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Updated November 2019
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Protein Info
Short Name:
LARP1
Full Name:
La-related protein 1
Alias:
KIAA0731; La ribonucleoprotein domain family 1; La ribonucleoprotein domain family, member 1; La-related protein 1: La ribonucleoprotein domain family member 1: La-related protein 1: La ribonucleoprotein domain family member 1: La-related protein 1: La ribonucleoprotein domain family member 1; LARP; MGC19556
Type:
RNA binding protein
Mass (Da):
123510
Number AA:
1096
UniProt ID:
Q6PKG0
International Prot ID:
IPI00185919
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S52
R
G
G
E
P
D
G
S
A
R
R
P
R
P
P
Site 2
T68
A
K
P
H
K
E
G
T
G
Q
Q
E
R
E
S
Site 3
S75
T
G
Q
Q
E
R
E
S
P
R
P
L
Q
L
P
Site 4
S90
G
A
E
G
P
A
I
S
D
G
E
E
G
G
G
Site 5
T128
P
P
K
V
N
P
W
T
K
N
A
L
P
P
V
Site 6
T137
N
A
L
P
P
V
L
T
T
V
N
G
Q
S
P
Site 7
T138
A
L
P
P
V
L
T
T
V
N
G
Q
S
P
P
Site 8
S143
L
T
T
V
N
G
Q
S
P
P
E
H
S
A
P
Site 9
S148
G
Q
S
P
P
E
H
S
A
P
A
K
V
V
R
Site 10
S165
V
P
K
Q
R
K
G
S
K
V
G
D
F
G
D
Site 11
T178
G
D
A
I
N
W
P
T
P
G
E
I
A
H
K
Site 12
S186
P
G
E
I
A
H
K
S
V
Q
P
Q
S
H
K
Site 13
S191
H
K
S
V
Q
P
Q
S
H
K
P
Q
P
T
R
Site 14
S215
E
Q
E
K
G
E
G
S
D
S
K
E
S
P
K
Site 15
S217
E
K
G
E
G
S
D
S
K
E
S
P
K
T
K
Site 16
S220
E
G
S
D
S
K
E
S
P
K
T
K
S
D
E
Site 17
T223
D
S
K
E
S
P
K
T
K
S
D
E
S
G
E
Site 18
S225
K
E
S
P
K
T
K
S
D
E
S
G
E
E
K
Site 19
S228
P
K
T
K
S
D
E
S
G
E
E
K
N
G
D
Site 20
S270
V
P
R
E
K
L
A
S
R
P
T
R
P
P
E
Site 21
T273
E
K
L
A
S
R
P
T
R
P
P
E
P
R
H
Site 22
S291
N
R
G
E
I
K
G
S
E
S
A
T
Y
V
P
Site 23
T295
I
K
G
S
E
S
A
T
Y
V
P
V
A
P
P
Site 24
Y296
K
G
S
E
S
A
T
Y
V
P
V
A
P
P
T
Site 25
T303
Y
V
P
V
A
P
P
T
P
A
W
Q
P
E
I
Site 26
T322
A
W
H
D
Q
D
E
T
S
S
V
K
S
D
G
Site 27
S323
W
H
D
Q
D
E
T
S
S
V
K
S
D
G
A
Site 28
S324
H
D
Q
D
E
T
S
S
V
K
S
D
G
A
G
Site 29
S327
D
E
T
S
S
V
K
S
D
G
A
G
G
A
R
Site 30
S336
G
A
G
G
A
R
A
S
F
R
G
R
G
R
G
Site 31
T355
R
G
R
G
R
G
G
T
R
T
H
F
D
Y
Q
Site 32
T357
R
G
R
G
G
T
R
T
H
F
D
Y
Q
F
G
Site 33
Y361
G
T
R
T
H
F
D
Y
Q
F
G
Y
R
K
F
Site 34
Y365
H
F
D
Y
Q
F
G
Y
R
K
F
D
G
V
E
Site 35
T376
D
G
V
E
G
P
R
T
P
K
Y
M
N
N
I
Site 36
Y379
E
G
P
R
T
P
K
Y
M
N
N
I
T
Y
Y
Site 37
Y385
K
Y
M
N
N
I
T
Y
Y
F
D
N
V
S
S
Site 38
Y386
Y
M
N
N
I
T
Y
Y
F
D
N
V
S
S
T
Site 39
S391
T
Y
Y
F
D
N
V
S
S
T
E
L
Y
S
V
Site 40
S392
Y
Y
F
D
N
V
S
S
T
E
L
Y
S
V
D
Site 41
T393
Y
F
D
N
V
S
S
T
E
L
Y
S
V
D
Q
Site 42
Y396
N
V
S
S
T
E
L
Y
S
V
D
Q
E
L
L
Site 43
S397
V
S
S
T
E
L
Y
S
V
D
Q
E
L
L
K
Site 44
Y406
D
Q
E
L
L
K
D
Y
I
K
R
Q
I
E
Y
Site 45
Y414
I
K
R
Q
I
E
Y
Y
F
S
V
D
N
L
E
Site 46
S416
R
Q
I
E
Y
Y
F
S
V
D
N
L
E
R
D
Site 47
Y491
P
L
P
P
I
V
D
Y
S
Q
T
D
F
S
Q
Site 48
S492
L
P
P
I
V
D
Y
S
Q
T
D
F
S
Q
L
Site 49
S497
D
Y
S
Q
T
D
F
S
Q
L
L
N
C
P
E
Site 50
Y511
E
F
V
P
R
Q
H
Y
Q
K
E
T
E
S
A
Site 51
T515
R
Q
H
Y
Q
K
E
T
E
S
A
P
G
S
P
Site 52
S517
H
Y
Q
K
E
T
E
S
A
P
G
S
P
R
A
Site 53
S521
E
T
E
S
A
P
G
S
P
R
A
V
T
P
V
Site 54
T526
P
G
S
P
R
A
V
T
P
V
P
T
K
T
E
Site 55
T530
R
A
V
T
P
V
P
T
K
T
E
E
V
S
N
Site 56
T532
V
T
P
V
P
T
K
T
E
E
V
S
N
L
K
Site 57
T540
E
E
V
S
N
L
K
T
L
P
K
G
L
S
A
Site 58
S546
K
T
L
P
K
G
L
S
A
S
L
P
D
L
D
Site 59
S548
L
P
K
G
L
S
A
S
L
P
D
L
D
S
E
Site 60
S554
A
S
L
P
D
L
D
S
E
N
W
I
E
V
K
Site 61
S567
V
K
K
R
P
R
P
S
P
A
R
P
K
K
S
Site 62
S574
S
P
A
R
P
K
K
S
E
E
S
R
F
S
H
Site 63
S577
R
P
K
K
S
E
E
S
R
F
S
H
L
T
S
Site 64
S580
K
S
E
E
S
R
F
S
H
L
T
S
L
P
Q
Site 65
T583
E
S
R
F
S
H
L
T
S
L
P
Q
Q
L
P
Site 66
S584
S
R
F
S
H
L
T
S
L
P
Q
Q
L
P
S
Site 67
S591
S
L
P
Q
Q
L
P
S
Q
Q
L
M
S
K
D
Site 68
S596
L
P
S
Q
Q
L
M
S
K
D
Q
D
E
Q
E
Site 69
T622
Q
M
D
G
R
K
N
T
F
T
A
W
S
D
E
Site 70
T624
D
G
R
K
N
T
F
T
A
W
S
D
E
E
S
Site 71
S627
K
N
T
F
T
A
W
S
D
E
E
S
D
Y
E
Site 72
S631
T
A
W
S
D
E
E
S
D
Y
E
I
D
D
R
Site 73
Y633
W
S
D
E
E
S
D
Y
E
I
D
D
R
D
V
Site 74
T647
V
N
K
I
L
I
V
T
Q
T
P
H
Y
M
R
Site 75
T649
K
I
L
I
V
T
Q
T
P
H
Y
M
R
R
H
Site 76
Y652
I
V
T
Q
T
P
H
Y
M
R
R
H
P
G
G
Site 77
T662
R
H
P
G
G
D
R
T
G
N
H
T
S
R
A
Site 78
T666
G
D
R
T
G
N
H
T
S
R
A
K
M
S
A
Site 79
S667
D
R
T
G
N
H
T
S
R
A
K
M
S
A
E
Site 80
Y685
V
I
N
D
G
L
F
Y
Y
E
Q
D
L
W
A
Site 81
Y686
I
N
D
G
L
F
Y
Y
E
Q
D
L
W
A
E
Site 82
Y699
A
E
K
F
E
P
E
Y
S
Q
I
K
Q
E
V
Site 83
S700
E
K
F
E
P
E
Y
S
Q
I
K
Q
E
V
E
Site 84
S716
F
K
K
V
N
M
I
S
R
E
Q
F
D
T
L
Site 85
T722
I
S
R
E
Q
F
D
T
L
T
P
E
P
P
V
Site 86
T724
R
E
Q
F
D
T
L
T
P
E
P
P
V
D
P
Site 87
S761
L
F
G
A
P
E
P
S
T
I
A
R
S
L
P
Site 88
T762
F
G
A
P
E
P
S
T
I
A
R
S
L
P
T
Site 89
S766
E
P
S
T
I
A
R
S
L
P
T
T
V
P
E
Site 90
T769
T
I
A
R
S
L
P
T
T
V
P
E
S
P
N
Site 91
T770
I
A
R
S
L
P
T
T
V
P
E
S
P
N
Y
Site 92
S774
L
P
T
T
V
P
E
S
P
N
Y
R
N
T
R
Site 93
Y777
T
V
P
E
S
P
N
Y
R
N
T
R
T
P
R
Site 94
T780
E
S
P
N
Y
R
N
T
R
T
P
R
T
P
R
Site 95
T782
P
N
Y
R
N
T
R
T
P
R
T
P
R
T
P
Site 96
T785
R
N
T
R
T
P
R
T
P
R
T
P
Q
L
K
Site 97
T788
R
T
P
R
T
P
R
T
P
Q
L
K
D
S
S
Site 98
S794
R
T
P
Q
L
K
D
S
S
Q
T
S
R
F
Y
Site 99
S795
T
P
Q
L
K
D
S
S
Q
T
S
R
F
Y
P
Site 100
S798
L
K
D
S
S
Q
T
S
R
F
Y
P
V
V
K
Site 101
Y801
S
S
Q
T
S
R
F
Y
P
V
V
K
E
G
R
Site 102
T820
K
M
P
R
K
R
K
T
R
H
S
S
N
P
P
Site 103
S823
R
K
R
K
T
R
H
S
S
N
P
P
L
E
S
Site 104
S824
K
R
K
T
R
H
S
S
N
P
P
L
E
S
H
Site 105
S830
S
S
N
P
P
L
E
S
H
V
G
W
V
M
D
Site 106
S838
H
V
G
W
V
M
D
S
R
E
H
R
P
R
T
Site 107
T845
S
R
E
H
R
P
R
T
A
S
I
S
S
S
P
Site 108
S847
E
H
R
P
R
T
A
S
I
S
S
S
P
S
E
Site 109
S849
R
P
R
T
A
S
I
S
S
S
P
S
E
G
T
Site 110
S850
P
R
T
A
S
I
S
S
S
P
S
E
G
T
P
Site 111
S851
R
T
A
S
I
S
S
S
P
S
E
G
T
P
T
Site 112
S853
A
S
I
S
S
S
P
S
E
G
T
P
T
V
G
Site 113
T856
S
S
S
P
S
E
G
T
P
T
V
G
S
Y
G
Site 114
T858
S
P
S
E
G
T
P
T
V
G
S
Y
G
C
T
Site 115
S861
E
G
T
P
T
V
G
S
Y
G
C
T
P
Q
S
Site 116
Y862
G
T
P
T
V
G
S
Y
G
C
T
P
Q
S
L
Site 117
T865
T
V
G
S
Y
G
C
T
P
Q
S
L
P
K
F
Site 118
S868
S
Y
G
C
T
P
Q
S
L
P
K
F
Q
H
P
Site 119
S876
L
P
K
F
Q
H
P
S
H
E
L
L
K
E
N
Site 120
Y890
N
G
F
T
Q
H
V
Y
H
K
Y
R
R
R
C
Site 121
Y893
T
Q
H
V
Y
H
K
Y
R
R
R
C
L
N
E
Site 122
S909
K
R
L
G
I
G
Q
S
Q
E
M
N
T
L
F
Site 123
Y932
D
H
F
N
K
K
M
Y
E
E
F
K
Q
L
A
Site 124
Y949
D
A
K
E
G
Y
R
Y
G
L
E
C
L
F
R
Site 125
Y957
G
L
E
C
L
F
R
Y
Y
S
Y
G
L
E
K
Site 126
Y958
L
E
C
L
F
R
Y
Y
S
Y
G
L
E
K
K
Site 127
S959
E
C
L
F
R
Y
Y
S
Y
G
L
E
K
K
F
Site 128
T978
F
K
D
F
Q
E
E
T
V
K
D
Y
E
A
G
Site 129
Y982
Q
E
E
T
V
K
D
Y
E
A
G
Q
L
Y
G
Site 130
Y1014
I
D
P
K
L
Q
E
Y
L
G
K
F
R
R
L
Site 131
S1040
E
G
N
H
K
R
H
S
V
V
A
G
G
G
G
Site 132
S1056
E
G
R
K
R
C
P
S
Q
S
S
S
R
P
A
Site 133
S1058
R
K
R
C
P
S
Q
S
S
S
R
P
A
A
M
Site 134
S1059
K
R
C
P
S
Q
S
S
S
R
P
A
A
M
I
Site 135
S1060
R
C
P
S
Q
S
S
S
R
P
A
A
M
I
S
Site 136
S1067
S
R
P
A
A
M
I
S
Q
P
P
T
P
P
T
Site 137
T1071
A
M
I
S
Q
P
P
T
P
P
T
G
Q
P
V
Site 138
T1074
S
Q
P
P
T
P
P
T
G
Q
P
V
R
E
D
Site 139
T1085
V
R
E
D
A
K
W
T
S
Q
H
S
N
T
Q
Site 140
S1086
R
E
D
A
K
W
T
S
Q
H
S
N
T
Q
T
Site 141
S1089
A
K
W
T
S
Q
H
S
N
T
Q
T
L
G
K
Site 142
T1091
W
T
S
Q
H
S
N
T
Q
T
L
G
K
_
_
Site 143
T1093
S
Q
H
S
N
T
Q
T
L
G
K
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation