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Updated November 2019
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Protein Info
Short Name:
FAM21A
Full Name:
WASH complex subunit FAM21A
Alias:
BA56A21.1; FA21A; FAM21; Loc387680
Type:
Uncharacterized protein
Mass (Da):
147184
Number AA:
1341
UniProt ID:
Q641Q2
International Prot ID:
IPI00792422
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
M
N
R
T
T
P
D
Q
E
L
A
P
Site 2
S15
D
Q
E
L
A
P
A
S
E
P
V
W
E
R
P
Site 3
S24
P
V
W
E
R
P
W
S
V
E
E
I
R
R
S
Site 4
S31
S
V
E
E
I
R
R
S
S
Q
S
W
S
L
A
Site 5
S32
V
E
E
I
R
R
S
S
Q
S
W
S
L
A
A
Site 6
S34
E
I
R
R
S
S
Q
S
W
S
L
A
A
D
A
Site 7
S36
R
R
S
S
Q
S
W
S
L
A
A
D
A
G
L
Site 8
S51
L
Q
F
L
Q
E
F
S
Q
Q
T
I
S
R
T
Site 9
S56
E
F
S
Q
Q
T
I
S
R
T
H
E
I
K
K
Site 10
T72
V
D
G
L
I
R
E
T
K
A
T
D
C
R
L
Site 11
T75
L
I
R
E
T
K
A
T
D
C
R
L
H
N
V
Site 12
T92
D
F
L
M
L
S
N
T
Q
F
I
E
N
R
V
Site 13
Y100
Q
F
I
E
N
R
V
Y
D
E
E
V
E
E
P
Site 14
T116
L
K
A
E
A
E
K
T
E
Q
E
K
T
R
E
Site 15
T121
E
K
T
E
Q
E
K
T
R
E
Q
K
E
V
D
Site 16
Y139
K
V
Q
E
A
V
N
Y
G
L
Q
V
L
D
S
Site 17
S158
L
D
I
K
A
G
N
S
D
S
E
E
D
D
A
Site 18
S160
I
K
A
G
N
S
D
S
E
E
D
D
A
N
G
Site 19
Y179
I
L
E
P
K
D
L
Y
I
D
R
P
L
P
Y
Site 20
Y186
Y
I
D
R
P
L
P
Y
L
I
G
S
K
L
F
Site 21
S205
D
V
G
L
G
E
L
S
S
E
E
G
S
V
G
Site 22
S206
V
G
L
G
E
L
S
S
E
E
G
S
V
G
S
Site 23
S210
E
L
S
S
E
E
G
S
V
G
S
D
R
G
S
Site 24
S213
S
E
E
G
S
V
G
S
D
R
G
S
I
V
D
Site 25
S217
S
V
G
S
D
R
G
S
I
V
D
T
E
E
E
Site 26
T221
D
R
G
S
I
V
D
T
E
E
E
K
E
E
E
Site 27
S230
E
E
K
E
E
E
E
S
D
E
D
F
A
H
H
Site 28
S238
D
E
D
F
A
H
H
S
D
N
E
Q
N
R
H
Site 29
T246
D
N
E
Q
N
R
H
T
T
Q
M
S
D
E
E
Site 30
T247
N
E
Q
N
R
H
T
T
Q
M
S
D
E
E
E
Site 31
S250
N
R
H
T
T
Q
M
S
D
E
E
E
D
D
D
Site 32
S265
G
C
D
L
F
A
D
S
E
K
E
E
E
D
I
Site 33
S284
E
N
T
R
P
K
R
S
R
P
T
S
F
A
D
Site 34
T287
R
P
K
R
S
R
P
T
S
F
A
D
E
L
A
Site 35
S288
P
K
R
S
R
P
T
S
F
A
D
E
L
A
A
Site 36
T310
G
R
V
D
E
E
P
T
T
L
P
S
G
E
A
Site 37
T311
R
V
D
E
E
P
T
T
L
P
S
G
E
A
K
Site 38
S314
E
E
P
T
T
L
P
S
G
E
A
K
P
R
K
Site 39
T322
G
E
A
K
P
R
K
T
L
K
E
K
K
E
R
Site 40
T331
K
E
K
K
E
R
R
T
P
S
D
D
E
E
D
Site 41
S333
K
K
E
R
R
T
P
S
D
D
E
E
D
N
L
Site 42
T347
L
F
A
P
P
K
L
T
D
E
D
F
S
P
F
Site 43
S352
K
L
T
D
E
D
F
S
P
F
G
S
G
G
G
Site 44
S356
E
D
F
S
P
F
G
S
G
G
G
L
F
S
G
Site 45
S362
G
S
G
G
G
L
F
S
G
G
K
G
L
F
D
Site 46
S375
F
D
D
E
D
E
E
S
D
L
F
T
E
A
P
Site 47
T379
D
E
E
S
D
L
F
T
E
A
P
Q
D
R
Q
Site 48
S390
Q
D
R
Q
A
G
A
S
V
K
E
E
S
S
S
Site 49
S395
G
A
S
V
K
E
E
S
S
S
S
K
P
G
K
Site 50
S396
A
S
V
K
E
E
S
S
S
S
K
P
G
K
K
Site 51
S397
S
V
K
E
E
S
S
S
S
K
P
G
K
K
I
Site 52
S398
V
K
E
E
S
S
S
S
K
P
G
K
K
I
P
Site 53
S423
T
D
V
F
G
A
A
S
V
P
S
M
K
E
P
Site 54
T437
P
Q
K
P
E
Q
P
T
P
R
K
S
P
Y
G
Site 55
S441
E
Q
P
T
P
R
K
S
P
Y
G
P
P
P
T
Site 56
Y443
P
T
P
R
K
S
P
Y
G
P
P
P
T
G
L
Site 57
T448
S
P
Y
G
P
P
P
T
G
L
F
D
D
D
D
Site 58
S464
D
D
D
D
D
F
F
S
A
P
H
S
K
P
S
Site 59
S468
D
F
F
S
A
P
H
S
K
P
S
K
T
G
K
Site 60
S471
S
A
P
H
S
K
P
S
K
T
G
K
V
Q
S
Site 61
T473
P
H
S
K
P
S
K
T
G
K
V
Q
S
T
A
Site 62
S478
S
K
T
G
K
V
Q
S
T
A
D
I
F
G
D
Site 63
S498
F
K
E
K
A
V
A
S
P
E
A
T
V
S
Q
Site 64
T502
A
V
A
S
P
E
A
T
V
S
Q
T
D
E
N
Site 65
S504
A
S
P
E
A
T
V
S
Q
T
D
E
N
K
A
Site 66
T518
A
R
A
E
K
K
V
T
L
S
S
S
K
N
L
Site 67
S520
A
E
K
K
V
T
L
S
S
S
K
N
L
K
P
Site 68
S522
K
K
V
T
L
S
S
S
K
N
L
K
P
S
S
Site 69
S529
S
K
N
L
K
P
S
S
E
T
K
T
Q
K
G
Site 70
T533
K
P
S
S
E
T
K
T
Q
K
G
L
F
S
D
Site 71
S539
K
T
Q
K
G
L
F
S
D
E
E
D
S
E
D
Site 72
S544
L
F
S
D
E
E
D
S
E
D
L
F
S
S
Q
Site 73
S549
E
D
S
E
D
L
F
S
S
Q
S
A
S
K
L
Site 74
S550
D
S
E
D
L
F
S
S
Q
S
A
S
K
L
K
Site 75
S552
E
D
L
F
S
S
Q
S
A
S
K
L
K
G
A
Site 76
S554
L
F
S
S
Q
S
A
S
K
L
K
G
A
S
L
Site 77
S571
G
K
L
P
T
L
V
S
L
F
D
D
E
D
E
Site 78
T592
G
T
A
A
K
K
Q
T
L
C
L
Q
A
Q
R
Site 79
S619
K
A
S
A
L
L
F
S
S
D
E
E
D
Q
W
Site 80
S620
A
S
A
L
L
F
S
S
D
E
E
D
Q
W
N
Site 81
S631
D
Q
W
N
I
P
A
S
Q
T
H
L
A
S
D
Site 82
S637
A
S
Q
T
H
L
A
S
D
S
R
S
K
G
E
Site 83
S639
Q
T
H
L
A
S
D
S
R
S
K
G
E
P
R
Site 84
S641
H
L
A
S
D
S
R
S
K
G
E
P
R
D
S
Site 85
S648
S
K
G
E
P
R
D
S
G
T
L
Q
S
Q
E
Site 86
T650
G
E
P
R
D
S
G
T
L
Q
S
Q
E
A
K
Site 87
S653
R
D
S
G
T
L
Q
S
Q
E
A
K
A
V
K
Site 88
S663
A
K
A
V
K
K
T
S
L
F
E
E
D
E
E
Site 89
S680
L
F
A
I
A
K
D
S
Q
K
K
T
Q
R
V
Site 90
T684
A
K
D
S
Q
K
K
T
Q
R
V
S
L
L
F
Site 91
S688
Q
K
K
T
Q
R
V
S
L
L
F
E
D
D
V
Site 92
S697
L
F
E
D
D
V
D
S
G
G
S
L
F
G
S
Site 93
S700
D
D
V
D
S
G
G
S
L
F
G
S
P
P
T
Site 94
S704
S
G
G
S
L
F
G
S
P
P
T
S
V
P
P
Site 95
T707
S
L
F
G
S
P
P
T
S
V
P
P
A
T
K
Site 96
S708
L
F
G
S
P
P
T
S
V
P
P
A
T
K
K
Site 97
T718
P
A
T
K
K
K
E
T
V
S
E
A
P
P
L
Site 98
S720
T
K
K
K
E
T
V
S
E
A
P
P
L
L
F
Site 99
S728
E
A
P
P
L
L
F
S
D
E
E
E
K
E
A
Site 100
S741
E
A
Q
L
G
V
K
S
V
D
K
K
V
E
S
Site 101
S748
S
V
D
K
K
V
E
S
A
K
E
S
L
K
F
Site 102
S752
K
V
E
S
A
K
E
S
L
K
F
G
R
T
D
Site 103
T758
E
S
L
K
F
G
R
T
D
V
A
E
S
E
K
Site 104
T770
S
E
K
E
G
L
L
T
R
S
A
Q
E
T
V
Site 105
S772
K
E
G
L
L
T
R
S
A
Q
E
T
V
K
H
Site 106
T776
L
T
R
S
A
Q
E
T
V
K
H
S
D
L
F
Site 107
S780
A
Q
E
T
V
K
H
S
D
L
F
S
S
S
S
Site 108
S784
V
K
H
S
D
L
F
S
S
S
S
P
W
D
K
Site 109
S785
K
H
S
D
L
F
S
S
S
S
P
W
D
K
G
Site 110
S786
H
S
D
L
F
S
S
S
S
P
W
D
K
G
T
Site 111
S787
S
D
L
F
S
S
S
S
P
W
D
K
G
T
K
Site 112
T793
S
S
P
W
D
K
G
T
K
P
R
T
K
T
V
Site 113
T797
D
K
G
T
K
P
R
T
K
T
V
L
S
L
F
Site 114
T799
G
T
K
P
R
T
K
T
V
L
S
L
F
D
E
Site 115
S802
P
R
T
K
T
V
L
S
L
F
D
E
E
E
D
Site 116
S836
D
P
D
A
H
P
K
S
T
G
V
F
Q
D
E
Site 117
T837
P
D
A
H
P
K
S
T
G
V
F
Q
D
E
E
Site 118
S874
K
T
K
L
L
E
P
S
V
G
S
L
F
G
D
Site 119
S877
L
L
E
P
S
V
G
S
L
F
G
D
D
E
D
Site 120
S889
D
E
D
D
D
L
F
S
S
A
K
S
Q
P
L
Site 121
S890
E
D
D
D
L
F
S
S
A
K
S
Q
P
L
V
Site 122
S893
D
L
F
S
S
A
K
S
Q
P
L
V
Q
E
K
Site 123
S909
R
V
V
K
K
D
H
S
V
D
S
F
K
N
Q
Site 124
S912
K
K
D
H
S
V
D
S
F
K
N
Q
K
H
P
Site 125
S921
K
N
Q
K
H
P
E
S
I
Q
G
S
K
E
K
Site 126
S925
H
P
E
S
I
Q
G
S
K
E
K
G
I
W
K
Site 127
T935
K
G
I
W
K
P
E
T
P
Q
D
S
S
G
L
Site 128
T947
S
G
L
A
P
F
K
T
K
E
P
S
T
R
I
Site 129
S951
P
F
K
T
K
E
P
S
T
R
I
G
K
I
Q
Site 130
T952
F
K
T
K
E
P
S
T
R
I
G
K
I
Q
A
Site 131
S991
P
E
L
A
F
P
S
S
E
H
R
R
S
H
G
Site 132
S996
P
S
S
E
H
R
R
S
H
G
L
E
S
V
P
Site 133
S1001
R
R
S
H
G
L
E
S
V
P
V
L
P
G
S
Site 134
S1008
S
V
P
V
L
P
G
S
G
E
A
G
V
S
F
Site 135
S1014
G
S
G
E
A
G
V
S
F
D
L
P
A
Q
A
Site 136
T1023
D
L
P
A
Q
A
D
T
L
H
S
A
N
K
S
Site 137
S1026
A
Q
A
D
T
L
H
S
A
N
K
S
R
V
K
Site 138
S1030
T
L
H
S
A
N
K
S
R
V
K
M
R
G
K
Site 139
T1042
R
G
K
R
R
P
Q
T
R
A
A
R
R
L
A
Site 140
S1053
R
R
L
A
A
Q
E
S
S
E
T
E
D
M
S
Site 141
S1054
R
L
A
A
Q
E
S
S
E
T
E
D
M
S
V
Site 142
T1056
A
A
Q
E
S
S
E
T
E
D
M
S
V
P
R
Site 143
S1060
S
S
E
T
E
D
M
S
V
P
R
G
P
I
A
Site 144
S1075
Q
W
A
D
G
A
I
S
P
N
G
H
R
P
Q
Site 145
S1087
R
P
Q
L
R
A
A
S
G
E
D
S
T
E
E
Site 146
S1091
R
A
A
S
G
E
D
S
T
E
E
A
L
A
A
Site 147
T1092
A
A
S
G
E
D
S
T
E
E
A
L
A
A
A
Site 148
S1114
P
V
P
G
V
D
R
S
P
F
A
K
S
L
G
Site 149
S1119
D
R
S
P
F
A
K
S
L
G
H
S
R
G
E
Site 150
S1123
F
A
K
S
L
G
H
S
R
G
E
A
D
L
F
Site 151
S1132
G
E
A
D
L
F
D
S
G
D
I
F
S
T
G
Site 152
S1137
F
D
S
G
D
I
F
S
T
G
T
G
S
Q
S
Site 153
T1138
D
S
G
D
I
F
S
T
G
T
G
S
Q
S
V
Site 154
T1140
G
D
I
F
S
T
G
T
G
S
Q
S
V
E
R
Site 155
S1142
I
F
S
T
G
T
G
S
Q
S
V
E
R
T
K
Site 156
S1144
S
T
G
T
G
S
Q
S
V
E
R
T
K
P
K
Site 157
T1148
G
S
Q
S
V
E
R
T
K
P
K
A
K
I
A
Site 158
S1169
P
V
G
G
K
A
K
S
P
M
F
P
A
L
G
Site 159
S1179
F
P
A
L
G
E
A
S
S
D
D
D
L
F
Q
Site 160
S1180
P
A
L
G
E
A
S
S
D
D
D
L
F
Q
S
Site 161
S1187
S
D
D
D
L
F
Q
S
A
K
P
K
P
A
K
Site 162
T1219
Q
K
V
K
K
N
E
T
K
S
N
S
Q
Q
D
Site 163
S1221
V
K
K
N
E
T
K
S
N
S
Q
Q
D
V
I
Site 164
S1223
K
N
E
T
K
S
N
S
Q
Q
D
V
I
L
T
Site 165
T1257
K
T
R
E
K
E
K
T
L
E
S
N
L
F
D
Site 166
T1274
I
D
I
F
A
D
L
T
V
K
P
K
E
K
S
Site 167
S1289
K
K
K
V
E
A
K
S
I
F
D
D
D
M
D
Site 168
T1307
S
S
G
I
Q
A
K
T
T
K
P
K
S
R
S
Site 169
T1308
S
G
I
Q
A
K
T
T
K
P
K
S
R
S
A
Site 170
S1312
A
K
T
T
K
P
K
S
R
S
A
Q
A
A
P
Site 171
S1328
P
R
F
E
H
K
V
S
N
I
F
D
D
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation