|
|
|
|
|
|
|
|
|
|
|
|
Protein Info
|
|
|
|
|
|
Short Name:
|
p38-beta
|
|
Full Name:
|
Mitogen-activated protein kinase 11
|
|
Alias:
|
EC 2.7.1.37; EC 2.7.11.24; MAPK11; MK11; P38 MAPK-beta; P38-2; P38b; PRKM11; SAPK2; Stress-activated protein kinase-2
|
|
Type:
|
Protein-serine kinase, CMGC group, MAPK family, p38 subfamily
|
|
Mass (Da):
|
41357
|
|
Number AA:
|
372
|
|
UniProt ID:
|
Q15759
|
|
International Prot ID:
|
IPI00019473
|
|
Sequence:
|
Retrieve full protein sequence
|
|
|
|
|
GO Terms
|
|
External Links
|
Internal Links
|
|
|
|
|
|
Cellular Component:
|
GO:0005829
GO:0005654
|
Uniprot
|
OncoNet
|
|
Molecular Function:
|
GO:0005524
GO:0008339
GO:0005515
|
PhosphoSite+
|
KinaseNET
|
|
|
Biological Process:
|
GO:0007265
GO:0006468
GO:0007243
|
Phosida
|
TranscriptoNet
|
|
|
|
|
STRING
|
Kinexus Products
Mitogen-activated protein-serine kinase p38 beta; Mitogen-activated protein kinase 11 pan-specific antibody AB-NK248-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK248-1#Mitogen-activated protein-serine kinase p38 beta; Mitogen-activated protein kinase 11 pan-specific antibody AB-NK248-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK248-2#Mitogen-activated protein-serine kinase p38 beta; Mitogen-activated protein kinase 11 T180+Y182 phosphosite-specific antibody AB-PK741#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK741#p38 MAPK KinSub - p38 MAPK peptide substrate - Powder PE-01ADG95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADG95#Mitogen-activated protein-serine kinase p38 beta / Mitogen-activated protein kinase 11 (M1-K15, human) peptide - Powder PE-01AYD85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AYD85#Mitogen-activated protein-serine kinase p38 beta / Mitogen-activated protein kinase 11 (A320-L334, human) peptide - Powder PE-01AYE85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AYE85#Mitogen-activated protein-serine kinase p38 beta / Mitogen-activated protein kinase 11 (P351-Q364, human) peptide - Powder PE-01AYF80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AYF80#p38Subtide - p38a MAPK (MAPK14) protein kinase substrate peptide - Powder PE-01BIK99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BIK99#Mitogen-activated protein-serine kinase p38 beta / Mitogen-activated protein kinase 11 (E177-Y182, human) pT180+pY182 phosphopeptide - Powder PE-04ADT80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADT80#Mitogen-activated protein-serine kinase p38 beta / Mitogen-activated protein kinase 11 (E177-V183, human) pT180+pY182 phosphopeptide - Powder PE-04BAP00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04BAP00
|
|
|
|
|
Info Box
|
|
A variety of parameters were considered in the selection of putative P-sites.
Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score
is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr
or P-Tyr sites. The Maximum KInase Score provides the calculated score for
highest match of 500 human protein kinases for the amino acid sequence
surrounding the target P-site as determined with Kinase Substrate Predictor V2.
The Sum KInase Score provides the additive sum of the positive individual Kinase
Substrate Predictor V2 scores from 500 human protein kinases. The Conservation
Score is the average of the percent similarity of the human P-site with the
equivalent P-site in 20 other diverse species. Click the coloured buttons below
to retrieve this and other information in the Info Box, or click the orange
buttons for relevant links. |
|
| Phosphosites | |
| |
| | | -7 | -6 | -5 | -4 | -3 | -2 | -1 | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | | Expt. conf. | Effect | Kinase | PPase | Kinexus Products | | Ref. | Evol. | Kinase Pred. | P-site Match |
| | Site 1 | S2 | _ | _ | _ | _ | _ | _ | M | S | G | P | R | A | G | F | Y | |  |  | | | | | |  | | |
| | Site 2 | Y9 | S | G | P | R | A | G | F | Y | R | Q | E | L | N | K | T | | | | | | | | | | | |
| | Site 3 | T16 | Y | R | Q | E | L | N | K | T | V | W | E | V | P | Q | R | | | | | | | | | | | |
| | Site 4 | Y35 | R | P | V | G | S | G | A | Y | G | S | V | C | S | A | Y | |  | | | | | | | | | |
| | Site 5 | Y42 | Y | G | S | V | C | S | A | Y | D | A | R | L | R | Q | K | | | | | | | | | | | |
| | Site 6 | T68 | S | L | I | H | A | R | R | T | Y | R | E | L | R | L | L | | | | | | | | | | | |
| | Site 7 | Y69 | L | I | H | A | R | R | T | Y | R | E | L | R | L | L | K | | | | | | | | | | | |
| | Site 8 | S95 | D | V | F | T | P | A | T | S | I | E | D | F | S | E | V | | | | | | | | | | | |
| | Site 9 | S123 | I | V | K | C | Q | A | L | S | D | E | H | V | Q | F | L | | | | | | | | | | | |
| | Site 10 | S143 | R | G | L | K | Y | I | H | S | A | G | I | I | H | R | D | | | | | | | | | | | |
| | Site 11 | S154 | I | H | R | D | L | K | P | S | N | V | A | V | N | E | D | | | | | | | | | | | |
| | Site 12 | T180 | R | Q | A | D | E | E | M | T | G | Y | V | A | T | R | W | | | | | |  Mitogen-activated protein-serine kinase p38 beta; Mitogen-activated protein kinase 11 T180+Y182 phosphosite-specific antibody AB-PK741#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK741#Mitogen-activated protein-serine kinase p38 beta / Mitogen-activated protein kinase 11 (E177-Y182, human) pT180+pY182 phosphopeptide - Powder PE-04ADT80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADT80#Mitogen-activated protein-serine kinase p38 beta / Mitogen-activated protein kinase 11 (E177-V183, human) pT180+pY182 phosphopeptide - Powder PE-04BAP00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04BAP00 | | | | | |
| | Site 13 | Y182 | A | D | E | E | M | T | G | Y | V | A | T | R | W | Y | R | | | | | | Mitogen-activated protein-serine kinase p38 beta; Mitogen-activated protein kinase 11 T180+Y182 phosphosite-specific antibody AB-PK741#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK741#Mitogen-activated protein-serine kinase p38 beta / Mitogen-activated protein kinase 11 (E177-Y182, human) pT180+pY182 phosphopeptide - Powder PE-04ADT80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ADT80#Mitogen-activated protein-serine kinase p38 beta / Mitogen-activated protein kinase 11 (E177-V183, human) pT180+pY182 phosphopeptide - Powder PE-04BAP00#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04BAP00 | | | | | |
| | Site 14 | Y188 | G | Y | V | A | T | R | W | Y | R | A | P | E | I | M | L | | | | | | | | | | | |
| | Site 15 | S226 | G | K | A | L | F | P | G | S | D | Y | I | D | Q | L | K | | | | | | | | | | | |
| | Site 16 | Y228 | A | L | F | P | G | S | D | Y | I | D | Q | L | K | R | I | | | | | | | | | | | |
| | Site 17 | S243 | M | E | V | V | G | T | P | S | P | E | V | L | A | K | I | | | | | | | | | | | |
| | Site 18 | S252 | E | V | L | A | K | I | S | S | E | H | A | R | T | Y | I | | | | | | | | | | | |
| | Site 19 | T257 | I | S | S | E | H | A | R | T | Y | I | Q | S | L | P | P | | | | | | | | | | | |
| | Site 20 | Y258 | S | S | E | H | A | R | T | Y | I | Q | S | L | P | P | M | | | | | | | | | | | |
| | Site 21 | S261 | H | A | R | T | Y | I | Q | S | L | P | P | M | P | Q | K | | | | | | | | | | | |
| | Site 22 | S271 | P | M | P | Q | K | D | L | S | S | I | F | R | G | A | N | | | | | | | | | | | |
| | Site 23 | S272 | M | P | Q | K | D | L | S | S | I | F | R | G | A | N | P | | | | | | | | | | | |
| | Site 24 | S293 | G | R | M | L | V | L | D | S | D | Q | R | V | S | A | A | | | | | | | | | | | |
| | Site 25 | S298 | L | D | S | D | Q | R | V | S | A | A | E | A | L | A | H | | | | | | | | | | | |
| | Site 26 | Y307 | A | E | A | L | A | H | A | Y | F | S | Q | Y | H | D | P | | | | | | | | | | | |
| | Site 27 | S309 | A | L | A | H | A | Y | F | S | Q | Y | H | D | P | E | D | | | | | | | | | | | |
| | Site 28 | Y311 | A | H | A | Y | F | S | Q | Y | H | D | P | E | D | E | P | | | | | | | | | | | |
| | Site 29 | Y323 | D | E | P | E | A | E | P | Y | D | E | S | V | E | A | K | | | | | | | | | | | |
| | Site 30 | S326 | E | A | E | P | Y | D | E | S | V | E | A | K | E | R | T | | | | | | | | | | | |
| | Site 31 | T341 | L | E | E | W | K | E | L | T | Y | Q | E | V | L | S | F | | | | | | | | | | | |
| | Site 32 | Y342 | E | E | W | K | E | L | T | Y | Q | E | V | L | S | F | K | | | | | | | | | | | |
| | Site 33 | S347 | L | T | Y | Q | E | V | L | S | F | K | P | P | E | P | P | | | | | | | | | | | |
| | Site 34 | S359 | E | P | P | K | P | P | G | S | L | E | I | E | Q | _ | _ | | | | | | | | | | | |
|
|
|
|
|
|
|
|
Legend
|
|
|
|
Confirmed in mammals
|
|
Confirmed in related proteins or other species
|
|
|
Predicted by Kinexus P-Site Prediction algorithm
|
|
|
No data/link available
|
|
|
Link available
|
|
|
Products available
|
|
|
|
|
|
|
|
|
|
2019 Kinexus Bioinformatics Corporation
|
|