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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNF20
Full Name:
E3 ubiquitin-protein ligase BRE1A
Alias:
BRE1; BRE1 E3 ubiquitin ligase; BRE1A; BRE1-A; FLJ11189; FLJ20382; KAIA2779; RING finger protein 20
Type:
Ubiquitin conjugating system; Ubiquitin ligase; Ligase; EC 6.3.2.-
Mass (Da):
113662
Number AA:
975
UniProt ID:
Q5VTR2
International Prot ID:
IPI00783711
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005694
GO:0005730
GO:0000151
Uniprot
OncoNet
Molecular Function:
GO:0042393
GO:0002039
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0033523
GO:0051568
GO:0034729
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
G
I
G
N
K
R
A
Site 2
T15
R
A
A
G
E
P
G
T
S
M
P
P
E
K
K
Site 3
S16
A
A
G
E
P
G
T
S
M
P
P
E
K
K
A
Site 4
S28
K
K
A
A
V
E
D
S
G
T
T
V
E
T
I
Site 5
T31
A
V
E
D
S
G
T
T
V
E
T
I
K
L
G
Site 6
T34
D
S
G
T
T
V
E
T
I
K
L
G
G
V
S
Site 7
S42
I
K
L
G
G
V
S
S
T
E
E
L
D
I
R
Site 8
T85
K
L
E
R
R
Q
A
T
D
D
A
S
L
L
I
Site 9
S89
R
Q
A
T
D
D
A
S
L
L
I
V
N
R
Y
Site 10
Y96
S
L
L
I
V
N
R
Y
W
S
Q
F
D
E
N
Site 11
Y111
I
R
I
I
L
K
R
Y
D
L
E
Q
G
L
G
Site 12
T122
Q
G
L
G
D
L
L
T
E
R
K
A
L
V
V
Site 13
S136
V
P
E
P
E
P
D
S
D
S
N
Q
E
R
K
Site 14
S138
E
P
E
P
D
S
D
S
N
Q
E
R
K
D
D
Site 15
S164
S
F
L
A
T
L
A
S
S
S
S
E
E
M
E
Site 16
S167
A
T
L
A
S
S
S
S
E
E
M
E
S
Q
L
Site 17
S172
S
S
S
E
E
M
E
S
Q
L
Q
E
R
V
E
Site 18
S180
Q
L
Q
E
R
V
E
S
S
R
R
A
V
S
Q
Site 19
S181
L
Q
E
R
V
E
S
S
R
R
A
V
S
Q
I
Site 20
S186
E
S
S
R
R
A
V
S
Q
I
V
T
V
Y
D
Site 21
T190
R
A
V
S
Q
I
V
T
V
Y
D
K
L
Q
E
Site 22
S223
E
A
V
Q
E
L
N
S
F
L
A
Q
E
N
M
Site 23
T236
N
M
R
L
Q
E
L
T
D
L
L
Q
E
K
H
Site 24
T245
L
L
Q
E
K
H
R
T
M
S
Q
E
F
S
K
Site 25
S247
Q
E
K
H
R
T
M
S
Q
E
F
S
K
L
Q
Site 26
S251
R
T
M
S
Q
E
F
S
K
L
Q
S
K
V
E
Site 27
S255
Q
E
F
S
K
L
Q
S
K
V
E
T
A
E
S
Site 28
T259
K
L
Q
S
K
V
E
T
A
E
S
R
V
S
V
Site 29
S262
S
K
V
E
T
A
E
S
R
V
S
V
L
E
S
Site 30
S265
E
T
A
E
S
R
V
S
V
L
E
S
M
I
D
Site 31
S269
S
R
V
S
V
L
E
S
M
I
D
D
L
Q
W
Site 32
S301
E
V
L
E
R
V
N
S
K
G
Y
K
V
Y
G
Site 33
Y307
N
S
K
G
Y
K
V
Y
G
A
G
S
S
L
Y
Site 34
Y314
Y
G
A
G
S
S
L
Y
G
G
T
I
T
I
N
Site 35
T317
G
S
S
L
Y
G
G
T
I
T
I
N
A
R
K
Site 36
T358
Q
D
F
E
E
V
T
T
Q
N
E
K
L
K
V
Site 37
T378
V
E
Q
V
V
K
E
T
P
E
Y
R
C
M
Q
Site 38
Y381
V
V
K
E
T
P
E
Y
R
C
M
Q
S
Q
F
Site 39
Y392
Q
S
Q
F
S
V
L
Y
N
E
S
L
Q
L
K
Site 40
T415
L
L
H
G
T
R
G
T
H
Q
H
Q
V
E
L
Site 41
S429
L
I
E
R
D
E
V
S
L
H
K
K
L
R
T
Site 42
T436
S
L
H
K
K
L
R
T
E
V
I
Q
L
E
D
Site 43
T444
E
V
I
Q
L
E
D
T
L
A
Q
V
R
K
E
Site 44
Y452
L
A
Q
V
R
K
E
Y
E
M
L
R
I
E
F
Site 45
T462
L
R
I
E
F
E
Q
T
L
A
A
N
E
Q
A
Site 46
Y497
L
K
G
E
V
L
R
Y
K
R
K
L
R
E
A
Site 47
S506
R
K
L
R
E
A
Q
S
D
L
N
K
T
R
L
Site 48
T511
A
Q
S
D
L
N
K
T
R
L
R
S
G
S
A
Site 49
S515
L
N
K
T
R
L
R
S
G
S
A
L
L
Q
S
Site 50
S517
K
T
R
L
R
S
G
S
A
L
L
Q
S
Q
S
Site 51
S522
S
G
S
A
L
L
Q
S
Q
S
S
T
E
D
P
Site 52
S524
S
A
L
L
Q
S
Q
S
S
T
E
D
P
K
D
Site 53
S525
A
L
L
Q
S
Q
S
S
T
E
D
P
K
D
E
Site 54
T526
L
L
Q
S
Q
S
S
T
E
D
P
K
D
E
P
Site 55
S540
P
A
E
L
K
P
D
S
E
D
L
S
S
Q
S
Site 56
S544
K
P
D
S
E
D
L
S
S
Q
S
S
A
S
K
Site 57
S545
P
D
S
E
D
L
S
S
Q
S
S
A
S
K
A
Site 58
S547
S
E
D
L
S
S
Q
S
S
A
S
K
A
S
Q
Site 59
S548
E
D
L
S
S
Q
S
S
A
S
K
A
S
Q
E
Site 60
S550
L
S
S
Q
S
S
A
S
K
A
S
Q
E
D
A
Site 61
S553
Q
S
S
A
S
K
A
S
Q
E
D
A
N
E
I
Site 62
S562
E
D
A
N
E
I
K
S
K
R
D
E
E
E
R
Site 63
S606
E
S
E
K
E
R
D
S
A
K
D
K
E
K
G
Site 64
Y650
M
K
L
L
L
D
M
Y
R
S
A
P
K
E
Q
Site 65
S652
L
L
L
D
M
Y
R
S
A
P
K
E
Q
R
D
Site 66
Y713
A
V
E
E
Q
I
E
Y
L
Q
K
K
L
A
M
Site 67
S730
Q
E
E
E
A
L
L
S
E
M
D
V
T
G
Q
Site 68
T735
L
L
S
E
M
D
V
T
G
Q
A
F
E
D
M
Site 69
S765
D
A
N
F
K
L
M
S
E
R
I
K
S
N
Q
Site 70
S770
L
M
S
E
R
I
K
S
N
Q
I
H
K
L
L
Site 71
S814
E
K
E
H
L
L
Q
S
N
I
G
T
G
E
K
Site 72
T818
L
L
Q
S
N
I
G
T
G
E
K
E
L
G
L
Site 73
S869
Q
D
E
I
V
E
N
S
V
T
K
E
K
D
M
Site 74
T871
E
I
V
E
N
S
V
T
K
E
K
D
M
F
N
Site 75
S887
K
R
A
Q
E
D
I
S
R
L
R
R
K
L
E
Site 76
T895
R
L
R
R
K
L
E
T
T
K
K
P
D
N
V
Site 77
T896
L
R
R
K
L
E
T
T
K
K
P
D
N
V
P
Site 78
Y916
L
M
E
E
I
K
D
Y
K
A
R
L
T
C
P
Site 79
Y950
F
E
C
V
K
T
R
Y
D
T
R
Q
R
K
C
Site 80
T952
C
V
K
T
R
Y
D
T
R
Q
R
K
C
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation