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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LASP1
Full Name:
LIM and SH3 domain protein 1
Alias:
LAS1; Lasp-1; LIM and SH3 protein 1; MLN 50; MLN50
Type:
Actin binding protein
Mass (Da):
29717
Number AA:
261
UniProt ID:
Q14847
International Prot ID:
IPI00000861
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0030863
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0004871
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
GO:0006811
GO:0051234
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
A
R
C
G
K
I
V
Y
P
T
E
K
V
N
C
Site 2
T38
H
C
E
T
C
K
M
T
L
N
M
K
N
Y
K
Site 3
Y44
M
T
L
N
M
K
N
Y
K
G
Y
E
K
K
P
Site 4
Y47
N
M
K
N
Y
K
G
Y
E
K
K
P
Y
C
N
Site 5
Y52
K
G
Y
E
K
K
P
Y
C
N
A
H
Y
P
K
Site 6
Y57
K
P
Y
C
N
A
H
Y
P
K
Q
S
F
T
M
Site 7
S61
N
A
H
Y
P
K
Q
S
F
T
M
V
A
D
T
Site 8
T63
H
Y
P
K
Q
S
F
T
M
V
A
D
T
P
E
Site 9
T68
S
F
T
M
V
A
D
T
P
E
N
L
R
L
K
Site 10
S78
N
L
R
L
K
Q
Q
S
E
L
Q
S
Q
V
R
Site 11
S82
K
Q
Q
S
E
L
Q
S
Q
V
R
Y
K
E
E
Site 12
Y86
E
L
Q
S
Q
V
R
Y
K
E
E
F
E
K
N
Site 13
S99
K
N
K
G
K
G
F
S
V
V
A
D
T
P
E
Site 14
T104
G
F
S
V
V
A
D
T
P
E
L
Q
R
I
K
Site 15
T113
E
L
Q
R
I
K
K
T
Q
D
Q
I
S
N
I
Site 16
S118
K
K
T
Q
D
Q
I
S
N
I
K
Y
H
E
E
Site 17
Y122
D
Q
I
S
N
I
K
Y
H
E
E
F
E
K
S
Site 18
S129
Y
H
E
E
F
E
K
S
R
M
G
P
S
G
G
Site 19
S146
M
E
P
E
R
R
D
S
Q
D
G
S
S
Y
R
Site 20
S150
R
R
D
S
Q
D
G
S
S
Y
R
R
P
L
E
Site 21
S151
R
D
S
Q
D
G
S
S
Y
R
R
P
L
E
Q
Site 22
Y152
D
S
Q
D
G
S
S
Y
R
R
P
L
E
Q
Q
Site 23
T166
Q
Q
P
H
H
I
P
T
S
A
P
V
Y
Q
Q
Site 24
S167
Q
P
H
H
I
P
T
S
A
P
V
Y
Q
Q
P
Site 25
Y171
I
P
T
S
A
P
V
Y
Q
Q
P
Q
Q
Q
P
Site 26
S182
Q
Q
Q
P
V
A
Q
S
Y
G
G
Y
K
E
P
Site 27
Y183
Q
Q
P
V
A
Q
S
Y
G
G
Y
K
E
P
A
Site 28
Y186
V
A
Q
S
Y
G
G
Y
K
E
P
A
A
P
V
Site 29
S194
K
E
P
A
A
P
V
S
I
Q
R
S
A
P
G
Site 30
S198
A
P
V
S
I
Q
R
S
A
P
G
G
G
G
K
Site 31
Y207
P
G
G
G
G
K
R
Y
R
A
V
Y
D
Y
S
Site 32
Y211
G
K
R
Y
R
A
V
Y
D
Y
S
A
A
D
E
Site 33
Y213
R
Y
R
A
V
Y
D
Y
S
A
A
D
E
D
E
Site 34
S222
A
A
D
E
D
E
V
S
F
Q
D
G
D
T
I
Site 35
Y241
Q
I
D
D
G
W
M
Y
G
T
V
E
R
T
G
Site 36
T243
D
D
G
W
M
Y
G
T
V
E
R
T
G
D
T
Site 37
Y257
T
G
M
L
P
A
N
Y
V
E
A
I
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation