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Updated November 2019
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Protein Info
Short Name:
NCOA1
Full Name:
Nuclear receptor coactivator 1
Alias:
NCoA-1; Steroid receptor coactivator 1
Type:
Transcription regulation protein
Mass (Da):
156757
Number AA:
1441
UniProt ID:
Q15788
International Prot ID:
IPI00470490
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0050681
GO:0004402
GO:0047485
PhosphoSite+
KinaseNET
Biological Process:
GO:0030521
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
G
L
G
D
S
S
S
Site 2
S7
_
M
S
G
L
G
D
S
S
S
D
P
A
N
P
Site 3
S8
M
S
G
L
G
D
S
S
S
D
P
A
N
P
D
Site 4
S9
S
G
L
G
D
S
S
S
D
P
A
N
P
D
S
Site 5
S16
S
D
P
A
N
P
D
S
H
K
R
K
G
S
P
Site 6
S22
D
S
H
K
R
K
G
S
P
C
D
T
L
A
S
Site 7
T26
R
K
G
S
P
C
D
T
L
A
S
S
T
E
K
Site 8
S30
P
C
D
T
L
A
S
S
T
E
K
R
R
R
E
Site 9
Y42
R
R
E
Q
E
N
K
Y
L
E
E
L
A
E
L
Site 10
S51
E
E
L
A
E
L
L
S
A
N
I
S
D
I
D
Site 11
S59
A
N
I
S
D
I
D
S
L
S
V
K
P
D
K
Site 12
S61
I
S
D
I
D
S
L
S
V
K
P
D
K
C
K
Site 13
T73
K
C
K
I
L
K
K
T
V
D
Q
I
Q
L
M
Site 14
S88
K
R
M
E
Q
E
K
S
T
T
D
D
D
V
Q
Site 15
T90
M
E
Q
E
K
S
T
T
D
D
D
V
Q
K
S
Site 16
S97
T
D
D
D
V
Q
K
S
D
I
S
S
S
S
Q
Site 17
S100
D
V
Q
K
S
D
I
S
S
S
S
Q
G
V
I
Site 18
S101
V
Q
K
S
D
I
S
S
S
S
Q
G
V
I
E
Site 19
S102
Q
K
S
D
I
S
S
S
S
Q
G
V
I
E
K
Site 20
S103
K
S
D
I
S
S
S
S
Q
G
V
I
E
K
E
Site 21
T154
N
Q
E
E
L
M
N
T
S
V
Y
S
I
L
H
Site 22
S155
Q
E
E
L
M
N
T
S
V
Y
S
I
L
H
V
Site 23
T188
V
P
W
P
Q
E
A
T
R
R
N
S
H
T
F
Site 24
T194
A
T
R
R
N
S
H
T
F
N
C
R
M
L
I
Site 25
T209
H
P
P
D
E
P
G
T
E
N
Q
E
A
C
Q
Site 26
T225
Y
E
V
M
Q
C
F
T
V
S
Q
P
K
S
I
Site 27
S227
V
M
Q
C
F
T
V
S
Q
P
K
S
I
Q
E
Site 28
S231
F
T
V
S
Q
P
K
S
I
Q
E
D
G
E
D
Site 29
S261
P
A
I
T
G
V
E
S
F
M
T
K
Q
D
T
Site 30
T264
T
G
V
E
S
F
M
T
K
Q
D
T
T
G
K
Site 31
S274
D
T
T
G
K
I
I
S
I
D
T
S
S
L
R
Site 32
S278
K
I
I
S
I
D
T
S
S
L
R
A
A
G
R
Site 33
T286
S
L
R
A
A
G
R
T
G
W
E
D
L
V
R
Site 34
Y297
D
L
V
R
K
C
I
Y
A
F
F
Q
P
Q
G
Site 35
S308
Q
P
Q
G
R
E
P
S
Y
A
R
Q
L
F
Q
Site 36
Y309
P
Q
G
R
E
P
S
Y
A
R
Q
L
F
Q
E
Site 37
T322
Q
E
V
M
T
R
G
T
A
S
S
P
S
Y
R
Site 38
S325
M
T
R
G
T
A
S
S
P
S
Y
R
F
I
L
Site 39
S327
R
G
T
A
S
S
P
S
Y
R
F
I
L
N
D
Site 40
Y328
G
T
A
S
S
P
S
Y
R
F
I
L
N
D
G
Site 41
T336
R
F
I
L
N
D
G
T
M
L
S
A
H
T
K
Site 42
S339
L
N
D
G
T
M
L
S
A
H
T
K
C
K
L
Site 43
S369
H
I
I
D
R
E
H
S
G
L
S
P
Q
D
D
Site 44
S372
D
R
E
H
S
G
L
S
P
Q
D
D
T
N
S
Site 45
T377
G
L
S
P
Q
D
D
T
N
S
G
M
S
I
P
Site 46
S379
S
P
Q
D
D
T
N
S
G
M
S
I
P
R
V
Site 47
S389
S
I
P
R
V
N
P
S
V
N
P
S
I
S
P
Site 48
S393
V
N
P
S
V
N
P
S
I
S
P
A
H
G
V
Site 49
S395
P
S
V
N
P
S
I
S
P
A
H
G
V
A
R
Site 50
S403
P
A
H
G
V
A
R
S
S
T
L
P
P
S
N
Site 51
S404
A
H
G
V
A
R
S
S
T
L
P
P
S
N
S
Site 52
T405
H
G
V
A
R
S
S
T
L
P
P
S
N
S
N
Site 53
S409
R
S
S
T
L
P
P
S
N
S
N
M
V
S
T
Site 54
S411
S
T
L
P
P
S
N
S
N
M
V
S
T
R
I
Site 55
S415
P
S
N
S
N
M
V
S
T
R
I
N
R
Q
Q
Site 56
S423
T
R
I
N
R
Q
Q
S
S
D
L
H
S
S
S
Site 57
S424
R
I
N
R
Q
Q
S
S
D
L
H
S
S
S
H
Site 58
S428
Q
Q
S
S
D
L
H
S
S
S
H
S
N
S
S
Site 59
S429
Q
S
S
D
L
H
S
S
S
H
S
N
S
S
N
Site 60
S430
S
S
D
L
H
S
S
S
H
S
N
S
S
N
S
Site 61
S432
D
L
H
S
S
S
H
S
N
S
S
N
S
Q
G
Site 62
S434
H
S
S
S
H
S
N
S
S
N
S
Q
G
S
F
Site 63
S435
S
S
S
H
S
N
S
S
N
S
Q
G
S
F
G
Site 64
S437
S
H
S
N
S
S
N
S
Q
G
S
F
G
C
S
Site 65
S440
N
S
S
N
S
Q
G
S
F
G
C
S
P
G
S
Site 66
S444
S
Q
G
S
F
G
C
S
P
G
S
Q
I
V
A
Site 67
S461
A
L
N
Q
G
Q
A
S
S
Q
S
S
N
P
S
Site 68
S462
L
N
Q
G
Q
A
S
S
Q
S
S
N
P
S
L
Site 69
S464
Q
G
Q
A
S
S
Q
S
S
N
P
S
L
N
L
Site 70
S465
G
Q
A
S
S
Q
S
S
N
P
S
L
N
L
N
Site 71
S468
S
S
Q
S
S
N
P
S
L
N
L
N
N
S
P
Site 72
S474
P
S
L
N
L
N
N
S
P
M
E
G
T
G
I
Site 73
S488
I
S
L
A
Q
F
M
S
P
R
R
Q
V
T
S
Site 74
T494
M
S
P
R
R
Q
V
T
S
G
L
A
T
R
P
Site 75
S495
S
P
R
R
Q
V
T
S
G
L
A
T
R
P
R
Site 76
T499
Q
V
T
S
G
L
A
T
R
P
R
M
P
N
N
Site 77
S507
R
P
R
M
P
N
N
S
F
P
P
N
I
S
T
Site 78
S513
N
S
F
P
P
N
I
S
T
L
S
S
P
V
G
Site 79
S516
P
P
N
I
S
T
L
S
S
P
V
G
M
T
S
Site 80
S517
P
N
I
S
T
L
S
S
P
V
G
M
T
S
S
Site 81
S523
S
S
P
V
G
M
T
S
S
A
C
N
N
N
N
Site 82
S524
S
P
V
G
M
T
S
S
A
C
N
N
N
N
R
Site 83
Y533
C
N
N
N
N
R
S
Y
S
N
I
P
V
T
S
Site 84
S534
N
N
N
N
R
S
Y
S
N
I
P
V
T
S
L
Site 85
S540
Y
S
N
I
P
V
T
S
L
Q
G
M
N
E
G
Site 86
S551
M
N
E
G
P
N
N
S
V
G
F
S
A
S
S
Site 87
S555
P
N
N
S
V
G
F
S
A
S
S
P
V
L
R
Site 88
S557
N
S
V
G
F
S
A
S
S
P
V
L
R
Q
M
Site 89
S558
S
V
G
F
S
A
S
S
P
V
L
R
Q
M
S
Site 90
S565
S
P
V
L
R
Q
M
S
S
Q
N
S
P
S
R
Site 91
S566
P
V
L
R
Q
M
S
S
Q
N
S
P
S
R
L
Site 92
S569
R
Q
M
S
S
Q
N
S
P
S
R
L
N
I
Q
Site 93
S582
I
Q
P
A
K
A
E
S
K
D
N
K
E
I
A
Site 94
S598
I
L
N
E
M
I
Q
S
D
N
S
S
S
D
G
Site 95
S601
E
M
I
Q
S
D
N
S
S
S
D
G
K
P
L
Site 96
S602
M
I
Q
S
D
N
S
S
S
D
G
K
P
L
D
Site 97
S603
I
Q
S
D
N
S
S
S
D
G
K
P
L
D
S
Site 98
S610
S
D
G
K
P
L
D
S
G
L
L
H
N
N
D
Site 99
S620
L
H
N
N
D
R
L
S
D
G
D
S
K
Y
S
Site 100
S624
D
R
L
S
D
G
D
S
K
Y
S
Q
T
S
H
Site 101
Y626
L
S
D
G
D
S
K
Y
S
Q
T
S
H
K
L
Site 102
S627
S
D
G
D
S
K
Y
S
Q
T
S
H
K
L
V
Site 103
T652
L
R
H
A
D
I
D
T
S
C
K
D
V
L
S
Site 104
S653
R
H
A
D
I
D
T
S
C
K
D
V
L
S
C
Site 105
S659
T
S
C
K
D
V
L
S
C
T
G
T
S
N
S
Site 106
T661
C
K
D
V
L
S
C
T
G
T
S
N
S
A
S
Site 107
T663
D
V
L
S
C
T
G
T
S
N
S
A
S
A
N
Site 108
S664
V
L
S
C
T
G
T
S
N
S
A
S
A
N
S
Site 109
S666
S
C
T
G
T
S
N
S
A
S
A
N
S
S
G
Site 110
S668
T
G
T
S
N
S
A
S
A
N
S
S
G
G
S
Site 111
S671
S
N
S
A
S
A
N
S
S
G
G
S
C
P
S
Site 112
S672
N
S
A
S
A
N
S
S
G
G
S
C
P
S
S
Site 113
S675
S
A
N
S
S
G
G
S
C
P
S
S
H
S
S
Site 114
S678
S
S
G
G
S
C
P
S
S
H
S
S
L
T
E
Site 115
S679
S
G
G
S
C
P
S
S
H
S
S
L
T
E
R
Site 116
S681
G
S
C
P
S
S
H
S
S
L
T
E
R
H
K
Site 117
S682
S
C
P
S
S
H
S
S
L
T
E
R
H
K
I
Site 118
T684
P
S
S
H
S
S
L
T
E
R
H
K
I
L
H
Site 119
S698
H
R
L
L
Q
E
G
S
P
S
D
I
T
T
L
Site 120
T703
E
G
S
P
S
D
I
T
T
L
S
V
E
P
D
Site 121
T704
G
S
P
S
D
I
T
T
L
S
V
E
P
D
K
Site 122
S706
P
S
D
I
T
T
L
S
V
E
P
D
K
K
D
Site 123
S714
V
E
P
D
K
K
D
S
A
S
T
S
V
S
V
Site 124
S716
P
D
K
K
D
S
A
S
T
S
V
S
V
T
G
Site 125
S718
K
K
D
S
A
S
T
S
V
S
V
T
G
Q
V
Site 126
S720
D
S
A
S
T
S
V
S
V
T
G
Q
V
Q
G
Site 127
T722
A
S
T
S
V
S
V
T
G
Q
V
Q
G
N
S
Site 128
S738
I
K
L
E
L
D
A
S
K
K
K
E
S
K
D
Site 129
Y751
K
D
H
Q
L
L
R
Y
L
L
D
K
D
E
K
Site 130
S762
K
D
E
K
D
L
R
S
T
P
N
L
S
L
D
Site 131
T763
D
E
K
D
L
R
S
T
P
N
L
S
L
D
D
Site 132
S767
L
R
S
T
P
N
L
S
L
D
D
V
K
V
K
Site 133
T789
D
P
C
N
T
N
P
T
P
M
T
K
P
T
P
Site 134
T795
P
T
P
M
T
K
P
T
P
E
E
I
K
L
E
Site 135
T833
Q
L
P
G
L
C
E
T
D
R
M
D
G
A
V
Site 136
S853
K
S
E
I
L
P
A
S
L
Q
S
A
T
A
R
Site 137
T858
P
A
S
L
Q
S
A
T
A
R
P
T
S
R
L
Site 138
T862
Q
S
A
T
A
R
P
T
S
R
L
N
R
L
P
Site 139
S863
S
A
T
A
R
P
T
S
R
L
N
R
L
P
E
Site 140
T892
T
G
D
Q
I
P
W
T
N
N
T
V
T
A
I
Site 141
T895
Q
I
P
W
T
N
N
T
V
T
A
I
N
Q
S
Site 142
S904
T
A
I
N
Q
S
K
S
E
D
Q
C
I
S
S
Site 143
S911
S
E
D
Q
C
I
S
S
Q
L
D
E
L
L
C
Site 144
T921
D
E
L
L
C
P
P
T
T
V
E
G
R
N
D
Site 145
T922
E
L
L
C
P
P
T
T
V
E
G
R
N
D
E
Site 146
S941
E
Q
L
V
S
F
L
S
G
K
D
E
T
E
L
Site 147
S970
G
G
G
L
D
V
L
S
E
R
F
P
P
Q
Q
Site 148
T979
R
F
P
P
Q
Q
A
T
P
P
L
I
M
E
E
Site 149
Y991
M
E
E
R
P
N
L
Y
S
Q
P
Y
S
S
P
Site 150
S992
E
E
R
P
N
L
Y
S
Q
P
Y
S
S
P
S
Site 151
Y995
P
N
L
Y
S
Q
P
Y
S
S
P
S
P
T
A
Site 152
S996
N
L
Y
S
Q
P
Y
S
S
P
S
P
T
A
N
Site 153
S997
L
Y
S
Q
P
Y
S
S
P
S
P
T
A
N
L
Site 154
S999
S
Q
P
Y
S
S
P
S
P
T
A
N
L
P
S
Site 155
T1001
P
Y
S
S
P
S
P
T
A
N
L
P
S
P
F
Site 156
S1006
S
P
T
A
N
L
P
S
P
F
Q
G
M
V
R
Site 157
S1017
G
M
V
R
Q
K
P
S
L
G
T
M
P
V
Q
Site 158
T1026
G
T
M
P
V
Q
V
T
P
P
R
G
A
F
S
Site 159
S1033
T
P
P
R
G
A
F
S
P
G
M
G
M
Q
P
Site 160
T1043
M
G
M
Q
P
R
Q
T
L
N
R
P
P
A
A
Site 161
T1099
S
G
M
Q
Q
Q
I
T
P
Q
P
P
L
N
A
Site 162
Y1117
A
Q
R
Q
R
E
L
Y
S
Q
Q
H
R
Q
R
Site 163
S1118
Q
R
Q
R
E
L
Y
S
Q
Q
H
R
Q
R
Q
Site 164
S1139
A
M
L
M
R
Q
Q
S
F
G
N
N
L
P
P
Site 165
S1147
F
G
N
N
L
P
P
S
S
G
L
P
V
Q
M
Site 166
S1148
G
N
N
L
P
P
S
S
G
L
P
V
Q
M
G
Site 167
Y1169
G
A
P
Q
Q
F
P
Y
P
P
N
Y
G
T
N
Site 168
Y1173
Q
F
P
Y
P
P
N
Y
G
T
N
P
G
T
P
Site 169
T1175
P
Y
P
P
N
Y
G
T
N
P
G
T
P
P
A
Site 170
T1179
N
Y
G
T
N
P
G
T
P
P
A
S
T
S
P
Site 171
S1183
N
P
G
T
P
P
A
S
T
S
P
F
S
Q
L
Site 172
T1184
P
G
T
P
P
A
S
T
S
P
F
S
Q
L
A
Site 173
S1185
G
T
P
P
A
S
T
S
P
F
S
Q
L
A
A
Site 174
S1188
P
A
S
T
S
P
F
S
Q
L
A
A
N
P
E
Site 175
S1197
L
A
A
N
P
E
A
S
L
A
N
R
N
S
M
Site 176
S1203
A
S
L
A
N
R
N
S
M
V
S
R
G
M
T
Site 177
S1206
A
N
R
N
S
M
V
S
R
G
M
T
G
N
I
Site 178
T1210
S
M
V
S
R
G
M
T
G
N
I
G
G
Q
F
Site 179
Y1232
M
Q
Q
N
V
F
Q
Y
P
G
A
G
M
V
P
Site 180
S1248
G
E
A
N
F
A
P
S
L
S
P
G
S
S
M
Site 181
S1250
A
N
F
A
P
S
L
S
P
G
S
S
M
V
P
Site 182
S1266
P
I
P
P
P
Q
S
S
L
L
Q
Q
T
P
P
Site 183
T1271
Q
S
S
L
L
Q
Q
T
P
P
A
S
G
Y
Q
Site 184
S1275
L
Q
Q
T
P
P
A
S
G
Y
Q
S
P
D
M
Site 185
Y1277
Q
T
P
P
A
S
G
Y
Q
S
P
D
M
K
A
Site 186
S1279
P
P
A
S
G
Y
Q
S
P
D
M
K
A
W
Q
Site 187
T1305
Q
A
V
Q
N
Q
P
T
P
A
Q
P
G
V
Y
Site 188
Y1312
T
P
A
Q
P
G
V
Y
N
N
M
S
I
T
V
Site 189
T1364
N
D
P
A
L
R
H
T
G
L
Y
C
N
Q
L
Site 190
Y1367
A
L
R
H
T
G
L
Y
C
N
Q
L
S
S
T
Site 191
S1372
G
L
Y
C
N
Q
L
S
S
T
D
L
L
K
T
Site 192
T1379
S
S
T
D
L
L
K
T
E
A
D
G
T
Q
Q
Site 193
T1384
L
K
T
E
A
D
G
T
Q
Q
V
Q
Q
V
Q
Site 194
Y1408
N
L
V
G
G
D
P
Y
L
N
Q
P
G
P
L
Site 195
T1417
N
Q
P
G
P
L
G
T
Q
K
P
T
S
G
P
Site 196
S1422
L
G
T
Q
K
P
T
S
G
P
Q
T
P
Q
A
Site 197
T1426
K
P
T
S
G
P
Q
T
P
Q
A
Q
Q
K
S
Site 198
S1433
T
P
Q
A
Q
Q
K
S
L
L
Q
Q
L
L
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation