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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NFAT3
Full Name:
Nuclear factor of activated T-cells, cytoplasmic 4
Alias:
Nuclear factor of activated T-cells, cytoplasmic 4: T-cell transcription factor NFAT3: Nuclear factor of activated T-cells, cytoplasmic 4: T-cell transcription factor NFAT3
Type:
Transcription protein
Mass (Da):
95449
Number AA:
902
UniProt ID:
Q14934
International Prot ID:
IPI00292684
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003713
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0006954
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S37
G
L
G
E
E
L
D
S
E
D
A
P
P
C
C
Site 2
S73
P
P
R
P
G
M
H
S
P
P
P
R
P
A
P
Site 3
S81
P
P
P
R
P
A
P
S
P
G
T
W
E
S
Q
Site 4
T84
R
P
A
P
S
P
G
T
W
E
S
Q
P
A
R
Site 5
S87
P
S
P
G
T
W
E
S
Q
P
A
R
S
V
R
Site 6
S92
W
E
S
Q
P
A
R
S
V
R
L
G
G
P
G
Site 7
T119
E
C
P
S
I
R
I
T
S
I
S
P
T
P
E
Site 8
S120
C
P
S
I
R
I
T
S
I
S
P
T
P
E
P
Site 9
S122
S
I
R
I
T
S
I
S
P
T
P
E
P
P
A
Site 10
T124
R
I
T
S
I
S
P
T
P
E
P
P
A
A
L
Site 11
S142
P
D
A
W
G
D
G
S
P
R
D
Y
P
P
P
Site 12
Y146
G
D
G
S
P
R
D
Y
P
P
P
E
G
F
G
Site 13
Y155
P
P
E
G
F
G
G
Y
R
E
A
G
G
Q
G
Site 14
S168
Q
G
G
G
A
F
F
S
P
S
P
G
S
S
S
Site 15
S170
G
G
A
F
F
S
P
S
P
G
S
S
S
L
S
Site 16
S173
F
F
S
P
S
P
G
S
S
S
L
S
S
W
S
Site 17
S174
F
S
P
S
P
G
S
S
S
L
S
S
W
S
F
Site 18
S175
S
P
S
P
G
S
S
S
L
S
S
W
S
F
F
Site 19
S177
S
P
G
S
S
S
L
S
S
W
S
F
F
S
D
Site 20
S178
P
G
S
S
S
L
S
S
W
S
F
F
S
D
A
Site 21
S180
S
S
S
L
S
S
W
S
F
F
S
D
A
S
D
Site 22
S183
L
S
S
W
S
F
F
S
D
A
S
D
E
A
A
Site 23
S186
W
S
F
F
S
D
A
S
D
E
A
A
L
Y
A
Site 24
Y192
A
S
D
E
A
A
L
Y
A
A
C
D
E
V
E
Site 25
S207
S
E
L
N
E
A
A
S
R
F
G
L
G
S
P
Site 26
S213
A
S
R
F
G
L
G
S
P
L
P
S
P
R
A
Site 27
S217
G
L
G
S
P
L
P
S
P
R
A
S
P
R
P
Site 28
S221
P
L
P
S
P
R
A
S
P
R
P
W
T
P
E
Site 29
T226
R
A
S
P
R
P
W
T
P
E
D
P
W
S
L
Site 30
S232
W
T
P
E
D
P
W
S
L
Y
G
P
S
P
G
Site 31
Y234
P
E
D
P
W
S
L
Y
G
P
S
P
G
G
R
Site 32
S237
P
W
S
L
Y
G
P
S
P
G
G
R
G
P
E
Site 33
S246
G
G
R
G
P
E
D
S
W
L
L
L
S
A
P
Site 34
S251
E
D
S
W
L
L
L
S
A
P
G
P
T
P
A
Site 35
T256
L
L
S
A
P
G
P
T
P
A
S
P
R
P
A
Site 36
S259
A
P
G
P
T
P
A
S
P
R
P
A
S
P
C
Site 37
S264
P
A
S
P
R
P
A
S
P
C
G
K
R
R
Y
Site 38
Y271
S
P
C
G
K
R
R
Y
S
S
S
G
T
P
S
Site 39
S272
P
C
G
K
R
R
Y
S
S
S
G
T
P
S
S
Site 40
S273
C
G
K
R
R
Y
S
S
S
G
T
P
S
S
A
Site 41
S274
G
K
R
R
Y
S
S
S
G
T
P
S
S
A
S
Site 42
T276
R
R
Y
S
S
S
G
T
P
S
S
A
S
P
A
Site 43
S278
Y
S
S
S
G
T
P
S
S
A
S
P
A
L
S
Site 44
S279
S
S
S
G
T
P
S
S
A
S
P
A
L
S
R
Site 45
S281
S
G
T
P
S
S
A
S
P
A
L
S
R
R
G
Site 46
S285
S
S
A
S
P
A
L
S
R
R
G
S
L
G
E
Site 47
S289
P
A
L
S
R
R
G
S
L
G
E
E
G
S
E
Site 48
S295
G
S
L
G
E
E
G
S
E
P
P
P
P
P
P
Site 49
S311
P
L
A
R
D
P
G
S
P
G
P
F
D
Y
V
Site 50
Y317
G
S
P
G
P
F
D
Y
V
G
A
P
P
A
E
Site 51
S325
V
G
A
P
P
A
E
S
I
P
Q
K
T
R
R
Site 52
T330
A
E
S
I
P
Q
K
T
R
R
T
S
S
E
Q
Site 53
T333
I
P
Q
K
T
R
R
T
S
S
E
Q
A
V
A
Site 54
S334
P
Q
K
T
R
R
T
S
S
E
Q
A
V
A
L
Site 55
S335
Q
K
T
R
R
T
S
S
E
Q
A
V
A
L
P
Site 56
S344
Q
A
V
A
L
P
R
S
E
E
P
A
S
C
N
Site 57
S349
P
R
S
E
E
P
A
S
C
N
G
K
L
P
L
Site 58
S361
L
P
L
G
A
E
E
S
V
A
P
P
G
G
S
Site 59
S387
V
P
S
P
L
A
W
S
K
A
R
I
G
G
H
Site 60
S395
K
A
R
I
G
G
H
S
P
I
F
R
T
S
A
Site 61
S401
H
S
P
I
F
R
T
S
A
L
P
P
L
D
W
Site 62
S412
P
L
D
W
P
L
P
S
Q
Y
E
Q
L
E
L
Site 63
Y433
R
A
H
H
R
A
H
Y
E
T
E
G
S
R
G
Site 64
T435
H
H
R
A
H
Y
E
T
E
G
S
R
G
A
V
Site 65
S438
A
H
Y
E
T
E
G
S
R
G
A
V
K
A
A
Site 66
T463
G
Y
S
E
K
P
L
T
L
Q
M
F
I
G
T
Site 67
Y482
N
L
R
P
H
A
F
Y
Q
V
H
R
I
T
G
Site 68
T510
G
T
K
V
L
E
M
T
L
L
P
E
N
N
M
Site 69
S532
G
I
L
K
L
R
N
S
D
I
E
L
R
K
G
Site 70
T548
T
D
I
G
R
K
N
T
R
V
R
L
V
F
R
Site 71
S578
A
S
V
P
I
E
C
S
Q
R
S
A
Q
E
L
Site 72
S592
L
P
Q
V
E
A
Y
S
P
S
A
C
S
V
R
Site 73
S594
Q
V
E
A
Y
S
P
S
A
C
S
V
R
G
G
Site 74
S597
A
Y
S
P
S
A
C
S
V
R
G
G
E
E
L
Site 75
T607
G
G
E
E
L
V
L
T
G
S
N
F
L
P
D
Site 76
S615
G
S
N
F
L
P
D
S
K
V
V
F
I
E
R
Site 77
T635
L
Q
W
E
E
E
A
T
V
N
R
L
Q
S
N
Site 78
S641
A
T
V
N
R
L
Q
S
N
E
V
T
L
T
L
Site 79
T645
R
L
Q
S
N
E
V
T
L
T
L
T
V
P
E
Site 80
T647
Q
S
N
E
V
T
L
T
L
T
V
P
E
Y
S
Site 81
T649
N
E
V
T
L
T
L
T
V
P
E
Y
S
N
K
Site 82
Y653
L
T
L
T
V
P
E
Y
S
N
K
R
V
S
R
Site 83
S654
T
L
T
V
P
E
Y
S
N
K
R
V
S
R
P
Site 84
S659
E
Y
S
N
K
R
V
S
R
P
V
Q
V
Y
F
Site 85
Y665
V
S
R
P
V
Q
V
Y
F
Y
V
S
N
G
R
Site 86
Y667
R
P
V
Q
V
Y
F
Y
V
S
N
G
R
R
K
Site 87
S669
V
Q
V
Y
F
Y
V
S
N
G
R
R
K
R
S
Site 88
S676
S
N
G
R
R
K
R
S
P
T
Q
S
F
R
F
Site 89
T678
G
R
R
K
R
S
P
T
Q
S
F
R
F
L
P
Site 90
S680
R
K
R
S
P
T
Q
S
F
R
F
L
P
V
I
Site 91
S696
K
E
E
P
L
P
D
S
S
L
R
G
F
P
S
Site 92
S697
E
E
P
L
P
D
S
S
L
R
G
F
P
S
A
Site 93
S703
S
S
L
R
G
F
P
S
A
S
A
T
P
F
G
Site 94
S705
L
R
G
F
P
S
A
S
A
T
P
F
G
T
D
Site 95
T707
G
F
P
S
A
S
A
T
P
F
G
T
D
M
D
Site 96
S716
F
G
T
D
M
D
F
S
P
P
R
P
P
Y
P
Site 97
Y722
F
S
P
P
R
P
P
Y
P
S
Y
P
H
E
D
Site 98
S724
P
P
R
P
P
Y
P
S
Y
P
H
E
D
P
A
Site 99
Y725
P
R
P
P
Y
P
S
Y
P
H
E
D
P
A
C
Site 100
T734
H
E
D
P
A
C
E
T
P
Y
L
S
E
G
F
Site 101
Y736
D
P
A
C
E
T
P
Y
L
S
E
G
F
G
Y
Site 102
Y743
Y
L
S
E
G
F
G
Y
G
M
P
P
L
Y
P
Site 103
Y749
G
Y
G
M
P
P
L
Y
P
Q
T
G
P
P
P
Site 104
T752
M
P
P
L
Y
P
Q
T
G
P
P
P
S
Y
R
Site 105
S757
P
Q
T
G
P
P
P
S
Y
R
P
G
L
R
M
Site 106
Y758
Q
T
G
P
P
P
S
Y
R
P
G
L
R
M
F
Site 107
T768
G
L
R
M
F
P
E
T
R
G
T
T
G
C
A
Site 108
T771
M
F
P
E
T
R
G
T
T
G
C
A
Q
P
P
Site 109
T772
F
P
E
T
R
G
T
T
G
C
A
Q
P
P
A
Site 110
S789
F
L
P
R
P
F
P
S
D
P
Y
G
G
R
G
Site 111
Y792
R
P
F
P
S
D
P
Y
G
G
R
G
S
S
F
Site 112
S797
D
P
Y
G
G
R
G
S
S
F
S
L
G
L
P
Site 113
S798
P
Y
G
G
R
G
S
S
F
S
L
G
L
P
F
Site 114
S800
G
G
R
G
S
S
F
S
L
G
L
P
F
S
P
Site 115
S819
R
P
P
P
L
P
A
S
P
P
L
E
G
P
F
Site 116
S828
P
L
E
G
P
F
P
S
Q
S
D
V
H
P
L
Site 117
S830
E
G
P
F
P
S
Q
S
D
V
H
P
L
P
A
Site 118
Y840
H
P
L
P
A
E
G
Y
N
K
V
G
P
G
Y
Site 119
Y847
Y
N
K
V
G
P
G
Y
G
P
G
E
G
A
P
Site 120
S859
G
A
P
E
Q
E
K
S
R
G
G
Y
S
S
G
Site 121
Y863
Q
E
K
S
R
G
G
Y
S
S
G
F
R
D
S
Site 122
S865
K
S
R
G
G
Y
S
S
G
F
R
D
S
V
P
Site 123
S870
Y
S
S
G
F
R
D
S
V
P
I
Q
G
I
T
Site 124
S890
E
I
I
G
R
D
L
S
G
F
P
A
P
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation