KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
YSK4
Full Name:
SPS1/STE20-related protein kinase YSK4
Alias:
FLJ23074; rck; regulated in COPD, protein kinase; ysk4; YSK4 Sps1/Ste20-related kinase
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
STE
group; STE11 family
Mass (Da):
150540
Number AA:
UniProt ID:
Q56UN5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
SPS1/STE20-related protein kinase YSK4; Mitogen-activated protein kinase kinase kinase 8; MAP3K19 pan-specific antibody AB-NK256-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK256-1#SPS1/STE20-related protein kinase YSK4; Mitogen-activated protein kinase kinase kinase 8 pan-specific antibody AB-NK256-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK256-2#SPS1/STE20-related protein kinase YSK4; Mitogen-activated protein kinase kinase kinase 8 pan-specific antibody AB-NK256-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK256-3#SPS1/STE20-related protein kinase YSK4 / Mitogen-activated protein kinase kinase kinase 8 / MAP3K19 (M1-L15, human) peptide - Powder PE-01AZK85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AZK85#SPS1/STE20-related protein kinase YSK4 / Mitogen-activated protein kinase kinase kinase 8 (S1314-H1328, human) peptide - Powder PE-01AZL90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AZL90#SPS1/STE20-related protein kinase YSK4 / Mitogen-activated protein kinase kinase kinase 8 (C350-Y366, human) peptide - Powder PE-01AZM99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AZM99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
K
P
E
R
H
A
E
S
L
L
D
I
C
H
D
Site 2
T21
L
L
D
I
C
H
D
T
N
S
S
P
T
D
L
Site 3
S23
D
I
C
H
D
T
N
S
S
P
T
D
L
M
T
Site 4
S24
I
C
H
D
T
N
S
S
P
T
D
L
M
T
V
Site 5
T30
S
S
P
T
D
L
M
T
V
T
K
N
Q
N
I
Site 6
S41
N
Q
N
I
I
L
Q
S
I
S
R
S
E
E
F
Site 7
S43
N
I
I
L
Q
S
I
S
R
S
E
E
F
D
Q
Site 8
S45
I
L
Q
S
I
S
R
S
E
E
F
D
Q
D
G
Site 9
T58
D
G
D
C
S
H
S
T
L
V
N
E
E
E
D
Site 10
S67
V
N
E
E
E
D
P
S
G
G
R
Q
D
W
Q
Site 11
T77
R
Q
D
W
Q
P
R
T
E
G
V
E
I
T
V
Site 12
T85
E
G
V
E
I
T
V
T
F
P
R
D
V
S
P
Site 13
S91
V
T
F
P
R
D
V
S
P
P
Q
E
M
S
Q
Site 14
S97
V
S
P
P
Q
E
M
S
Q
E
D
L
K
E
K
Site 15
T128
S
H
P
N
E
I
E
T
V
E
L
R
K
K
K
Site 16
T137
E
L
R
K
K
K
L
T
M
R
P
L
V
L
Q
Site 17
S148
L
V
L
Q
K
E
E
S
S
R
E
L
C
N
V
Site 18
S171
S
C
L
E
L
N
I
S
K
S
V
T
R
E
D
Site 19
S173
L
E
L
N
I
S
K
S
V
T
R
E
D
A
P
Site 20
T175
L
N
I
S
K
S
V
T
R
E
D
A
P
H
F
Site 21
S190
L
K
E
Q
Q
R
K
S
E
E
F
S
T
S
H
Site 22
S194
Q
R
K
S
E
E
F
S
T
S
H
M
K
Y
S
Site 23
T195
R
K
S
E
E
F
S
T
S
H
M
K
Y
S
G
Site 24
S196
K
S
E
E
F
S
T
S
H
M
K
Y
S
G
R
Site 25
Y200
F
S
T
S
H
M
K
Y
S
G
R
S
I
K
F
Site 26
S201
S
T
S
H
M
K
Y
S
G
R
S
I
K
F
L
Site 27
T223
P
T
R
S
G
V
L
T
I
P
Q
N
H
K
F
Site 28
S240
E
K
E
R
N
I
P
S
L
T
S
F
V
P
K
Site 29
S249
T
S
F
V
P
K
L
S
V
S
V
R
Q
S
D
Site 30
S251
F
V
P
K
L
S
V
S
V
R
Q
S
D
E
L
Site 31
S255
L
S
V
S
V
R
Q
S
D
E
L
S
P
S
N
Site 32
S259
V
R
Q
S
D
E
L
S
P
S
N
E
P
P
G
Site 33
S261
Q
S
D
E
L
S
P
S
N
E
P
P
G
A
L
Site 34
S271
P
P
G
A
L
V
K
S
L
M
D
P
T
L
R
Site 35
T276
V
K
S
L
M
D
P
T
L
R
S
S
D
G
F
Site 36
S279
L
M
D
P
T
L
R
S
S
D
G
F
I
W
S
Site 37
S280
M
D
P
T
L
R
S
S
D
G
F
I
W
S
R
Site 38
S329
T
H
F
E
K
G
Q
S
L
V
S
F
E
N
L
Site 39
S332
E
K
G
Q
S
L
V
S
F
E
N
L
K
E
G
Site 40
S354
E
D
I
D
C
H
G
S
K
T
R
K
P
E
E
Site 41
T356
I
D
C
H
G
S
K
T
R
K
P
E
E
E
N
Site 42
S364
R
K
P
E
E
E
N
S
Q
Y
L
S
S
R
K
Site 43
Y366
P
E
E
E
N
S
Q
Y
L
S
S
R
K
N
E
Site 44
S368
E
E
N
S
Q
Y
L
S
S
R
K
N
E
S
S
Site 45
S369
E
N
S
Q
Y
L
S
S
R
K
N
E
S
S
V
Site 46
S375
S
S
R
K
N
E
S
S
V
A
K
N
Y
E
Q
Site 47
T389
Q
D
P
E
I
V
C
T
I
P
S
K
F
Q
E
Site 48
S400
K
F
Q
E
T
Q
H
S
E
I
T
P
S
Q
D
Site 49
T403
E
T
Q
H
S
E
I
T
P
S
Q
D
E
E
M
Site 50
S405
Q
H
S
E
I
T
P
S
Q
D
E
E
M
R
N
Site 51
S417
M
R
N
N
K
A
A
S
K
R
V
S
L
H
K
Site 52
S421
K
A
A
S
K
R
V
S
L
H
K
N
E
A
M
Site 53
T438
N
N
I
L
E
E
C
T
V
L
K
S
L
S
S
Site 54
S460
D
K
L
P
E
G
C
S
S
M
E
T
N
I
K
Site 55
S461
K
L
P
E
G
C
S
S
M
E
T
N
I
K
I
Site 56
T464
E
G
C
S
S
M
E
T
N
I
K
I
S
I
A
Site 57
T511
S
L
Q
T
R
K
G
T
I
H
N
N
H
S
V
Site 58
S533
N
D
K
H
K
M
N
S
H
R
S
K
L
D
S
Site 59
S536
H
K
M
N
S
H
R
S
K
L
D
S
K
T
K
Site 60
S540
S
H
R
S
K
L
D
S
K
T
K
T
S
K
K
Site 61
T542
R
S
K
L
D
S
K
T
K
T
S
K
K
T
P
Site 62
T544
K
L
D
S
K
T
K
T
S
K
K
T
P
Q
N
Site 63
T548
K
T
K
T
S
K
K
T
P
Q
N
F
V
I
S
Site 64
T567
I
K
P
T
M
H
K
T
S
I
K
T
Q
I
F
Site 65
S602
P
Q
I
A
K
K
Q
S
T
H
R
T
Q
K
P
Site 66
T606
K
K
Q
S
T
H
R
T
Q
K
P
K
K
Q
S
Site 67
S626
K
N
P
G
T
Q
K
S
C
V
P
L
S
V
Q
Site 68
S631
Q
K
S
C
V
P
L
S
V
Q
P
T
E
P
R
Site 69
T635
V
P
L
S
V
Q
P
T
E
P
R
L
N
Y
L
Site 70
Y641
P
T
E
P
R
L
N
Y
L
D
L
K
Y
S
D
Site 71
Y646
L
N
Y
L
D
L
K
Y
S
D
M
F
K
E
I
Site 72
S655
D
M
F
K
E
I
N
S
T
A
N
G
P
G
I
Site 73
T656
M
F
K
E
I
N
S
T
A
N
G
P
G
I
Y
Site 74
Y671
E
M
F
G
T
P
V
Y
C
H
V
R
E
T
E
Site 75
T683
E
T
E
R
D
E
N
T
Y
Y
R
E
I
C
S
Site 76
Y684
T
E
R
D
E
N
T
Y
Y
R
E
I
C
S
A
Site 77
Y685
E
R
D
E
N
T
Y
Y
R
E
I
C
S
A
P
Site 78
S690
T
Y
Y
R
E
I
C
S
A
P
S
G
R
R
I
Site 79
S693
R
E
I
C
S
A
P
S
G
R
R
I
T
N
K
Site 80
T698
A
P
S
G
R
R
I
T
N
K
C
R
S
S
H
Site 81
S704
I
T
N
K
C
R
S
S
H
S
E
R
K
S
N
Site 82
S706
N
K
C
R
S
S
H
S
E
R
K
S
N
I
R
Site 83
S710
S
S
H
S
E
R
K
S
N
I
R
T
R
L
S
Site 84
T714
E
R
K
S
N
I
R
T
R
L
S
Q
K
K
T
Site 85
S717
S
N
I
R
T
R
L
S
Q
K
K
T
H
M
K
Site 86
T721
T
R
L
S
Q
K
K
T
H
M
K
C
P
K
T
Site 87
T728
T
H
M
K
C
P
K
T
S
F
G
I
K
Q
E
Site 88
S741
Q
E
H
K
V
L
I
S
K
E
K
S
S
K
A
Site 89
S745
V
L
I
S
K
E
K
S
S
K
A
V
H
S
N
Site 90
S763
I
E
N
G
D
G
I
S
E
P
D
W
Q
I
K
Site 91
S771
E
P
D
W
Q
I
K
S
S
G
N
E
F
L
S
Site 92
S772
P
D
W
Q
I
K
S
S
G
N
E
F
L
S
S
Site 93
S778
S
S
G
N
E
F
L
S
S
K
D
E
I
H
P
Site 94
S779
S
G
N
E
F
L
S
S
K
D
E
I
H
P
M
Site 95
T791
H
P
M
N
L
A
Q
T
P
E
Q
S
M
K
Q
Site 96
S805
Q
N
E
F
P
P
V
S
D
L
S
I
V
E
E
Site 97
S814
L
S
I
V
E
E
V
S
M
E
E
S
T
G
D
Site 98
S818
E
E
V
S
M
E
E
S
T
G
D
R
D
I
S
Site 99
S825
S
T
G
D
R
D
I
S
N
N
Q
I
L
T
T
Site 100
S833
N
N
Q
I
L
T
T
S
L
R
D
L
Q
E
L
Site 101
S855
P
F
I
P
S
E
D
S
W
A
V
P
S
E
K
Site 102
S860
E
D
S
W
A
V
P
S
E
K
N
S
N
K
Y
Site 103
S864
A
V
P
S
E
K
N
S
N
K
Y
V
Q
Q
E
Site 104
Y867
S
E
K
N
S
N
K
Y
V
Q
Q
E
K
Q
N
Site 105
T875
V
Q
Q
E
K
Q
N
T
A
S
L
S
K
V
N
Site 106
S877
Q
E
K
Q
N
T
A
S
L
S
K
V
N
A
S
Site 107
S879
K
Q
N
T
A
S
L
S
K
V
N
A
S
R
I
Site 108
T888
V
N
A
S
R
I
L
T
N
D
L
E
F
D
S
Site 109
S895
T
N
D
L
E
F
D
S
V
S
D
H
S
K
T
Site 110
S897
D
L
E
F
D
S
V
S
D
H
S
K
T
L
T
Site 111
T902
S
V
S
D
H
S
K
T
L
T
N
F
S
F
Q
Site 112
T904
S
D
H
S
K
T
L
T
N
F
S
F
Q
A
K
Site 113
S907
S
K
T
L
T
N
F
S
F
Q
A
K
Q
E
S
Site 114
S914
S
F
Q
A
K
Q
E
S
A
S
S
Q
T
Y
Q
Site 115
S917
A
K
Q
E
S
A
S
S
Q
T
Y
Q
Y
W
V
Site 116
Y920
E
S
A
S
S
Q
T
Y
Q
Y
W
V
H
Y
L
Site 117
Y926
T
Y
Q
Y
W
V
H
Y
L
D
H
D
S
L
A
Site 118
S931
V
H
Y
L
D
H
D
S
L
A
N
K
S
I
T
Site 119
T945
T
Y
Q
M
F
G
K
T
L
S
G
T
N
S
I
Site 120
S947
Q
M
F
G
K
T
L
S
G
T
N
S
I
S
Q
Site 121
T949
F
G
K
T
L
S
G
T
N
S
I
S
Q
E
I
Site 122
S951
K
T
L
S
G
T
N
S
I
S
Q
E
I
M
D
Site 123
S953
L
S
G
T
N
S
I
S
Q
E
I
M
D
S
V
Site 124
S959
I
S
Q
E
I
M
D
S
V
N
N
E
E
L
T
Site 125
T966
S
V
N
N
E
E
L
T
D
E
L
L
G
C
L
Site 126
S1009
L
V
L
R
W
R
G
S
T
P
K
E
M
G
R
Site 127
T1010
V
L
R
W
R
G
S
T
P
K
E
M
G
R
E
Site 128
T1018
P
K
E
M
G
R
E
T
T
K
V
K
I
Q
R
Site 129
T1019
K
E
M
G
R
E
T
T
K
V
K
I
Q
R
H
Site 130
S1027
K
V
K
I
Q
R
H
S
S
G
L
R
I
Y
D
Site 131
S1028
V
K
I
Q
R
H
S
S
G
L
R
I
Y
D
R
Site 132
Y1033
H
S
S
G
L
R
I
Y
D
R
E
E
K
F
L
Site 133
S1049
S
N
E
K
K
I
F
S
E
N
S
L
K
S
E
Site 134
S1052
K
K
I
F
S
E
N
S
L
K
S
E
E
P
I
Site 135
S1055
F
S
E
N
S
L
K
S
E
E
P
I
L
W
T
Site 136
Y1076
K
G
A
Y
G
T
V
Y
C
G
L
T
S
Q
G
Site 137
T1095
V
K
Q
V
A
L
D
T
S
N
K
L
A
A
E
Site 138
S1096
K
Q
V
A
L
D
T
S
N
K
L
A
A
E
K
Site 139
Y1166
P
E
M
V
F
C
K
Y
T
K
Q
I
L
Q
G
Site 140
S1221
A
G
L
N
G
T
H
S
D
M
L
K
S
M
H
Site 141
Y1232
K
S
M
H
G
T
P
Y
W
M
A
P
E
V
I
Site 142
Y1244
E
V
I
N
E
S
G
Y
G
R
K
S
D
I
W
Site 143
S1248
E
S
G
Y
G
R
K
S
D
I
W
S
I
G
C
Site 144
S1269
T
G
K
P
P
L
A
S
M
D
R
M
A
A
M
Site 145
S1294
P
P
L
P
D
H
F
S
E
N
A
A
D
F
V
Site 146
S1314
R
D
Q
H
E
R
P
S
A
L
Q
L
L
K
H
Site 147
S1322
A
L
Q
L
L
K
H
S
F
L
E
R
S
H
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation