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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
E4BP4
Full Name:
Nuclear factor interleukin-3-regulated protein
Alias:
E4 promoter-binding protein 4;Interleukin-3 promoter transcriptional activator;Interleukin-3-binding protein 1;Transcriptional activator NF-IL3A
Type:
Transcription protein
Mass (Da):
51472
Number AA:
462
UniProt ID:
Q16649
International Prot ID:
IPI00290562
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0046983
GO:0043565
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0006355
GO:0048511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
Q
L
R
K
M
Q
T
V
K
K
E
Q
A
S
Site 2
S15
T
V
K
K
E
Q
A
S
L
D
A
S
S
N
V
Site 3
S19
E
Q
A
S
L
D
A
S
S
N
V
D
K
M
M
Site 4
S30
D
K
M
M
V
L
N
S
A
L
T
E
V
S
E
Site 5
S39
L
T
E
V
S
E
D
S
T
T
G
E
E
L
L
Site 6
T40
T
E
V
S
E
D
S
T
T
G
E
E
L
L
L
Site 7
T41
E
V
S
E
D
S
T
T
G
E
E
L
L
L
S
Site 8
S48
T
G
E
E
L
L
L
S
E
G
S
V
G
K
N
Site 9
S51
E
L
L
L
S
E
G
S
V
G
K
N
K
S
S
Site 10
S57
G
S
V
G
K
N
K
S
S
A
C
R
R
K
R
Site 11
S58
S
V
G
K
N
K
S
S
A
C
R
R
K
R
E
Site 12
Y76
D
E
K
K
D
A
M
Y
W
E
K
R
R
K
N
Site 13
T114
A
L
G
E
E
N
A
T
L
K
A
E
L
L
S
Site 14
Y134
G
L
I
S
S
T
A
Y
A
Q
E
I
Q
K
L
Site 15
S142
A
Q
E
I
Q
K
L
S
N
S
T
A
V
Y
F
Site 16
S144
E
I
Q
K
L
S
N
S
T
A
V
Y
F
Q
D
Site 17
Y148
L
S
N
S
T
A
V
Y
F
Q
D
Y
Q
T
S
Site 18
Y152
T
A
V
Y
F
Q
D
Y
Q
T
S
K
S
N
V
Site 19
S155
Y
F
Q
D
Y
Q
T
S
K
S
N
V
S
S
F
Site 20
S157
Q
D
Y
Q
T
S
K
S
N
V
S
S
F
V
D
Site 21
S161
T
S
K
S
N
V
S
S
F
V
D
E
H
E
P
Site 22
S169
F
V
D
E
H
E
P
S
M
V
S
S
S
C
I
Site 23
S172
E
H
E
P
S
M
V
S
S
S
C
I
S
V
I
Site 24
S174
E
P
S
M
V
S
S
S
C
I
S
V
I
K
H
Site 25
S182
C
I
S
V
I
K
H
S
P
Q
S
S
L
S
D
Site 26
S185
V
I
K
H
S
P
Q
S
S
L
S
D
V
S
E
Site 27
S186
I
K
H
S
P
Q
S
S
L
S
D
V
S
E
V
Site 28
S188
H
S
P
Q
S
S
L
S
D
V
S
E
V
S
S
Site 29
S191
Q
S
S
L
S
D
V
S
E
V
S
S
V
E
H
Site 30
S195
S
D
V
S
E
V
S
S
V
E
H
T
Q
E
S
Site 31
T199
E
V
S
S
V
E
H
T
Q
E
S
S
V
Q
G
Site 32
S202
S
V
E
H
T
Q
E
S
S
V
Q
G
S
C
R
Site 33
S203
V
E
H
T
Q
E
S
S
V
Q
G
S
C
R
S
Site 34
S207
Q
E
S
S
V
Q
G
S
C
R
S
P
E
N
K
Site 35
S210
S
V
Q
G
S
C
R
S
P
E
N
K
F
Q
I
Site 36
S227
Q
E
P
M
E
L
E
S
Y
T
R
E
P
R
D
Site 37
Y228
E
P
M
E
L
E
S
Y
T
R
E
P
R
D
D
Site 38
T229
P
M
E
L
E
S
Y
T
R
E
P
R
D
D
R
Site 39
S238
E
P
R
D
D
R
G
S
Y
T
A
S
I
Y
Q
Site 40
Y239
P
R
D
D
R
G
S
Y
T
A
S
I
Y
Q
N
Site 41
T240
R
D
D
R
G
S
Y
T
A
S
I
Y
Q
N
Y
Site 42
Y244
G
S
Y
T
A
S
I
Y
Q
N
Y
M
G
N
S
Site 43
Y247
T
A
S
I
Y
Q
N
Y
M
G
N
S
F
S
G
Site 44
S253
N
Y
M
G
N
S
F
S
G
Y
S
H
S
P
P
Site 45
Y255
M
G
N
S
F
S
G
Y
S
H
S
P
P
L
L
Site 46
S256
G
N
S
F
S
G
Y
S
H
S
P
P
L
L
Q
Site 47
S258
S
F
S
G
Y
S
H
S
P
P
L
L
Q
V
N
Site 48
S267
P
L
L
Q
V
N
R
S
S
S
N
S
P
R
T
Site 49
S268
L
L
Q
V
N
R
S
S
S
N
S
P
R
T
S
Site 50
S269
L
Q
V
N
R
S
S
S
N
S
P
R
T
S
E
Site 51
S271
V
N
R
S
S
S
N
S
P
R
T
S
E
T
D
Site 52
S275
S
S
N
S
P
R
T
S
E
T
D
D
G
V
V
Site 53
S285
D
D
G
V
V
G
K
S
S
D
G
E
D
E
Q
Site 54
S286
D
G
V
V
G
K
S
S
D
G
E
D
E
Q
Q
Site 55
S301
V
P
K
G
P
I
H
S
P
V
E
L
K
H
V
Site 56
S321
K
V
P
E
V
N
S
S
A
L
P
H
K
L
R
Site 57
T348
F
D
N
E
F
E
A
T
Q
K
L
S
S
P
I
Site 58
S352
F
E
A
T
Q
K
L
S
S
P
I
D
M
T
S
Site 59
S353
E
A
T
Q
K
L
S
S
P
I
D
M
T
S
K
Site 60
S359
S
S
P
I
D
M
T
S
K
R
H
F
E
L
E
Site 61
S369
H
F
E
L
E
K
H
S
A
P
S
M
V
H
S
Site 62
S372
L
E
K
H
S
A
P
S
M
V
H
S
S
L
T
Site 63
S382
H
S
S
L
T
P
F
S
V
Q
V
T
N
I
Q
Site 64
T386
T
P
F
S
V
Q
V
T
N
I
Q
D
W
S
L
Site 65
S410
L
S
G
K
T
Q
N
S
F
K
T
G
V
V
E
Site 66
S421
G
V
V
E
M
K
D
S
G
Y
K
V
S
D
P
Site 67
Y423
V
E
M
K
D
S
G
Y
K
V
S
D
P
E
N
Site 68
S426
K
D
S
G
Y
K
V
S
D
P
E
N
L
Y
L
Site 69
Y432
V
S
D
P
E
N
L
Y
L
K
Q
G
I
A
N
Site 70
T453
S
L
K
R
L
I
A
T
Q
P
I
S
A
S
D
Site 71
S459
A
T
Q
P
I
S
A
S
D
S
G
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation