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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SAPLa
Full Name:
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Alias:
C11orf23; DKFZp781E17107; DKFZp781E2374; DKFZp781O2362; FLJ11058; FLJ43065; KIAA1558; MGC125711; MGC125712; PP6R3; Protein phosphatase 6 regulatory 3; Protein phosphatase 6 regulatory subunit 3; SAP190; SAPL; SAPS domain family, member 3; SAPS3; Sporulation-induced transcript 4-associated protein; Sporulation-induced transcript 4-associated protein SAPL
Type:
Unknown function
Mass (Da):
97669
Number AA:
873
UniProt ID:
Q5H9R7
International Prot ID:
IPI00719821
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0019903
PhosphoSite+
KinaseNET
Biological Process:
GO:0043666
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
K
F
D
L
H
S
S
S
H
I
D
T
L
L
E
Site 2
T15
H
S
S
S
H
I
D
T
L
L
E
R
E
D
V
Site 3
T23
L
L
E
R
E
D
V
T
L
K
E
L
M
D
E
Site 4
Y75
D
M
D
E
K
I
R
Y
K
Y
P
N
I
S
C
Site 5
Y77
D
E
K
I
R
Y
K
Y
P
N
I
S
C
E
L
Site 6
S81
R
Y
K
Y
P
N
I
S
C
E
L
L
T
S
D
Site 7
T86
N
I
S
C
E
L
L
T
S
D
V
S
Q
M
N
Site 8
S87
I
S
C
E
L
L
T
S
D
V
S
Q
M
N
D
Site 9
S90
E
L
L
T
S
D
V
S
Q
M
N
D
R
L
G
Site 10
S101
D
R
L
G
E
D
E
S
L
L
M
K
L
Y
S
Site 11
S108
S
L
L
M
K
L
Y
S
F
L
L
N
D
S
P
Site 12
S202
L
V
E
I
V
H
P
S
Q
E
E
D
R
H
S
Site 13
S209
S
Q
E
E
D
R
H
S
N
A
S
Q
S
L
C
Site 14
S212
E
D
R
H
S
N
A
S
Q
S
L
C
E
I
V
Site 15
S214
R
H
S
N
A
S
Q
S
L
C
E
I
V
R
L
Site 16
S232
Q
M
L
Q
I
Q
N
S
T
E
P
D
P
L
L
Site 17
S253
E
I
I
E
Q
L
L
S
N
I
F
H
K
E
K
Site 18
S263
F
H
K
E
K
N
E
S
A
I
V
S
A
I
Q
Site 19
T282
L
L
E
T
R
R
P
T
F
E
G
H
I
E
I
Site 20
S297
C
P
P
G
M
S
H
S
A
C
S
V
N
K
S
Site 21
S300
G
M
S
H
S
A
C
S
V
N
K
S
V
L
E
Site 22
S315
A
I
R
G
R
L
G
S
F
H
E
L
L
L
E
Site 23
S327
L
L
E
P
P
K
K
S
V
M
K
T
T
W
G
Site 24
T331
P
K
K
S
V
M
K
T
T
W
G
V
L
D
P
Site 25
T359
S
S
L
L
Q
T
N
T
S
S
I
N
G
D
L
Site 26
S360
S
L
L
Q
T
N
T
S
S
I
N
G
D
L
M
Site 27
S361
L
L
Q
T
N
T
S
S
I
N
G
D
L
M
E
Site 28
T413
N
T
E
N
A
T
I
T
D
Q
D
S
T
G
D
Site 29
S417
A
T
I
T
D
Q
D
S
T
G
D
N
L
L
L
Site 30
T418
T
I
T
D
Q
D
S
T
G
D
N
L
L
L
K
Site 31
Y457
E
G
G
R
R
H
G
Y
M
G
H
L
T
R
I
Site 32
S478
S
T
D
K
G
P
N
S
A
L
V
Q
Q
L
I
Site 33
T498
E
V
R
E
R
W
E
T
F
C
T
S
S
L
G
Site 34
T501
E
R
W
E
T
F
C
T
S
S
L
G
E
T
N
Site 35
S503
W
E
T
F
C
T
S
S
L
G
E
T
N
K
R
Site 36
T507
C
T
S
S
L
G
E
T
N
K
R
N
T
V
D
Site 37
T512
G
E
T
N
K
R
N
T
V
D
L
V
T
T
C
Site 38
T517
R
N
T
V
D
L
V
T
T
C
H
I
H
S
S
Site 39
S523
V
T
T
C
H
I
H
S
S
S
D
D
E
I
D
Site 40
S524
T
T
C
H
I
H
S
S
S
D
D
E
I
D
F
Site 41
S525
T
C
H
I
H
S
S
S
D
D
E
I
D
F
K
Site 42
S537
D
F
K
E
T
G
F
S
Q
D
S
S
L
Q
Q
Site 43
S541
T
G
F
S
Q
D
S
S
L
Q
Q
A
F
S
D
Site 44
S547
S
S
L
Q
Q
A
F
S
D
Y
Q
M
Q
Q
M
Site 45
Y549
L
Q
Q
A
F
S
D
Y
Q
M
Q
Q
M
T
S
Site 46
S579
Q
D
D
I
G
N
V
S
F
D
R
V
S
D
I
Site 47
S584
N
V
S
F
D
R
V
S
D
I
N
F
T
L
N
Site 48
S617
Q
Q
F
D
D
G
G
S
D
E
E
D
I
W
E
Site 49
T631
E
E
K
H
I
A
F
T
P
E
S
Q
R
R
S
Site 50
S634
H
I
A
F
T
P
E
S
Q
R
R
S
S
S
G
Site 51
S638
T
P
E
S
Q
R
R
S
S
S
G
S
T
D
S
Site 52
S639
P
E
S
Q
R
R
S
S
S
G
S
T
D
S
E
Site 53
S640
E
S
Q
R
R
S
S
S
G
S
T
D
S
E
E
Site 54
S642
Q
R
R
S
S
S
G
S
T
D
S
E
E
S
T
Site 55
T643
R
R
S
S
S
G
S
T
D
S
E
E
S
T
D
Site 56
S645
S
S
S
G
S
T
D
S
E
E
S
T
D
S
E
Site 57
T649
S
T
D
S
E
E
S
T
D
S
E
E
E
D
G
Site 58
S651
D
S
E
E
S
T
D
S
E
E
E
D
G
A
K
Site 59
S666
Q
D
L
F
E
P
S
S
A
N
T
E
D
K
M
Site 60
S678
D
K
M
E
V
D
L
S
E
P
P
N
W
S
A
Site 61
S684
L
S
E
P
P
N
W
S
A
N
F
D
V
P
M
Site 62
S701
T
H
G
A
P
L
D
S
V
G
S
D
V
W
S
Site 63
S704
A
P
L
D
S
V
G
S
D
V
W
S
T
E
E
Site 64
S708
S
V
G
S
D
V
W
S
T
E
E
P
M
P
T
Site 65
T709
V
G
S
D
V
W
S
T
E
E
P
M
P
T
K
Site 66
T715
S
T
E
E
P
M
P
T
K
E
T
G
W
A
S
Site 67
S722
T
K
E
T
G
W
A
S
F
S
E
F
T
S
S
Site 68
S724
E
T
G
W
A
S
F
S
E
F
T
S
S
L
S
Site 69
S728
A
S
F
S
E
F
T
S
S
L
S
T
K
D
S
Site 70
S729
S
F
S
E
F
T
S
S
L
S
T
K
D
S
L
Site 71
S731
S
E
F
T
S
S
L
S
T
K
D
S
L
R
S
Site 72
T732
E
F
T
S
S
L
S
T
K
D
S
L
R
S
N
Site 73
S735
S
S
L
S
T
K
D
S
L
R
S
N
S
P
V
Site 74
S738
S
T
K
D
S
L
R
S
N
S
P
V
E
M
E
Site 75
S740
K
D
S
L
R
S
N
S
P
V
E
M
E
T
S
Site 76
S747
S
P
V
E
M
E
T
S
T
E
P
M
D
P
L
Site 77
S770
V
Q
P
E
A
A
G
S
V
A
M
E
A
S
S
Site 78
S785
D
G
E
E
D
A
E
S
T
D
K
V
T
E
T
Site 79
T790
A
E
S
T
D
K
V
T
E
T
V
M
N
G
G
Site 80
T792
S
T
D
K
V
T
E
T
V
M
N
G
G
M
K
Site 81
S803
G
G
M
K
E
T
L
S
L
T
V
D
A
K
T
Site 82
T805
M
K
E
T
L
S
L
T
V
D
A
K
T
E
T
Site 83
T810
S
L
T
V
D
A
K
T
E
T
A
V
F
K
S
Site 84
S817
T
E
T
A
V
F
K
S
E
E
G
K
L
S
T
Site 85
S823
K
S
E
E
G
K
L
S
T
S
Q
D
A
A
C
Site 86
S825
E
E
G
K
L
S
T
S
Q
D
A
A
C
K
D
Site 87
T839
D
A
E
E
C
P
E
T
A
E
A
K
C
A
A
Site 88
S851
C
A
A
P
R
P
P
S
S
S
P
E
Q
R
T
Site 89
S852
A
A
P
R
P
P
S
S
S
P
E
Q
R
T
G
Site 90
S853
A
P
R
P
P
S
S
S
P
E
Q
R
T
G
Q
Site 91
T858
S
S
S
P
E
Q
R
T
G
Q
P
S
A
P
G
Site 92
S862
E
Q
R
T
G
Q
P
S
A
P
G
D
T
S
V
Site 93
S868
P
S
A
P
G
D
T
S
V
N
G
P
V
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation