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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STXBP5
Full Name:
Syntaxin-binding protein 5
Alias:
Lethal(2) giant larvae protein homolog 3; LLGL3; STXB5; Syntaxin binding protein 5; Tomosyn; Tomosyn-1
Type:
Vesicle protein
Mass (Da):
127573
Number AA:
1151
UniProt ID:
Q5T5C0
International Prot ID:
IPI00171407
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0019898
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006887
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
R
K
V
L
D
G
L
T
A
G
S
S
S
A
S
Site 2
S17
L
D
G
L
T
A
G
S
S
S
A
S
Q
Q
Q
Site 3
S18
D
G
L
T
A
G
S
S
S
A
S
Q
Q
Q
Q
Site 4
S21
T
A
G
S
S
S
A
S
Q
Q
Q
Q
Q
Q
H
Site 5
T40
R
E
P
E
I
Q
E
T
L
Q
S
E
H
F
Q
Site 6
Y58
T
V
R
H
G
F
P
Y
Q
P
S
A
L
A
F
Site 7
T76
Q
K
I
L
A
V
G
T
Q
T
G
A
L
R
L
Site 8
Y92
G
R
P
G
V
E
C
Y
C
Q
H
D
S
G
A
Site 9
Y158
P
F
Q
S
K
W
L
Y
V
G
T
E
R
G
N
Site 10
S190
W
N
K
A
I
E
L
S
S
K
S
H
P
G
P
Site 11
S191
N
K
A
I
E
L
S
S
K
S
H
P
G
P
V
Site 12
S193
A
I
E
L
S
S
K
S
H
P
G
P
V
V
H
Site 13
S202
P
G
P
V
V
H
I
S
D
N
P
M
D
E
G
Site 14
Y232
L
K
S
K
K
A
D
Y
R
Y
T
Y
D
E
A
Site 15
Y234
S
K
K
A
D
Y
R
Y
T
Y
D
E
A
I
H
Site 16
T235
K
K
A
D
Y
R
Y
T
Y
D
E
A
I
H
S
Site 17
Y236
K
A
D
Y
R
Y
T
Y
D
E
A
I
H
S
V
Site 18
S242
T
Y
D
E
A
I
H
S
V
A
W
H
H
E
G
Site 19
S255
E
G
K
Q
F
I
C
S
H
S
D
G
T
L
T
Site 20
T262
S
H
S
D
G
T
L
T
I
W
N
V
R
S
P
Site 21
S268
L
T
I
W
N
V
R
S
P
A
K
P
V
Q
T
Site 22
T275
S
P
A
K
P
V
Q
T
I
T
P
H
G
K
Q
Site 23
T277
A
K
P
V
Q
T
I
T
P
H
G
K
Q
L
K
Site 24
T302
I
L
K
V
E
F
K
T
T
R
S
G
E
P
F
Site 25
T303
L
K
V
E
F
K
T
T
R
S
G
E
P
F
I
Site 26
T320
S
G
G
L
S
Y
D
T
V
G
R
R
P
C
L
Site 27
T328
V
G
R
R
P
C
L
T
V
M
H
G
K
S
T
Site 28
T353
D
F
L
T
L
C
E
T
P
Y
P
N
D
F
Q
Site 29
Y355
L
T
L
C
E
T
P
Y
P
N
D
F
Q
E
P
Site 30
Y383
I
D
L
A
Q
N
G
Y
P
I
F
E
N
P
Y
Site 31
Y390
Y
P
I
F
E
N
P
Y
P
L
S
I
H
E
S
Site 32
S393
F
E
N
P
Y
P
L
S
I
H
E
S
P
V
T
Site 33
T400
S
I
H
E
S
P
V
T
C
C
E
Y
F
A
D
Site 34
S418
D
L
I
P
A
L
Y
S
V
G
A
R
Q
K
R
Site 35
Y428
A
R
Q
K
R
Q
G
Y
S
K
K
E
W
P
I
Site 36
S459
I
T
G
H
A
D
G
S
V
K
F
W
D
A
S
Site 37
T478
Q
V
L
Y
K
L
K
T
S
K
V
F
E
K
S
Site 38
S485
T
S
K
V
F
E
K
S
R
N
K
D
D
R
P
Site 39
T494
N
K
D
D
R
P
N
T
D
I
V
D
E
D
P
Site 40
Y502
D
I
V
D
E
D
P
Y
A
I
Q
I
I
S
W
Site 41
T556
Y
E
I
N
D
V
E
T
P
E
G
E
Q
P
P
Site 42
T567
E
Q
P
P
P
L
P
T
P
V
G
G
S
N
P
Site 43
S581
P
Q
P
I
P
P
Q
S
H
P
S
T
S
S
S
Site 44
S584
I
P
P
Q
S
H
P
S
T
S
S
S
S
S
D
Site 45
T585
P
P
Q
S
H
P
S
T
S
S
S
S
S
D
G
Site 46
S586
P
Q
S
H
P
S
T
S
S
S
S
S
D
G
L
Site 47
S587
Q
S
H
P
S
T
S
S
S
S
S
D
G
L
R
Site 48
S588
S
H
P
S
T
S
S
S
S
S
D
G
L
R
D
Site 49
S590
P
S
T
S
S
S
S
S
D
G
L
R
D
N
V
Site 50
S605
P
C
L
K
V
K
N
S
P
L
K
Q
S
P
G
Site 51
S610
K
N
S
P
L
K
Q
S
P
G
Y
Q
T
E
L
Site 52
Y613
P
L
K
Q
S
P
G
Y
Q
T
E
L
V
I
Q
Site 53
S634
E
P
P
Q
Q
I
T
S
L
A
V
N
S
S
Y
Site 54
T668
A
V
L
L
N
L
G
T
I
E
L
Y
G
S
N
Site 55
Y672
N
L
G
T
I
E
L
Y
G
S
N
D
P
Y
R
Site 56
S674
G
T
I
E
L
Y
G
S
N
D
P
Y
R
R
E
Site 57
Y678
L
Y
G
S
N
D
P
Y
R
R
E
P
R
S
P
Site 58
S684
P
Y
R
R
E
P
R
S
P
R
K
S
R
Q
P
Site 59
S688
E
P
R
S
P
R
K
S
R
Q
P
S
G
A
G
Site 60
S692
P
R
K
S
R
Q
P
S
G
A
G
L
C
D
I
Site 61
S700
G
A
G
L
C
D
I
S
E
G
T
V
V
P
E
Site 62
T703
L
C
D
I
S
E
G
T
V
V
P
E
D
R
C
Site 63
S712
V
P
E
D
R
C
K
S
P
T
S
G
S
S
S
Site 64
T714
E
D
R
C
K
S
P
T
S
G
S
S
S
P
H
Site 65
S715
D
R
C
K
S
P
T
S
G
S
S
S
P
H
N
Site 66
S717
C
K
S
P
T
S
G
S
S
S
P
H
N
S
D
Site 67
S718
K
S
P
T
S
G
S
S
S
P
H
N
S
D
D
Site 68
S719
S
P
T
S
G
S
S
S
P
H
N
S
D
D
E
Site 69
S723
G
S
S
S
P
H
N
S
D
D
E
Q
K
M
N
Site 70
T738
N
F
I
E
K
V
K
T
K
S
R
K
F
S
K
Site 71
S740
I
E
K
V
K
T
K
S
R
K
F
S
K
M
V
Site 72
S744
K
T
K
S
R
K
F
S
K
M
V
A
N
D
I
Site 73
S755
A
N
D
I
A
K
M
S
R
K
L
S
L
P
T
Site 74
S759
A
K
M
S
R
K
L
S
L
P
T
D
L
K
P
Site 75
T762
S
R
K
L
S
L
P
T
D
L
K
P
D
L
D
Site 76
S774
D
L
D
V
K
D
N
S
F
S
R
S
R
S
S
Site 77
S776
D
V
K
D
N
S
F
S
R
S
R
S
S
S
V
Site 78
S778
K
D
N
S
F
S
R
S
R
S
S
S
V
T
S
Site 79
S780
N
S
F
S
R
S
R
S
S
S
V
T
S
I
D
Site 80
S781
S
F
S
R
S
R
S
S
S
V
T
S
I
D
K
Site 81
S782
F
S
R
S
R
S
S
S
V
T
S
I
D
K
E
Site 82
T784
R
S
R
S
S
S
V
T
S
I
D
K
E
S
R
Site 83
S785
S
R
S
S
S
V
T
S
I
D
K
E
S
R
E
Site 84
S790
V
T
S
I
D
K
E
S
R
E
A
I
S
A
L
Site 85
T802
S
A
L
H
F
C
E
T
F
T
R
K
T
D
S
Site 86
T807
C
E
T
F
T
R
K
T
D
S
S
P
S
P
C
Site 87
S809
T
F
T
R
K
T
D
S
S
P
S
P
C
L
W
Site 88
S810
F
T
R
K
T
D
S
S
P
S
P
C
L
W
V
Site 89
S812
R
K
T
D
S
S
P
S
P
C
L
W
V
G
T
Site 90
Y875
G
C
L
I
P
P
A
Y
E
P
W
R
E
H
N
Site 91
S900
L
K
K
R
R
P
V
S
V
S
P
S
S
S
Q
Site 92
S902
K
R
R
P
V
S
V
S
P
S
S
S
Q
E
I
Site 93
S904
R
P
V
S
V
S
P
S
S
S
Q
E
I
S
E
Site 94
S905
P
V
S
V
S
P
S
S
S
Q
E
I
S
E
N
Site 95
S906
V
S
V
S
P
S
S
S
Q
E
I
S
E
N
Q
Site 96
S910
P
S
S
S
Q
E
I
S
E
N
Q
Y
A
V
I
Site 97
Y914
Q
E
I
S
E
N
Q
Y
A
V
I
C
S
E
K
Site 98
S927
E
K
Q
A
K
V
I
S
L
P
T
Q
N
C
A
Site 99
S943
K
Q
N
I
T
E
T
S
F
V
L
R
G
D
I
Site 100
Y984
R
P
L
L
D
V
Y
Y
L
P
L
T
N
M
R
Site 101
T988
D
V
Y
Y
L
P
L
T
N
M
R
I
A
R
T
Site 102
Y1006
T
N
N
G
Q
A
L
Y
L
V
S
P
T
E
I
Site 103
T1017
P
T
E
I
Q
R
L
T
Y
S
Q
E
T
C
E
Site 104
Y1018
T
E
I
Q
R
L
T
Y
S
Q
E
T
C
E
N
Site 105
S1019
E
I
Q
R
L
T
Y
S
Q
E
T
C
E
N
L
Site 106
T1035
E
M
L
G
E
L
F
T
P
V
E
T
P
E
A
Site 107
T1039
E
L
F
T
P
V
E
T
P
E
A
P
N
R
G
Site 108
S1058
L
F
G
G
G
A
Q
S
L
D
R
E
E
L
F
Site 109
S1069
E
E
L
F
G
E
S
S
S
G
K
A
S
R
S
Site 110
S1070
E
L
F
G
E
S
S
S
G
K
A
S
R
S
L
Site 111
S1074
E
S
S
S
G
K
A
S
R
S
L
A
Q
H
I
Site 112
S1076
S
S
G
K
A
S
R
S
L
A
Q
H
I
P
G
Site 113
S1127
E
R
T
A
A
M
L
S
S
A
E
S
F
S
K
Site 114
S1128
R
T
A
A
M
L
S
S
A
E
S
F
S
K
H
Site 115
S1131
A
M
L
S
S
A
E
S
F
S
K
H
A
H
E
Site 116
Y1143
A
H
E
I
M
L
K
Y
K
D
K
K
W
Y
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation