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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NFE2L2
Full Name:
Nuclear factor erythroid 2-related factor 2
Alias:
HEBP1; NF2L2; NF-E2 related factor 2; NFE2-related factor 2; NF-E2-related factor 2; NFL2; Nrf2; NRF-2; Nuclear factor (erythroid-derived 2)-like 2; Nuclear factor erythroid 2 related factor 2; Nuclear factor, erythroid derived 2, like 2
Type:
Transcription protein
Mass (Da):
67827
Number AA:
605
UniProt ID:
Q16236
International Prot ID:
IPI00000712
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0046983
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006366
GO:0006350
GO:0006351
Phosida
TranscriptoNet
STRING
Kinexus Products
Nuclear factor erythroid 2-related factor 2 pan-specific antibody AB-NN140-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN140-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
L
P
P
P
G
L
P
S
Q
Q
D
M
D
L
I
Site 2
S40
S
R
E
V
F
D
F
S
Q
R
R
K
E
Y
E
Site 3
Y46
F
S
Q
R
R
K
E
Y
E
L
E
K
Q
K
K
Site 4
S94
Q
P
A
Q
H
I
Q
S
E
T
S
G
S
A
N
Site 5
S97
Q
H
I
Q
S
E
T
S
G
S
A
N
Y
S
Q
Site 6
S99
I
Q
S
E
T
S
G
S
A
N
Y
S
Q
V
A
Site 7
S103
T
S
G
S
A
N
Y
S
Q
V
A
H
I
P
K
Site 8
S111
Q
V
A
H
I
P
K
S
D
A
L
Y
F
D
D
Site 9
Y115
I
P
K
S
D
A
L
Y
F
D
D
C
M
Q
L
Site 10
S137
V
D
D
N
E
V
S
S
A
T
F
Q
S
L
V
Site 11
S164
I
A
T
N
Q
A
Q
S
P
E
T
S
V
A
Q
Site 12
S168
Q
A
Q
S
P
E
T
S
V
A
Q
V
A
P
V
Site 13
T211
N
D
K
L
V
E
T
T
M
V
P
S
P
E
A
Site 14
S215
V
E
T
T
M
V
P
S
P
E
A
K
L
T
E
Site 15
T221
P
S
P
E
A
K
L
T
E
V
D
N
Y
H
F
Site 16
Y226
K
L
T
E
V
D
N
Y
H
F
Y
S
S
I
P
Site 17
Y229
E
V
D
N
Y
H
F
Y
S
S
I
P
S
M
E
Site 18
S234
H
F
Y
S
S
I
P
S
M
E
K
E
V
G
N
Site 19
S243
E
K
E
V
G
N
C
S
P
H
F
L
N
A
F
Site 20
S255
N
A
F
E
D
S
F
S
S
I
L
S
T
E
D
Site 21
S259
D
S
F
S
S
I
L
S
T
E
D
P
N
Q
L
Site 22
T260
S
F
S
S
I
L
S
T
E
D
P
N
Q
L
T
Site 23
T267
T
E
D
P
N
Q
L
T
V
N
S
L
N
S
D
Site 24
S270
P
N
Q
L
T
V
N
S
L
N
S
D
A
T
V
Site 25
T276
N
S
L
N
S
D
A
T
V
N
T
D
F
G
D
Site 26
Y286
T
D
F
G
D
E
F
Y
S
A
F
I
A
E
P
Site 27
S294
S
A
F
I
A
E
P
S
I
S
N
S
M
P
S
Site 28
S296
F
I
A
E
P
S
I
S
N
S
M
P
S
P
A
Site 29
S298
A
E
P
S
I
S
N
S
M
P
S
P
A
T
L
Site 30
S301
S
I
S
N
S
M
P
S
P
A
T
L
S
H
S
Site 31
T304
N
S
M
P
S
P
A
T
L
S
H
S
L
S
E
Site 32
S308
S
P
A
T
L
S
H
S
L
S
E
L
L
N
G
Site 33
S335
F
N
Q
N
H
P
E
S
T
A
E
F
N
D
S
Site 34
S342
S
T
A
E
F
N
D
S
D
S
G
I
S
L
N
Site 35
S344
A
E
F
N
D
S
D
S
G
I
S
L
N
T
S
Site 36
S347
N
D
S
D
S
G
I
S
L
N
T
S
P
S
V
Site 37
S351
S
G
I
S
L
N
T
S
P
S
V
A
S
P
E
Site 38
S353
I
S
L
N
T
S
P
S
V
A
S
P
E
H
S
Site 39
S356
N
T
S
P
S
V
A
S
P
E
H
S
V
E
S
Site 40
S360
S
V
A
S
P
E
H
S
V
E
S
S
S
Y
G
Site 41
S364
P
E
H
S
V
E
S
S
S
Y
G
D
T
L
L
Site 42
S365
E
H
S
V
E
S
S
S
Y
G
D
T
L
L
G
Site 43
Y366
H
S
V
E
S
S
S
Y
G
D
T
L
L
G
L
Site 44
T369
E
S
S
S
Y
G
D
T
L
L
G
L
S
D
S
Site 45
S374
G
D
T
L
L
G
L
S
D
S
E
V
E
E
L
Site 46
S376
T
L
L
G
L
S
D
S
E
V
E
E
L
D
S
Site 47
S383
S
E
V
E
E
L
D
S
A
P
G
S
V
K
Q
Site 48
S387
E
L
D
S
A
P
G
S
V
K
Q
N
G
P
K
Site 49
T395
V
K
Q
N
G
P
K
T
P
V
H
S
S
G
D
Site 50
S400
P
K
T
P
V
H
S
S
G
D
M
V
Q
P
L
Site 51
S408
G
D
M
V
Q
P
L
S
P
S
Q
G
Q
S
T
Site 52
S410
M
V
Q
P
L
S
P
S
Q
G
Q
S
T
H
V
Site 53
S414
L
S
P
S
Q
G
Q
S
T
H
V
H
D
A
Q
Site 54
T425
H
D
A
Q
C
E
N
T
P
E
K
E
L
P
V
Site 55
S433
P
E
K
E
L
P
V
S
P
G
H
R
K
T
P
Site 56
T439
V
S
P
G
H
R
K
T
P
F
T
K
D
K
H
Site 57
T442
G
H
R
K
T
P
F
T
K
D
K
H
S
S
R
Site 58
S447
P
F
T
K
D
K
H
S
S
R
L
E
A
H
L
Site 59
T455
S
R
L
E
A
H
L
T
R
D
E
L
R
A
K
Site 60
S549
E
K
G
E
N
D
K
S
L
H
L
L
K
K
Q
Site 61
S558
H
L
L
K
K
Q
L
S
T
L
Y
L
E
V
F
Site 62
T559
L
L
K
K
Q
L
S
T
L
Y
L
E
V
F
S
Site 63
Y561
K
K
Q
L
S
T
L
Y
L
E
V
F
S
M
L
Site 64
Y576
R
D
E
D
G
K
P
Y
S
P
S
E
Y
S
L
Site 65
S577
D
E
D
G
K
P
Y
S
P
S
E
Y
S
L
Q
Site 66
S579
D
G
K
P
Y
S
P
S
E
Y
S
L
Q
Q
T
Site 67
S582
P
Y
S
P
S
E
Y
S
L
Q
Q
T
R
D
G
Site 68
T586
S
E
Y
S
L
Q
Q
T
R
D
G
N
V
F
L
Site 69
S597
N
V
F
L
V
P
K
S
K
K
P
D
V
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation