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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMC1A
Full Name:
Structural maintenance of chromosomes protein 1A
Alias:
Chromosome segregation protein SmcB; DXS423E; KIAA0178; Sb1.8; SB1.8/DXS423E protein; SM1A; SMC1alpha protein; SMC1L1
Type:
DNA replication protein
Mass (Da):
143233
Number AA:
1233
UniProt ID:
Q14683
International Prot ID:
IPI00291939
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008280
GO:0000777
GO:0000794
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003682
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0042770
GO:0006281
GO:0000075
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T28
I
G
P
F
Q
R
F
T
A
I
I
G
P
N
G
Site 2
S36
A
I
I
G
P
N
G
S
G
K
S
N
L
M
D
Site 3
S39
G
P
N
G
S
G
K
S
N
L
M
D
A
I
S
Site 4
S54
F
V
L
G
E
K
T
S
N
L
R
V
K
T
L
Site 5
T60
T
S
N
L
R
V
K
T
L
R
D
L
I
H
G
Site 6
S81
A
A
N
R
A
F
V
S
M
V
Y
S
E
E
G
Site 7
S85
A
F
V
S
M
V
Y
S
E
E
G
A
E
D
R
Site 8
T93
E
E
G
A
E
D
R
T
F
A
R
V
I
V
G
Site 9
S142
V
F
Q
G
A
V
E
S
I
A
M
K
N
P
K
Site 10
S159
T
A
L
F
E
E
I
S
R
S
G
E
L
A
Q
Site 11
S161
L
F
E
E
I
S
R
S
G
E
L
A
Q
E
Y
Site 12
Y168
S
G
E
L
A
Q
E
Y
D
K
R
K
K
E
M
Site 13
Y186
E
E
D
T
Q
F
N
Y
H
R
K
K
N
I
A
Site 14
Y209
E
K
E
E
A
D
R
Y
Q
R
L
K
D
E
V
Site 15
S244
K
L
N
K
E
L
A
S
K
N
K
E
I
E
K
Site 16
Y298
L
N
Q
K
R
P
Q
Y
I
K
A
K
E
N
T
Site 17
S318
K
L
E
A
A
K
K
S
L
Q
N
A
Q
K
H
Site 18
S342
E
L
E
K
E
M
L
S
V
E
K
A
R
Q
E
Site 19
S358
E
E
R
M
E
E
E
S
Q
S
Q
G
R
D
L
Site 20
S360
R
M
E
E
E
S
Q
S
Q
G
R
D
L
T
L
Site 21
T366
Q
S
Q
G
R
D
L
T
L
E
E
N
Q
V
K
Site 22
Y375
E
E
N
Q
V
K
K
Y
H
R
L
K
E
E
A
Site 23
S383
H
R
L
K
E
E
A
S
K
R
A
A
T
L
A
Site 24
T388
E
A
S
K
R
A
A
T
L
A
Q
E
L
E
K
Site 25
T417
E
E
R
K
K
V
E
T
E
A
K
I
K
Q
K
Site 26
Y441
R
I
E
K
L
E
E
Y
I
T
T
S
K
Q
S
Site 27
T443
E
K
L
E
E
Y
I
T
T
S
K
Q
S
L
E
Site 28
T444
K
L
E
E
Y
I
T
T
S
K
Q
S
L
E
E
Site 29
T460
K
K
L
E
G
E
L
T
E
E
V
E
M
A
K
Site 30
S494
A
R
I
D
R
Q
E
S
S
R
Q
Q
R
K
A
Site 31
S506
R
K
A
E
I
M
E
S
I
K
R
L
Y
P
G
Site 32
Y511
M
E
S
I
K
R
L
Y
P
G
S
V
Y
G
R
Site 33
S514
I
K
R
L
Y
P
G
S
V
Y
G
R
L
I
D
Site 34
Y516
R
L
Y
P
G
S
V
Y
G
R
L
I
D
L
C
Site 35
Y530
C
Q
P
T
Q
K
K
Y
Q
I
A
V
T
K
V
Site 36
T552
I
I
V
D
S
E
K
T
G
R
D
C
I
Q
Y
Site 37
Y559
T
G
R
D
C
I
Q
Y
I
K
E
Q
R
G
E
Site 38
T569
E
Q
R
G
E
P
E
T
F
L
P
L
D
Y
L
Site 39
Y575
E
T
F
L
P
L
D
Y
L
E
V
K
P
T
D
Site 40
T581
D
Y
L
E
V
K
P
T
D
E
K
L
R
E
L
Site 41
Y600
L
V
I
D
V
I
R
Y
E
P
P
H
I
K
K
Site 42
Y611
H
I
K
K
A
L
Q
Y
A
C
G
N
A
L
V
Site 43
T638
G
G
H
Q
R
H
K
T
V
A
L
D
G
T
L
Site 44
S653
F
Q
K
S
G
V
I
S
G
G
A
S
D
L
K
Site 45
S657
G
V
I
S
G
G
A
S
D
L
K
A
K
A
R
Site 46
T682
K
E
K
K
E
R
L
T
E
E
L
K
E
Q
M
Site 47
S703
A
E
L
R
Q
V
Q
S
Q
A
H
G
L
Q
M
Site 48
Y714
G
L
Q
M
R
L
K
Y
S
Q
S
D
L
E
Q
Site 49
S715
L
Q
M
R
L
K
Y
S
Q
S
D
L
E
Q
T
Site 50
S717
M
R
L
K
Y
S
Q
S
D
L
E
Q
T
K
T
Site 51
T722
S
Q
S
D
L
E
Q
T
K
T
R
H
L
A
L
Site 52
T724
S
D
L
E
Q
T
K
T
R
H
L
A
L
N
L
Site 53
S735
A
L
N
L
Q
E
K
S
K
L
E
S
E
L
A
Site 54
S739
Q
E
K
S
K
L
E
S
E
L
A
N
F
G
P
Site 55
S757
D
I
K
R
I
I
Q
S
R
E
R
E
M
K
D
Site 56
T815
L
E
F
E
N
Q
K
T
R
L
G
I
Q
L
D
Site 57
T866
H
M
K
I
I
D
E
T
M
A
Q
L
Q
D
L
Site 58
S924
T
K
L
E
Q
K
R
S
D
R
H
N
L
L
Q
Site 59
S943
Q
D
I
K
L
P
L
S
K
G
T
M
D
D
I
Site 60
S951
K
G
T
M
D
D
I
S
Q
E
E
G
S
S
Q
Site 61
S956
D
I
S
Q
E
E
G
S
S
Q
G
E
D
S
V
Site 62
S957
I
S
Q
E
E
G
S
S
Q
G
E
D
S
V
S
Site 63
S962
G
S
S
Q
G
E
D
S
V
S
G
S
Q
R
I
Site 64
S964
S
Q
G
E
D
S
V
S
G
S
Q
R
I
S
S
Site 65
S966
G
E
D
S
V
S
G
S
Q
R
I
S
S
I
Y
Site 66
S970
V
S
G
S
Q
R
I
S
S
I
Y
A
R
E
A
Site 67
S971
S
G
S
Q
R
I
S
S
I
Y
A
R
E
A
L
Site 68
Y973
S
Q
R
I
S
S
I
Y
A
R
E
A
L
I
E
Site 69
S1015
Q
K
L
N
E
Q
Q
S
V
L
Q
R
I
A
A
Site 70
S1033
K
A
M
E
K
L
E
S
V
R
D
K
F
Q
E
Site 71
S1042
R
D
K
F
Q
E
T
S
D
E
F
E
A
A
R
Site 72
Y1085
A
T
N
I
D
E
I
Y
K
A
L
S
R
N
S
Site 73
S1089
D
E
I
Y
K
A
L
S
R
N
S
S
A
Q
A
Site 74
S1092
Y
K
A
L
S
R
N
S
S
A
Q
A
F
L
G
Site 75
S1093
K
A
L
S
R
N
S
S
A
Q
A
F
L
G
P
Site 76
Y1107
P
E
N
P
E
E
P
Y
L
D
G
I
N
Y
N
Site 77
Y1113
P
Y
L
D
G
I
N
Y
N
C
V
A
P
G
K
Site 78
S1129
F
R
P
M
D
N
L
S
G
G
E
K
T
V
A
Site 79
Y1194
I
S
L
K
E
E
F
Y
T
K
A
E
S
L
I
Site 80
T1195
S
L
K
E
E
F
Y
T
K
A
E
S
L
I
G
Site 81
S1199
E
F
Y
T
K
A
E
S
L
I
G
V
Y
P
E
Site 82
T1221
K
V
L
T
F
D
L
T
K
Y
P
D
A
N
P
Site 83
Y1223
L
T
F
D
L
T
K
Y
P
D
A
N
P
N
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation