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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PKN1
Full Name:
Serine/threonine-protein kinase N1
Alias:
EC 2.7.11.13; PAK-1; PKN; PRK1; PRKCL1; Protease-activated kinase 1; Protein kinase C-like 1; Protein kinase C-like PKN; Protein-kinase C-related kinase 1
Type:
Protein-serine kinase, AGC group, PKN family
Mass (Da):
103990
Number AA:
942
UniProt ID:
Q16512
International Prot ID:
IPI00002803
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004697
PhosphoSite+
KinaseNET
Biological Process:
GO:0007257
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein kinase C-related protein-serine kinase 1; Protein kinase N1 T774 phosphosite-specific antibody AB-PK781#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK781#Protein kinase C-related protein-serine kinase 1 / Protein kinase N1 (R771-G777, human) pT774 phosphopeptide - Powder PE-04ADX99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADX99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
D
A
V
Q
S
E
P
Site 2
S8
M
A
S
D
A
V
Q
S
E
P
R
S
W
S
L
Site 3
S12
A
V
Q
S
E
P
R
S
W
S
L
L
E
Q
L
Site 4
S14
Q
S
E
P
R
S
W
S
L
L
E
Q
L
G
L
Site 5
T63
A
E
N
L
R
R
A
T
T
D
L
G
R
S
L
Site 6
T64
E
N
L
R
R
A
T
T
D
L
G
R
S
L
G
Site 7
S69
A
T
T
D
L
G
R
S
L
G
P
V
E
L
L
Site 8
S81
E
L
L
L
R
G
S
S
R
R
L
D
L
L
H
Site 9
S112
A
T
H
D
G
P
Q
S
P
G
A
G
G
P
T
Site 10
S121
G
A
G
G
P
T
C
S
A
T
N
L
S
R
V
Site 11
T123
G
G
P
T
C
S
A
T
N
L
S
R
V
A
G
Site 12
Y152
A
E
N
M
I
Q
T
Y
S
N
G
S
T
K
D
Site 13
T157
Q
T
Y
S
N
G
S
T
K
D
R
K
L
L
L
Site 14
T165
K
D
R
K
L
L
L
T
A
Q
Q
M
L
Q
D
Site 15
S173
A
Q
Q
M
L
Q
D
S
K
T
K
I
D
I
I
Site 16
T175
Q
M
L
Q
D
S
K
T
K
I
D
I
I
R
M
Site 17
T202
N
Q
A
A
P
D
D
T
Q
G
S
P
D
L
G
Site 18
S205
A
P
D
D
T
Q
G
S
P
D
L
G
A
V
E
Site 19
S240
K
N
V
L
R
L
L
S
A
A
K
A
P
D
R
Site 20
S301
A
A
S
S
A
A
F
S
T
R
L
A
G
P
F
Site 21
S314
P
F
P
A
T
H
Y
S
T
L
C
K
P
A
P
Site 22
T315
F
P
A
T
H
Y
S
T
L
C
K
P
A
P
L
Site 23
T339
G
C
R
D
L
P
E
T
I
P
W
N
P
T
P
Site 24
T345
E
T
I
P
W
N
P
T
P
S
M
G
G
P
G
Site 25
S347
I
P
W
N
P
T
P
S
M
G
G
P
G
T
P
Site 26
T353
P
S
M
G
G
P
G
T
P
D
S
R
P
P
F
Site 27
S356
G
G
P
G
T
P
D
S
R
P
P
F
L
S
R
Site 28
S362
D
S
R
P
P
F
L
S
R
P
A
R
G
L
Y
Site 29
Y369
S
R
P
A
R
G
L
Y
S
R
S
G
S
L
S
Site 30
S370
R
P
A
R
G
L
Y
S
R
S
G
S
L
S
G
Site 31
S372
A
R
G
L
Y
S
R
S
G
S
L
S
G
R
S
Site 32
S374
G
L
Y
S
R
S
G
S
L
S
G
R
S
S
L
Site 33
S376
Y
S
R
S
G
S
L
S
G
R
S
S
L
K
A
Site 34
S380
G
S
L
S
G
R
S
S
L
K
A
E
A
E
N
Site 35
T388
L
K
A
E
A
E
N
T
S
E
V
S
T
V
L
Site 36
T393
E
N
T
S
E
V
S
T
V
L
K
L
D
N
T
Site 37
S418
G
P
N
A
W
D
Q
S
F
T
L
E
L
E
R
Site 38
S495
R
R
Q
K
K
I
F
S
K
Q
Q
G
K
A
F
Site 39
T514
Q
M
N
I
D
V
A
T
W
V
R
L
L
R
R
Site 40
T527
R
R
L
I
P
N
A
T
G
T
G
T
F
S
P
Site 41
T529
L
I
P
N
A
T
G
T
G
T
F
S
P
G
A
Site 42
T531
P
N
A
T
G
T
G
T
F
S
P
G
A
S
P
Site 43
S533
A
T
G
T
G
T
F
S
P
G
A
S
P
G
S
Site 44
S537
G
T
F
S
P
G
A
S
P
G
S
E
A
R
T
Site 45
S540
S
P
G
A
S
P
G
S
E
A
R
T
T
G
D
Site 46
T544
S
P
G
S
E
A
R
T
T
G
D
I
S
V
E
Site 47
T545
P
G
S
E
A
R
T
T
G
D
I
S
V
E
K
Site 48
S549
A
R
T
T
G
D
I
S
V
E
K
L
N
L
G
Site 49
T557
V
E
K
L
N
L
G
T
D
S
D
S
S
P
Q
Site 50
S559
K
L
N
L
G
T
D
S
D
S
S
P
Q
K
S
Site 51
S561
N
L
G
T
D
S
D
S
S
P
Q
K
S
S
R
Site 52
S562
L
G
T
D
S
D
S
S
P
Q
K
S
S
R
D
Site 53
S566
S
D
S
S
P
Q
K
S
S
R
D
P
P
S
S
Site 54
S567
D
S
S
P
Q
K
S
S
R
D
P
P
S
S
P
Site 55
S572
K
S
S
R
D
P
P
S
S
P
S
S
L
S
S
Site 56
S573
S
S
R
D
P
P
S
S
P
S
S
L
S
S
P
Site 57
S575
R
D
P
P
S
S
P
S
S
L
S
S
P
I
Q
Site 58
S576
D
P
P
S
S
P
S
S
L
S
S
P
I
Q
E
Site 59
S578
P
S
S
P
S
S
L
S
S
P
I
Q
E
S
T
Site 60
S579
S
S
P
S
S
L
S
S
P
I
Q
E
S
T
A
Site 61
S584
L
S
S
P
I
Q
E
S
T
A
P
E
L
P
S
Site 62
T585
S
S
P
I
Q
E
S
T
A
P
E
L
P
S
E
Site 63
T596
L
P
S
E
T
Q
E
T
P
G
P
A
L
C
S
Site 64
S603
T
P
G
P
A
L
C
S
P
L
R
K
S
P
L
Site 65
S608
L
C
S
P
L
R
K
S
P
L
T
L
E
D
F
Site 66
T611
P
L
R
K
S
P
L
T
L
E
D
F
K
F
L
Site 67
S632
H
F
G
K
V
L
L
S
E
F
R
P
S
G
E
Site 68
S659
V
A
R
D
E
V
E
S
L
M
C
E
K
R
I
Site 69
S709
D
L
M
L
H
I
H
S
D
V
F
S
E
P
R
Site 70
Y768
L
C
K
E
G
M
G
Y
G
D
R
T
S
T
F
Site 71
T772
G
M
G
Y
G
D
R
T
S
T
F
C
G
T
P
Site 72
S773
M
G
Y
G
D
R
T
S
T
F
C
G
T
P
E
Site 73
T774
G
Y
G
D
R
T
S
T
F
C
G
T
P
E
F
Protein kinase C-related protein-serine kinase 1; Protein kinase N1 T774 phosphosite-specific antibody AB-PK781#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK781#Protein kinase C-related protein-serine kinase 1 / Protein kinase N1 (R771-G777, human) pT774 phosphopeptide - Powder PE-04ADX99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADX99
Site 74
T778
R
T
S
T
F
C
G
T
P
E
F
L
A
P
E
Site 75
S791
P
E
V
L
T
D
T
S
Y
T
R
A
V
D
W
Site 76
Y792
E
V
L
T
D
T
S
Y
T
R
A
V
D
W
W
Site 77
S813
Y
E
M
L
V
G
E
S
P
F
P
G
D
D
E
Site 78
S826
D
E
E
E
V
F
D
S
I
V
N
D
E
V
R
Site 79
Y834
I
V
N
D
E
V
R
Y
P
R
F
L
S
A
E
Site 80
S860
N
P
E
R
R
L
G
S
S
E
R
D
A
E
D
Site 81
S861
P
E
R
R
L
G
S
S
E
R
D
A
E
D
V
Site 82
S896
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
Site 83
S902
L
S
G
R
T
D
V
S
N
F
D
E
E
F
T
Site 84
T914
E
F
T
G
E
A
P
T
L
S
P
P
R
D
A
Site 85
S916
T
G
E
A
P
T
L
S
P
P
R
D
A
R
P
Site 86
T925
P
R
D
A
R
P
L
T
A
A
E
Q
A
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation