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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MAPKAPK3
Full Name:
MAP kinase-activated protein kinase 3
Alias:
3PK; EC 2.7.11.1; Kinase MAPKAPK3; MAPK3; MAPKAP3; Mitogen activated protein kinase activated protein kinase-3; Similar to mitogen-activated protein kinase-activated protein kinase 3
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
CAMK
group; MAPKAPK family; MAPKAPK subfamily
Mass (Da):
42987
Number AA:
382
UniProt ID:
Q16644
International Prot ID:
IPI00005777
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004708
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0006468
GO:0006950
Phosida
TranscriptoNet
STRING
Kinexus Products
MAP kinase-activated protein kinase 3 Y76 phosphosite-specific antibody AB-PK692#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK692#HSP27 (81-86) KinSub - Based on Heat shock protein 27 (L81-S86, mouse) peptide; HSP27tide protein kinase substrate peptide - Powder PE-01ACZ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACZ95#MAPKAPK3Subtide - MAPKAPK2 protein kinase substrate peptide - Powder PE-01BIA90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BIA90#MAP kinase-activated protein kinase 3 (K73-P79, human) pY76 phosphopeptide - Powder PE-04ANP99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANP99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
D
G
E
T
A
E
E
Q
G
G
P
Site 2
Y37
G
R
R
E
P
K
K
Y
A
V
T
D
D
Y
Q
Site 3
Y43
K
Y
A
V
T
D
D
Y
Q
L
S
K
Q
V
L
Site 4
S46
V
T
D
D
Y
Q
L
S
K
Q
V
L
G
L
G
Site 5
T66
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
Site 6
Y76
K
C
A
L
K
L
L
Y
D
S
P
K
A
R
Q
MAP kinase-activated protein kinase 3 Y76 phosphosite-specific antibody AB-PK692#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK692#MAP kinase-activated protein kinase 3 (K73-P79, human) pY76 phosphopeptide - Powder PE-04ANP99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANP99
Site 7
S78
A
L
K
L
L
Y
D
S
P
K
A
R
Q
E
V
Site 8
Y174
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
Site 9
T201
T
T
Q
N
A
L
Q
T
P
C
Y
T
P
Y
Y
Site 10
Y204
N
A
L
Q
T
P
C
Y
T
P
Y
Y
V
A
P
Site 11
T205
A
L
Q
T
P
C
Y
T
P
Y
Y
V
A
P
E
Site 12
Y207
Q
T
P
C
Y
T
P
Y
Y
V
A
P
E
V
L
Site 13
Y208
T
P
C
Y
T
P
Y
Y
V
A
P
E
V
L
G
Site 14
Y219
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
Site 15
S244
C
G
F
P
P
F
Y
S
N
T
G
Q
A
I
S
Site 16
T246
F
P
P
F
Y
S
N
T
G
Q
A
I
S
P
G
Site 17
S251
S
N
T
G
Q
A
I
S
P
G
M
K
R
R
I
Site 18
Y263
R
R
I
R
L
G
Q
Y
G
F
P
N
P
E
W
Site 19
S271
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Site 20
T287
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
Site 21
T290
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
Site 22
T294
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
Site 23
S307
N
H
P
W
I
N
Q
S
M
V
V
P
Q
T
P
Site 24
T313
Q
S
M
V
V
P
Q
T
P
L
H
T
A
R
V
Site 25
T317
V
P
Q
T
P
L
H
T
A
R
V
L
Q
E
D
Site 26
T341
E
M
T
S
A
L
A
T
M
R
V
D
Y
D
Q
Site 27
Y346
L
A
T
M
R
V
D
Y
D
Q
V
K
I
K
D
Site 28
T356
V
K
I
K
D
L
K
T
S
N
N
R
L
L
N
Site 29
S357
K
I
K
D
L
K
T
S
N
N
R
L
L
N
K
Site 30
S372
R
R
K
K
Q
A
G
S
S
S
A
S
Q
G
C
Site 31
S373
R
K
K
Q
A
G
S
S
S
A
S
Q
G
C
N
Site 32
S374
K
K
Q
A
G
S
S
S
A
S
Q
G
C
N
N
Site 33
S376
Q
A
G
S
S
S
A
S
Q
G
C
N
N
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation