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Updated November 2019
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Protein Info
Short Name:
PACS1
Full Name:
Phosphofurin acidic cluster sorting protein 1
Alias:
Cytosolic sorting protein PACS-1; FLJ10209; KIAA1175; PCS1_HUMAN
Type:
Adaptor/scaffold
Mass (Da):
104898
Number AA:
963
UniProt ID:
Q6VY07
International Prot ID:
IPI00376229
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
P
G
G
A
G
G
G
S
G
Q
R
G
S
G
V
Site 2
S23
G
G
S
G
Q
R
G
S
G
V
A
Q
S
P
Q
Site 3
S28
R
G
S
G
V
A
Q
S
P
Q
Q
P
P
P
Q
Site 4
T46
Q
Q
P
P
Q
Q
P
T
P
P
K
L
A
Q
A
Site 5
T54
P
P
K
L
A
Q
A
T
S
S
S
S
S
T
S
Site 6
S55
P
K
L
A
Q
A
T
S
S
S
S
S
T
S
A
Site 7
S56
K
L
A
Q
A
T
S
S
S
S
S
T
S
A
A
Site 8
S57
L
A
Q
A
T
S
S
S
S
S
T
S
A
A
A
Site 9
S59
Q
A
T
S
S
S
S
S
T
S
A
A
A
A
S
Site 10
T60
A
T
S
S
S
S
S
T
S
A
A
A
A
S
S
Site 11
S61
T
S
S
S
S
S
T
S
A
A
A
A
S
S
S
Site 12
S66
S
T
S
A
A
A
A
S
S
S
S
S
S
T
S
Site 13
S67
T
S
A
A
A
A
S
S
S
S
S
S
T
S
T
Site 14
S68
S
A
A
A
A
S
S
S
S
S
S
T
S
T
S
Site 15
S69
A
A
A
A
S
S
S
S
S
S
T
S
T
S
M
Site 16
S70
A
A
A
S
S
S
S
S
S
T
S
T
S
M
A
Site 17
S71
A
A
S
S
S
S
S
S
T
S
T
S
M
A
V
Site 18
T72
A
S
S
S
S
S
S
T
S
T
S
M
A
V
A
Site 19
S73
S
S
S
S
S
S
T
S
T
S
M
A
V
A
V
Site 20
T95
G
G
P
G
P
G
R
T
P
A
P
V
Q
M
N
Site 21
Y104
A
P
V
Q
M
N
L
Y
A
T
W
E
V
D
R
Site 22
S112
A
T
W
E
V
D
R
S
S
S
S
C
V
P
R
Site 23
S113
T
W
E
V
D
R
S
S
S
S
C
V
P
R
L
Site 24
S114
W
E
V
D
R
S
S
S
S
C
V
P
R
L
F
Site 25
S115
E
V
D
R
S
S
S
S
C
V
P
R
L
F
S
Site 26
T124
V
P
R
L
F
S
L
T
L
K
K
L
V
M
L
Site 27
S150
I
A
V
K
L
Q
G
S
K
R
I
L
R
S
N
Site 28
S156
G
S
K
R
I
L
R
S
N
E
I
V
L
P
A
Site 29
T174
V
E
T
E
L
Q
L
T
F
S
L
Q
Y
P
H
Site 30
Y200
M
L
Q
R
R
K
R
Y
K
N
R
T
I
L
G
Site 31
T204
R
K
R
Y
K
N
R
T
I
L
G
Y
K
T
L
Site 32
S242
H
S
N
V
K
D
V
S
V
P
V
A
E
I
K
Site 33
Y251
P
V
A
E
I
K
I
Y
S
L
S
S
Q
P
I
Site 34
S254
E
I
K
I
Y
S
L
S
S
Q
P
I
D
H
E
Site 35
S255
I
K
I
Y
S
L
S
S
Q
P
I
D
H
E
G
Site 36
S265
I
D
H
E
G
I
K
S
K
L
S
D
R
S
P
Site 37
S268
E
G
I
K
S
K
L
S
D
R
S
P
D
I
D
Site 38
S271
K
S
K
L
S
D
R
S
P
D
I
D
N
Y
S
Site 39
Y277
R
S
P
D
I
D
N
Y
S
E
E
E
E
E
S
Site 40
S278
S
P
D
I
D
N
Y
S
E
E
E
E
E
S
F
Site 41
S284
Y
S
E
E
E
E
E
S
F
S
S
E
Q
E
G
Site 42
S286
E
E
E
E
E
S
F
S
S
E
Q
E
G
S
D
Site 43
S287
E
E
E
E
S
F
S
S
E
Q
E
G
S
D
D
Site 44
S292
F
S
S
E
Q
E
G
S
D
D
P
L
H
G
Q
Site 45
Y303
L
H
G
Q
D
L
F
Y
E
D
E
D
L
R
K
Site 46
T314
D
L
R
K
V
K
K
T
R
R
K
L
T
S
T
Site 47
T319
K
K
T
R
R
K
L
T
S
T
S
A
I
T
R
Site 48
S320
K
T
R
R
K
L
T
S
T
S
A
I
T
R
Q
Site 49
T321
T
R
R
K
L
T
S
T
S
A
I
T
R
Q
P
Site 50
S322
R
R
K
L
T
S
T
S
A
I
T
R
Q
P
N
Site 51
S355
G
F
G
L
E
H
V
S
R
E
Q
I
R
E
V
Site 52
Y370
E
E
D
L
D
E
L
Y
D
S
L
E
M
Y
N
Site 53
S372
D
L
D
E
L
Y
D
S
L
E
M
Y
N
P
S
Site 54
Y376
L
Y
D
S
L
E
M
Y
N
P
S
D
S
G
P
Site 55
S379
S
L
E
M
Y
N
P
S
D
S
G
P
E
M
E
Site 56
S381
E
M
Y
N
P
S
D
S
G
P
E
M
E
E
T
Site 57
T388
S
G
P
E
M
E
E
T
E
S
I
L
S
T
P
Site 58
S390
P
E
M
E
E
T
E
S
I
L
S
T
P
K
P
Site 59
S393
E
E
T
E
S
I
L
S
T
P
K
P
K
L
K
Site 60
T394
E
T
E
S
I
L
S
T
P
K
P
K
L
K
P
Site 61
S407
K
P
F
F
E
G
M
S
Q
S
S
S
Q
T
E
Site 62
S409
F
F
E
G
M
S
Q
S
S
S
Q
T
E
I
G
Site 63
S410
F
E
G
M
S
Q
S
S
S
Q
T
E
I
G
S
Site 64
S411
E
G
M
S
Q
S
S
S
Q
T
E
I
G
S
L
Site 65
T413
M
S
Q
S
S
S
Q
T
E
I
G
S
L
N
S
Site 66
S417
S
S
Q
T
E
I
G
S
L
N
S
K
G
S
L
Site 67
S423
G
S
L
N
S
K
G
S
L
G
K
D
T
T
S
Site 68
T428
K
G
S
L
G
K
D
T
T
S
P
M
E
L
A
Site 69
T429
G
S
L
G
K
D
T
T
S
P
M
E
L
A
A
Site 70
S430
S
L
G
K
D
T
T
S
P
M
E
L
A
A
L
Site 71
S442
A
A
L
E
K
I
K
S
T
W
I
K
N
Q
D
Site 72
S451
W
I
K
N
Q
D
D
S
L
T
E
T
D
T
L
Site 73
T453
K
N
Q
D
D
S
L
T
E
T
D
T
L
E
I
Site 74
T455
Q
D
D
S
L
T
E
T
D
T
L
E
I
T
D
Site 75
T457
D
S
L
T
E
T
D
T
L
E
I
T
D
Q
D
Site 76
T481
V
V
P
E
K
V
K
T
P
M
K
S
S
K
T
Site 77
S485
K
V
K
T
P
M
K
S
S
K
T
D
L
Q
G
Site 78
T488
T
P
M
K
S
S
K
T
D
L
Q
G
S
A
S
Site 79
S493
S
K
T
D
L
Q
G
S
A
S
P
S
K
V
E
Site 80
S495
T
D
L
Q
G
S
A
S
P
S
K
V
E
G
V
Site 81
S497
L
Q
G
S
A
S
P
S
K
V
E
G
V
H
T
Site 82
T504
S
K
V
E
G
V
H
T
P
R
Q
K
R
S
T
Site 83
S510
H
T
P
R
Q
K
R
S
T
P
L
K
E
R
Q
Site 84
T511
T
P
R
Q
K
R
S
T
P
L
K
E
R
Q
L
Site 85
S519
P
L
K
E
R
Q
L
S
K
P
L
S
E
R
T
Site 86
S523
R
Q
L
S
K
P
L
S
E
R
T
N
S
S
D
Site 87
T526
S
K
P
L
S
E
R
T
N
S
S
D
S
E
R
Site 88
S528
P
L
S
E
R
T
N
S
S
D
S
E
R
S
P
Site 89
S529
L
S
E
R
T
N
S
S
D
S
E
R
S
P
D
Site 90
S531
E
R
T
N
S
S
D
S
E
R
S
P
D
L
G
Site 91
S534
N
S
S
D
S
E
R
S
P
D
L
G
H
S
T
Site 92
T541
S
P
D
L
G
H
S
T
Q
I
P
R
K
V
V
Site 93
S558
Q
L
N
Q
I
L
V
S
D
A
A
L
P
E
N
Site 94
Y578
T
T
D
W
Q
G
Q
Y
V
A
E
L
L
Q
D
Site 95
Y613
L
L
T
R
I
Q
R
Y
C
N
C
N
S
S
M
Site 96
S645
I
L
R
F
F
V
K
S
L
A
N
K
T
S
D
Site 97
S651
K
S
L
A
N
K
T
S
D
W
L
G
Y
M
R
Site 98
Y672
G
S
H
P
V
A
K
Y
L
G
S
V
D
S
K
Site 99
S675
P
V
A
K
Y
L
G
S
V
D
S
K
Y
S
S
Site 100
S678
K
Y
L
G
S
V
D
S
K
Y
S
S
S
F
L
Site 101
Y680
L
G
S
V
D
S
K
Y
S
S
S
F
L
D
S
Site 102
S681
G
S
V
D
S
K
Y
S
S
S
F
L
D
S
G
Site 103
S682
S
V
D
S
K
Y
S
S
S
F
L
D
S
G
W
Site 104
S683
V
D
S
K
Y
S
S
S
F
L
D
S
G
W
R
Site 105
S687
Y
S
S
S
F
L
D
S
G
W
R
D
L
F
S
Site 106
S694
S
G
W
R
D
L
F
S
R
S
E
P
P
V
S
Site 107
S696
W
R
D
L
F
S
R
S
E
P
P
V
S
E
Q
Site 108
S701
S
R
S
E
P
P
V
S
E
Q
L
D
V
A
G
Site 109
T731
P
V
A
E
A
M
L
T
C
R
H
K
F
P
D
Site 110
Y742
K
F
P
D
E
D
S
Y
Q
K
F
I
P
F
I
Site 111
S760
K
V
G
L
V
E
D
S
P
S
T
A
G
D
G
Site 112
S762
G
L
V
E
D
S
P
S
T
A
G
D
G
D
D
Site 113
T763
L
V
E
D
S
P
S
T
A
G
D
G
D
D
S
Site 114
S770
T
A
G
D
G
D
D
S
P
V
V
S
L
T
V
Site 115
S774
G
D
D
S
P
V
V
S
L
T
V
P
S
T
S
Site 116
T776
D
S
P
V
V
S
L
T
V
P
S
T
S
P
P
Site 117
S779
V
V
S
L
T
V
P
S
T
S
P
P
S
S
S
Site 118
T780
V
S
L
T
V
P
S
T
S
P
P
S
S
S
G
Site 119
S781
S
L
T
V
P
S
T
S
P
P
S
S
S
G
L
Site 120
S784
V
P
S
T
S
P
P
S
S
S
G
L
S
R
D
Site 121
S785
P
S
T
S
P
P
S
S
S
G
L
S
R
D
A
Site 122
S786
S
T
S
P
P
S
S
S
G
L
S
R
D
A
T
Site 123
S789
P
P
S
S
S
G
L
S
R
D
A
T
A
T
P
Site 124
T793
S
G
L
S
R
D
A
T
A
T
P
P
S
S
P
Site 125
T795
L
S
R
D
A
T
A
T
P
P
S
S
P
S
M
Site 126
S798
D
A
T
A
T
P
P
S
S
P
S
M
S
S
A
Site 127
S799
A
T
A
T
P
P
S
S
P
S
M
S
S
A
L
Site 128
S811
S
A
L
A
I
V
G
S
P
N
S
P
Y
G
D
Site 129
Y816
V
G
S
P
N
S
P
Y
G
D
V
I
G
L
Q
Site 130
S844
E
G
D
K
R
D
A
S
S
K
N
T
L
K
S
Site 131
S845
G
D
K
R
D
A
S
S
K
N
T
L
K
S
V
Site 132
T848
R
D
A
S
S
K
N
T
L
K
S
V
F
R
S
Site 133
S851
S
S
K
N
T
L
K
S
V
F
R
S
V
Q
V
Site 134
S855
T
L
K
S
V
F
R
S
V
Q
V
S
R
L
P
Site 135
S859
V
F
R
S
V
Q
V
S
R
L
P
H
S
G
E
Site 136
S864
Q
V
S
R
L
P
H
S
G
E
A
Q
L
S
G
Site 137
S870
H
S
G
E
A
Q
L
S
G
T
M
A
M
T
V
Site 138
T876
L
S
G
T
M
A
M
T
V
V
T
K
E
K
N
Site 139
S892
K
V
P
T
I
F
L
S
K
K
P
R
E
K
E
Site 140
S902
P
R
E
K
E
V
D
S
K
S
Q
V
I
E
G
Site 141
S904
E
K
E
V
D
S
K
S
Q
V
I
E
G
I
S
Site 142
T922
C
S
A
K
Q
Q
Q
T
M
L
R
V
S
I
D
Site 143
S927
Q
Q
T
M
L
R
V
S
I
D
G
V
E
W
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation