KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DPYSL2
Full Name:
Dihydropyrimidinase-related protein 2
Alias:
Collapsin response mediator protein 2; CRMP2; DHPRP2; Dihydropyrimidinase related protein-2; Dihydropyrimidinase-like 2; DPYL2; DRP2; DRP-2; N2A3; TOAD-64; Turned on after division, 64 kDa protein; ULIP 2 protein; ULIP2
Type:
Motility/polarity/chemotaxis; Microtubule binding protein
Mass (Da):
62294
Number AA:
572
UniProt ID:
Q16555
International Prot ID:
IPI00257508
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0004157
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007399
GO:0006139
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
Y
Q
G
K
K
N
I
Site 2
Y3
_
_
_
_
_
M
S
Y
Q
G
K
K
N
I
P
Site 3
T13
K
K
N
I
P
R
I
T
S
D
R
L
L
I
K
Site 4
S14
K
N
I
P
R
I
T
S
D
R
L
L
I
K
G
Site 5
S30
K
I
V
N
D
D
Q
S
F
Y
A
D
I
Y
M
Site 6
Y32
V
N
D
D
Q
S
F
Y
A
D
I
Y
M
E
D
Site 7
Y36
Q
S
F
Y
A
D
I
Y
M
E
D
G
L
I
K
Site 8
T57
I
V
P
G
G
V
K
T
I
E
A
H
S
R
M
Site 9
T74
P
G
G
I
D
V
H
T
R
F
Q
M
P
D
Q
Site 10
S85
M
P
D
Q
G
M
T
S
A
D
D
F
F
Q
G
Site 11
Y135
D
S
K
S
C
C
D
Y
S
L
H
V
D
I
S
Site 12
S136
S
K
S
C
C
D
Y
S
L
H
V
D
I
S
E
Site 13
T177
F
K
D
R
F
Q
L
T
D
C
Q
I
Y
E
V
Site 14
Y182
Q
L
T
D
C
Q
I
Y
E
V
L
S
V
I
R
Site 15
S226
G
P
E
G
H
V
L
S
R
P
E
E
V
E
A
Site 16
T241
E
A
V
N
R
A
I
T
I
A
N
Q
T
N
C
Site 17
Y251
N
Q
T
N
C
P
L
Y
I
T
K
V
M
S
K
Site 18
T253
T
N
C
P
L
Y
I
T
K
V
M
S
K
S
S
Site 19
Y275
R
K
K
G
T
V
V
Y
G
E
P
I
T
A
S
Site 20
S282
Y
G
E
P
I
T
A
S
L
G
T
D
G
S
H
Site 21
Y290
L
G
T
D
G
S
H
Y
W
S
K
N
W
A
K
Site 22
S292
T
D
G
S
H
Y
W
S
K
N
W
A
K
A
A
Site 23
S304
K
A
A
A
F
V
T
S
P
P
L
S
P
D
P
Site 24
S308
F
V
T
S
P
P
L
S
P
D
P
T
T
P
D
Site 25
T312
P
P
L
S
P
D
P
T
T
P
D
F
L
N
S
Site 26
T313
P
L
S
P
D
P
T
T
P
D
F
L
N
S
L
Site 27
S331
G
D
L
Q
V
T
G
S
A
H
C
T
F
N
T
Site 28
T335
V
T
G
S
A
H
C
T
F
N
T
A
Q
K
A
Site 29
T349
A
V
G
K
D
N
F
T
L
I
P
E
G
T
N
Site 30
S363
N
G
T
E
E
R
M
S
V
I
W
D
K
A
V
Site 31
Y395
A
A
K
V
F
N
L
Y
P
R
K
G
R
I
A
Site 32
S405
K
G
R
I
A
V
G
S
D
A
D
L
V
I
W
Site 33
S421
P
D
S
V
K
T
I
S
A
K
T
H
N
S
S
Site 34
T424
V
K
T
I
S
A
K
T
H
N
S
S
L
E
Y
Site 35
Y431
T
H
N
S
S
L
E
Y
N
I
F
E
G
M
E
Site 36
S442
E
G
M
E
C
R
G
S
P
L
V
V
I
S
Q
Site 37
T458
K
I
V
L
E
D
G
T
L
H
V
T
E
G
S
Site 38
S465
T
L
H
V
T
E
G
S
G
R
Y
I
P
R
K
Site 39
Y468
V
T
E
G
S
G
R
Y
I
P
R
K
P
F
P
Site 40
Y479
K
P
F
P
D
F
V
Y
K
R
I
K
A
R
S
Site 41
S486
Y
K
R
I
K
A
R
S
R
L
A
E
L
R
G
Site 42
Y499
R
G
V
P
R
G
L
Y
D
G
P
V
C
E
V
Site 43
S507
D
G
P
V
C
E
V
S
V
T
P
K
T
V
T
Site 44
T509
P
V
C
E
V
S
V
T
P
K
T
V
T
P
A
Site 45
T512
E
V
S
V
T
P
K
T
V
T
P
A
S
S
A
Site 46
T514
S
V
T
P
K
T
V
T
P
A
S
S
A
K
T
Site 47
S517
P
K
T
V
T
P
A
S
S
A
K
T
S
P
A
Site 48
S518
K
T
V
T
P
A
S
S
A
K
T
S
P
A
K
Site 49
T521
T
P
A
S
S
A
K
T
S
P
A
K
Q
Q
A
Site 50
S522
P
A
S
S
A
K
T
S
P
A
K
Q
Q
A
P
Site 51
S537
P
V
R
N
L
H
Q
S
G
F
S
L
S
G
A
Site 52
S540
N
L
H
Q
S
G
F
S
L
S
G
A
Q
I
D
Site 53
S542
H
Q
S
G
F
S
L
S
G
A
Q
I
D
D
N
Site 54
T554
D
D
N
I
P
R
R
T
T
Q
R
I
V
A
P
Site 55
T555
D
N
I
P
R
R
T
T
Q
R
I
V
A
P
P
Site 56
S570
G
G
R
A
N
I
T
S
L
G
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation