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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FKBP15
Full Name:
FK506-binding protein 15
Alias:
FK506 binding protein 15, 133kDa; FKB15; KIAA0674; WASP and FKBP-like
Type:
Unknown function
Mass (Da):
133630
Number AA:
1219
UniProt ID:
Q5T1M5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030424
GO:0005769
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0006457
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
G
A
G
D
E
D
D
T
D
F
L
S
P
S
G
Site 2
S14
E
D
D
T
D
F
L
S
P
S
G
G
A
R
L
Site 3
S16
D
T
D
F
L
S
P
S
G
G
A
R
L
A
S
Site 4
Y41
H
G
N
E
F
F
Q
Y
T
A
P
K
Q
P
K
Site 5
T42
G
N
E
F
F
Q
Y
T
A
P
K
Q
P
K
K
Site 6
T61
A
A
T
G
N
Q
A
T
P
K
T
A
P
A
T
Site 7
T64
G
N
Q
A
T
P
K
T
A
P
A
T
M
S
T
Site 8
T68
T
P
K
T
A
P
A
T
M
S
T
P
T
I
L
Site 9
T86
A
V
H
A
Y
R
Y
T
N
G
Q
Y
V
K
Q
Site 10
Y90
Y
R
Y
T
N
G
Q
Y
V
K
Q
G
K
F
G
Site 11
Y109
G
N
H
T
A
R
E
Y
R
I
L
L
Y
I
S
Site 12
Y114
R
E
Y
R
I
L
L
Y
I
S
Q
Q
Q
P
V
Site 13
T122
I
S
Q
Q
Q
P
V
T
V
A
R
I
H
V
N
Site 14
T141
V
R
P
N
N
Y
S
T
F
Y
D
D
Q
R
Q
Site 15
Y143
P
N
N
Y
S
T
F
Y
D
D
Q
R
Q
N
W
Site 16
S177
A
K
C
N
S
T
S
S
L
D
A
V
L
S
Q
Site 17
T221
L
G
Q
V
F
D
S
T
A
N
K
D
K
L
L
Site 18
S295
R
V
K
F
A
R
D
S
G
S
D
G
H
S
V
Site 19
S297
K
F
A
R
D
S
G
S
D
G
H
S
V
S
S
Site 20
S301
D
S
G
S
D
G
H
S
V
S
S
R
D
S
A
Site 21
S303
G
S
D
G
H
S
V
S
S
R
D
S
A
A
P
Site 22
S304
S
D
G
H
S
V
S
S
R
D
S
A
A
P
S
Site 23
S307
H
S
V
S
S
R
D
S
A
A
P
S
P
I
P
Site 24
S311
S
R
D
S
A
A
P
S
P
I
P
G
A
D
N
Site 25
S326
L
S
A
D
P
V
V
S
P
P
T
S
I
P
F
Site 26
T329
D
P
V
V
S
P
P
T
S
I
P
F
K
S
G
Site 27
S330
P
V
V
S
P
P
T
S
I
P
F
K
S
G
E
Site 28
S335
P
T
S
I
P
F
K
S
G
E
P
A
L
R
T
Site 29
T342
S
G
E
P
A
L
R
T
K
S
N
S
L
S
E
Site 30
S344
E
P
A
L
R
T
K
S
N
S
L
S
E
Q
L
Site 31
S346
A
L
R
T
K
S
N
S
L
S
E
Q
L
A
I
Site 32
S348
R
T
K
S
N
S
L
S
E
Q
L
A
I
N
T
Site 33
S356
E
Q
L
A
I
N
T
S
P
D
A
V
K
A
K
Site 34
S385
I
L
P
P
Q
L
D
S
N
D
S
E
I
E
D
Site 35
T395
S
E
I
E
D
V
N
T
L
Q
G
G
G
Q
P
Site 36
T405
G
G
G
Q
P
V
V
T
P
S
V
Q
P
S
L
Site 37
S407
G
Q
P
V
V
T
P
S
V
Q
P
S
L
H
P
Site 38
S411
V
T
P
S
V
Q
P
S
L
H
P
A
H
P
A
Site 39
S424
P
A
L
P
Q
M
T
S
Q
A
P
Q
P
S
V
Site 40
S430
T
S
Q
A
P
Q
P
S
V
T
G
L
Q
A
P
Site 41
S449
M
Q
V
S
S
L
D
S
H
S
A
V
S
G
N
Site 42
S451
V
S
S
L
D
S
H
S
A
V
S
G
N
A
Q
Site 43
S459
A
V
S
G
N
A
Q
S
F
Q
P
Y
A
G
M
Site 44
Y463
N
A
Q
S
F
Q
P
Y
A
G
M
Q
A
Y
A
Site 45
Y469
P
Y
A
G
M
Q
A
Y
A
Y
P
Q
A
S
A
Site 46
S475
A
Y
A
Y
P
Q
A
S
A
V
T
S
Q
L
Q
Site 47
S479
P
Q
A
S
A
V
T
S
Q
L
Q
P
V
R
P
Site 48
Y488
L
Q
P
V
R
P
L
Y
P
A
P
L
S
Q
P
Site 49
S493
P
L
Y
P
A
P
L
S
Q
P
P
H
F
Q
G
Site 50
S506
Q
G
S
G
D
M
A
S
F
L
M
T
E
A
R
Site 51
T510
D
M
A
S
F
L
M
T
E
A
R
Q
H
N
T
Site 52
S548
Q
K
H
S
A
G
N
S
M
L
I
P
S
M
S
Site 53
S585
K
Q
E
I
L
E
K
S
N
R
I
E
E
Q
N
Site 54
Y605
L
I
E
R
N
Q
R
Y
V
E
Q
S
N
L
M
Site 55
S619
M
M
E
K
R
N
N
S
L
Q
T
A
T
E
N
Site 56
T660
S
H
L
Q
L
K
M
T
A
H
Q
K
K
E
T
Site 57
T674
T
E
L
Q
M
Q
L
T
E
S
L
K
E
T
D
Site 58
S676
L
Q
M
Q
L
T
E
S
L
K
E
T
D
L
L
Site 59
T680
L
T
E
S
L
K
E
T
D
L
L
R
G
Q
L
Site 60
S695
T
K
V
Q
A
K
L
S
E
L
Q
E
T
S
E
Site 61
T700
K
L
S
E
L
Q
E
T
S
E
Q
A
Q
S
K
Site 62
S701
L
S
E
L
Q
E
T
S
E
Q
A
Q
S
K
F
Site 63
S706
E
T
S
E
Q
A
Q
S
K
F
K
S
E
K
Q
Site 64
S710
Q
A
Q
S
K
F
K
S
E
K
Q
N
R
K
Q
Site 65
T723
K
Q
L
E
L
K
V
T
S
L
E
E
E
L
T
Site 66
S724
Q
L
E
L
K
V
T
S
L
E
E
E
L
T
D
Site 67
T730
T
S
L
E
E
E
L
T
D
L
R
V
E
K
E
Site 68
S738
D
L
R
V
E
K
E
S
L
E
K
N
L
S
E
Site 69
S744
E
S
L
E
K
N
L
S
E
R
K
K
K
S
A
Site 70
S750
L
S
E
R
K
K
K
S
A
Q
E
R
S
Q
A
Site 71
S755
K
K
S
A
Q
E
R
S
Q
A
E
E
E
I
D
Site 72
S767
E
I
D
E
I
R
K
S
Y
Q
E
E
L
D
K
Site 73
Y768
I
D
E
I
R
K
S
Y
Q
E
E
L
D
K
L
Site 74
S785
L
L
K
K
T
R
V
S
T
D
Q
A
A
A
E
Site 75
T786
L
K
K
T
R
V
S
T
D
Q
A
A
A
E
Q
Site 76
Y824
K
D
E
H
L
Q
Q
Y
Q
E
V
C
A
Q
R
Site 77
Y834
V
C
A
Q
R
D
A
Y
Q
Q
K
L
V
Q
L
Site 78
S871
K
E
L
E
K
N
K
S
Q
M
S
G
V
E
A
Site 79
S874
E
K
N
K
S
Q
M
S
G
V
E
A
A
A
S
Site 80
S881
S
G
V
E
A
A
A
S
D
P
S
E
K
V
K
Site 81
S897
I
M
N
Q
V
F
Q
S
L
R
R
E
F
E
L
Site 82
S907
R
E
F
E
L
E
E
S
Y
N
G
R
T
I
L
Site 83
S939
Q
E
Q
E
K
E
E
S
S
S
E
E
E
E
E
Site 84
S940
E
Q
E
K
E
E
S
S
S
E
E
E
E
E
K
Site 85
S941
Q
E
K
E
E
S
S
S
E
E
E
E
E
K
A
Site 86
S956
E
E
R
P
R
R
P
S
Q
E
Q
S
A
S
A
Site 87
S960
R
R
P
S
Q
E
Q
S
A
S
A
S
S
G
Q
Site 88
S962
P
S
Q
E
Q
S
A
S
A
S
S
G
Q
P
Q
Site 89
S964
Q
E
Q
S
A
S
A
S
S
G
Q
P
Q
A
P
Site 90
S979
L
N
R
E
R
P
E
S
P
M
V
P
S
E
Q
Site 91
S984
P
E
S
P
M
V
P
S
E
Q
V
V
E
E
A
Site 92
T1000
P
L
P
P
Q
A
L
T
T
S
Q
D
G
H
R
Site 93
S1002
P
P
Q
A
L
T
T
S
Q
D
G
H
R
R
K
Site 94
S1012
G
H
R
R
K
G
D
S
E
A
E
A
L
S
E
Site 95
S1018
D
S
E
A
E
A
L
S
E
I
K
D
G
S
L
Site 96
S1024
L
S
E
I
K
D
G
S
L
P
P
E
L
S
C
Site 97
S1030
G
S
L
P
P
E
L
S
C
I
P
S
H
R
V
Site 98
S1034
P
E
L
S
C
I
P
S
H
R
V
L
G
P
P
Site 99
T1042
H
R
V
L
G
P
P
T
S
I
P
P
E
P
L
Site 100
S1043
R
V
L
G
P
P
T
S
I
P
P
E
P
L
G
Site 101
S1053
P
E
P
L
G
P
V
S
M
D
S
E
C
E
E
Site 102
S1056
L
G
P
V
S
M
D
S
E
C
E
E
S
L
A
Site 103
S1061
M
D
S
E
C
E
E
S
L
A
A
S
P
M
A
Site 104
S1065
C
E
E
S
L
A
A
S
P
M
A
A
K
P
D
Site 105
S1092
P
D
G
P
L
Q
E
S
S
T
R
L
S
L
T
Site 106
S1093
D
G
P
L
Q
E
S
S
T
R
L
S
L
T
S
Site 107
T1094
G
P
L
Q
E
S
S
T
R
L
S
L
T
S
D
Site 108
S1097
Q
E
S
S
T
R
L
S
L
T
S
D
P
E
E
Site 109
T1099
S
S
T
R
L
S
L
T
S
D
P
E
E
G
D
Site 110
S1100
S
T
R
L
S
L
T
S
D
P
E
E
G
D
P
Site 111
S1114
P
L
A
L
G
P
E
S
P
G
E
P
Q
P
P
Site 112
T1129
Q
L
K
K
D
D
V
T
S
S
T
G
P
H
K
Site 113
S1131
K
K
D
D
V
T
S
S
T
G
P
H
K
E
L
Site 114
S1139
P
L
A
L
G
P
E
S
P
G
E
P
Q
P
P
Site 115
S1140
G
P
H
K
E
L
S
S
T
E
A
G
S
T
V
Site 116
T1141
P
H
K
E
L
S
S
T
E
A
G
S
T
V
A
Site 117
T1146
S
S
T
E
A
G
S
T
V
A
G
A
A
L
R
Site 118
S1155
A
G
A
A
L
R
P
S
H
H
S
Q
R
S
S
Site 119
S1158
A
L
R
P
S
H
H
S
Q
R
S
S
L
S
G
Site 120
S1161
P
S
H
H
S
Q
R
S
S
L
S
G
D
E
E
Site 121
S1162
S
H
H
S
Q
R
S
S
L
S
G
D
E
E
D
Site 122
S1164
H
S
Q
R
S
S
L
S
G
D
E
E
D
E
L
Site 123
S1195
E
E
D
E
D
E
V
S
M
K
G
R
P
P
P
Site 124
T1203
M
K
G
R
P
P
P
T
P
L
F
G
D
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation