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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RRP12
Full Name:
RRP12-like protein
Alias:
KIAA0690; Ribosomal RNA processing 12
Type:
Membrane protein, integral
Mass (Da):
143702
Number AA:
1297
UniProt ID:
Q5JTH9
International Prot ID:
IPI00101186
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
G
R
S
G
K
L
P
S
G
V
Site 2
S9
G
R
S
G
K
L
P
S
G
V
S
A
K
L
K
Site 3
S12
G
K
L
P
S
G
V
S
A
K
L
K
R
W
K
Site 4
S23
K
R
W
K
K
G
H
S
S
D
S
N
P
A
I
Site 5
S24
R
W
K
K
G
H
S
S
D
S
N
P
A
I
C
Site 6
S26
K
K
G
H
S
S
D
S
N
P
A
I
C
R
H
Site 7
S39
R
H
R
Q
A
A
R
S
R
F
F
S
R
P
S
Site 8
S43
A
A
R
S
R
F
F
S
R
P
S
G
R
S
D
Site 9
S46
S
R
F
F
S
R
P
S
G
R
S
D
L
T
V
Site 10
S49
F
S
R
P
S
G
R
S
D
L
T
V
D
A
V
Site 11
T52
P
S
G
R
S
D
L
T
V
D
A
V
K
L
H
Site 12
S64
K
L
H
N
E
L
Q
S
G
S
L
R
L
G
K
Site 13
S66
H
N
E
L
Q
S
G
S
L
R
L
G
K
S
E
Site 14
S72
G
S
L
R
L
G
K
S
E
A
P
E
T
P
M
Site 15
T77
G
K
S
E
A
P
E
T
P
M
E
E
E
A
E
Site 16
T88
E
E
A
E
L
V
L
T
E
K
S
S
G
T
F
Site 17
S91
E
L
V
L
T
E
K
S
S
G
T
F
L
S
G
Site 18
S92
L
V
L
T
E
K
S
S
G
T
F
L
S
G
L
Site 19
T94
L
T
E
K
S
S
G
T
F
L
S
G
L
S
D
Site 20
S97
K
S
S
G
T
F
L
S
G
L
S
D
C
T
N
Site 21
S100
G
T
F
L
S
G
L
S
D
C
T
N
V
T
F
Site 22
T106
L
S
D
C
T
N
V
T
F
S
K
V
Q
R
F
Site 23
S137
A
V
T
E
V
I
R
S
Q
G
G
K
E
T
E
Site 24
Y147
G
K
E
T
E
T
E
Y
F
A
A
L
M
T
T
Site 25
S199
K
A
F
M
D
I
M
S
A
Q
A
S
S
G
S
Site 26
S206
S
A
Q
A
S
S
G
S
T
S
V
L
R
W
V
Site 27
S208
Q
A
S
S
G
S
T
S
V
L
R
W
V
L
S
Site 28
Y231
Q
D
L
E
A
W
G
Y
P
V
T
L
Q
V
Y
Site 29
S243
Q
V
Y
H
G
L
L
S
F
T
V
H
P
K
P
Site 30
T245
Y
H
G
L
L
S
F
T
V
H
P
K
P
K
I
Site 31
S262
A
A
Q
H
G
V
C
S
V
L
K
G
S
E
F
Site 32
S295
C
I
Q
E
I
E
K
S
G
G
S
K
E
A
T
Site 33
T302
S
G
G
S
K
E
A
T
T
T
L
H
M
L
T
Site 34
S325
F
P
E
G
L
V
K
S
C
S
E
T
L
L
R
Site 35
T361
H
A
R
P
G
L
S
T
L
S
A
E
L
N
A
Site 36
Y375
A
Q
I
I
T
A
L
Y
D
Y
V
P
S
E
N
Site 37
S380
A
L
Y
D
Y
V
P
S
E
N
D
L
Q
P
L
Site 38
T433
S
P
H
S
Q
V
L
T
A
A
T
Q
S
L
K
Site 39
S456
P
H
M
A
D
I
G
S
V
T
S
S
A
S
G
Site 40
S459
A
D
I
G
S
V
T
S
S
A
S
G
P
A
Q
Site 41
S460
D
I
G
S
V
T
S
S
A
S
G
P
A
Q
S
Site 42
S462
G
S
V
T
S
S
A
S
G
P
A
Q
S
V
A
Site 43
S467
S
A
S
G
P
A
Q
S
V
A
K
M
F
R
A
Site 44
T480
R
A
V
E
E
G
L
T
Y
K
F
H
A
A
W
Site 45
Y481
A
V
E
E
G
L
T
Y
K
F
H
A
A
W
S
Site 46
S522
S
L
C
D
L
R
L
S
P
H
F
P
H
T
A
Site 47
S558
V
P
L
E
I
D
G
S
E
E
T
L
D
F
P
Site 48
S567
E
T
L
D
F
P
R
S
W
L
L
P
V
I
R
Site 49
T595
Y
F
L
P
L
A
N
T
L
K
S
K
A
M
D
Site 50
S598
P
L
A
N
T
L
K
S
K
A
M
D
L
A
Q
Site 51
S608
M
D
L
A
Q
A
G
S
T
V
E
S
K
I
Y
Site 52
T609
D
L
A
Q
A
G
S
T
V
E
S
K
I
Y
D
Site 53
S612
Q
A
G
S
T
V
E
S
K
I
Y
D
T
L
Q
Site 54
Y615
S
T
V
E
S
K
I
Y
D
T
L
Q
W
Q
M
Site 55
T634
P
G
F
C
T
R
P
T
D
V
A
I
S
F
K
Site 56
S639
R
P
T
D
V
A
I
S
F
K
G
L
A
R
T
Site 57
S652
R
T
L
G
M
A
I
S
E
R
P
D
L
R
V
Site 58
T660
E
R
P
D
L
R
V
T
V
C
Q
A
L
R
T
Site 59
T706
Q
P
V
A
A
G
D
T
P
A
P
R
R
A
V
Site 60
T716
P
R
R
A
V
L
E
T
I
R
T
Y
L
T
I
Site 61
S737
N
S
L
L
E
K
A
S
E
K
V
L
D
P
A
Site 62
S745
E
K
V
L
D
P
A
S
S
D
F
T
R
L
S
Site 63
S746
K
V
L
D
P
A
S
S
D
F
T
R
L
S
V
Site 64
T749
D
P
A
S
S
D
F
T
R
L
S
V
L
D
L
Site 65
S770
C
A
D
E
A
A
I
S
K
L
Y
S
T
I
R
Site 66
Y773
E
A
A
I
S
K
L
Y
S
T
I
R
P
Y
L
Site 67
S774
A
A
I
S
K
L
Y
S
T
I
R
P
Y
L
E
Site 68
T775
A
I
S
K
L
Y
S
T
I
R
P
Y
L
E
S
Site 69
Y779
L
Y
S
T
I
R
P
Y
L
E
S
K
A
H
G
Site 70
S782
T
I
R
P
Y
L
E
S
K
A
H
G
V
Q
K
Site 71
Y792
H
G
V
Q
K
K
A
Y
R
V
L
E
E
V
C
Site 72
T820
H
L
E
D
L
K
K
T
L
L
D
S
L
R
S
Site 73
S824
L
K
K
T
L
L
D
S
L
R
S
T
S
S
P
Site 74
S827
T
L
L
D
S
L
R
S
T
S
S
P
A
K
R
Site 75
T828
L
L
D
S
L
R
S
T
S
S
P
A
K
R
P
Site 76
S829
L
D
S
L
R
S
T
S
S
P
A
K
R
P
R
Site 77
S830
D
S
L
R
S
T
S
S
P
A
K
R
P
R
L
Site 78
S848
L
H
I
V
R
K
L
S
A
E
H
K
E
F
I
Site 79
S893
H
A
F
L
R
F
G
S
N
Q
E
E
A
L
Q
Site 80
T939
K
G
L
M
G
T
S
T
V
E
Q
L
L
E
N
Site 81
S993
M
E
A
I
G
K
L
S
D
D
M
R
R
H
F
Site 82
Y1028
K
R
L
L
P
E
E
Y
H
R
V
L
V
N
I
Site 83
S1049
A
K
R
H
R
A
L
S
Q
A
A
V
E
E
E
Site 84
S1072
P
A
Q
G
K
G
D
S
I
E
E
I
L
A
D
Site 85
S1080
I
E
E
I
L
A
D
S
E
D
E
E
D
N
E
Site 86
S1092
D
N
E
E
E
E
R
S
R
G
K
E
Q
R
K
Site 87
S1105
R
K
L
A
R
Q
R
S
R
A
W
L
K
E
G
Site 88
T1132
V
A
Q
R
V
L
A
T
Q
P
G
P
G
R
G
Site 89
S1149
K
D
H
G
F
K
V
S
A
D
G
R
L
I
I
Site 90
Y1212
E
L
E
I
P
P
Q
Y
Q
A
G
G
S
G
I
Site 91
S1217
P
Q
Y
Q
A
G
G
S
G
I
H
R
P
V
A
Site 92
Y1251
K
K
G
R
P
D
P
Y
A
Y
I
P
L
N
R
Site 93
Y1253
G
R
P
D
P
Y
A
Y
I
P
L
N
R
S
K
Site 94
S1284
V
K
A
A
R
R
G
S
Q
V
G
H
K
N
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation