PhosphoNET

           
Protein Info 
   
Short Name:  SPEG
Full Name:  Striated muscle preferentially expressed protein kinase
Alias:  Aortic preferentially expressed protein 1; APEG1; EC 2.7.11.1; KIAA1297
Type:  Nucleus protein; Protein-serine kinase, CAMK group, Trio family
Mass (Da):  354289
Number AA:  3267
UniProt ID:  Q15772
International Prot ID:  IPI00745128
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0004674   PhosphoSite+ KinaseNET
Biological Process:  GO:0007517  GO:0008285  GO:0006468 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T7_MQKARGTRGEDAGT
Site 2T14TRGEDAGTRAPPSPG
Site 3S19AGTRAPPSPGVPPKR
Site 4T69LRVVVSGTPQPSLRW
Site 5S73VSGTPQPSLRWFRDG
Site 6S91PAPAPEPSCLWLRRC
Site 7S118QNERGRASCEAVLTV
Site 8S131TVLEVGDSETAEDDI
Site 9S139ETAEDDISDVQGTQR
Site 10T144DISDVQGTQRLELRD
Site 11S156LRDDGAFSTPTGGSD
Site 12T157RDDGAFSTPTGGSDT
Site 13T164TPTGGSDTLVGTSLD
Site 14T175TSLDTPPTSVTGTSE
Site 15S176SLDTPPTSVTGTSEE
Site 16T180PPTSVTGTSEEQVSW
Site 17S181PTSVTGTSEEQVSWW
Site 18S186GTSEEQVSWWGSGQT
Site 19S190EQVSWWGSGQTVLEQ
Site 20T205EAGSGGGTRRLPGSP
Site 21S211GTRRLPGSPRQAQAT
Site 22T218SPRQAQATGAGPRHL
Site 23S248ASWGSEDSLSVASDL
Site 24S250WGSEDSLSVASDLYG
Site 25S253EDSLSVASDLYGSAF
Site 26S261DLYGSAFSLYRGRAL
Site 27S269LYRGRALSIHVSVPQ
Site 28S273RALSIHVSVPQSGLR
Site 29S277IHVSVPQSGLRREEP
Site 30S304RPAQPPPSKSALLPP
Site 31S306AQPPPSKSALLPPPS
Site 32S313SALLPPPSPRVGKRS
Site 33S320SPRVGKRSPPGPPAQ
Site 34T331PPAQPAATPTSPHRR
Site 35T333AQPAATPTSPHRRTQ
Site 36S334QPAATPTSPHRRTQE
Site 37T339PTSPHRRTQEPVLPE
Site 38T349PVLPEDTTTEEKRGK
Site 39T350VLPEDTTTEEKRGKK
Site 40S358EEKRGKKSKSSGPSL
Site 41S360KRGKKSKSSGPSLAG
Site 42S361RGKKSKSSGPSLAGT
Site 43S364KSKSSGPSLAGTAES
Site 44T368SGPSLAGTAESRPQT
Site 45S371SLAGTAESRPQTPLS
Site 46T375TAESRPQTPLSEASG
Site 47S378SRPQTPLSEASGRLS
Site 48S381QTPLSEASGRLSALG
Site 49S385SEASGRLSALGRSPR
Site 50S390RLSALGRSPRLVRAG
Site 51S398PRLVRAGSRILDKLQ
Site 52S413FFEERRRSLERSDSP
Site 53S417RRRSLERSDSPPAPL
Site 54S419RSLERSDSPPAPLRP
Site 55S435VPLRKARSLEQPKSE
Site 56S441RSLEQPKSERGAPWG
Site 57T449ERGAPWGTPGASQEE
Site 58S453PWGTPGASQEELRAP
Site 59S462EELRAPGSVAERRRL
Site 60S476LFQQKAASLDERTRQ
Site 61T481AASLDERTRQRSPAS
Site 62S485DERTRQRSPASDLEL
Site 63S488TRQRSPASDLELRFA
Site 64S504ELGRIRRSTSREELV
Site 65T505LGRIRRSTSREELVR
Site 66S506GRIRRSTSREELVRS
Site 67S513SREELVRSHESLRAT
Site 68S516ELVRSHESLRATLQR
Site 69T520SHESLRATLQRAPSP
Site 70S526ATLQRAPSPREPGEP
Site 71S537PGEPPLFSRPSTPKT
Site 72S540PPLFSRPSTPKTSRA
Site 73T541PLFSRPSTPKTSRAV
Site 74T544SRPSTPKTSRAVSPA
Site 75S545RPSTPKTSRAVSPAA
Site 76S549PKTSRAVSPAAAQPP
Site 77S557PAAAQPPSPSSAEKP
Site 78S559AAQPPSPSSAEKPGD
Site 79S560AQPPSPSSAEKPGDE
Site 80S573DEPGRPRSRGPAGRT
Site 81T599RRDQFPLTRSRAIQE
Site 82S601DQFPLTRSRAIQECR
Site 83S609RAIQECRSPVPPPAA
Site 84T623ADPPEARTKAPPGRK
Site 85T656EGAAVPQTLEKNRAG
Site 86S690WDRRGARSQGKGRRA
Site 87T700KGRRARPTSPELESS
Site 88S701GRRARPTSPELESSD
Site 89S706PTSPELESSDDSYVS
Site 90S707TSPELESSDDSYVSA
Site 91S710ELESSDDSYVSAGEE
Site 92Y711LESSDDSYVSAGEEP
Site 93S713SSDDSYVSAGEEPLE
Site 94S754ANPPPQVSWHKDGSA
Site 95S760VSWHKDGSALRSEGR
Site 96S764KDGSALRSEGRLLLR
Site 97T778RAEGERHTLLLREAR
Site 98S791ARAADAGSYMATATN
Site 99T795DAGSYMATATNELGQ
Site 100S816LTVRPGGSTSPFSSP
Site 101T817TVRPGGSTSPFSSPI
Site 102S818VRPGGSTSPFSSPIT
Site 103S821GGSTSPFSSPITSDE
Site 104S822GSTSPFSSPITSDEE
Site 105T825SPFSSPITSDEEYLS
Site 106S826PFSSPITSDEEYLSP
Site 107Y830PITSDEEYLSPPEEF
Site 108S832TSDEEYLSPPEEFPE
Site 109T843EFPEPGETWPRTPTM
Site 110T847PGETWPRTPTMKPSP
Site 111T849ETWPRTPTMKPSPSQ
Site 112S853RTPTMKPSPSQNRRS
Site 113S855PTMKPSPSQNRRSSD
Site 114S860SPSQNRRSSDTGSKA
Site 115S861PSQNRRSSDTGSKAP
Site 116T863QNRRSSDTGSKAPPT
Site 117S865RRSSDTGSKAPPTFK
Site 118T870TGSKAPPTFKVSLMD
Site 119S874APPTFKVSLMDQSVR
Site 120S879KVSLMDQSVREGQDV
Site 121S889EGQDVIMSIRVQGEP
Site 122T941RGDAGFYTCKAVNEY
Site 123S965EVRAHPESRSLAVLA
Site 124S967RAHPESRSLAVLAPL
Site 125S1036TSVHEDDSGVYTCKL
Site 126T1040EDDSGVYTCKLSTAK
Site 127T1051STAKDELTCSARLTV
Site 128S1053AKDELTCSARLTVRP
Site 129S1120RQDGGLHSLHIAHVG
Site 130S1128LHIAHVGSEDEGLYA
Site 131Y1134GSEDEGLYAVSAVNT
Site 132Y1152AHCSAQLYVEEPRTA
Site 133T1158LYVEEPRTAASGPSS
Site 134S1161EEPRTAASGPSSKLE
Site 135S1165TAASGPSSKLEKMPS
Site 136S1172SKLEKMPSIPEEPEQ
Site 137S1186QGELERLSIPDFLRP
Site 138S1230HNGHRIQSSDDRRMT
Site 139S1231NGHRIQSSDDRRMTQ
Site 140T1237SSDDRRMTQYRDVHR
Site 141Y1239DDRRMTQYRDVHRLV
Site 142Y1258GPQHAGVYKSVIANK
Site 143S1260QHAGVYKSVIANKLG
Site 144T1300AVTGRMVTLTWNPPR
Site 145T1302TGRMVTLTWNPPRSL
Site 146S1308LTWNPPRSLDMAIDP
Site 147S1317DMAIDPDSLTYTVQH
Site 148T1319AIDPDSLTYTVQHQV
Site 149T1321DPDSLTYTVQHQVLG
Site 150S1361QHIFRVLSTTVKSSS
Site 151T1362HIFRVLSTTVKSSSK
Site 152T1363IFRVLSTTVKSSSKP
Site 153S1366VLSTTVKSSSKPSPP
Site 154S1367LSTTVKSSSKPSPPS
Site 155S1368STTVKSSSKPSPPSE
Site 156S1371VKSSSKPSPPSEPVQ
Site 157S1374SSKPSPPSEPVQLLE
Site 158T1385QLLEHGPTLEEAPAM
Site 159Y1400LDKPDIVYVVEGQPA
Site 160T1410EGQPASVTVTFNHVE
Site 161T1412QPASVTVTFNHVEAQ
Site 162S1424EAQVVWRSCRGALLE
Site 163S1440RAGVYELSQPDDDQY
Site 164Y1447SQPDDDQYCLRICRV
Site 165T1463RRDMGALTCTARNRH
Site 166T1465DMGALTCTARNRHGT
Site 167T1472TARNRHGTQTCSVTL
Site 168T1474RNRHGTQTCSVTLEL
Site 169S1476RHGTQTCSVTLELAE
Site 170S1489AEAPRFESIMEDVEV
Site 171T1526YKDEVLLTESSHVSF
Site 172S1532LTESSHVSFVYEENE
Site 173Y1535SSHVSFVYEENECSL
Site 174S1598DHRGRRLSDFYDIHQ
Site 175Y1601GRRLSDFYDIHQEIG
Site 176S1613EIGRGAFSYLRRIVE
Site 177Y1614IGRGAFSYLRRIVER
Site 178S1622LRRIVERSSGLEFAA
Site 179S1623RRIVERSSGLEFAAK
Site 180S1634FAAKFIPSQAKPKAS
Site 181S1641SQAKPKASARREARL
Site 182Y1659LQHDCVLYFHEAFER
Site 183T1690ERIARKPTVCESEIR
Site 184S1694RKPTVCESEIRAYMR
Site 185Y1699CESEIRAYMRQVLEG
Site 186T1749FGNAQELTPGEPQYC
Site 187Y1755LTPGEPQYCQYGTPE
Site 188Y1758GEPQYCQYGTPEFVA
Site 189T1760PQYCQYGTPEFVAPE
Site 190S1772APEIVNQSPVSGVTD
Site 191T1804FVGENDRTTLMNIRN
Site 192T1805VGENDRTTLMNIRNY
Site 193Y1812TLMNIRNYNVAFEET
Site 194T1820NVAFEETTFLSLSRE
Site 195S1823FEETTFLSLSREARG
Site 196S1825ETTFLSLSREARGFL
Site 197T1844VQDRLRPTAEETLEH
Site 198T1856LEHPWFKTQAKGAEV
Site 199S1873DHLKLFLSRRRWQRS
Site 200S1880SRRRWQRSQISYKCH
Site 201Y1884WQRSQISYKCHLVLR
Site 202T1907PPERVWVTMPRRPPP
Site 203S1915MPRRPPPSGGLSSSS
Site 204S1919PPPSGGLSSSSDSEE
Site 205S1920PPSGGLSSSSDSEEE
Site 206S1921PSGGLSSSSDSEEEE
Site 207S1922SGGLSSSSDSEEEEL
Site 208S1924GLSSSSDSEEEELEE
Site 209S1934EELEELPSVPRPLQP
Site 210S1944RPLQPEFSGSRVSLT
Site 211S1946LQPEFSGSRVSLTDI
Site 212S1949EFSGSRVSLTDIPTE
Site 213T1951SGSRVSLTDIPTEDE
Site 214T1955VSLTDIPTEDEALGT
Site 215T1962TEDEALGTPETGAAT
Site 216T1965EALGTPETGAATPMD
Site 217T1969TPETGAATPMDWQEQ
Site 218S1981QEQGRAPSQDQEAPS
Site 219S1988SQDQEAPSPEALPSP
Site 220S1994PSPEALPSPGQEPAA
Site 221S2004QEPAAGASPRRGELR
Site 222S2014RGELRRGSSAESALP
Site 223S2015GELRRGSSAESALPR
Site 224S2018RRGSSAESALPRAGP
Site 225S2037RGLHKAASVELPQRR
Site 226S2045VELPQRRSPSPGATR
Site 227S2047LPQRRSPSPGATRLA
Site 228T2051RSPSPGATRLARGGL
Site 229Y2063GGLGEGEYAQRLQAL
Site 230S2094LRGPLLESLGGRARD
Site 231S2109PRMARAASSEAAPHH
Site 232S2110RMARAASSEAAPHHQ
Site 233S2128ENRGLQKSSSFSQGE
Site 234S2129NRGLQKSSSFSQGEA
Site 235S2130RGLQKSSSFSQGEAE
Site 236S2132LQKSSSFSQGEAEPR
Site 237S2164GARRLQESPSLSALS
Site 238S2166RRLQESPSLSALSEA
Site 239S2168LQESPSLSALSEAQP
Site 240S2171SPSLSALSEAQPSSP
Site 241S2176ALSEAQPSSPARPSA
Site 242S2177LSEAQPSSPARPSAP
Site 243S2182PSSPARPSAPKPSTP
Site 244S2187RPSAPKPSTPKSAEP
Site 245T2188PSAPKPSTPKSAEPS
Site 246S2191PKPSTPKSAEPSATT
Site 247S2195TPKSAEPSATTPSDA
Site 248T2197KSAEPSATTPSDAPQ
Site 249T2198SAEPSATTPSDAPQP
Site 250S2200EPSATTPSDAPQPPA
Site 251S2226RPEPVRASKPAPPPQ
Site 252S2251PYAQIIQSLQLSGHA
Site 253S2255IIQSLQLSGHAQGPS
Site 254S2262SGHAQGPSQGPAAPP
Site 255S2270QGPAAPPSEPKPHAA
Site 256S2296APEKRVPSAGGPPVL
Site 257T2311AEKARVPTVPPRPGS
Site 258S2318TVPPRPGSSLSSSIE
Site 259S2319VPPRPGSSLSSSIEN
Site 260S2321PRPGSSLSSSIENLE
Site 261S2322RPGSSLSSSIENLES
Site 262S2323PGSSLSSSIENLESE
Site 263S2329SSIENLESEAVFEAK
Site 264S2340FEAKFKRSRESPLSL
Site 265S2343KFKRSRESPLSLGLR
Site 266S2346RSRESPLSLGLRLLS
Site 267S2353SLGLRLLSRSRSEER
Site 268S2355GLRLLSRSRSEERGP
Site 269S2357RLLSRSRSEERGPFR
Site 270Y2373AEEEDGIYRPSPAGT
Site 271S2376EDGIYRPSPAGTPLE
Site 272T2380YRPSPAGTPLELVRR
Site 273S2391LVRRPERSRSVQDLR
Site 274S2393RRPERSRSVQDLRAV
Site 275S2410PGLVRRLSLSLSQRL
Site 276S2412LVRRLSLSLSQRLRR
Site 277S2414RRLSLSLSQRLRRTP
Site 278T2420LSQRLRRTPPAQRHP
Site 279S2438ARGGDGESSEGGSSA
Site 280S2439RGGDGESSEGGSSAR
Site 281S2443GESSEGGSSARGSPV
Site 282S2444ESSEGGSSARGSPVL
Site 283S2448GGSSARGSPVLAMRR
Site 284S2458LAMRRRLSFTLERLS
Site 285T2460MRRRLSFTLERLSSR
Site 286S2465SFTLERLSSRLQRSG
Site 287S2466FTLERLSSRLQRSGS
Site 288S2471LSSRLQRSGSSEDSG
Site 289S2473SRLQRSGSSEDSGGA
Site 290S2474RLQRSGSSEDSGGAS
Site 291S2477RSGSSEDSGGASGRS
Site 292S2481SEDSGGASGRSTPLF
Site 293S2484SGGASGRSTPLFGRL
Site 294T2485GGASGRSTPLFGRLR
Site 295T2495FGRLRRATSEGESLR
Site 296S2496GRLRRATSEGESLRR
Site 297S2500RATSEGESLRRLGLP
Site 298T2518LAAQAGATTPSAESL
Site 299T2519AAQAGATTPSAESLG
Site 300S2521QAGATTPSAESLGSE
Site 301S2524ATTPSAESLGSEASA
Site 302S2527PSAESLGSEASATSG
Site 303S2530ESLGSEASATSGSSA
Site 304T2532LGSEASATSGSSAPG
Site 305S2533GSEASATSGSSAPGE
Site 306S2535EASATSGSSAPGESR
Site 307S2536ASATSGSSAPGESRS
Site 308S2541GSSAPGESRSRLRWG
Site 309S2543SAPGESRSRLRWGFS
Site 310S2550SRLRWGFSRPRKDKG
Site 311S2559PRKDKGLSPPNLSAS
Site 312S2564GLSPPNLSASVQEEL
Site 313S2566SPPNLSASVQEELGH
Site 314Y2575QEELGHQYVRSESDF
Site 315S2578LGHQYVRSESDFPPV
Site 316S2580HQYVRSESDFPPVFH
Site 317S2623SWMKDKKSLRSEPSV
Site 318S2629KSLRSEPSVIIVSCK
Site 319S2643KDGRQLLSIPRAGKR
Site 320Y2655GKRHAGLYECSATNV
Site 321T2689APPEVPQTYQDTALV
Site 322Y2709DSRAPCTYTLERRVD
Site 323T2710SRAPCTYTLERRVDG
Site 324S2719ERRVDGESVWHPVSS
Site 325Y2732SSGIPDCYYNVTHLP
Site 326Y2733SGIPDCYYNVTHLPV
Site 327S2760RAGQGPFSNSSEKVF
Site 328S2762GQGPFSNSSEKVFVR
Site 329S2763QGPFSNSSEKVFVRG
Site 330T2771EKVFVRGTQDSSAVP
Site 331S2774FVRGTQDSSAVPSAA
Site 332S2775VRGTQDSSAVPSAAH
Site 333S2779QDSSAVPSAAHQEAP
Site 334T2788AHQEAPVTSRPARAR
Site 335S2799ARARPPDSPTSLAPP
Site 336S2802RPPDSPTSLAPPLAP
Site 337S2816PAAPTPPSVTVSPSS
Site 338T2818APTPPSVTVSPSSPP
Site 339S2820TPPSVTVSPSSPPTP
Site 340S2822PSVTVSPSSPPTPPS
Site 341S2823SVTVSPSSPPTPPSQ
Site 342T2826VSPSSPPTPPSQALS
Site 343S2829SSPPTPPSQALSSLK
Site 344S2833TPPSQALSSLKAVGP
Site 345S2834PPSQALSSLKAVGPP
Site 346T2844AVGPPPQTPPRRHRG
Site 347T2861AARPAEPTLPSTHVT
Site 348S2864PAEPTLPSTHVTPSE
Site 349T2865AEPTLPSTHVTPSEP
Site 350T2868TLPSTHVTPSEPKPF
Site 351S2870PSTHVTPSEPKPFVL
Site 352T2879PKPFVLDTGTPIPAS
Site 353S2886TGTPIPASTPQGVKP
Site 354T2887GTPIPASTPQGVKPV
Site 355S2895PQGVKPVSSSTPVYV
Site 356T2928PPEPTKVTVQSLSPA
Site 357S2931PTKVTVQSLSPAKEV
Site 358S2933KVTVQSLSPAKEVVS
Site 359S2940SPAKEVVSSPGSSPR
Site 360S2941PAKEVVSSPGSSPRS
Site 361S2944EVVSSPGSSPRSSPR
Site 362S2945VVSSPGSSPRSSPRP
Site 363S2948SPGSSPRSSPRPEGT
Site 364S2949PGSSPRSSPRPEGTT
Site 365T2955SSPRPEGTTLRQGPP
Site 366T2956SPRPEGTTLRQGPPQ
Site 367Y2966QGPPQKPYTFLEEKA
Site 368T2967GPPQKPYTFLEEKAR
Site 369T2988RACRENATGRTFVAK
Site 370Y3011KRRVLQEYEVLRTLH
Site 371T3016QEYEVLRTLHHERIM
Site 372S3024LHHERIMSLHEAYIT
Site 373S3052RELLCGLSDRFRYSE
Site 374Y3057GLSDRFRYSEDDVAT
Site 375S3058LSDRFRYSEDDVATY
Site 376T3064YSEDDVATYMVQLLQ
Site 377Y3065SEDDVATYMVQLLQG
Site 378S3106LKIVDFGSAQPYNPQ
Site 379Y3110DFGSAQPYNPQALRP
Site 380T3124PLGHRTGTLEFMAPE
Site 381S3140VKGEPIGSATDIWGA
Site 382S3159YIMLSGRSPFYEPDP
Site 383Y3162LSGRSPFYEPDPQET
Site 384Y3184RFDAFQLYPNTSQSA
Site 385S3190LYPNTSQSATLFLRK
Site 386T3192PNTSQSATLFLRKVL
Site 387S3200LFLRKVLSVHPWSRP
Site 388S3205VLSVHPWSRPSLQDC
Site 389S3208VHPWSRPSLQDCLAH
Site 390Y3222HPWLQDAYLMKLRRQ
Site 391T3230LMKLRRQTLTFTTNR
Site 392T3232KLRRQTLTFTTNRLK
Site 393T3254RRRAEAATRHKVLLR
Site 394S3262RHKVLLRSYPGGP__
Site 395Y3263HKVLLRSYPGGP___
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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