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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZCCHC8
Full Name:
Zinc finger CCHC domain-containing protein 8
Alias:
DKFZp434E2220; FLJ90157; ZCHC8; zinc finger CCHC domain-containing 8; zinc finger, CCHC domain containing 8
Type:
Mass (Da):
78577
Number AA:
707
UniProt ID:
Q6NZY4
International Prot ID:
IPI00556594
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005681
GO:0030529
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006396
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
P
F
D
H
P
E
E
S
I
P
K
P
V
H
T
Site 2
T59
R
L
R
Q
C
E
E
T
I
E
Q
L
R
A
E
Site 3
T88
S
G
I
L
V
N
D
T
K
L
D
G
P
I
L
Site 4
S117
Q
E
I
E
E
F
V
S
N
L
V
K
R
F
E
Site 5
S135
K
N
D
V
E
K
T
S
F
N
L
L
P
Q
P
Site 6
S143
F
N
L
L
P
Q
P
S
S
I
V
L
E
E
D
Site 7
S144
N
L
L
P
Q
P
S
S
I
V
L
E
E
D
H
Site 8
S167
K
N
N
K
E
A
F
S
V
V
G
S
V
L
Y
Site 9
S195
L
N
E
N
P
Q
L
S
E
G
W
E
I
P
K
Site 10
Y203
E
G
W
E
I
P
K
Y
H
Q
V
F
S
H
I
Site 11
S208
P
K
Y
H
Q
V
F
S
H
I
V
S
L
E
G
Site 12
S212
Q
V
F
S
H
I
V
S
L
E
G
Q
E
I
Q
Site 13
S252
P
R
N
A
A
R
I
S
E
K
R
K
E
Y
M
Site 14
Y258
I
S
E
K
R
K
E
Y
M
D
A
C
G
E
A
Site 15
Y311
K
S
L
P
P
F
I
Y
R
M
R
Q
L
G
Y
Site 16
Y318
Y
R
M
R
Q
L
G
Y
P
P
G
W
L
K
E
Site 17
S331
K
E
A
E
L
E
N
S
G
L
A
L
Y
D
G
Site 18
Y336
E
N
S
G
L
A
L
Y
D
G
K
D
G
T
D
Site 19
T342
L
Y
D
G
K
D
G
T
D
G
E
T
E
V
G
Site 20
T346
K
D
G
T
D
G
E
T
E
V
G
E
I
Q
Q
Site 21
S356
G
E
I
Q
Q
N
K
S
V
T
Y
D
L
S
K
Site 22
S362
K
S
V
T
Y
D
L
S
K
L
V
N
Y
P
G
Site 23
Y367
D
L
S
K
L
V
N
Y
P
G
F
N
I
S
T
Site 24
S373
N
Y
P
G
F
N
I
S
T
P
R
G
I
P
D
Site 25
T374
Y
P
G
F
N
I
S
T
P
R
G
I
P
D
E
Site 26
Y402
Q
K
D
V
F
A
N
Y
L
T
S
N
F
Q
A
Site 27
S414
F
Q
A
P
G
V
K
S
G
N
K
R
S
S
S
Site 28
S419
V
K
S
G
N
K
R
S
S
S
H
S
S
P
G
Site 29
S420
K
S
G
N
K
R
S
S
S
H
S
S
P
G
S
Site 30
S421
S
G
N
K
R
S
S
S
H
S
S
P
G
S
P
Site 31
S423
N
K
R
S
S
S
H
S
S
P
G
S
P
K
K
Site 32
S424
K
R
S
S
S
H
S
S
P
G
S
P
K
K
Q
Site 33
S427
S
S
H
S
S
P
G
S
P
K
K
Q
K
N
E
Site 34
S435
P
K
K
Q
K
N
E
S
N
S
A
G
S
P
A
Site 35
S440
N
E
S
N
S
A
G
S
P
A
D
M
E
L
D
Site 36
S448
P
A
D
M
E
L
D
S
D
M
E
V
P
H
G
Site 37
S456
D
M
E
V
P
H
G
S
Q
S
S
E
S
F
Q
Site 38
S458
E
V
P
H
G
S
Q
S
S
E
S
F
Q
F
Q
Site 39
S459
V
P
H
G
S
Q
S
S
E
S
F
Q
F
Q
P
Site 40
S461
H
G
S
Q
S
S
E
S
F
Q
F
Q
P
P
L
Site 41
T472
Q
P
P
L
P
P
D
T
P
P
L
P
R
G
T
Site 42
T479
T
P
P
L
P
R
G
T
P
P
P
V
F
T
P
Site 43
T485
G
T
P
P
P
V
F
T
P
P
L
P
K
G
T
Site 44
T492
T
P
P
L
P
K
G
T
P
P
L
T
P
S
D
Site 45
T496
P
K
G
T
P
P
L
T
P
S
D
S
P
Q
T
Site 46
S498
G
T
P
P
L
T
P
S
D
S
P
Q
T
R
T
Site 47
S500
P
P
L
T
P
S
D
S
P
Q
T
R
T
A
S
Site 48
T503
T
P
S
D
S
P
Q
T
R
T
A
S
G
A
V
Site 49
S507
S
P
Q
T
R
T
A
S
G
A
V
D
E
D
A
Site 50
T516
A
V
D
E
D
A
L
T
L
E
E
L
E
E
Q
Site 51
S536
A
A
L
E
Q
A
E
S
V
N
S
D
S
D
V
Site 52
S539
E
Q
A
E
S
V
N
S
D
S
D
V
P
V
D
Site 53
S541
A
E
S
V
N
S
D
S
D
V
P
V
D
T
P
Site 54
T547
D
S
D
V
P
V
D
T
P
L
T
G
N
S
V
Site 55
S553
D
T
P
L
T
G
N
S
V
A
S
S
P
C
P
Site 56
S557
T
G
N
S
V
A
S
S
P
C
P
N
E
L
D
Site 57
S573
P
V
P
E
G
K
T
S
E
K
Q
T
L
D
E
Site 58
T577
G
K
T
S
E
K
Q
T
L
D
E
P
E
V
P
Site 59
S591
P
E
I
F
T
K
K
S
E
A
G
H
A
S
S
Site 60
S597
K
S
E
A
G
H
A
S
S
P
D
S
E
V
T
Site 61
S598
S
E
A
G
H
A
S
S
P
D
S
E
V
T
S
Site 62
S601
G
H
A
S
S
P
D
S
E
V
T
S
L
C
Q
Site 63
S605
S
P
D
S
E
V
T
S
L
C
Q
K
E
K
A
Site 64
S636
V
V
P
N
C
D
I
S
N
G
G
S
Q
K
L
Site 65
S640
C
D
I
S
N
G
G
S
Q
K
L
F
P
A
D
Site 66
T648
Q
K
L
F
P
A
D
T
S
P
S
T
A
T
K
Site 67
S649
K
L
F
P
A
D
T
S
P
S
T
A
T
K
I
Site 68
T652
P
A
D
T
S
P
S
T
A
T
K
I
H
S
P
Site 69
T654
D
T
S
P
S
T
A
T
K
I
H
S
P
I
P
Site 70
S658
S
T
A
T
K
I
H
S
P
I
P
D
M
S
K
Site 71
S664
H
S
P
I
P
D
M
S
K
F
A
T
G
I
T
Site 72
T668
P
D
M
S
K
F
A
T
G
I
T
P
F
E
F
Site 73
T671
S
K
F
A
T
G
I
T
P
F
E
F
E
N
M
Site 74
Y685
M
A
E
S
T
G
M
Y
L
R
I
R
S
L
L
Site 75
S690
G
M
Y
L
R
I
R
S
L
L
K
N
S
P
R
Site 76
S695
I
R
S
L
L
K
N
S
P
R
N
Q
Q
K
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation