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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MLF1IP
Full Name:
Centromere protein U
Alias:
CENP-50; CENPU; CENP-U; CENP-U(50); FLJ23468; KLIP1; MLF1 interacting protein; PBIP1
Type:
Cell cycle regulation
Mass (Da):
47522
Number AA:
418
UniProt ID:
Q71F23
International Prot ID:
IPI00002828
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000777
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
R
R
P
R
P
H
R
S
E
G
A
R
R
S
K
Site 2
S20
R
S
E
G
A
R
R
S
K
N
T
L
E
R
T
Site 3
T23
G
A
R
R
S
K
N
T
L
E
R
T
H
S
M
Site 4
S29
N
T
L
E
R
T
H
S
M
K
D
K
A
G
Q
Site 5
S50
V
F
D
F
P
D
N
S
D
V
S
S
I
G
R
Site 6
S53
F
P
D
N
S
D
V
S
S
I
G
R
L
G
E
Site 7
S54
P
D
N
S
D
V
S
S
I
G
R
L
G
E
N
Site 8
T67
E
N
E
K
D
E
E
T
Y
E
T
F
D
P
P
Site 9
Y68
N
E
K
D
E
E
T
Y
E
T
F
D
P
P
L
Site 10
T70
K
D
E
E
T
Y
E
T
F
D
P
P
L
H
S
Site 11
S77
T
F
D
P
P
L
H
S
T
A
I
Y
A
D
E
Site 12
T78
F
D
P
P
L
H
S
T
A
I
Y
A
D
E
E
Site 13
Y81
P
L
H
S
T
A
I
Y
A
D
E
E
E
F
S
Site 14
S88
Y
A
D
E
E
E
F
S
K
H
C
G
L
S
L
Site 15
S94
F
S
K
H
C
G
L
S
L
S
S
T
P
P
G
Site 16
S96
K
H
C
G
L
S
L
S
S
T
P
P
G
K
E
Site 17
S97
H
C
G
L
S
L
S
S
T
P
P
G
K
E
A
Site 18
T98
C
G
L
S
L
S
S
T
P
P
G
K
E
A
K
Site 19
S107
P
G
K
E
A
K
R
S
S
D
T
S
G
N
E
Site 20
S108
G
K
E
A
K
R
S
S
D
T
S
G
N
E
A
Site 21
T110
E
A
K
R
S
S
D
T
S
G
N
E
A
S
E
Site 22
S111
A
K
R
S
S
D
T
S
G
N
E
A
S
E
I
Site 23
S116
D
T
S
G
N
E
A
S
E
I
E
S
V
K
I
Site 24
S120
N
E
A
S
E
I
E
S
V
K
I
S
A
K
K
Site 25
S124
E
I
E
S
V
K
I
S
A
K
K
P
G
R
K
Site 26
S136
G
R
K
L
R
P
I
S
D
D
S
E
S
I
E
Site 27
S139
L
R
P
I
S
D
D
S
E
S
I
E
E
S
D
Site 28
S141
P
I
S
D
D
S
E
S
I
E
E
S
D
T
R
Site 29
S145
D
S
E
S
I
E
E
S
D
T
R
R
K
V
K
Site 30
T147
E
S
I
E
E
S
D
T
R
R
K
V
K
S
A
Site 31
S153
D
T
R
R
K
V
K
S
A
E
K
I
S
T
Q
Site 32
T159
K
S
A
E
K
I
S
T
Q
R
H
E
V
I
R
Site 33
T167
Q
R
H
E
V
I
R
T
T
A
S
S
E
L
S
Site 34
T168
R
H
E
V
I
R
T
T
A
S
S
E
L
S
E
Site 35
S170
E
V
I
R
T
T
A
S
S
E
L
S
E
K
P
Site 36
S171
V
I
R
T
T
A
S
S
E
L
S
E
K
P
A
Site 37
S174
T
T
A
S
S
E
L
S
E
K
P
A
E
S
V
Site 38
S180
L
S
E
K
P
A
E
S
V
T
S
K
K
T
G
Site 39
T182
E
K
P
A
E
S
V
T
S
K
K
T
G
P
L
Site 40
S183
K
P
A
E
S
V
T
S
K
K
T
G
P
L
S
Site 41
T186
E
S
V
T
S
K
K
T
G
P
L
S
A
Q
P
Site 42
S190
S
K
K
T
G
P
L
S
A
Q
P
S
V
E
K
Site 43
S194
G
P
L
S
A
Q
P
S
V
E
K
E
N
L
A
Site 44
S204
K
E
N
L
A
I
E
S
Q
S
K
T
Q
K
K
Site 45
T208
A
I
E
S
Q
S
K
T
Q
K
K
G
K
I
S
Site 46
S215
T
Q
K
K
G
K
I
S
H
D
K
R
K
K
S
Site 47
S222
S
H
D
K
R
K
K
S
R
S
K
A
I
G
S
Site 48
S224
D
K
R
K
K
S
R
S
K
A
I
G
S
D
T
Site 49
S229
S
R
S
K
A
I
G
S
D
T
S
D
I
V
H
Site 50
T231
S
K
A
I
G
S
D
T
S
D
I
V
H
I
W
Site 51
S232
K
A
I
G
S
D
T
S
D
I
V
H
I
W
C
Site 52
T245
W
C
P
E
G
M
K
T
S
D
I
K
E
L
N
Site 53
S246
C
P
E
G
M
K
T
S
D
I
K
E
L
N
I
Site 54
T261
V
L
P
E
F
E
K
T
H
L
E
H
Q
Q
R
Site 55
S271
E
H
Q
Q
R
I
E
S
K
V
C
K
A
A
I
Site 56
S296
F
I
K
M
L
K
E
S
Q
M
L
T
N
L
K
Site 57
T300
L
K
E
S
Q
M
L
T
N
L
K
R
K
N
A
Site 58
S311
R
K
N
A
K
M
I
S
D
I
E
K
K
R
Q
Site 59
Y341
L
K
Q
L
Q
T
K
Y
D
E
L
K
E
R
K
Site 60
S349
D
E
L
K
E
R
K
S
S
L
R
N
A
A
Y
Site 61
S350
E
L
K
E
R
K
S
S
L
R
N
A
A
Y
F
Site 62
Y356
S
S
L
R
N
A
A
Y
F
L
S
N
L
K
Q
Site 63
Y365
L
S
N
L
K
Q
L
Y
Q
D
Y
S
D
V
Q
Site 64
Y368
L
K
Q
L
Y
Q
D
Y
S
D
V
Q
A
Q
E
Site 65
S369
K
Q
L
Y
Q
D
Y
S
D
V
Q
A
Q
E
P
Site 66
T381
Q
E
P
N
V
K
E
T
Y
D
S
S
S
L
P
Site 67
Y382
E
P
N
V
K
E
T
Y
D
S
S
S
L
P
A
Site 68
S384
N
V
K
E
T
Y
D
S
S
S
L
P
A
L
L
Site 69
S386
K
E
T
Y
D
S
S
S
L
P
A
L
L
F
K
Site 70
S402
R
T
L
L
G
A
E
S
H
L
R
N
I
N
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation