KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CDCA8
Full Name:
Borealin
Alias:
BOREA; Cell division cycle-associated protein 8; Dasra-B; HDasra-B; PESCRG3; Pluripotent embryonic stem cell-related gene 3 protein
Type:
Chromosomal passenger complex protein; Chromosome, pericentric region, cytoplasm, nucleus
Mass (Da):
31323
Number AA:
280
UniProt ID:
Q53HL2
International Prot ID:
IPI00303099
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032133
GO:0000775
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0051276
GO:0000089
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
P
R
K
G
S
S
R
V
A
K
T
N
Site 2
T13
G
S
S
R
V
A
K
T
N
S
L
R
R
R
K
Site 3
S15
S
R
V
A
K
T
N
S
L
R
R
R
K
L
A
Site 4
S23
L
R
R
R
K
L
A
S
F
L
K
D
F
D
R
Site 5
S41
I
R
I
K
Q
I
E
S
D
R
Q
N
L
L
K
Site 6
Y73
R
E
M
N
W
L
D
Y
F
A
L
G
G
N
K
Site 7
T88
Q
A
L
E
E
A
A
T
A
D
L
D
I
T
E
Site 8
T94
A
T
A
D
L
D
I
T
E
I
N
K
L
T
A
Site 9
T100
I
T
E
I
N
K
L
T
A
E
A
I
Q
T
P
Site 10
T106
L
T
A
E
A
I
Q
T
P
L
K
S
A
K
T
Site 11
S110
A
I
Q
T
P
L
K
S
A
K
T
R
K
V
I
Site 12
T139
N
E
R
K
N
L
Q
T
A
R
V
K
R
C
P
Site 13
S148
R
V
K
R
C
P
P
S
K
K
R
T
Q
S
I
Site 14
T152
C
P
P
S
K
K
R
T
Q
S
I
Q
G
K
G
Site 15
S154
P
S
K
K
R
T
Q
S
I
Q
G
K
G
K
G
Site 16
S164
G
K
G
K
G
K
R
S
S
R
A
N
T
V
T
Site 17
S165
K
G
K
G
K
R
S
S
R
A
N
T
V
T
P
Site 18
T169
K
R
S
S
R
A
N
T
V
T
P
A
V
G
R
Site 19
T171
S
S
R
A
N
T
V
T
P
A
V
G
R
L
E
Site 20
S180
A
V
G
R
L
E
V
S
M
V
K
P
T
P
G
Site 21
T185
E
V
S
M
V
K
P
T
P
G
L
T
P
R
F
Site 22
T189
V
K
P
T
P
G
L
T
P
R
F
D
S
R
V
Site 23
S194
G
L
T
P
R
F
D
S
R
V
F
K
T
P
G
Site 24
T199
F
D
S
R
V
F
K
T
P
G
L
R
T
P
A
Site 25
T204
F
K
T
P
G
L
R
T
P
A
A
G
E
R
I
Site 26
Y212
P
A
A
G
E
R
I
Y
N
I
S
G
N
G
S
Site 27
S215
G
E
R
I
Y
N
I
S
G
N
G
S
P
L
A
Site 28
S219
Y
N
I
S
G
N
G
S
P
L
A
D
S
K
E
Site 29
S224
N
G
S
P
L
A
D
S
K
E
I
F
L
T
V
Site 30
T230
D
S
K
E
I
F
L
T
V
P
V
G
G
G
E
Site 31
S238
V
P
V
G
G
G
E
S
L
R
L
L
A
S
D
Site 32
S244
E
S
L
R
L
L
A
S
D
L
Q
R
H
S
I
Site 33
S250
A
S
D
L
Q
R
H
S
I
A
Q
L
D
P
E
Site 34
S266
L
G
N
I
K
K
L
S
N
R
L
A
Q
I
C
Site 35
S274
N
R
L
A
Q
I
C
S
S
I
R
T
H
K
_
Site 36
S275
R
L
A
Q
I
C
S
S
I
R
T
H
K
_
_
Site 37
T278
Q
I
C
S
S
I
R
T
H
K
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation