
R
Y
S
A
P
P
M
D
G
Site 24
S186
N
T
T
Y
R
R
Y
S
A
P
P
M
D
G
S
Site 25
S193
S
A
P
P
M
D
G
S
P
G
K
Y
M
S
H
Site 26
Y197
M
D
G
S
P
G
K
Y
M
S
H
L
A
S
C
Site 27
S199
G
S
P
G
K
Y
M
S
H
L
A
S
C
G
M
Site 28
T247
L
R
Q
L
P
H
L
T
L
A
R
D
T
L
H
Site 29
S268
G
H
I
R
L
P
A
S
G
P
Q
D
T
A
T
Site 30
T273
P
A
S
G
P
Q
D
T
A
T
L
F
S
T
L
Site 31
T275
S
G
P
Q
D
T
A
T
L
F
S
T
L
D
T
Site 32
Y289
T
Q
L
L
M
T
L
Y
V
G
K
D
E
T
G
Site 33
T295
L
Y
V
G
K
D
E
T
G
F
Y
V
S
K
A
Site 34
Y298
G
K
D
E
T
G
F
Y
V
S
K
A
L
V
H
Site 35
T325
A
P
A
D
G
P
T
T
D
E
V
T
L
Q
V
Site 36
T329
G
P
T
T
D
E
V
T
L
Q
V
S
G
E
R
Site 37
S333
D
E
V
T
L
Q
V
S
G
E
R
E
G
S
P
Site 38
S339
V
S
G
E
R
E
G
S
P
S
T
A
V
R
Y
Site 39
S341
G
E
R
E
G
S
P
S
T
A
V
R
Y
P
S
Site 40
T342
E
R
E
G
S
P
S
T
A
V
R
Y
P
S
G
Site 41
Y346
S
P
S
T
A
V
R
Y
P
S
G
S
V
A
L
Site 42
S348
S
T
A
V
R
Y
P
S
G
S
V
A
L
P
S
Site 43
S350
A
V
R
Y
P
S
G
S
V
A
L
P
S
Q
W
Site 44
T379
T
M
L
R
V
H
P
T
L
G
S
G
T
A
E
Site 45
T387
L
G
S
G
T
A
E
T
R
P
P
E
N
T
Q
Site 46
T393
E
T
R
P
P
E
N
T
Q
A
P
A
F
F
L
Site 47
S406
F
L
E
L
L
S
L
S
R
E
K
L
W
D
S
Site 48
S413
S
R
E
K
L
W
D
S
E
L
H
P
E
E
K
Site 49
T421
E
L
H
P
E
E
K
T
P
D
S
Y
L
G
L
Site 50
S424
P
E
E
K
T
P
D
S
Y
L
G
L
G
P
Q
Site 51
Y425
E
E
K
T
P
D
S
Y
L
G
L
G
P
Q
D
Site 52
T465
V
V
E
K
Q
Q
E
T
P
L
A
P
A
D
F
Site 53
S476
P
A
D
F
A
H
I
S
Q
D
A
Q
S
L
H
Site 54
S481
H
I
S
Q
D
A
Q
S
L
H
S
G
A
T
R
Site 55
S490
H
S
G
A
T
R
R
S
Q
K
R
L
Q
S
P
Site 56
S496
R
S
Q
K
R
L
Q
S
P
S
K
Q
A
Q
P
Site 57
S498
Q
K
R
L
Q
S
P
S
K
Q
A
Q
P
L
D
Site 58
T513
D
P
E
A
E
Q
L
T
V
V
G
K
I
S
F
Site 59
S568
E
V
Q
L
L
Q
E
S
D
R
H
P
N
V
L
Site 60
Y577
R
H
P
N
V
L
R
Y
F
C
T
E
R
G
P
Site 61
Y588
E
R
G
P
Q
F
H
Y
I
A
L
E
L
C
R
Site 62
S597
A
L
E
L
C
R
A
S
L
Q
E
Y
V
E
N
Site 63
Y601
C
R
A
S
L
Q
E
Y
V
E
N
P
D
L
D
Site 64
S630
S
G
L
A
H
L
H
S
L
H
I
V
H
R
D
Site 65
T646
K
P
G
N
I
L
I
T
G
P
D
S
Q
G
L
Site 66
S673
K
L
P
A
G
R
C
S
F
S
L
H
S
G
I
Site 67
S675
P
A
G
R
C
S
F
S
L
H
S
G
I
P
G
Site 68
S678
R
C
S
F
S
L
H
S
G
I
P
G
T
E
G
Site 69
S727
G
S
H
P
F
G
D
S
L
Y
R
Q
A
N
I
Site 70
Y729
H
P
F
G
D
S
L
Y
R
Q
A
N
I
L
T
Site 71
S763
D
L
V
G
A
M
L
S
P
L
P
Q
P
R
P
Site 72
S771
P
L
P
Q
P
R
P
S
A
P
Q
V
L
A
H
Site 73
S795
L
Q
F
F
Q
D
V
S
D
W
L
E
K
E
S
Site 74
S840
T
D
L
R
K
F
R
S
Y
K
G
T
S
V
R
Site 75
Y841
D
L
R
K
F
R
S
Y
K
G
T
S
V
R
D
Site 76
T844
K
F
R
S
Y
K
G
T
S
V
R
D
L
L
R
Site 77
S845
F
R
S
Y
K
G
T
S
V
R
D
L
L
R
A
Site 78
Y860
V
R
N
K
K
H
H
Y
R
E
L
P
V
E
V
Site 79
Y881
V
P
D
G
F
V
Q
Y
F
T
N
R
F
P
R
Site 80
T883
D
G
F
V
Q
Y
F
T
N
R
F
P
R
L
L
Site 81
T893
F
P
R
L
L
L
H
T
H
R
A
M
R
S
C
Site 82
S899
H
T
H
R
A
M
R
S
C
A
S
E
S
L
F
Site 83
S902
R
A
M
R
S
C
A
S
E
S
L
F
L
P
Y
Site 84
S904
M
R
S
C
A
S
E
S
L
F
L
P
Y
Y
P
Site 85
Y909
S
E
S
L
F
L
P
Y
Y
P
P
D
S
E
A
Site 86
Y910
E
S
L
F
L
P
Y
Y
P
P
D
S
E
A
R
Site 87
S914
L
P
Y
Y
P
P
D
S
E
A
R
R
P
C
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation