KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PLEKHG6
Full Name:
Pleckstrin homology domain-containing family G member 6
Alias:
MyoGEF; Myosin-interacting guanine nucleotide exchange factor
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
88961
Number AA:
790
UniProt ID:
Q3KR16
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005819
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
L
V
A
S
R
I
E
T
Y
G
G
R
H
R
A
Site 2
S30
Y
G
G
R
H
R
A
S
A
Q
S
T
A
G
R
Site 3
S33
R
H
R
A
S
A
Q
S
T
A
G
R
L
Y
P
Site 4
T34
H
R
A
S
A
Q
S
T
A
G
R
L
Y
P
R
Site 5
Y39
Q
S
T
A
G
R
L
Y
P
R
G
Y
P
V
L
Site 6
Y43
G
R
L
Y
P
R
G
Y
P
V
L
D
P
S
R
Site 7
S49
G
Y
P
V
L
D
P
S
R
R
R
L
Q
Q
Y
Site 8
Y56
S
R
R
R
L
Q
Q
Y
V
P
F
A
R
G
S
Site 9
S63
Y
V
P
F
A
R
G
S
G
Q
A
R
G
L
S
Site 10
S70
S
G
Q
A
R
G
L
S
P
M
R
L
R
D
P
Site 11
S137
E
I
G
E
G
G
D
S
G
L
T
I
E
K
S
Site 12
T140
E
G
G
D
S
G
L
T
I
E
K
S
W
R
E
Site 13
S144
S
G
L
T
I
E
K
S
W
R
E
L
V
P
G
Site 14
Y176
L
L
T
T
E
L
I
Y
V
R
K
L
K
I
M
Site 15
S214
T
L
F
G
N
V
P
S
L
I
R
T
H
R
S
Site 16
T218
N
V
P
S
L
I
R
T
H
R
S
F
W
D
E
Site 17
S221
S
L
I
R
T
H
R
S
F
W
D
E
V
L
G
Site 18
S237
T
L
E
E
T
R
A
S
G
Q
P
L
D
P
I
Site 19
T252
G
L
Q
S
G
F
L
T
F
G
Q
R
F
H
P
Site 20
Y260
F
G
Q
R
F
H
P
Y
V
Q
Y
C
L
R
V
Site 21
Y263
R
F
H
P
Y
V
Q
Y
C
L
R
V
K
Q
T
Site 22
Y273
R
V
K
Q
T
M
A
Y
A
R
E
Q
Q
E
T
Site 23
T280
Y
A
R
E
Q
Q
E
T
N
P
L
F
H
A
F
Site 24
T314
I
K
P
H
Q
R
I
T
K
Y
P
L
L
L
H
Site 25
Y316
P
H
Q
R
I
T
K
Y
P
L
L
L
H
A
V
Site 26
S327
L
H
A
V
L
K
R
S
P
E
A
R
A
Q
E
Site 27
S362
R
Q
G
E
E
Q
E
S
L
A
A
A
A
Q
R
Site 28
Y373
A
A
Q
R
I
G
P
Y
E
V
L
E
P
P
S
Site 29
S380
Y
E
V
L
E
P
P
S
D
E
V
E
K
N
L
Site 30
S391
E
K
N
L
R
P
F
S
T
L
D
L
T
S
P
Site 31
T392
K
N
L
R
P
F
S
T
L
D
L
T
S
P
M
Site 32
S471
Q
P
L
R
D
P
D
S
F
L
L
I
H
L
T
Site 33
S493
A
L
L
V
H
C
P
S
P
T
D
R
A
Q
W
Site 34
T495
L
V
H
C
P
S
P
T
D
R
A
Q
W
L
E
Site 35
Y519
Q
K
L
K
A
E
E
Y
V
Q
Q
K
R
E
L
Site 36
T528
Q
Q
K
R
E
L
L
T
L
Y
R
D
Q
D
R
Site 37
Y530
K
R
E
L
L
T
L
Y
R
D
Q
D
R
E
S
Site 38
S537
Y
R
D
Q
D
R
E
S
P
S
T
R
P
S
T
Site 39
S539
D
Q
D
R
E
S
P
S
T
R
P
S
T
P
S
Site 40
T540
Q
D
R
E
S
P
S
T
R
P
S
T
P
S
L
Site 41
S543
E
S
P
S
T
R
P
S
T
P
S
L
E
G
S
Site 42
T544
S
P
S
T
R
P
S
T
P
S
L
E
G
S
Q
Site 43
S546
S
T
R
P
S
T
P
S
L
E
G
S
Q
S
S
Site 44
S550
S
T
P
S
L
E
G
S
Q
S
S
A
E
G
R
Site 45
S552
P
S
L
E
G
S
Q
S
S
A
E
G
R
T
P
Site 46
S553
S
L
E
G
S
Q
S
S
A
E
G
R
T
P
E
Site 47
T558
Q
S
S
A
E
G
R
T
P
E
F
S
T
I
I
Site 48
S562
E
G
R
T
P
E
F
S
T
I
I
P
H
L
V
Site 49
T574
H
L
V
V
T
E
D
T
D
E
D
A
P
L
V
Site 50
T585
A
P
L
V
P
D
D
T
S
D
S
G
Y
G
T
Site 51
S586
P
L
V
P
D
D
T
S
D
S
G
Y
G
T
L
Site 52
S588
V
P
D
D
T
S
D
S
G
Y
G
T
L
I
P
Site 53
Y590
D
D
T
S
D
S
G
Y
G
T
L
I
P
G
T
Site 54
T592
T
S
D
S
G
Y
G
T
L
I
P
G
T
P
T
Site 55
T597
Y
G
T
L
I
P
G
T
P
T
G
S
R
S
P
Site 56
T599
T
L
I
P
G
T
P
T
G
S
R
S
P
L
S
Site 57
S601
I
P
G
T
P
T
G
S
R
S
P
L
S
R
L
Site 58
S603
G
T
P
T
G
S
R
S
P
L
S
R
L
R
Q
Site 59
S606
T
G
S
R
S
P
L
S
R
L
R
Q
R
A
L
Site 60
T620
L
R
R
D
P
R
L
T
F
S
T
L
E
L
R
Site 61
T623
D
P
R
L
T
F
S
T
L
E
L
R
D
I
P
Site 62
S645
P
Q
A
P
Q
R
R
S
A
P
E
L
P
E
G
Site 63
S658
E
G
I
L
K
G
G
S
L
P
Q
E
D
P
P
Site 64
T666
L
P
Q
E
D
P
P
T
W
S
E
E
E
D
G
Site 65
S668
Q
E
D
P
P
T
W
S
E
E
E
D
G
A
S
Site 66
S675
S
E
E
E
D
G
A
S
E
R
G
N
V
V
V
Site 67
T684
R
G
N
V
V
V
E
T
L
H
R
A
R
L
R
Site 68
S696
R
L
R
G
Q
L
P
S
S
P
T
H
A
D
S
Site 69
S697
L
R
G
Q
L
P
S
S
P
T
H
A
D
S
A
Site 70
T699
G
Q
L
P
S
S
P
T
H
A
D
S
A
G
E
Site 71
S703
S
S
P
T
H
A
D
S
A
G
E
S
P
W
E
Site 72
S707
H
A
D
S
A
G
E
S
P
W
E
S
S
G
E
Site 73
S711
A
G
E
S
P
W
E
S
S
G
E
E
E
E
E
Site 74
S729
F
L
K
A
G
H
T
S
L
R
P
M
R
A
E
Site 75
S748
E
I
R
E
E
L
A
S
Q
R
I
E
G
A
E
Site 76
S760
G
A
E
E
P
R
D
S
R
P
R
K
L
T
R
Site 77
T766
D
S
R
P
R
K
L
T
R
A
Q
L
Q
R
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation