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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Smad2
Full Name:
Mothers against decapentaplegic homolog 2
Alias:
JV18-1; MADH2; MADR2; Mad-related protein 2; Mothers against DPP homolog 2; Smad 2; SMAD family member 2
Type:
Transcription protein
Mass (Da):
52306
Number AA:
467
UniProt ID:
Q15796
International Prot ID:
IPI00019548
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032444
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0070412
GO:0070410
GO:0003690
PhosphoSite+
KinaseNET
Biological Process:
GO:0007183
GO:0009952
GO:0045165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
I
L
P
F
T
P
Site 2
T8
M
S
S
I
L
P
F
T
P
P
V
V
K
R
L
Site 3
S21
R
L
L
G
W
K
K
S
A
G
G
S
G
G
A
Site 4
S25
W
K
K
S
A
G
G
S
G
G
A
G
G
G
E
Site 5
S47
W
C
E
K
A
V
K
S
L
V
K
K
L
K
K
Site 6
T66
D
E
L
E
K
A
I
T
T
Q
N
C
N
T
K
Site 7
T89
S
E
I
W
G
L
S
T
P
N
T
I
D
Q
W
Site 8
T99
T
I
D
Q
W
D
T
T
G
L
Y
S
F
S
E
Site 9
Y102
Q
W
D
T
T
G
L
Y
S
F
S
E
Q
T
R
Site 10
S103
W
D
T
T
G
L
Y
S
F
S
E
Q
T
R
S
Site 11
S105
T
T
G
L
Y
S
F
S
E
Q
T
R
S
L
D
Site 12
S110
S
F
S
E
Q
T
R
S
L
D
G
R
L
Q
V
Site 13
S118
L
D
G
R
L
Q
V
S
H
R
K
G
L
P
H
Site 14
Y128
K
G
L
P
H
V
I
Y
C
R
L
W
R
W
P
Site 15
Y151
K
A
I
E
N
C
E
Y
A
F
N
L
K
K
D
Site 16
Y165
D
E
V
C
V
N
P
Y
H
Y
Q
R
V
E
T
Site 17
Y167
V
C
V
N
P
Y
H
Y
Q
R
V
E
T
P
V
Site 18
T172
Y
H
Y
Q
R
V
E
T
P
V
L
P
P
V
L
Site 19
T188
P
R
H
T
E
I
L
T
E
L
P
P
L
D
D
Site 20
Y196
E
L
P
P
L
D
D
Y
T
H
S
I
P
E
N
Site 21
T197
L
P
P
L
D
D
Y
T
H
S
I
P
E
N
T
Site 22
S199
P
L
D
D
Y
T
H
S
I
P
E
N
T
N
F
Site 23
S214
P
A
G
I
E
P
Q
S
N
Y
I
P
E
T
P
Site 24
Y216
G
I
E
P
Q
S
N
Y
I
P
E
T
P
P
P
Site 25
T220
Q
S
N
Y
I
P
E
T
P
P
P
G
Y
I
S
Site 26
Y225
P
E
T
P
P
P
G
Y
I
S
E
D
G
E
T
Site 27
S227
T
P
P
P
G
Y
I
S
E
D
G
E
T
S
D
Site 28
T232
Y
I
S
E
D
G
E
T
S
D
Q
Q
L
N
Q
Site 29
S240
S
D
Q
Q
L
N
Q
S
M
D
T
G
S
P
A
Site 30
T243
Q
L
N
Q
S
M
D
T
G
S
P
A
E
L
S
Site 31
S245
N
Q
S
M
D
T
G
S
P
A
E
L
S
P
T
Site 32
S250
T
G
S
P
A
E
L
S
P
T
T
L
S
P
V
Site 33
T252
S
P
A
E
L
S
P
T
T
L
S
P
V
N
H
Site 34
T253
P
A
E
L
S
P
T
T
L
S
P
V
N
H
S
Site 35
S255
E
L
S
P
T
T
L
S
P
V
N
H
S
L
D
Site 36
S260
T
L
S
P
V
N
H
S
L
D
L
Q
P
V
T
Site 37
T267
S
L
D
L
Q
P
V
T
Y
S
E
P
A
F
W
Site 38
Y280
F
W
C
S
I
A
Y
Y
E
L
N
Q
R
V
G
Site 39
T289
L
N
Q
R
V
G
E
T
F
H
A
S
Q
P
S
Site 40
S293
V
G
E
T
F
H
A
S
Q
P
S
L
T
V
D
Site 41
S296
T
F
H
A
S
Q
P
S
L
T
V
D
G
F
T
Site 42
T298
H
A
S
Q
P
S
L
T
V
D
G
F
T
D
P
Site 43
T303
S
L
T
V
D
G
F
T
D
P
S
N
S
E
R
Site 44
S306
V
D
G
F
T
D
P
S
N
S
E
R
F
C
L
Site 45
S308
G
F
T
D
P
S
N
S
E
R
F
C
L
G
L
Site 46
S317
R
F
C
L
G
L
L
S
N
V
N
R
N
A
T
Site 47
T324
S
N
V
N
R
N
A
T
V
E
M
T
R
R
H
Site 48
T328
R
N
A
T
V
E
M
T
R
R
H
I
G
R
G
Site 49
T372
R
Y
G
W
H
P
A
T
V
C
K
I
P
P
G
Site 50
Y406
N
Q
G
F
E
A
V
Y
Q
L
T
R
M
C
T
Site 51
S417
R
M
C
T
I
R
M
S
F
V
K
G
W
G
A
Site 52
Y426
V
K
G
W
G
A
E
Y
R
R
Q
T
V
T
S
Site 53
T430
G
A
E
Y
R
R
Q
T
V
T
S
T
P
C
W
Site 54
T432
E
Y
R
R
Q
T
V
T
S
T
P
C
W
I
E
Site 55
S433
Y
R
R
Q
T
V
T
S
T
P
C
W
I
E
L
Site 56
T434
R
R
Q
T
V
T
S
T
P
C
W
I
E
L
H
Site 57
T454
Q
W
L
D
K
V
L
T
Q
M
G
S
P
S
V
Site 58
S458
K
V
L
T
Q
M
G
S
P
S
V
R
C
S
S
Site 59
S460
L
T
Q
M
G
S
P
S
V
R
C
S
S
M
S
Site 60
S464
G
S
P
S
V
R
C
S
S
M
S
_
_
_
_
Site 61
S465
S
P
S
V
R
C
S
S
M
S
_
_
_
_
_
Site 62
S467
S
V
R
C
S
S
M
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation