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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RIF1
Full Name:
Telomere-associated protein RIF1
Alias:
DKFZp434D193; FLJ10599; FLJ12870; RAP1 interacting factor; Rap1 interacting factor 1; Rap1-interacting factor 1 homolog
Type:
DNA repair protein
Mass (Da):
274466
Number AA:
2472
UniProt ID:
Q5UIP0
International Prot ID:
IPI00375454
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000781
GO:0005634
GO:0005819
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0006974
GO:0007049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
T
A
R
G
Q
S
P
L
A
P
L
L
E
Site 2
T15
P
L
A
P
L
L
E
T
L
E
D
P
S
A
S
Site 3
S20
L
E
T
L
E
D
P
S
A
S
H
G
G
Q
T
Site 4
Y30
H
G
G
Q
T
D
A
Y
L
T
L
T
S
R
M
Site 5
T32
G
Q
T
D
A
Y
L
T
L
T
S
R
M
T
G
Site 6
T34
T
D
A
Y
L
T
L
T
S
R
M
T
G
E
E
Site 7
T38
L
T
L
T
S
R
M
T
G
E
E
G
K
E
V
Site 8
Y57
E
K
K
L
P
R
L
Y
K
V
L
K
T
H
I
Site 9
T62
R
L
Y
K
V
L
K
T
H
I
S
S
Q
N
S
Site 10
S65
K
V
L
K
T
H
I
S
S
Q
N
S
E
L
S
Site 11
S66
V
L
K
T
H
I
S
S
Q
N
S
E
L
S
S
Site 12
S69
T
H
I
S
S
Q
N
S
E
L
S
S
A
A
L
Site 13
S72
S
S
Q
N
S
E
L
S
S
A
A
L
Q
A
L
Site 14
S73
S
Q
N
S
E
L
S
S
A
A
L
Q
A
L
G
Site 15
Y84
Q
A
L
G
F
C
L
Y
N
P
K
I
T
S
E
Site 16
S93
P
K
I
T
S
E
L
S
E
A
N
A
L
E
L
Site 17
T107
L
L
S
K
L
N
D
T
I
K
N
S
D
K
N
Site 18
S111
L
N
D
T
I
K
N
S
D
K
N
V
R
T
R
Site 19
S124
T
R
A
L
W
V
I
S
K
Q
T
F
P
S
E
Site 20
S143
M
V
S
S
I
I
D
S
L
E
I
L
F
N
K
Site 21
T247
L
F
M
S
K
N
E
T
Y
V
L
K
L
W
P
Site 22
Y248
F
M
S
K
N
E
T
Y
V
L
K
L
W
P
L
Site 23
T263
F
V
K
L
L
G
R
T
L
H
R
S
G
S
F
Site 24
S267
L
G
R
T
L
H
R
S
G
S
F
I
N
S
L
Site 25
S269
R
T
L
H
R
S
G
S
F
I
N
S
L
L
Q
Site 26
S273
R
S
G
S
F
I
N
S
L
L
Q
L
E
E
L
Site 27
S325
K
L
L
M
Q
P
L
S
S
I
H
V
R
T
E
Site 28
T333
S
I
H
V
R
T
E
T
L
A
L
T
K
L
E
Site 29
Y344
T
K
L
E
V
W
W
Y
L
L
M
R
L
G
P
Site 30
S370
P
L
I
Q
S
T
I
S
I
D
S
N
A
S
P
Site 31
S373
Q
S
T
I
S
I
D
S
N
A
S
P
Q
G
N
Site 32
S376
I
S
I
D
S
N
A
S
P
Q
G
N
S
C
H
Site 33
S381
N
A
S
P
Q
G
N
S
C
H
V
A
T
S
P
Site 34
S387
N
S
C
H
V
A
T
S
P
G
L
N
P
M
T
Site 35
T394
S
P
G
L
N
P
M
T
P
V
H
K
G
A
S
Site 36
S401
T
P
V
H
K
G
A
S
S
P
Y
G
A
P
G
Site 37
S402
P
V
H
K
G
A
S
S
P
Y
G
A
P
G
T
Site 38
Y404
H
K
G
A
S
S
P
Y
G
A
P
G
T
P
R
Site 39
T409
S
P
Y
G
A
P
G
T
P
R
M
N
L
S
S
Site 40
S415
G
T
P
R
M
N
L
S
S
N
L
G
G
M
A
Site 41
S416
T
P
R
M
N
L
S
S
N
L
G
G
M
A
T
Site 42
S446
L
L
G
P
E
A
L
S
F
A
K
Q
N
K
L
Site 43
S456
K
Q
N
K
L
V
L
S
L
E
P
L
E
H
P
Site 44
S466
P
L
E
H
P
L
I
S
S
P
S
F
F
S
K
Site 45
S467
L
E
H
P
L
I
S
S
P
S
F
F
S
K
H
Site 46
S469
H
P
L
I
S
S
P
S
F
F
S
K
H
A
N
Site 47
S511
E
L
I
S
L
V
K
S
V
T
E
S
G
N
K
Site 48
S515
L
V
K
S
V
T
E
S
G
N
K
K
E
K
P
Site 49
S524
N
K
K
E
K
P
G
S
E
V
L
T
L
L
L
Site 50
S566
L
P
Q
K
V
L
G
S
P
A
Y
Q
V
A
N
Site 51
T700
E
Q
R
F
P
V
A
T
M
K
T
L
L
R
T
Site 52
T703
F
P
V
A
T
M
K
T
L
L
R
T
W
S
E
Site 53
S709
K
T
L
L
R
T
W
S
E
L
Y
R
A
F
A
Site 54
S740
E
L
S
S
K
I
M
S
S
L
E
D
E
G
F
Site 55
S741
L
S
S
K
I
M
S
S
L
E
D
E
G
F
S
Site 56
S770
M
V
D
C
I
D
F
S
P
Y
N
I
K
Y
Q
Site 57
Y772
D
C
I
D
F
S
P
Y
N
I
K
Y
Q
P
K
Site 58
Y776
F
S
P
Y
N
I
K
Y
Q
P
K
V
K
S
P
Site 59
S782
K
Y
Q
P
K
V
K
S
P
Q
R
P
S
D
W
Site 60
S787
V
K
S
P
Q
R
P
S
D
W
S
K
K
K
N
Site 61
S790
P
Q
R
P
S
D
W
S
K
K
K
N
E
P
L
Site 62
T816
K
V
I
Y
S
F
H
T
L
S
F
K
E
A
H
Site 63
S818
I
Y
S
F
H
T
L
S
F
K
E
A
H
S
D
Site 64
S824
L
S
F
K
E
A
H
S
D
T
L
F
T
I
G
Site 65
T826
F
K
E
A
H
S
D
T
L
F
T
I
G
N
S
Site 66
S869
L
A
L
F
Y
E
N
S
K
L
D
E
V
P
K
Site 67
T901
A
C
L
Q
F
S
Y
T
G
T
Y
D
S
E
L
Site 68
T903
L
Q
F
S
Y
T
G
T
Y
D
S
E
L
L
E
Site 69
S906
S
Y
T
G
T
Y
D
S
E
L
L
E
Q
L
S
Site 70
T956
E
E
L
K
P
V
L
T
Q
A
K
Q
K
F
L
Site 71
S978
T
V
E
M
M
E
E
S
S
G
P
Y
S
D
G
Site 72
S979
V
E
M
M
E
E
S
S
G
P
Y
S
D
G
T
Site 73
S983
E
E
S
S
G
P
Y
S
D
G
T
E
N
S
Q
Site 74
T986
S
G
P
Y
S
D
G
T
E
N
S
Q
L
N
V
Site 75
S989
Y
S
D
G
T
E
N
S
Q
L
N
V
K
I
S
Site 76
S996
S
Q
L
N
V
K
I
S
G
M
E
R
K
S
N
Site 77
S1002
I
S
G
M
E
R
K
S
N
G
K
R
D
S
F
Site 78
S1008
K
S
N
G
K
R
D
S
F
L
A
Q
T
K
N
Site 79
S1030
A
A
K
L
K
L
E
S
S
S
L
K
V
K
G
Site 80
S1031
A
K
L
K
L
E
S
S
S
L
K
V
K
G
E
Site 81
S1032
K
L
K
L
E
S
S
S
L
K
V
K
G
E
I
Site 82
S1046
I
L
L
E
E
E
K
S
T
D
F
V
F
I
P
Site 83
T1047
L
L
E
E
E
K
S
T
D
F
V
F
I
P
P
Site 84
T1065
D
A
K
E
R
I
L
T
D
H
Q
K
E
V
L
Site 85
T1074
H
Q
K
E
V
L
K
T
K
R
C
D
I
P
A
Site 86
Y1083
R
C
D
I
P
A
M
Y
N
N
L
D
V
S
Q
Site 87
T1092
N
L
D
V
S
Q
D
T
L
F
T
Q
Y
S
Q
Site 88
S1098
D
T
L
F
T
Q
Y
S
Q
E
E
P
M
E
I
Site 89
T1107
E
E
P
M
E
I
P
T
L
T
R
K
P
K
E
Site 90
T1109
P
M
E
I
P
T
L
T
R
K
P
K
E
D
S
Site 91
S1127
I
T
E
E
Q
M
D
S
D
I
V
I
P
Q
D
Site 92
S1149
A
E
H
L
E
K
S
S
L
S
N
N
E
C
G
Site 93
S1151
H
L
E
K
S
S
L
S
N
N
E
C
G
S
L
Site 94
S1157
L
S
N
N
E
C
G
S
L
D
K
T
S
P
E
Site 95
T1161
E
C
G
S
L
D
K
T
S
P
E
M
S
N
S
Site 96
S1162
C
G
S
L
D
K
T
S
P
E
M
S
N
S
N
Site 97
S1166
D
K
T
S
P
E
M
S
N
S
N
N
D
E
R
Site 98
S1168
T
S
P
E
M
S
N
S
N
N
D
E
R
K
K
Site 99
S1179
E
R
K
K
A
L
I
S
S
R
K
T
S
T
E
Site 100
S1180
R
K
K
A
L
I
S
S
R
K
T
S
T
E
C
Site 101
T1183
A
L
I
S
S
R
K
T
S
T
E
C
A
S
S
Site 102
S1184
L
I
S
S
R
K
T
S
T
E
C
A
S
S
T
Site 103
T1185
I
S
S
R
K
T
S
T
E
C
A
S
S
T
E
Site 104
S1189
K
T
S
T
E
C
A
S
S
T
E
N
S
F
V
Site 105
S1190
T
S
T
E
C
A
S
S
T
E
N
S
F
V
V
Site 106
T1191
S
T
E
C
A
S
S
T
E
N
S
F
V
V
S
Site 107
S1194
C
A
S
S
T
E
N
S
F
V
V
S
S
S
S
Site 108
S1198
T
E
N
S
F
V
V
S
S
S
S
V
S
N
T
Site 109
S1199
E
N
S
F
V
V
S
S
S
S
V
S
N
T
T
Site 110
T1205
S
S
S
S
V
S
N
T
T
V
A
G
T
P
P
Site 111
T1206
S
S
S
V
S
N
T
T
V
A
G
T
P
P
Y
Site 112
T1210
S
N
T
T
V
A
G
T
P
P
Y
P
T
S
R
Site 113
Y1213
T
V
A
G
T
P
P
Y
P
T
S
R
R
Q
T
Site 114
T1215
A
G
T
P
P
Y
P
T
S
R
R
Q
T
F
I
Site 115
S1216
G
T
P
P
Y
P
T
S
R
R
Q
T
F
I
T
Site 116
T1220
Y
P
T
S
R
R
Q
T
F
I
T
L
E
K
F
Site 117
T1223
S
R
R
Q
T
F
I
T
L
E
K
F
D
G
S
Site 118
S1230
T
L
E
K
F
D
G
S
E
N
R
P
F
S
P
Site 119
S1236
G
S
E
N
R
P
F
S
P
S
P
L
N
N
I
Site 120
S1238
E
N
R
P
F
S
P
S
P
L
N
N
I
S
S
Site 121
S1245
S
P
L
N
N
I
S
S
T
V
T
V
K
N
N
Site 122
T1246
P
L
N
N
I
S
S
T
V
T
V
K
N
N
Q
Site 123
T1248
N
N
I
S
S
T
V
T
V
K
N
N
Q
E
T
Site 124
T1271
K
A
K
Q
R
E
G
T
F
S
K
S
D
S
E
Site 125
S1273
K
Q
R
E
G
T
F
S
K
S
D
S
E
K
I
Site 126
S1275
R
E
G
T
F
S
K
S
D
S
E
K
I
V
N
Site 127
S1277
G
T
F
S
K
S
D
S
E
K
I
V
N
G
T
Site 128
T1284
S
E
K
I
V
N
G
T
K
R
S
S
R
R
A
Site 129
S1287
I
V
N
G
T
K
R
S
S
R
R
A
G
K
A
Site 130
S1288
V
N
G
T
K
R
S
S
R
R
A
G
K
A
E
Site 131
S1308
R
S
K
P
L
M
R
S
E
P
E
K
N
T
E
Site 132
S1317
P
E
K
N
T
E
E
S
V
E
G
I
V
V
L
Site 133
T1335
P
P
G
L
L
N
Q
T
E
C
V
S
D
N
Q
Site 134
S1346
S
D
N
Q
V
H
L
S
E
S
T
M
E
H
D
Site 135
T1349
Q
V
H
L
S
E
S
T
M
E
H
D
N
T
K
Site 136
T1355
S
T
M
E
H
D
N
T
K
L
K
A
A
T
V
Site 137
T1372
A
V
L
L
E
T
N
T
V
E
E
K
N
V
E
Site 138
S1384
N
V
E
I
N
L
E
S
K
E
N
T
P
P
V
Site 139
T1388
N
L
E
S
K
E
N
T
P
P
V
V
I
S
A
Site 140
S1394
N
T
P
P
V
V
I
S
A
D
Q
M
V
N
E
Site 141
S1403
D
Q
M
V
N
E
D
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L
H
N
Y
S
G
S
Q
L
F
E
M
H
E
Site 294
S2461
S
V
I
K
N
L
Q
S
R
W
R
S
P
S
H
Site 295
S2465
N
L
Q
S
R
W
R
S
P
S
H
E
N
S
I
Site 296
S2467
Q
S
R
W
R
S
P
S
H
E
N
S
I
_
_
Site 297
S2471
R
S
P
S
H
E
N
S
I
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation