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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP17
Full Name:
Rho GTPase-activating protein 17
Alias:
NADRIN; Neuron-associated developmentally regulated protein; RHG17; Rho GTPase activating protein 17; RhoGAP interacting with CIP4 homologues 1; RICH1; RICH1B; WBP15
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
95437
Number AA:
881
UniProt ID:
Q68EM7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
GO:0005923
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0017124
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
T
V
G
R
A
E
K
T
E
V
L
S
E
D
L
Site 2
T38
Q
I
E
R
R
L
D
T
V
R
S
I
C
H
H
Site 3
S41
R
R
L
D
T
V
R
S
I
C
H
H
S
H
K
Site 4
T72
R
H
K
K
L
P
L
T
A
L
A
Q
N
M
Q
Site 5
S88
A
S
T
Q
L
E
D
S
L
L
G
K
M
L
E
Site 6
S109
N
Q
L
A
L
E
L
S
Q
H
E
V
F
V
E
Site 7
Y124
K
E
I
V
D
P
L
Y
G
I
A
E
V
E
I
Site 8
S161
R
W
N
Q
A
H
K
S
S
G
T
N
F
Q
G
Site 9
S162
W
N
Q
A
H
K
S
S
G
T
N
F
Q
G
L
Site 10
T175
G
L
P
S
K
I
D
T
L
K
E
E
M
D
E
Site 11
Y199
D
Q
L
A
A
D
M
Y
N
F
M
A
K
E
G
Site 12
Y222
L
L
E
A
Q
A
D
Y
H
R
K
A
L
A
V
Site 13
T252
A
E
K
P
A
F
G
T
P
L
E
E
H
L
K
Site 14
S306
L
K
A
A
L
D
C
S
T
S
H
L
D
E
F
Site 15
S308
A
A
L
D
C
S
T
S
H
L
D
E
F
Y
S
Site 16
Y314
T
S
H
L
D
E
F
Y
S
D
P
H
A
V
A
Site 17
S315
S
H
L
D
E
F
Y
S
D
P
H
A
V
A
G
Site 18
Y327
V
A
G
A
L
K
S
Y
L
R
E
L
P
E
P
Site 19
T337
E
L
P
E
P
L
M
T
F
N
L
Y
E
E
W
Site 20
Y341
P
L
M
T
F
N
L
Y
E
E
W
T
Q
V
A
Site 21
S389
L
A
K
L
A
Q
T
S
D
V
N
K
M
T
P
Site 22
T395
T
S
D
V
N
K
M
T
P
S
N
I
A
I
V
Site 23
T458
S
E
A
F
V
P
L
T
T
P
S
S
N
H
S
Site 24
T459
E
A
F
V
P
L
T
T
P
S
S
N
H
S
F
Site 25
S461
F
V
P
L
T
T
P
S
S
N
H
S
F
H
T
Site 26
S462
V
P
L
T
T
P
S
S
N
H
S
F
H
T
G
Site 27
S465
T
T
P
S
S
N
H
S
F
H
T
G
N
D
S
Site 28
T468
S
S
N
H
S
F
H
T
G
N
D
S
D
S
G
Site 29
S472
S
F
H
T
G
N
D
S
D
S
G
T
L
E
R
Site 30
S474
H
T
G
N
D
S
D
S
G
T
L
E
R
K
R
Site 31
T476
G
N
D
S
D
S
G
T
L
E
R
K
R
P
A
Site 32
S484
L
E
R
K
R
P
A
S
M
A
V
M
E
G
D
Site 33
S497
G
D
L
V
K
K
E
S
F
G
V
K
L
M
D
Site 34
T513
Q
A
H
R
R
G
G
T
L
N
R
K
H
I
S
Site 35
S520
T
L
N
R
K
H
I
S
P
A
F
Q
P
P
L
Site 36
T530
F
Q
P
P
L
P
P
T
D
G
S
T
V
V
P
Site 37
S533
P
L
P
P
T
D
G
S
T
V
V
P
A
G
P
Site 38
T534
L
P
P
T
D
G
S
T
V
V
P
A
G
P
E
Site 39
S546
G
P
E
P
P
P
Q
S
S
R
A
E
S
S
S
Site 40
S547
P
E
P
P
P
Q
S
S
R
A
E
S
S
S
G
Site 41
S551
P
Q
S
S
R
A
E
S
S
S
G
G
G
T
V
Site 42
S553
S
S
R
A
E
S
S
S
G
G
G
T
V
P
S
Site 43
T557
E
S
S
S
G
G
G
T
V
P
S
S
A
G
I
Site 44
S560
S
G
G
G
T
V
P
S
S
A
G
I
L
E
Q
Site 45
S561
G
G
G
T
V
P
S
S
A
G
I
L
E
Q
G
Site 46
S570
G
I
L
E
Q
G
P
S
P
G
D
G
S
P
P
Site 47
S575
G
P
S
P
G
D
G
S
P
P
K
P
K
D
P
Site 48
S584
P
K
P
K
D
P
V
S
A
A
V
P
A
P
G
Site 49
S595
P
A
P
G
R
N
N
S
Q
I
A
S
G
Q
N
Site 50
S599
R
N
N
S
Q
I
A
S
G
Q
N
Q
P
Q
A
Site 51
S610
Q
P
Q
A
A
A
G
S
H
Q
L
S
M
G
Q
Site 52
S614
A
A
G
S
H
Q
L
S
M
G
Q
P
H
N
A
Site 53
S625
P
H
N
A
A
G
P
S
P
H
T
L
R
R
A
Site 54
T628
A
A
G
P
S
P
H
T
L
R
R
A
V
K
K
Site 55
S655
P
G
H
P
G
G
Q
S
S
S
G
T
S
Q
H
Site 56
S656
G
H
P
G
G
Q
S
S
S
G
T
S
Q
H
P
Site 57
S657
H
P
G
G
Q
S
S
S
G
T
S
Q
H
P
P
Site 58
T659
G
G
Q
S
S
S
G
T
S
Q
H
P
P
S
L
Site 59
S660
G
Q
S
S
S
G
T
S
Q
H
P
P
S
L
S
Site 60
S665
G
T
S
Q
H
P
P
S
L
S
P
K
P
P
T
Site 61
S667
S
Q
H
P
P
S
L
S
P
K
P
P
T
R
S
Site 62
T672
S
L
S
P
K
P
P
T
R
S
P
S
P
P
T
Site 63
S674
S
P
K
P
P
T
R
S
P
S
P
P
T
Q
H
Site 64
S676
K
P
P
T
R
S
P
S
P
P
T
Q
H
T
G
Site 65
T679
T
R
S
P
S
P
P
T
Q
H
T
G
Q
P
P
Site 66
T682
P
S
P
P
T
Q
H
T
G
Q
P
P
G
Q
P
Site 67
S690
G
Q
P
P
G
Q
P
S
A
P
S
Q
L
S
A
Site 68
S693
P
G
Q
P
S
A
P
S
Q
L
S
A
P
R
R
Site 69
S696
P
S
A
P
S
Q
L
S
A
P
R
R
Y
S
S
Site 70
Y701
Q
L
S
A
P
R
R
Y
S
S
S
L
S
P
I
Site 71
S702
L
S
A
P
R
R
Y
S
S
S
L
S
P
I
Q
Site 72
S703
S
A
P
R
R
Y
S
S
S
L
S
P
I
Q
A
Site 73
S704
A
P
R
R
Y
S
S
S
L
S
P
I
Q
A
P
Site 74
S706
R
R
Y
S
S
S
L
S
P
I
Q
A
P
N
H
Site 75
T720
H
P
P
P
Q
P
P
T
Q
A
T
P
L
M
H
Site 76
T723
P
Q
P
P
T
Q
A
T
P
L
M
H
T
K
P
Site 77
S732
L
M
H
T
K
P
N
S
Q
G
P
P
N
P
M
Site 78
S743
P
N
P
M
A
L
P
S
E
H
G
L
E
Q
P
Site 79
S751
E
H
G
L
E
Q
P
S
H
T
P
P
Q
T
P
Site 80
T753
G
L
E
Q
P
S
H
T
P
P
Q
T
P
T
P
Site 81
T757
P
S
H
T
P
P
Q
T
P
T
P
P
S
T
P
Site 82
T759
H
T
P
P
Q
T
P
T
P
P
S
T
P
P
L
Site 83
S762
P
Q
T
P
T
P
P
S
T
P
P
L
G
K
Q
Site 84
T763
Q
T
P
T
P
P
S
T
P
P
L
G
K
Q
N
Site 85
T778
P
S
L
P
A
P
Q
T
L
A
G
G
N
P
E
Site 86
T786
L
A
G
G
N
P
E
T
A
Q
P
H
A
G
T
Site 87
S808
P
K
P
R
N
R
P
S
V
P
P
P
P
Q
P
Site 88
S820
P
Q
P
P
G
V
H
S
A
G
D
S
S
L
T
Site 89
S824
G
V
H
S
A
G
D
S
S
L
T
N
T
A
P
Site 90
S825
V
H
S
A
G
D
S
S
L
T
N
T
A
P
T
Site 91
T829
G
D
S
S
L
T
N
T
A
P
T
A
S
K
I
Site 92
T838
P
T
A
S
K
I
V
T
D
S
N
S
R
V
S
Site 93
S840
A
S
K
I
V
T
D
S
N
S
R
V
S
E
P
Site 94
S842
K
I
V
T
D
S
N
S
R
V
S
E
P
H
R
Site 95
S845
T
D
S
N
S
R
V
S
E
P
H
R
S
I
F
Site 96
S850
R
V
S
E
P
H
R
S
I
F
P
E
M
H
S
Site 97
S857
S
I
F
P
E
M
H
S
D
S
A
S
K
D
V
Site 98
S859
F
P
E
M
H
S
D
S
A
S
K
D
V
P
G
Site 99
S861
E
M
H
S
D
S
A
S
K
D
V
P
G
R
I
Site 100
T876
L
L
D
I
D
N
D
T
E
S
T
A
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation