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Updated November 2019
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Protein Info
Short Name:
RAPH1
Full Name:
Ras-associated and pleckstrin homology domains-containing protein 1
Alias:
ALS2CR18; ALS2CR9; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 18; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 9; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 18; KIAA1681; Lamellipodin; PREL-2; Proline-rich EVH1 ligand 2; RalGDS/AF-6; Ras association (RalGDS/AF-6) and pleckstriny domains 1; Ras association and pleckstrin homology domains 1; RMO1
Type:
Adapter/scaffold protein
Mass (Da):
135256
Number AA:
1250
UniProt ID:
Q70E73
International Prot ID:
IPI00871620
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0005886
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0007165
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
E
Q
L
S
D
E
E
I
D
H
G
Site 2
S17
D
H
G
A
E
E
D
S
D
K
E
D
Q
D
L
Site 3
T39
L
G
E
L
D
K
L
T
Q
S
L
D
S
D
K
Site 4
S41
E
L
D
K
L
T
Q
S
L
D
S
D
K
P
M
Site 5
S44
K
L
T
Q
S
L
D
S
D
K
P
M
E
P
V
Site 6
S54
P
M
E
P
V
K
R
S
P
L
R
Q
E
T
N
Site 7
T60
R
S
P
L
R
Q
E
T
N
M
A
N
F
S
Y
Site 8
S70
A
N
F
S
Y
R
F
S
I
Y
N
L
N
E
A
Site 9
S101
C
S
I
E
Q
E
L
S
S
I
G
S
G
N
S
Site 10
S102
S
I
E
Q
E
L
S
S
I
G
S
G
N
S
K
Site 11
S105
Q
E
L
S
S
I
G
S
G
N
S
K
R
Q
I
Site 12
S108
S
S
I
G
S
G
N
S
K
R
Q
I
T
E
T
Site 13
T113
G
N
S
K
R
Q
I
T
E
T
K
A
T
Q
K
Site 14
T115
S
K
R
Q
I
T
E
T
K
A
T
Q
K
L
P
Site 15
T118
Q
I
T
E
T
K
A
T
Q
K
L
P
V
S
R
Site 16
S124
A
T
Q
K
L
P
V
S
R
H
T
L
K
H
G
Site 17
T127
K
L
P
V
S
R
H
T
L
K
H
G
T
L
K
Site 18
T132
R
H
T
L
K
H
G
T
L
K
G
L
S
S
S
Site 19
S137
H
G
T
L
K
G
L
S
S
S
S
N
R
I
A
Site 20
S138
G
T
L
K
G
L
S
S
S
S
N
R
I
A
K
Site 21
S139
T
L
K
G
L
S
S
S
S
N
R
I
A
K
P
Site 22
S140
L
K
G
L
S
S
S
S
N
R
I
A
K
P
S
Site 23
S147
S
N
R
I
A
K
P
S
H
A
S
Y
S
L
D
Site 24
S152
K
P
S
H
A
S
Y
S
L
D
D
V
T
A
Q
Site 25
T157
S
Y
S
L
D
D
V
T
A
Q
L
E
Q
A
S
Site 26
S164
T
A
Q
L
E
Q
A
S
L
S
M
D
E
A
A
Site 27
S166
Q
L
E
Q
A
S
L
S
M
D
E
A
A
Q
Q
Site 28
T190
V
T
N
Q
H
R
R
T
A
S
A
G
T
V
S
Site 29
S192
N
Q
H
R
R
T
A
S
A
G
T
V
S
D
A
Site 30
S203
V
S
D
A
E
V
H
S
I
S
N
S
S
H
S
Site 31
S205
D
A
E
V
H
S
I
S
N
S
S
H
S
S
I
Site 32
S207
E
V
H
S
I
S
N
S
S
H
S
S
I
T
S
Site 33
S208
V
H
S
I
S
N
S
S
H
S
S
I
T
S
A
Site 34
S210
S
I
S
N
S
S
H
S
S
I
T
S
A
A
S
Site 35
S211
I
S
N
S
S
H
S
S
I
T
S
A
A
S
S
Site 36
T213
N
S
S
H
S
S
I
T
S
A
A
S
S
M
D
Site 37
S214
S
S
H
S
S
I
T
S
A
A
S
S
M
D
S
Site 38
S218
S
I
T
S
A
A
S
S
M
D
S
L
D
I
D
Site 39
S221
S
A
A
S
S
M
D
S
L
D
I
D
K
V
T
Site 40
T228
S
L
D
I
D
K
V
T
R
P
Q
E
L
D
L
Site 41
T236
R
P
Q
E
L
D
L
T
H
Q
G
Q
P
I
T
Site 42
S278
L
V
I
R
V
H
M
S
D
D
S
S
K
T
M
Site 43
S282
V
H
M
S
D
D
S
S
K
T
M
M
V
D
E
Site 44
T292
M
M
V
D
E
R
Q
T
V
R
Q
V
L
D
N
Site 45
Y308
M
D
K
S
H
C
G
Y
S
L
D
W
S
L
V
Site 46
S309
D
K
S
H
C
G
Y
S
L
D
W
S
L
V
E
Site 47
S313
C
G
Y
S
L
D
W
S
L
V
E
T
V
S
E
Site 48
T317
L
D
W
S
L
V
E
T
V
S
E
L
Q
M
E
Site 49
Y357
F
M
E
R
I
E
K
Y
A
L
F
K
N
P
Q
Site 50
S412
L
K
D
D
G
K
K
S
W
K
K
R
Y
F
L
Site 51
Y417
K
K
S
W
K
K
R
Y
F
L
L
R
A
S
G
Site 52
S423
R
Y
F
L
L
R
A
S
G
I
Y
Y
V
P
K
Site 53
Y426
L
L
R
A
S
G
I
Y
Y
V
P
K
G
K
A
Site 54
Y427
L
R
A
S
G
I
Y
Y
V
P
K
G
K
A
K
Site 55
Y452
L
D
H
V
N
V
Y
Y
G
Q
D
Y
R
N
K
Site 56
Y456
N
V
Y
Y
G
Q
D
Y
R
N
K
Y
K
A
P
Site 57
Y460
G
Q
D
Y
R
N
K
Y
K
A
P
T
D
Y
C
Site 58
Y466
K
Y
K
A
P
T
D
Y
C
L
V
L
K
H
P
Site 59
Y484
K
K
S
Q
Y
I
K
Y
L
C
C
D
D
V
R
Site 60
Y505
N
G
I
R
I
A
K
Y
G
K
Q
L
Y
M
N
Site 61
Y510
A
K
Y
G
K
Q
L
Y
M
N
Y
Q
E
A
L
Site 62
Y513
G
K
Q
L
Y
M
N
Y
Q
E
A
L
K
R
T
Site 63
S522
E
A
L
K
R
T
E
S
A
Y
D
W
T
S
L
Site 64
Y524
L
K
R
T
E
S
A
Y
D
W
T
S
L
S
S
Site 65
T527
T
E
S
A
Y
D
W
T
S
L
S
S
S
S
I
Site 66
S528
E
S
A
Y
D
W
T
S
L
S
S
S
S
I
K
Site 67
S530
A
Y
D
W
T
S
L
S
S
S
S
I
K
S
G
Site 68
S531
Y
D
W
T
S
L
S
S
S
S
I
K
S
G
S
Site 69
S532
D
W
T
S
L
S
S
S
S
I
K
S
G
S
S
Site 70
S533
W
T
S
L
S
S
S
S
I
K
S
G
S
S
S
Site 71
S536
L
S
S
S
S
I
K
S
G
S
S
S
S
S
I
Site 72
S538
S
S
S
I
K
S
G
S
S
S
S
S
I
P
E
Site 73
S539
S
S
I
K
S
G
S
S
S
S
S
I
P
E
S
Site 74
S540
S
I
K
S
G
S
S
S
S
S
I
P
E
S
Q
Site 75
S541
I
K
S
G
S
S
S
S
S
I
P
E
S
Q
S
Site 76
S542
K
S
G
S
S
S
S
S
I
P
E
S
Q
S
N
Site 77
S546
S
S
S
S
I
P
E
S
Q
S
N
H
S
N
Q
Site 78
S548
S
S
I
P
E
S
Q
S
N
H
S
N
Q
S
D
Site 79
S551
P
E
S
Q
S
N
H
S
N
Q
S
D
S
G
V
Site 80
S554
Q
S
N
H
S
N
Q
S
D
S
G
V
S
D
T
Site 81
S556
N
H
S
N
Q
S
D
S
G
V
S
D
T
Q
P
Site 82
T561
S
D
S
G
V
S
D
T
Q
P
A
G
H
V
R
Site 83
S569
Q
P
A
G
H
V
R
S
Q
S
I
V
S
S
V
Site 84
S571
A
G
H
V
R
S
Q
S
I
V
S
S
V
F
S
Site 85
S574
V
R
S
Q
S
I
V
S
S
V
F
S
E
A
W
Site 86
S575
R
S
Q
S
I
V
S
S
V
F
S
E
A
W
K
Site 87
S578
S
I
V
S
S
V
F
S
E
A
W
K
R
G
T
Site 88
T585
S
E
A
W
K
R
G
T
Q
L
E
E
S
S
K
Site 89
S591
G
T
Q
L
E
E
S
S
K
A
R
M
E
S
M
Site 90
S597
S
S
K
A
R
M
E
S
M
N
R
P
Y
T
S
Site 91
Y602
M
E
S
M
N
R
P
Y
T
S
L
V
P
P
L
Site 92
T603
E
S
M
N
R
P
Y
T
S
L
V
P
P
L
S
Site 93
S604
S
M
N
R
P
Y
T
S
L
V
P
P
L
S
P
Site 94
S610
T
S
L
V
P
P
L
S
P
Q
P
K
I
V
T
Site 95
T617
S
P
Q
P
K
I
V
T
P
Y
T
A
S
Q
P
Site 96
Y619
Q
P
K
I
V
T
P
Y
T
A
S
Q
P
S
P
Site 97
T620
P
K
I
V
T
P
Y
T
A
S
Q
P
S
P
P
Site 98
S622
I
V
T
P
Y
T
A
S
Q
P
S
P
P
L
P
Site 99
S625
P
Y
T
A
S
Q
P
S
P
P
L
P
P
P
P
Site 100
S651
P
P
P
P
P
L
P
S
Q
S
A
P
S
A
G
Site 101
S653
P
P
P
L
P
S
Q
S
A
P
S
A
G
S
A
Site 102
S659
Q
S
A
P
S
A
G
S
A
A
P
M
F
V
K
Site 103
S677
I
T
R
L
Q
N
A
S
Q
H
S
G
A
L
F
Site 104
T688
G
A
L
F
K
P
P
T
P
P
V
M
Q
S
Q
Site 105
S694
P
T
P
P
V
M
Q
S
Q
S
V
K
P
Q
I
Site 106
S696
P
P
V
M
Q
S
Q
S
V
K
P
Q
I
L
V
Site 107
T720
P
P
P
P
P
P
P
T
P
G
S
A
M
A
Q
Site 108
S723
P
P
P
P
T
P
G
S
A
M
A
Q
L
K
P
Site 109
S736
K
P
A
P
C
A
P
S
L
P
Q
F
S
A
P
Site 110
S741
A
P
S
L
P
Q
F
S
A
P
P
P
P
L
K
Site 111
T762
I
T
Q
V
A
P
P
T
P
P
P
P
P
P
I
Site 112
T793
P
A
P
T
S
T
K
T
V
A
P
V
V
T
Q
Site 113
T805
V
T
Q
A
A
P
P
T
P
T
P
P
V
P
P
Site 114
T807
Q
A
A
P
P
T
P
T
P
P
V
P
P
A
K
Site 115
S822
K
Q
P
A
F
P
A
S
Y
I
P
P
S
P
P
Site 116
Y823
Q
P
A
F
P
A
S
Y
I
P
P
S
P
P
T
Site 117
S827
P
A
S
Y
I
P
P
S
P
P
T
P
P
V
P
Site 118
T830
Y
I
P
P
S
P
P
T
P
P
V
P
V
P
P
Site 119
T839
P
V
P
V
P
P
P
T
L
P
K
Q
Q
S
F
Site 120
S845
P
T
L
P
K
Q
Q
S
F
C
A
K
P
P
P
Site 121
S853
F
C
A
K
P
P
P
S
P
L
S
P
V
P
S
Site 122
S856
K
P
P
P
S
P
L
S
P
V
P
S
V
V
K
Site 123
S867
S
V
V
K
Q
I
A
S
Q
F
P
P
P
P
T
Site 124
T874
S
Q
F
P
P
P
P
T
P
P
A
M
E
S
Q
Site 125
S880
P
T
P
P
A
M
E
S
Q
P
L
K
P
V
P
Site 126
S894
P
A
N
V
A
P
Q
S
P
P
A
V
K
A
K
Site 127
S907
A
K
P
K
W
Q
P
S
S
I
P
V
P
S
P
Site 128
S908
K
P
P
P
S
P
L
S
P
V
P
S
V
V
K
Site 129
S913
P
S
S
I
P
V
P
S
P
D
F
P
P
P
P
Site 130
S923
F
P
P
P
P
P
E
S
S
L
V
F
P
P
P
Site 131
S924
P
P
P
P
P
E
S
S
L
V
F
P
P
P
P
Site 132
S933
V
F
P
P
P
P
P
S
P
V
P
A
P
P
P
Site 133
T945
P
P
P
P
P
P
P
T
A
S
P
T
P
D
K
Site 134
S947
P
P
P
P
P
T
A
S
P
T
P
D
K
S
G
Site 135
T949
P
P
P
T
A
S
P
T
P
D
K
S
G
S
P
Site 136
S953
A
S
P
T
P
D
K
S
G
S
P
G
K
K
T
Site 137
S955
P
T
P
D
K
S
G
S
P
G
K
K
T
S
K
Site 138
T960
S
G
S
P
G
K
K
T
S
K
T
S
S
P
G
Site 139
S961
G
S
P
G
K
K
T
S
K
T
S
S
P
G
G
Site 140
T963
P
G
K
K
T
S
K
T
S
S
P
G
G
K
K
Site 141
S965
K
K
T
S
K
T
S
S
P
G
G
K
K
P
P
Site 142
T974
G
G
K
K
P
P
P
T
P
Q
R
N
S
S
I
Site 143
S979
P
P
T
P
Q
R
N
S
S
I
K
S
S
S
G
Site 144
S980
P
T
P
Q
R
N
S
S
I
K
S
S
S
G
A
Site 145
S983
Q
R
N
S
S
I
K
S
S
S
G
A
E
H
P
Site 146
S984
R
N
S
S
I
K
S
S
S
G
A
E
H
P
E
Site 147
S985
N
S
S
I
K
S
S
S
G
A
E
H
P
E
P
Site 148
S996
H
P
E
P
K
R
P
S
V
D
S
L
V
S
K
Site 149
S999
P
K
R
P
S
V
D
S
L
V
S
K
F
T
P
Site 150
S1002
P
S
V
D
S
L
V
S
K
F
T
P
P
A
E
Site 151
T1005
D
S
L
V
S
K
F
T
P
P
A
E
S
G
S
Site 152
S1010
K
F
T
P
P
A
E
S
G
S
P
S
K
E
T
Site 153
S1012
T
P
P
A
E
S
G
S
P
S
K
E
T
L
P
Site 154
S1014
P
A
E
S
G
S
P
S
K
E
T
L
P
P
P
Site 155
T1017
S
G
S
P
S
K
E
T
L
P
P
P
A
A
P
Site 156
S1033
K
P
G
K
L
N
L
S
G
V
N
L
P
G
V
Site 157
S1054
S
A
K
A
P
V
L
S
G
R
G
K
D
S
V
Site 158
S1060
L
S
G
R
G
K
D
S
V
V
E
F
P
S
P
Site 159
S1066
D
S
V
V
E
F
P
S
P
P
S
D
S
D
F
Site 160
S1069
V
E
F
P
S
P
P
S
D
S
D
F
P
P
P
Site 161
S1071
V
E
F
P
S
P
P
S
D
S
D
F
P
P
P
Site 162
T1080
F
P
P
P
P
P
E
T
E
L
P
L
P
P
I
Site 163
S1115
P
Q
Q
W
S
K
M
S
V
K
K
A
P
P
P
Site 164
S1130
T
R
P
K
R
N
D
S
T
R
L
T
Q
A
E
Site 165
T1134
R
N
D
S
T
R
L
T
Q
A
E
I
S
E
Q
Site 166
T1143
A
E
I
S
E
Q
P
T
M
A
T
V
V
P
Q
Site 167
T1146
S
E
Q
P
T
M
A
T
V
V
P
Q
V
P
T
Site 168
T1153
T
V
V
P
Q
V
P
T
S
P
K
S
S
L
S
Site 169
S1154
V
V
P
Q
V
P
T
S
P
K
S
S
L
S
V
Site 170
S1157
Q
V
P
T
S
P
K
S
S
L
S
V
Q
P
G
Site 171
S1158
V
P
T
S
P
K
S
S
L
S
V
Q
P
G
F
Site 172
S1160
T
S
P
K
S
S
L
S
V
Q
P
G
F
L
A
Site 173
T1172
F
L
A
D
L
N
R
T
L
Q
R
K
S
I
T
Site 174
S1177
N
R
T
L
Q
R
K
S
I
T
R
H
G
S
L
Site 175
T1179
T
L
Q
R
K
S
I
T
R
H
G
S
L
S
S
Site 176
S1183
K
S
I
T
R
H
G
S
L
S
S
R
M
S
R
Site 177
S1185
I
T
R
H
G
S
L
S
S
R
M
S
R
A
E
Site 178
S1189
G
S
L
S
S
R
M
S
R
A
E
P
T
A
T
Site 179
T1196
S
R
A
E
P
T
A
T
M
D
D
M
A
L
P
Site 180
S1211
P
P
P
P
E
L
L
S
D
Q
Q
K
A
G
Y
Site 181
S1224
G
Y
G
G
S
H
I
S
G
Y
A
T
L
R
R
Site 182
Y1226
G
G
S
H
I
S
G
Y
A
T
L
R
R
G
P
Site 183
T1228
S
H
I
S
G
Y
A
T
L
R
R
G
P
P
P
Site 184
T1244
P
P
K
R
D
Q
N
T
K
L
S
R
D
W
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation