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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TERF2
Full Name:
Telomeric repeat-binding factor 2
Alias:
Telomeric DNA binding protein; Telomeric DNA-binding protein; Telomeric repeat binding factor 2; TRBF2; TTAGGG repeat binding factor 2; TTAGGG repeat-binding factor 2
Type:
DNA repair; DNA binding protein
Mass (Da):
55551
Number AA:
500
UniProt ID:
Q15554
International Prot ID:
IPI00024214
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030870
GO:0000783
Uniprot
OncoNet
Molecular Function:
GO:0003691
GO:0008022
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0001309
GO:0007049
GO:0032214
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
G
G
G
G
S
S
D
G
S
G
R
A
Site 2
S11
G
G
G
S
S
D
G
S
G
R
A
A
G
R
R
Site 3
S20
R
A
A
G
R
R
A
S
R
S
S
G
R
A
R
Site 4
S22
A
G
R
R
A
S
R
S
S
G
R
A
R
R
G
Site 5
S23
G
R
R
A
S
R
S
S
G
R
A
R
R
G
R
Site 6
Y60
N
R
W
V
L
K
F
Y
F
H
E
A
L
R
A
Site 7
S71
A
L
R
A
F
R
G
S
R
Y
G
D
F
R
Q
Site 8
Y73
R
A
F
R
G
S
R
Y
G
D
F
R
Q
I
R
Site 9
T96
R
P
L
G
K
E
H
T
V
S
R
L
L
R
V
Site 10
S98
L
G
K
E
H
T
V
S
R
L
L
R
V
M
Q
Site 11
S108
L
R
V
M
Q
C
L
S
R
I
E
E
G
E
N
Site 12
S119
E
G
E
N
L
D
C
S
F
D
M
E
A
E
L
Site 13
T127
F
D
M
E
A
E
L
T
P
L
E
S
A
I
N
Site 14
S152
L
T
E
A
V
V
E
S
S
R
K
L
V
K
E
Site 15
S175
N
K
E
F
E
K
A
S
K
I
L
K
K
H
M
Site 16
S183
K
I
L
K
K
H
M
S
K
D
P
T
T
Q
K
Site 17
T187
K
H
M
S
K
D
P
T
T
Q
K
L
R
N
D
Site 18
T188
H
M
S
K
D
P
T
T
Q
K
L
R
N
D
L
Site 19
Y214
P
V
I
Q
N
F
S
Y
E
T
F
Q
Q
K
M
Site 20
S227
K
M
L
R
F
L
E
S
H
L
D
D
A
E
P
Site 21
S246
M
A
K
K
A
L
K
S
E
S
A
A
S
S
T
Site 22
S248
K
K
A
L
K
S
E
S
A
A
S
S
T
G
K
Site 23
S252
K
S
E
S
A
A
S
S
T
G
K
E
D
K
Q
Site 24
T281
R
Q
L
R
N
P
P
T
T
I
G
M
M
T
L
Site 25
T282
Q
L
R
N
P
P
T
T
I
G
M
M
T
L
K
Site 26
T294
T
L
K
A
A
F
K
T
L
S
G
A
Q
D
S
Site 27
S296
K
A
A
F
K
T
L
S
G
A
Q
D
S
E
A
Site 28
S323
P
T
Q
A
L
P
A
S
P
A
L
K
N
K
R
Site 29
S339
R
K
D
E
N
E
S
S
A
P
A
D
G
E
G
Site 30
T358
Q
P
K
N
K
R
M
T
I
S
R
L
V
L
E
Site 31
S360
K
N
K
R
M
T
I
S
R
L
V
L
E
E
D
Site 32
S368
R
L
V
L
E
E
D
S
Q
S
T
E
P
S
A
Site 33
S370
V
L
E
E
D
S
Q
S
T
E
P
S
A
G
L
Site 34
S374
D
S
Q
S
T
E
P
S
A
G
L
N
S
S
Q
Site 35
S379
E
P
S
A
G
L
N
S
S
Q
E
A
A
S
A
Site 36
S380
P
S
A
G
L
N
S
S
Q
E
A
A
S
A
P
Site 37
S385
N
S
S
Q
E
A
A
S
A
P
P
S
K
P
T
Site 38
S389
E
A
A
S
A
P
P
S
K
P
T
V
L
N
Q
Site 39
T392
S
A
P
P
S
K
P
T
V
L
N
Q
P
L
P
Site 40
S413
V
P
K
G
K
W
N
S
S
N
G
V
E
E
K
Site 41
S414
P
K
G
K
W
N
S
S
N
G
V
E
E
K
E
Site 42
T422
N
G
V
E
E
K
E
T
W
V
E
E
D
E
L
Site 43
S440
Q
A
A
P
D
E
D
S
T
T
N
I
T
K
K
Site 44
T441
A
A
P
D
E
D
S
T
T
N
I
T
K
K
Q
Site 45
T442
A
P
D
E
D
S
T
T
N
I
T
K
K
Q
K
Site 46
T451
I
T
K
K
Q
K
W
T
V
E
E
S
E
W
V
Site 47
Y465
V
K
A
G
V
Q
K
Y
G
E
G
N
W
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation