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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NUMA1
Full Name:
Nuclear mitotic apparatus protein 1
Alias:
Nuclear mitotic apparatus protein 1: SP-H antigen: NUMA1 variant protein: Nuclear mitotic apparatus protein 1: SP-H antigen; NuMA protein
Type:
Cell cycle regulation
Mass (Da):
238260
Number AA:
2115
UniProt ID:
Q14980
International Prot ID:
IPI00292771
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005654
GO:0005876
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0000090
GO:0006997
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T2
_
_
_
_
_
_
M
T
L
H
A
T
R
G
A
Site 2
T6
_
_
M
T
L
H
A
T
R
G
A
A
L
L
S
Site 3
T46
I
I
D
R
I
H
G
T
E
E
G
Q
Q
I
L
Site 4
S58
Q
I
L
K
Q
P
V
S
E
R
L
D
F
V
C
Site 5
S66
E
R
L
D
F
V
C
S
F
L
Q
K
N
R
K
Site 6
S76
Q
K
N
R
K
H
P
S
S
P
E
C
L
V
S
Site 7
S77
K
N
R
K
H
P
S
S
P
E
C
L
V
S
A
Site 8
S83
S
S
P
E
C
L
V
S
A
Q
K
V
L
E
G
Site 9
S91
A
Q
K
V
L
E
G
S
E
L
E
L
A
K
M
Site 10
Y104
K
M
T
M
L
L
L
Y
H
S
T
M
S
S
K
Site 11
S106
T
M
L
L
L
Y
H
S
T
M
S
S
K
S
P
Site 12
T107
M
L
L
L
Y
H
S
T
M
S
S
K
S
P
R
Site 13
S110
L
Y
H
S
T
M
S
S
K
S
P
R
D
W
E
Site 14
S112
H
S
T
M
S
S
K
S
P
R
D
W
E
Q
F
Site 15
Y121
R
D
W
E
Q
F
E
Y
K
I
Q
A
E
L
A
Site 16
S158
L
Q
K
A
P
V
P
S
T
C
S
S
T
F
P
Site 17
T159
Q
K
A
P
V
P
S
T
C
S
S
T
F
P
E
Site 18
S162
P
V
P
S
T
C
S
S
T
F
P
E
E
L
S
Site 19
T163
V
P
S
T
C
S
S
T
F
P
E
E
L
S
P
Site 20
S169
S
T
F
P
E
E
L
S
P
P
S
H
Q
A
K
Site 21
S172
P
E
E
L
S
P
P
S
H
Q
A
K
R
E
I
Site 22
S189
L
E
L
Q
K
V
A
S
S
S
S
G
N
N
F
Site 23
S192
Q
K
V
A
S
S
S
S
G
N
N
F
L
S
G
Site 24
S198
S
S
G
N
N
F
L
S
G
S
P
A
S
P
M
Site 25
S200
G
N
N
F
L
S
G
S
P
A
S
P
M
G
D
Site 26
S203
F
L
S
G
S
P
A
S
P
M
G
D
I
L
Q
Site 27
T211
P
M
G
D
I
L
Q
T
P
Q
F
Q
M
R
R
Site 28
S228
K
Q
L
A
D
E
R
S
N
R
D
E
L
E
L
Site 29
S271
L
N
E
K
Q
A
A
S
P
L
E
P
K
E
L
Site 30
S287
E
L
R
D
K
N
E
S
L
T
M
R
L
H
E
Site 31
T289
R
D
K
N
E
S
L
T
M
R
L
H
E
T
L
Site 32
T304
K
Q
C
Q
D
L
K
T
E
K
S
Q
M
D
R
Site 33
S307
Q
D
L
K
T
E
K
S
Q
M
D
R
K
I
N
Site 34
S317
D
R
K
I
N
Q
L
S
E
E
N
G
D
L
S
Site 35
S324
S
E
E
N
G
D
L
S
F
K
L
R
E
F
A
Site 36
S332
F
K
L
R
E
F
A
S
H
L
Q
Q
L
Q
D
Site 37
S367
A
Q
L
E
K
E
L
S
A
A
L
Q
D
K
K
Site 38
S388
E
I
L
Q
G
K
L
S
Q
L
E
E
H
L
S
Site 39
S395
S
Q
L
E
E
H
L
S
Q
L
Q
D
N
P
P
Site 40
T441
A
R
V
E
M
L
E
T
E
R
G
Q
Q
E
A
Site 41
S466
E
E
K
Q
Q
L
S
S
L
I
T
D
L
Q
S
Site 42
T469
Q
Q
L
S
S
L
I
T
D
L
Q
S
S
I
S
Site 43
S473
S
L
I
T
D
L
Q
S
S
I
S
N
L
S
Q
Site 44
S476
T
D
L
Q
S
S
I
S
N
L
S
Q
A
K
E
Site 45
S479
Q
S
S
I
S
N
L
S
Q
A
K
E
E
L
E
Site 46
T509
S
L
T
S
E
L
T
T
L
N
A
T
I
Q
Q
Site 47
S557
R
H
Q
V
E
Q
L
S
S
S
L
K
Q
K
E
Site 48
S559
Q
V
E
Q
L
S
S
S
L
K
Q
K
E
Q
Q
Site 49
S595
A
A
E
E
R
E
A
S
L
R
E
R
D
A
A
Site 50
S633
V
A
N
E
A
R
D
S
A
Q
T
S
V
T
Q
Site 51
S637
A
R
D
S
A
Q
T
S
V
T
Q
A
Q
R
E
Site 52
S649
Q
R
E
K
A
E
L
S
R
K
V
E
E
L
Q
Site 53
S717
S
L
K
V
T
K
G
S
L
E
E
E
K
R
R
Site 54
S737
E
E
Q
Q
R
C
I
S
E
L
K
A
E
T
R
Site 55
S801
A
A
Q
H
T
A
E
S
E
C
E
Q
L
V
K
Site 56
Y817
V
A
A
W
R
E
R
Y
E
D
S
Q
Q
E
E
Site 57
S820
W
R
E
R
Y
E
D
S
Q
Q
E
E
A
Q
Y
Site 58
Y827
S
Q
Q
E
E
A
Q
Y
G
A
M
F
Q
E
Q
Site 59
T837
M
F
Q
E
Q
L
M
T
L
K
E
E
C
E
K
Site 60
S861
E
K
V
A
G
I
E
S
H
S
E
L
Q
I
S
Site 61
S863
V
A
G
I
E
S
H
S
E
L
Q
I
S
R
Q
Site 62
S868
S
H
S
E
L
Q
I
S
R
Q
Q
N
E
L
A
Site 63
S903
Q
K
L
A
D
D
L
S
T
L
Q
E
K
M
A
Site 64
T921
K
E
V
A
R
L
E
T
L
V
R
K
A
G
E
Site 65
T932
K
A
G
E
Q
Q
E
T
A
S
R
E
L
V
K
Site 66
T963
Q
G
R
Q
F
C
S
T
Q
A
A
L
Q
A
M
Site 67
S991
L
R
A
A
L
M
E
S
Q
G
Q
Q
Q
E
E
Site 68
T1010
E
R
E
V
A
R
L
T
Q
E
R
G
R
A
Q
Site 69
T1047
E
Q
R
V
E
F
A
T
L
Q
E
A
L
A
H
Site 70
T1086
E
L
E
E
L
R
Q
T
V
K
Q
L
K
E
Q
Site 71
S1103
K
K
E
K
E
H
A
S
G
S
G
A
Q
S
E
Site 72
S1105
E
K
E
H
A
S
G
S
G
A
Q
S
E
A
A
Site 73
S1109
A
S
G
S
G
A
Q
S
E
A
A
G
R
T
E
Site 74
S1130
E
A
L
R
A
E
V
S
K
L
E
Q
Q
C
Q
Site 75
S1145
K
Q
Q
E
Q
A
D
S
L
E
R
S
L
E
A
Site 76
S1149
Q
A
D
S
L
E
R
S
L
E
A
E
R
A
S
Site 77
S1156
S
L
E
A
E
R
A
S
R
A
E
R
D
S
A
Site 78
S1162
A
S
R
A
E
R
D
S
A
L
E
T
L
Q
G
Site 79
T1166
E
R
D
S
A
L
E
T
L
Q
G
Q
L
E
E
Site 80
S1181
K
A
Q
E
L
G
H
S
Q
S
A
L
A
S
A
Site 81
S1183
Q
E
L
G
H
S
Q
S
A
L
A
S
A
Q
R
Site 82
S1187
H
S
Q
S
A
L
A
S
A
Q
R
E
L
A
A
Site 83
S1203
R
T
K
V
Q
D
H
S
K
A
E
D
E
W
K
Site 84
S1225
Q
E
A
E
R
K
N
S
L
I
S
S
L
E
E
Site 85
S1228
E
R
K
N
S
L
I
S
S
L
E
E
E
V
S
Site 86
S1229
R
K
N
S
L
I
S
S
L
E
E
E
V
S
I
Site 87
S1235
S
S
L
E
E
E
V
S
I
L
N
R
Q
V
L
Site 88
S1262
V
M
A
E
S
E
K
S
Q
K
L
E
E
R
L
Site 89
T1276
L
R
L
L
Q
A
E
T
A
S
N
S
A
R
A
Site 90
S1278
L
L
Q
A
E
T
A
S
N
S
A
R
A
A
E
Site 91
S1280
Q
A
E
T
A
S
N
S
A
R
A
A
E
R
S
Site 92
S1287
S
A
R
A
A
E
R
S
S
A
L
R
E
E
V
Site 93
S1288
A
R
A
A
E
R
S
S
A
L
R
E
E
V
Q
Site 94
S1296
A
L
R
E
E
V
Q
S
L
R
E
E
A
E
K
Site 95
S1308
A
E
K
Q
R
V
A
S
E
N
L
R
Q
E
L
Site 96
S1317
N
L
R
Q
E
L
T
S
Q
A
E
R
A
E
E
Site 97
S1344
F
Q
K
E
Q
A
L
S
T
L
Q
L
E
H
T
Site 98
T1353
L
Q
L
E
H
T
S
T
Q
A
L
V
S
E
L
Site 99
S1388
H
R
E
E
L
E
Q
S
K
Q
A
A
G
G
L
Site 100
S1432
Q
L
R
A
E
K
A
S
Y
A
E
Q
L
S
M
Site 101
Y1433
L
R
A
E
K
A
S
Y
A
E
Q
L
S
M
L
Site 102
S1438
A
S
Y
A
E
Q
L
S
M
L
K
K
A
H
G
Site 103
Y1476
L
D
Q
A
R
E
K
Y
V
Q
E
L
A
A
V
Site 104
T1489
A
V
R
A
D
A
E
T
R
L
A
E
V
Q
R
Site 105
S1500
E
V
Q
R
E
A
Q
S
T
A
R
E
L
E
V
Site 106
T1501
V
Q
R
E
A
Q
S
T
A
R
E
L
E
V
M
Site 107
T1548
E
V
F
Q
R
E
Q
T
K
Q
V
E
E
L
S
Site 108
S1561
L
S
K
K
L
A
D
S
D
Q
A
S
K
V
Q
Site 109
S1565
L
A
D
S
D
Q
A
S
K
V
Q
Q
Q
K
L
Site 110
S1582
V
Q
A
Q
G
G
E
S
Q
Q
E
A
Q
R
L
Site 111
S1601
N
E
L
Q
A
Q
L
S
Q
K
E
Q
A
A
E
Site 112
T1619
L
Q
M
E
K
A
K
T
H
Y
D
A
K
K
Q
Site 113
S1637
E
L
Q
E
Q
L
R
S
L
E
Q
L
Q
K
E
Site 114
T1672
K
T
K
E
A
E
Q
T
C
R
H
L
T
A
Q
Site 115
T1677
E
Q
T
C
R
H
L
T
A
Q
V
R
S
L
E
Site 116
S1721
A
K
P
Q
L
D
L
S
I
D
S
L
D
L
S
Site 117
S1724
Q
L
D
L
S
I
D
S
L
D
L
S
C
E
E
Site 118
S1728
S
I
D
S
L
D
L
S
C
E
E
G
T
P
L
Site 119
T1733
D
L
S
C
E
E
G
T
P
L
S
I
T
S
K
Site 120
S1736
C
E
E
G
T
P
L
S
I
T
S
K
L
P
R
Site 121
S1739
G
T
P
L
S
I
T
S
K
L
P
R
T
Q
P
Site 122
T1744
I
T
S
K
L
P
R
T
Q
P
D
G
T
S
V
Site 123
T1749
P
R
T
Q
P
D
G
T
S
V
P
G
E
P
A
Site 124
S1750
R
T
Q
P
D
G
T
S
V
P
G
E
P
A
S
Site 125
S1757
S
V
P
G
E
P
A
S
P
I
S
Q
R
L
P
Site 126
S1760
G
E
P
A
S
P
I
S
Q
R
L
P
P
K
V
Site 127
S1769
R
L
P
P
K
V
E
S
L
E
S
L
Y
F
T
Site 128
S1772
P
K
V
E
S
L
E
S
L
Y
F
T
P
I
P
Site 129
Y1774
V
E
S
L
E
S
L
Y
F
T
P
I
P
A
R
Site 130
T1776
S
L
E
S
L
Y
F
T
P
I
P
A
R
S
Q
Site 131
S1782
F
T
P
I
P
A
R
S
Q
A
P
L
E
S
S
Site 132
S1788
R
S
Q
A
P
L
E
S
S
L
D
S
L
G
D
Site 133
S1789
S
Q
A
P
L
E
S
S
L
D
S
L
G
D
V
Site 134
S1792
P
L
E
S
S
L
D
S
L
G
D
V
F
L
D
Site 135
S1800
L
G
D
V
F
L
D
S
G
R
K
T
R
S
A
Site 136
T1804
F
L
D
S
G
R
K
T
R
S
A
R
R
R
T
Site 137
S1806
D
S
G
R
K
T
R
S
A
R
R
R
T
T
Q
Site 138
T1811
T
R
S
A
R
R
R
T
T
Q
I
I
N
I
T
Site 139
T1812
R
S
A
R
R
R
T
T
Q
I
I
N
I
T
M
Site 140
T1818
T
T
Q
I
I
N
I
T
M
T
K
K
L
D
V
Site 141
T1820
Q
I
I
N
I
T
M
T
K
K
L
D
V
E
E
Site 142
S1830
L
D
V
E
E
P
D
S
A
N
S
S
F
Y
S
Site 143
S1833
E
E
P
D
S
A
N
S
S
F
Y
S
T
R
S
Site 144
S1834
E
P
D
S
A
N
S
S
F
Y
S
T
R
S
A
Site 145
Y1836
D
S
A
N
S
S
F
Y
S
T
R
S
A
P
A
Site 146
S1837
S
A
N
S
S
F
Y
S
T
R
S
A
P
A
S
Site 147
T1838
A
N
S
S
F
Y
S
T
R
S
A
P
A
S
Q
Site 148
S1840
S
S
F
Y
S
T
R
S
A
P
A
S
Q
A
S
Site 149
S1844
S
T
R
S
A
P
A
S
Q
A
S
L
R
A
T
Site 150
S1847
S
A
P
A
S
Q
A
S
L
R
A
T
S
S
T
Site 151
T1851
S
Q
A
S
L
R
A
T
S
S
T
Q
S
L
A
Site 152
S1852
Q
A
S
L
R
A
T
S
S
T
Q
S
L
A
R
Site 153
S1853
A
S
L
R
A
T
S
S
T
Q
S
L
A
R
L
Site 154
T1854
S
L
R
A
T
S
S
T
Q
S
L
A
R
L
G
Site 155
S1856
R
A
T
S
S
T
Q
S
L
A
R
L
G
S
P
Site 156
S1862
Q
S
L
A
R
L
G
S
P
D
Y
G
N
S
A
Site 157
Y1865
A
R
L
G
S
P
D
Y
G
N
S
A
L
L
S
Site 158
S1868
G
S
P
D
Y
G
N
S
A
L
L
S
L
P
G
Site 159
S1872
Y
G
N
S
A
L
L
S
L
P
G
Y
R
P
T
Site 160
Y1876
A
L
L
S
L
P
G
Y
R
P
T
T
R
S
S
Site 161
T1879
S
L
P
G
Y
R
P
T
T
R
S
S
A
R
R
Site 162
T1880
L
P
G
Y
R
P
T
T
R
S
S
A
R
R
S
Site 163
S1882
G
Y
R
P
T
T
R
S
S
A
R
R
S
Q
A
Site 164
S1883
Y
R
P
T
T
R
S
S
A
R
R
S
Q
A
G
Site 165
S1887
T
R
S
S
A
R
R
S
Q
A
G
V
S
S
G
Site 166
S1892
R
R
S
Q
A
G
V
S
S
G
A
P
P
G
R
Site 167
S1901
G
A
P
P
G
R
N
S
F
Y
M
G
T
C
Q
Site 168
T1936
V
C
P
P
H
L
K
T
C
Y
P
L
E
S
R
Site 169
Y1938
P
P
H
L
K
T
C
Y
P
L
E
S
R
P
S
Site 170
S1942
K
T
C
Y
P
L
E
S
R
P
S
L
S
L
G
Site 171
S1945
Y
P
L
E
S
R
P
S
L
S
L
G
T
I
T
Site 172
S1947
L
E
S
R
P
S
L
S
L
G
T
I
T
D
E
Site 173
T1950
R
P
S
L
S
L
G
T
I
T
D
E
E
M
K
Site 174
T1952
S
L
S
L
G
T
I
T
D
E
E
M
K
T
G
Site 175
T1958
I
T
D
E
E
M
K
T
G
D
P
Q
E
T
L
Site 176
T1964
K
T
G
D
P
Q
E
T
L
R
R
A
S
M
Q
Site 177
S1969
Q
E
T
L
R
R
A
S
M
Q
P
I
Q
I
A
Site 178
S1991
R
Q
Q
R
K
R
V
S
L
E
P
H
Q
G
P
Site 179
T2000
E
P
H
Q
G
P
G
T
P
E
S
K
K
A
T
Site 180
S2003
Q
G
P
G
T
P
E
S
K
K
A
T
S
C
F
Site 181
T2007
T
P
E
S
K
K
A
T
S
C
F
P
R
P
M
Site 182
S2008
P
E
S
K
K
A
T
S
C
F
P
R
P
M
T
Site 183
T2015
S
C
F
P
R
P
M
T
P
R
D
R
H
E
G
Site 184
S2026
R
H
E
G
R
K
Q
S
T
T
E
A
Q
K
K
Site 185
T2027
H
E
G
R
K
Q
S
T
T
E
A
Q
K
K
A
Site 186
T2028
E
G
R
K
Q
S
T
T
E
A
Q
K
K
A
A
Site 187
S2047
K
Q
A
D
R
R
Q
S
M
A
F
S
I
L
N
Site 188
S2051
R
R
Q
S
M
A
F
S
I
L
N
T
P
K
K
Site 189
T2055
M
A
F
S
I
L
N
T
P
K
K
L
G
N
S
Site 190
S2062
T
P
K
K
L
G
N
S
L
L
R
R
G
A
S
Site 191
S2069
S
L
L
R
R
G
A
S
K
K
A
L
S
K
A
Site 192
S2074
G
A
S
K
K
A
L
S
K
A
S
P
N
T
R
Site 193
S2077
K
K
A
L
S
K
A
S
P
N
T
R
S
G
T
Site 194
T2080
L
S
K
A
S
P
N
T
R
S
G
T
R
R
S
Site 195
S2082
K
A
S
P
N
T
R
S
G
T
R
R
S
P
R
Site 196
T2084
S
P
N
T
R
S
G
T
R
R
S
P
R
I
A
Site 197
S2087
T
R
S
G
T
R
R
S
P
R
I
A
T
T
T
Site 198
T2092
R
R
S
P
R
I
A
T
T
T
A
S
A
A
T
Site 199
T2106
T
A
A
A
I
G
A
T
P
R
A
K
G
K
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation