KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ZYX
Full Name:
Zyxin
Alias:
Zyxin: Zyxin-2: ZYX protein; Zyxin-2
Type:
Adhesion protein
Mass (Da):
61277
Number AA:
572
UniProt ID:
Q15942
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005913
GO:0005737
GO:0005925
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0007267
GO:0044419
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
S
V
S
A
P
A
F
Y
A
P
Q
K
K
F
G
Site 2
S44
N
P
F
R
P
G
D
S
E
P
P
P
A
P
G
Site 3
S103
P
P
P
P
I
E
E
S
F
P
P
A
P
L
E
Site 4
S116
L
E
E
E
I
F
P
S
P
P
P
P
P
E
E
Site 5
S142
P
Q
P
R
E
K
V
S
S
I
D
L
E
I
D
Site 6
S143
Q
P
R
E
K
V
S
S
I
D
L
E
I
D
S
Site 7
S150
S
I
D
L
E
I
D
S
L
S
S
L
L
D
D
Site 8
S152
D
L
E
I
D
S
L
S
S
L
L
D
D
M
T
Site 9
S153
L
E
I
D
S
L
S
S
L
L
D
D
M
T
K
Site 10
T159
S
S
L
L
D
D
M
T
K
N
D
P
F
K
A
Site 11
S169
D
P
F
K
A
R
V
S
S
G
Y
V
P
P
P
Site 12
S170
P
F
K
A
R
V
S
S
G
Y
V
P
P
P
V
Site 13
Y172
K
A
R
V
S
S
G
Y
V
P
P
P
V
A
T
Site 14
T179
Y
V
P
P
P
V
A
T
P
F
S
S
K
S
S
Site 15
S182
P
P
V
A
T
P
F
S
S
K
S
S
T
K
P
Site 16
S183
P
V
A
T
P
F
S
S
K
S
S
T
K
P
A
Site 17
S185
A
T
P
F
S
S
K
S
S
T
K
P
A
A
G
Site 18
S186
T
P
F
S
S
K
S
S
T
K
P
A
A
G
G
Site 19
T187
P
F
S
S
K
S
S
T
K
P
A
A
G
G
T
Site 20
S202
A
P
L
P
P
W
K
S
P
S
S
S
Q
P
L
Site 21
S204
L
P
P
W
K
S
P
S
S
S
Q
P
L
P
Q
Site 22
S205
P
P
W
K
S
P
S
S
S
Q
P
L
P
Q
V
Site 23
S206
P
W
K
S
P
S
S
S
Q
P
L
P
Q
V
P
Site 24
S218
Q
V
P
A
P
A
Q
S
Q
T
Q
F
H
V
Q
Site 25
S240
Q
V
Q
L
H
V
Q
S
Q
T
Q
P
V
S
L
Site 26
T242
Q
L
H
V
Q
S
Q
T
Q
P
V
S
L
A
N
Site 27
S246
Q
S
Q
T
Q
P
V
S
L
A
N
T
Q
P
R
Site 28
T250
Q
P
V
S
L
A
N
T
Q
P
R
G
P
P
A
Site 29
S258
Q
P
R
G
P
P
A
S
S
P
A
P
A
P
K
Site 30
S259
P
R
G
P
P
A
S
S
P
A
P
A
P
K
F
Site 31
S267
P
A
P
A
P
K
F
S
P
V
T
P
K
F
T
Site 32
T270
A
P
K
F
S
P
V
T
P
K
F
T
P
V
A
Site 33
T274
S
P
V
T
P
K
F
T
P
V
A
S
K
F
S
Site 34
S278
P
K
F
T
P
V
A
S
K
F
S
P
G
A
P
Site 35
S281
T
P
V
A
S
K
F
S
P
G
A
P
G
G
S
Site 36
S288
S
P
G
A
P
G
G
S
G
S
Q
P
N
Q
K
Site 37
S290
G
A
P
G
G
S
G
S
Q
P
N
Q
K
L
G
Site 38
S303
L
G
H
P
E
A
L
S
A
G
T
G
S
P
Q
Site 39
T306
P
E
A
L
S
A
G
T
G
S
P
Q
P
P
S
Site 40
S308
A
L
S
A
G
T
G
S
P
Q
P
P
S
F
T
Site 41
S313
T
G
S
P
Q
P
P
S
F
T
Y
A
Q
Q
R
Site 42
T315
S
P
Q
P
P
S
F
T
Y
A
Q
Q
R
E
K
Site 43
Y316
P
Q
P
P
S
F
T
Y
A
Q
Q
R
E
K
P
Site 44
S344
Q
N
Q
N
Q
V
R
S
P
G
A
P
G
P
L
Site 45
T352
P
G
A
P
G
P
L
T
L
K
E
V
E
E
L
Site 46
S426
L
Q
G
Q
Q
F
Y
S
L
E
G
A
P
Y
C
Site 47
Y432
Y
S
L
E
G
A
P
Y
C
E
G
C
Y
T
D
Site 48
T446
D
T
L
E
K
C
N
T
C
G
E
P
I
T
D
Site 49
T452
N
T
C
G
E
P
I
T
D
R
M
L
R
A
T
Site 50
T459
T
D
R
M
L
R
A
T
G
K
A
Y
H
P
H
Site 51
S481
A
R
P
L
E
G
T
S
F
I
V
D
Q
A
N
Site 52
Y496
R
P
H
C
V
P
D
Y
H
K
Q
Y
A
P
R
Site 53
Y500
V
P
D
Y
H
K
Q
Y
A
P
R
C
S
V
C
Site 54
S505
K
Q
Y
A
P
R
C
S
V
C
S
E
P
I
M
Site 55
S508
A
P
R
C
S
V
C
S
E
P
I
M
P
E
P
Site 56
T520
P
E
P
G
R
D
E
T
V
R
V
V
A
L
D
Site 57
S545
E
D
C
G
K
P
L
S
I
E
A
D
D
N
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation