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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF318
Full Name:
Zinc finger protein 318
Alias:
HRIHFB2436
Type:
Transcription, coactivator/corepressor
Mass (Da):
251112
Number AA:
2279
UniProt ID:
Q5VUA4
International Prot ID:
IPI00413365
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007126
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
Y
R
S
S
A
R
S
S
V
S
S
Site 2
S8
M
Y
R
S
S
A
R
S
S
V
S
S
H
R
P
Site 3
S9
Y
R
S
S
A
R
S
S
V
S
S
H
R
P
K
Site 4
S12
S
A
R
S
S
V
S
S
H
R
P
K
D
D
G
Site 5
S25
D
G
G
G
G
P
R
S
G
R
S
S
G
S
S
Site 6
S28
G
G
P
R
S
G
R
S
S
G
S
S
S
G
P
Site 7
S29
G
P
R
S
G
R
S
S
G
S
S
S
G
P
A
Site 8
S31
R
S
G
R
S
S
G
S
S
S
G
P
A
R
R
Site 9
S32
S
G
R
S
S
G
S
S
S
G
P
A
R
R
S
Site 10
S33
G
R
S
S
G
S
S
S
G
P
A
R
R
S
S
Site 11
S39
S
S
G
P
A
R
R
S
S
P
P
P
P
P
S
Site 12
S40
S
G
P
A
R
R
S
S
P
P
P
P
P
S
G
Site 13
S46
S
S
P
P
P
P
P
S
G
S
S
S
R
T
P
Site 14
S48
P
P
P
P
P
S
G
S
S
S
R
T
P
A
R
Site 15
S49
P
P
P
P
S
G
S
S
S
R
T
P
A
R
R
Site 16
S50
P
P
P
S
G
S
S
S
R
T
P
A
R
R
P
Site 17
T52
P
S
G
S
S
S
R
T
P
A
R
R
P
R
S
Site 18
S59
T
P
A
R
R
P
R
S
P
S
G
H
R
G
R
Site 19
S61
A
R
R
P
R
S
P
S
G
H
R
G
R
R
A
Site 20
S69
G
H
R
G
R
R
A
S
P
S
P
P
R
G
R
Site 21
S71
R
G
R
R
A
S
P
S
P
P
R
G
R
R
V
Site 22
S79
P
P
R
G
R
R
V
S
P
S
P
P
R
A
R
Site 23
S81
R
G
R
R
V
S
P
S
P
P
R
A
R
R
G
Site 24
S89
P
P
R
A
R
R
G
S
P
S
P
P
R
G
R
Site 25
S91
R
A
R
R
G
S
P
S
P
P
R
G
R
R
L
Site 26
S109
G
P
A
G
F
R
G
S
S
R
G
E
S
R
A
Site 27
S110
P
A
G
F
R
G
S
S
R
G
E
S
R
A
D
Site 28
S114
R
G
S
S
R
G
E
S
R
A
D
Y
A
R
D
Site 29
Y118
R
G
E
S
R
A
D
Y
A
R
D
G
R
G
D
Site 30
S130
R
G
D
H
P
G
D
S
G
S
R
R
R
S
P
Site 31
S132
D
S
G
S
R
R
R
S
P
G
L
C
S
D
S
Site 32
S136
D
S
G
S
R
R
R
S
P
G
L
C
S
D
S
Site 33
S141
R
R
S
P
G
L
C
S
D
S
L
E
K
S
L
Site 34
S143
S
P
G
L
C
S
D
S
L
E
K
S
L
R
I
Site 35
S147
C
S
D
S
L
E
K
S
L
R
I
T
V
G
N
Site 36
T151
L
E
K
S
L
R
I
T
V
G
N
D
H
F
C
Site 37
S160
G
N
D
H
F
C
V
S
T
P
E
R
R
R
L
Site 38
T161
N
D
H
F
C
V
S
T
P
E
R
R
R
L
S
Site 39
S168
T
P
E
R
R
R
L
S
D
R
L
G
S
P
V
Site 40
S173
R
L
S
D
R
L
G
S
P
V
D
N
L
E
D
Site 41
T187
D
M
D
R
D
D
L
T
D
D
S
V
F
T
R
Site 42
S190
R
D
D
L
T
D
D
S
V
F
T
R
S
S
Q
Site 43
S195
D
D
S
V
F
T
R
S
S
Q
C
S
R
G
L
Site 44
S196
D
S
V
F
T
R
S
S
Q
C
S
R
G
L
E
Site 45
S199
F
T
R
S
S
Q
C
S
R
G
L
E
R
Y
I
Site 46
Y205
C
S
R
G
L
E
R
Y
I
S
Q
E
E
G
P
Site 47
S207
R
G
L
E
R
Y
I
S
Q
E
E
G
P
L
S
Site 48
S214
S
Q
E
E
G
P
L
S
P
F
L
G
Q
L
D
Site 49
Y224
L
G
Q
L
D
E
D
Y
R
T
K
E
T
F
L
Site 50
T226
Q
L
D
E
D
Y
R
T
K
E
T
F
L
H
R
Site 51
T229
E
D
Y
R
T
K
E
T
F
L
H
R
S
D
Y
Site 52
S234
K
E
T
F
L
H
R
S
D
Y
S
P
H
I
S
Site 53
Y236
T
F
L
H
R
S
D
Y
S
P
H
I
S
C
H
Site 54
S237
F
L
H
R
S
D
Y
S
P
H
I
S
C
H
D
Site 55
S241
S
D
Y
S
P
H
I
S
C
H
D
E
L
L
R
Site 56
T250
H
D
E
L
L
R
G
T
E
R
N
R
E
K
L
Site 57
Y260
N
R
E
K
L
K
G
Y
S
I
R
S
E
E
R
Site 58
S261
R
E
K
L
K
G
Y
S
I
R
S
E
E
R
S
Site 59
S264
L
K
G
Y
S
I
R
S
E
E
R
S
R
E
A
Site 60
S268
S
I
R
S
E
E
R
S
R
E
A
K
R
P
R
Site 61
Y276
R
E
A
K
R
P
R
Y
D
D
T
V
K
I
N
Site 62
T279
K
R
P
R
Y
D
D
T
V
K
I
N
S
M
G
Site 63
S284
P
G
I
P
K
D
N
S
P
L
R
E
K
F
G
Site 64
S291
S
M
G
G
D
H
P
S
F
T
S
G
T
R
N
Site 65
S294
G
D
H
P
S
F
T
S
G
T
R
N
Y
R
Q
Site 66
T296
H
P
S
F
T
S
G
T
R
N
Y
R
Q
R
R
Site 67
Y299
F
T
S
G
T
R
N
Y
R
Q
R
R
R
S
P
Site 68
S305
N
Y
R
Q
R
R
R
S
P
S
P
R
F
L
D
Site 69
S307
R
Q
R
R
R
S
P
S
P
R
F
L
D
P
E
Site 70
S332
R
E
E
E
E
E
R
S
R
S
L
S
Q
E
L
Site 71
S334
E
E
E
E
R
S
R
S
L
S
Q
E
L
V
G
Site 72
S336
E
E
R
S
R
S
L
S
Q
E
L
V
G
V
D
Site 73
T359
P
G
L
S
G
V
L
T
A
S
E
P
G
Y
S
Site 74
Y365
L
T
A
S
E
P
G
Y
S
L
H
R
P
E
E
Site 75
S366
T
A
S
E
P
G
Y
S
L
H
R
P
E
E
V
Site 76
S374
L
H
R
P
E
E
V
S
V
M
P
K
K
S
I
Site 77
S380
V
S
V
M
P
K
K
S
I
L
K
K
R
I
E
Site 78
S394
E
V
D
I
M
E
P
S
M
Q
L
E
S
F
S
Site 79
S399
E
P
S
M
Q
L
E
S
F
S
S
S
T
S
S
Site 80
S401
S
M
Q
L
E
S
F
S
S
S
T
S
S
S
Q
Site 81
S402
M
Q
L
E
S
F
S
S
S
T
S
S
S
Q
D
Site 82
S403
Q
L
E
S
F
S
S
S
T
S
S
S
Q
D
H
Site 83
S405
E
S
F
S
S
S
T
S
S
S
Q
D
H
P
L
Site 84
S406
S
F
S
S
S
T
S
S
S
Q
D
H
P
L
Y
Site 85
S407
F
S
S
S
T
S
S
S
Q
D
H
P
L
Y
S
Site 86
Y413
S
S
Q
D
H
P
L
Y
S
G
H
P
S
L
P
Site 87
S414
S
Q
D
H
P
L
Y
S
G
H
P
S
L
P
L
Site 88
T437
S
E
I
E
N
K
G
T
M
V
E
T
A
L
K
Site 89
Y451
K
E
P
Q
G
N
L
Y
Q
W
G
P
L
P
G
Site 90
S464
P
G
I
P
K
D
N
S
P
L
R
E
K
F
G
Site 91
S472
P
L
R
E
K
F
G
S
F
L
C
H
K
D
N
Site 92
T491
A
E
G
P
E
R
H
T
D
F
L
L
P
H
E
Site 93
S501
L
L
P
H
E
R
A
S
Q
D
G
S
G
F
S
Site 94
S505
E
R
A
S
Q
D
G
S
G
F
S
R
I
L
S
Site 95
S508
S
Q
D
G
S
G
F
S
R
I
L
S
M
L
A
Site 96
S512
S
G
F
S
R
I
L
S
M
L
A
D
S
T
S
Site 97
S517
I
L
S
M
L
A
D
S
T
S
T
Q
E
K
R
Site 98
S519
S
M
L
A
D
S
T
S
T
Q
E
K
R
R
R
Site 99
S527
T
Q
E
K
R
R
R
S
F
P
D
I
E
D
E
Site 100
Y539
E
D
E
E
K
F
L
Y
G
D
E
E
E
D
L
Site 101
S550
E
E
D
L
K
A
E
S
V
P
K
P
L
G
S
Site 102
S557
S
V
P
K
P
L
G
S
S
E
S
E
V
M
R
Site 103
S560
K
P
L
G
S
S
E
S
E
V
M
R
Q
K
A
Site 104
S568
E
V
M
R
Q
K
A
S
S
L
P
S
S
A
P
Site 105
S569
V
M
R
Q
K
A
S
S
L
P
S
S
A
P
A
Site 106
S572
Q
K
A
S
S
L
P
S
S
A
P
A
V
K
L
Site 107
S573
K
A
S
S
L
P
S
S
A
P
A
V
K
L
E
Site 108
Y589
L
E
E
T
N
P
E
Y
A
K
I
H
D
L
L
Site 109
S625
R
L
H
G
K
K
P
S
L
R
S
S
A
D
R
Site 110
S628
G
K
K
P
S
L
R
S
S
A
D
R
R
S
S
Site 111
S629
K
K
P
S
L
R
S
S
A
D
R
R
S
S
V
Site 112
S634
R
S
S
A
D
R
R
S
S
V
D
R
Y
F
S
Site 113
S635
S
S
A
D
R
R
S
S
V
D
R
Y
F
S
A
Site 114
Y639
R
R
S
S
V
D
R
Y
F
S
A
D
H
C
S
Site 115
S641
S
S
V
D
R
Y
F
S
A
D
H
C
S
S
V
Site 116
S653
S
S
V
D
H
R
F
S
A
D
R
C
S
S
V
Site 117
S658
R
F
S
A
D
R
C
S
S
V
D
H
C
F
S
Site 118
S659
F
S
A
D
R
C
S
S
V
D
H
C
F
S
A
Site 119
S665
S
S
V
D
H
C
F
S
A
D
R
R
S
S
D
Site 120
S670
C
F
S
A
D
R
R
S
S
D
P
H
R
L
E
Site 121
S671
F
S
A
D
R
R
S
S
D
P
H
R
L
E
S
Site 122
S678
S
D
P
H
R
L
E
S
R
E
A
H
H
S
N
Site 123
S684
E
S
R
E
A
H
H
S
N
T
H
S
P
E
V
Site 124
T686
R
E
A
H
H
S
N
T
H
S
P
E
V
S
H
Site 125
S688
A
H
H
S
N
T
H
S
P
E
V
S
H
P
H
Site 126
S692
N
T
H
S
P
E
V
S
H
P
H
P
P
S
P
Site 127
S698
V
S
H
P
H
P
P
S
P
V
D
P
Y
L
L
Site 128
Y703
P
P
S
P
V
D
P
Y
L
L
T
K
N
S
P
Site 129
T706
P
V
D
P
Y
L
L
T
K
N
S
P
P
F
L
Site 130
S709
P
Y
L
L
T
K
N
S
P
P
F
L
K
S
D
Site 131
S715
N
S
P
P
F
L
K
S
D
H
P
V
G
H
I
Site 132
T755
A
P
I
R
L
P
H
T
A
A
L
S
Q
F
H
Site 133
S759
L
P
H
T
A
A
L
S
Q
F
H
M
P
R
A
Site 134
S767
Q
F
H
M
P
R
A
S
Q
F
A
A
A
R
I
Site 135
Y778
A
A
R
I
P
P
N
Y
Q
G
P
A
I
P
P
Site 136
S787
G
P
A
I
P
P
A
S
F
D
A
Y
R
H
Y
Site 137
Y791
P
P
A
S
F
D
A
Y
R
H
Y
M
A
Y
A
Site 138
Y794
S
F
D
A
Y
R
H
Y
M
A
Y
A
A
S
R
Site 139
Y805
A
A
S
R
W
P
M
Y
P
T
S
Q
P
S
N
Site 140
T807
S
R
W
P
M
Y
P
T
S
Q
P
S
N
H
P
Site 141
S808
R
W
P
M
Y
P
T
S
Q
P
S
N
H
P
V
Site 142
S811
M
Y
P
T
S
Q
P
S
N
H
P
V
P
E
P
Site 143
T825
P
H
R
I
M
P
I
T
K
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T
I
E
S
K
A
Site 296
T1992
V
H
P
E
L
T
V
T
I
E
S
K
A
L
E
Site 297
T2026
D
M
P
V
D
F
C
T
T
R
V
S
P
A
H
Site 298
S2030
D
F
C
T
T
R
V
S
P
A
H
R
S
P
T
Site 299
S2035
R
V
S
P
A
H
R
S
P
T
V
L
C
Q
K
Site 300
T2037
S
P
A
H
R
S
P
T
V
L
C
Q
K
V
C
Site 301
S2048
Q
K
V
C
E
E
N
S
V
S
P
I
G
C
N
Site 302
S2050
V
C
E
E
N
S
V
S
P
I
G
C
N
S
S
Site 303
S2057
S
P
I
G
C
N
S
S
D
P
A
D
F
E
P
Site 304
S2067
A
D
F
E
P
I
P
S
F
S
G
F
P
L
D
Site 305
S2069
F
E
P
I
P
S
F
S
G
F
P
L
D
S
P
Site 306
S2091
E
T
E
G
E
R
N
S
P
N
P
R
S
V
R
Site 307
S2096
R
N
S
P
N
P
R
S
V
R
I
P
S
P
N
Site 308
S2101
P
R
S
V
R
I
P
S
P
N
I
L
K
T
G
Site 309
T2107
P
S
P
N
I
L
K
T
G
L
T
E
N
V
D
Site 310
T2110
N
I
L
K
T
G
L
T
E
N
V
D
R
G
L
Site 311
S2143
P
E
E
V
K
E
S
S
Q
L
D
K
Q
E
S
Site 312
S2150
S
Q
L
D
K
Q
E
S
L
G
L
E
L
K
T
Site 313
S2160
L
E
L
K
T
I
N
S
A
G
L
G
P
S
P
Site 314
T2177
P
D
L
V
D
F
V
T
R
T
S
G
V
Q
K
Site 315
S2180
V
D
F
V
T
R
T
S
G
V
Q
K
D
K
L
Site 316
S2189
V
Q
K
D
K
L
C
S
P
L
S
E
P
G
D
Site 317
S2192
D
K
L
C
S
P
L
S
E
P
G
D
P
S
K
Site 318
S2198
L
S
E
P
G
D
P
S
K
C
S
S
L
E
L
Site 319
S2201
P
G
D
P
S
K
C
S
S
L
E
L
G
P
L
Site 320
S2202
G
D
P
S
K
C
S
S
L
E
L
G
P
L
Q
Site 321
S2213
G
P
L
Q
L
E
I
S
N
A
S
T
T
E
V
Site 322
S2229
I
L
Q
V
D
D
D
S
G
D
P
L
N
L
V
Site 323
S2241
N
L
V
K
A
P
V
S
R
S
P
P
R
E
Q
Site 324
S2243
V
K
A
P
V
S
R
S
P
P
R
E
Q
V
I
Site 325
T2265
G
M
P
E
Q
E
T
T
V
G
A
I
Q
D
H
Site 326
T2273
V
G
A
I
Q
D
H
T
E
S
S
V
H
N
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation