KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MDC1
Full Name:
Mediator of DNA damage checkpoint protein 1
Alias:
DKFZp781A0122; Em:AB023051.5; IER3; KIAA0170; Mediator of DNA damage checkpoint 1; Mediator of DNA-damage checkpoint 1; MGC166888; NFBD1; Nuclear factor with BRCT domains 1
Type:
Cell cycle regulation
Mass (Da):
226666
Number AA:
2089
UniProt ID:
Q14676
International Prot ID:
IPI00552897
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0005925
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0007049
GO:0031573
Phosida
TranscriptoNet
STRING
Kinexus Products
Mediator of DNA damage checkpoint protein 1 pan-specific antibody AB-NN289-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN289-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
E
D
T
Q
A
I
D
W
D
V
Site 2
T17
D
V
E
E
E
E
E
T
E
Q
S
S
E
S
L
Site 3
S20
E
E
E
E
T
E
Q
S
S
E
S
L
R
C
N
Site 4
S21
E
E
E
T
E
Q
S
S
E
S
L
R
C
N
V
Site 5
S23
E
T
E
Q
S
S
E
S
L
R
C
N
V
E
P
Site 6
S38
V
G
R
L
H
I
F
S
G
A
H
G
P
E
K
Site 7
S70
S
V
A
L
P
F
P
S
I
S
K
Q
H
A
E
Site 8
T98
D
C
G
S
L
N
G
T
Q
I
L
R
P
P
K
Site 9
S108
L
R
P
P
K
V
L
S
P
G
V
S
H
R
L
Site 10
S112
K
V
L
S
P
G
V
S
H
R
L
R
D
Q
E
Site 11
S136
Q
Y
H
R
L
D
V
S
L
P
F
V
S
R
G
Site 12
T146
F
V
S
R
G
P
L
T
V
E
E
T
P
R
V
Site 13
T150
G
P
L
T
V
E
E
T
P
R
V
Q
G
E
T
Site 14
T157
T
P
R
V
Q
G
E
T
Q
P
Q
R
L
L
L
Site 15
S168
R
L
L
L
A
E
D
S
E
E
E
V
D
F
L
Site 16
S176
E
E
E
V
D
F
L
S
E
R
R
M
V
K
K
Site 17
S184
E
R
R
M
V
K
K
S
R
T
T
S
S
S
V
Site 18
T186
R
M
V
K
K
S
R
T
T
S
S
S
V
I
V
Site 19
T187
M
V
K
K
S
R
T
T
S
S
S
V
I
V
P
Site 20
S188
V
K
K
S
R
T
T
S
S
S
V
I
V
P
E
Site 21
S189
K
K
S
R
T
T
S
S
S
V
I
V
P
E
S
Site 22
S190
K
S
R
T
T
S
S
S
V
I
V
P
E
S
D
Site 23
S196
S
S
V
I
V
P
E
S
D
E
E
G
H
S
P
Site 24
S202
E
S
D
E
E
G
H
S
P
V
L
G
G
L
G
Site 25
S218
P
F
A
F
N
L
N
S
D
T
D
V
E
E
G
Site 26
T220
A
F
N
L
N
S
D
T
D
V
E
E
G
Q
Q
Site 27
T230
E
E
G
Q
Q
P
A
T
E
E
A
S
S
A
A
Site 28
S235
P
A
T
E
E
A
S
S
A
A
R
R
G
A
T
Site 29
T242
S
A
A
R
R
G
A
T
V
E
A
K
Q
S
E
Site 30
S248
A
T
V
E
A
K
Q
S
E
A
E
V
V
T
E
Site 31
T272
V
K
E
R
D
N
D
T
K
V
K
R
G
A
G
Site 32
S292
A
G
V
I
L
E
R
S
Q
P
P
G
E
D
S
Site 33
S299
S
Q
P
P
G
E
D
S
D
T
D
V
D
D
D
Site 34
T301
P
P
G
E
D
S
D
T
D
V
D
D
D
S
R
Site 35
S307
D
T
D
V
D
D
D
S
R
P
P
G
R
P
A
Site 36
S329
Q
P
F
G
F
I
D
S
D
T
D
A
E
E
E
Site 37
T331
F
G
F
I
D
S
D
T
D
A
E
E
E
R
I
Site 38
T341
E
E
E
R
I
P
A
T
P
V
V
I
P
M
K
Site 39
S372
G
L
A
H
L
Q
E
S
Q
A
G
S
D
T
D
Site 40
S376
L
Q
E
S
Q
A
G
S
D
T
D
V
E
E
G
Site 41
T378
E
S
Q
A
G
S
D
T
D
V
E
E
G
K
A
Site 42
S394
Q
A
V
P
L
E
K
S
Q
A
S
M
V
I
N
Site 43
S397
P
L
E
K
S
Q
A
S
M
V
I
N
S
D
T
Site 44
S402
Q
A
S
M
V
I
N
S
D
T
D
D
E
E
E
Site 45
T404
S
M
V
I
N
S
D
T
D
D
E
E
E
V
S
Site 46
S411
T
D
D
E
E
E
V
S
A
A
L
T
L
A
H
Site 47
T415
E
E
V
S
A
A
L
T
L
A
H
L
K
E
S
Site 48
S422
T
L
A
H
L
K
E
S
Q
P
A
I
W
N
R
Site 49
S445
R
V
V
L
L
Q
R
S
Q
T
T
T
E
R
D
Site 50
T447
V
L
L
Q
R
S
Q
T
T
T
E
R
D
S
D
Site 51
T448
L
L
Q
R
S
Q
T
T
T
E
R
D
S
D
T
Site 52
T449
L
Q
R
S
Q
T
T
T
E
R
D
S
D
T
D
Site 53
S453
Q
T
T
T
E
R
D
S
D
T
D
V
E
E
E
Site 54
T455
T
T
E
R
D
S
D
T
D
V
E
E
E
E
L
Site 55
T475
E
A
V
L
K
D
H
T
K
I
R
A
L
V
R
Site 56
S485
R
A
L
V
R
A
H
S
E
K
D
Q
P
P
F
Site 57
S495
D
Q
P
P
F
G
D
S
D
D
S
V
E
A
D
Site 58
S498
P
F
G
D
S
D
D
S
V
E
A
D
K
S
S
Site 59
S504
D
S
V
E
A
D
K
S
S
P
G
I
H
L
E
Site 60
S505
S
V
E
A
D
K
S
S
P
G
I
H
L
E
R
Site 61
S513
P
G
I
H
L
E
R
S
Q
A
S
T
T
V
D
Site 62
S516
H
L
E
R
S
Q
A
S
T
T
V
D
I
N
T
Site 63
T517
L
E
R
S
Q
A
S
T
T
V
D
I
N
T
Q
Site 64
T518
E
R
S
Q
A
S
T
T
V
D
I
N
T
Q
V
Site 65
T523
S
T
T
V
D
I
N
T
Q
V
E
K
E
V
P
Site 66
S533
E
K
E
V
P
P
G
S
A
I
I
H
I
K
K
Site 67
S544
H
I
K
K
H
Q
V
S
V
E
G
T
N
Q
T
Site 68
T579
P
L
H
G
D
C
E
T
D
A
E
E
G
T
S
Site 69
S590
E
G
T
S
L
T
A
S
V
V
A
D
V
R
K
Site 70
S598
V
V
A
D
V
R
K
S
Q
L
P
A
E
G
D
Site 71
S641
V
E
Q
D
L
P
I
S
R
E
N
L
T
D
L
Site 72
T652
L
T
D
L
V
V
D
T
D
T
L
G
E
S
T
Site 73
T654
D
L
V
V
D
T
D
T
L
G
E
S
T
Q
P
Site 74
S658
D
T
D
T
L
G
E
S
T
Q
P
Q
R
E
G
Site 75
T659
T
D
T
L
G
E
S
T
Q
P
Q
R
E
G
A
Site 76
S684
H
V
G
G
T
K
D
S
E
D
N
Y
G
D
S
Site 77
Y688
T
K
D
S
E
D
N
Y
G
D
S
E
D
L
D
Site 78
S691
S
E
D
N
Y
G
D
S
E
D
L
D
L
Q
A
Site 79
T699
E
D
L
D
L
Q
A
T
Q
C
F
L
E
N
Q
Site 80
S713
Q
G
L
E
A
V
Q
S
M
E
D
E
P
T
Q
Site 81
T719
Q
S
M
E
D
E
P
T
Q
A
F
M
L
T
P
Site 82
T725
P
T
Q
A
F
M
L
T
P
P
Q
E
L
G
P
Site 83
S733
P
P
Q
E
L
G
P
S
H
C
S
F
Q
T
T
Site 84
S736
E
L
G
P
S
H
C
S
F
Q
T
T
G
T
L
Site 85
T740
S
H
C
S
F
Q
T
T
G
T
L
D
E
P
W
Site 86
T752
E
P
W
E
V
L
A
T
Q
P
F
C
L
R
E
Site 87
S760
Q
P
F
C
L
R
E
S
E
D
S
E
T
Q
P
Site 88
S763
C
L
R
E
S
E
D
S
E
T
Q
P
F
D
T
Site 89
T765
R
E
S
E
D
S
E
T
Q
P
F
D
T
H
L
Site 90
S780
E
A
Y
G
P
C
L
S
P
P
R
A
I
P
G
Site 91
S793
P
G
D
Q
H
P
E
S
P
V
H
T
E
P
M
Site 92
T797
H
P
E
S
P
V
H
T
E
P
M
G
I
Q
G
Site 93
T809
I
Q
G
R
G
R
Q
T
V
D
K
V
M
G
I
Site 94
T835
R
G
P
L
E
R
E
T
E
K
L
L
P
E
R
Site 95
T844
K
L
L
P
E
R
Q
T
D
V
T
G
E
E
E
Site 96
T847
P
E
R
Q
T
D
V
T
G
E
E
E
L
T
K
Site 97
T853
V
T
G
E
E
E
L
T
K
G
K
Q
D
R
E
Site 98
T869
K
Q
L
L
A
R
D
T
Q
R
Q
E
S
D
K
Site 99
S874
R
D
T
Q
R
Q
E
S
D
K
N
G
E
S
A
Site 100
S882
D
K
N
G
E
S
A
S
P
E
R
D
R
E
S
Site 101
S889
S
P
E
R
D
R
E
S
L
K
V
E
I
E
T
Site 102
S897
L
K
V
E
I
E
T
S
E
E
I
Q
E
K
Q
Site 103
T946
K
V
I
L
E
R
D
T
Q
R
G
E
P
E
G
Site 104
S955
R
G
E
P
E
G
G
S
Q
D
Q
K
G
Q
A
Site 105
S963
Q
D
Q
K
G
Q
A
S
S
P
T
P
E
P
G
Site 106
S964
D
Q
K
G
Q
A
S
S
P
T
P
E
P
G
V
Site 107
T966
K
G
Q
A
S
S
P
T
P
E
P
G
V
G
A
Site 108
T980
A
G
D
L
P
G
P
T
S
A
P
V
P
S
G
Site 109
S981
G
D
L
P
G
P
T
S
A
P
V
P
S
G
S
Site 110
S986
P
T
S
A
P
V
P
S
G
S
Q
S
G
G
R
Site 111
S988
S
A
P
V
P
S
G
S
Q
S
G
G
R
G
S
Site 112
S990
P
V
P
S
G
S
Q
S
G
G
R
G
S
P
V
Site 113
S995
S
Q
S
G
G
R
G
S
P
V
S
P
R
R
H
Site 114
S998
G
G
R
G
S
P
V
S
P
R
R
H
Q
K
G
Site 115
S1033
V
S
R
G
D
Q
E
S
P
D
A
C
L
P
P
Site 116
T1041
P
D
A
C
L
P
P
T
V
P
E
A
P
A
P
Site 117
S1055
P
P
Q
K
P
L
N
S
Q
S
Q
K
H
L
A
Site 118
S1057
Q
K
P
L
N
S
Q
S
Q
K
H
L
A
P
P
Site 119
S1068
L
A
P
P
P
L
L
S
P
L
L
P
S
I
K
Site 120
T1077
L
L
P
S
I
K
P
T
V
R
K
T
R
Q
D
Site 121
T1081
I
K
P
T
V
R
K
T
R
Q
D
G
S
Q
E
Site 122
S1086
R
K
T
R
Q
D
G
S
Q
E
A
P
E
A
P
Site 123
S1095
E
A
P
E
A
P
L
S
S
E
L
E
P
F
H
Site 124
S1096
A
P
E
A
P
L
S
S
E
L
E
P
F
H
P
Site 125
S1112
P
K
I
R
T
R
K
S
S
R
M
T
P
F
P
Site 126
S1113
K
I
R
T
R
K
S
S
R
M
T
P
F
P
A
Site 127
T1116
T
R
K
S
S
R
M
T
P
F
P
A
T
S
A
Site 128
S1122
M
T
P
F
P
A
T
S
A
A
P
E
P
H
P
Site 129
S1130
A
A
P
E
P
H
P
S
T
S
T
A
Q
P
V
Site 130
S1132
P
E
P
H
P
S
T
S
T
A
Q
P
V
T
P
Site 131
T1138
T
S
T
A
Q
P
V
T
P
K
P
T
S
Q
A
Site 132
S1143
P
V
T
P
K
P
T
S
Q
A
T
R
S
R
T
Site 133
S1148
P
T
S
Q
A
T
R
S
R
T
N
R
S
S
V
Site 134
T1150
S
Q
A
T
R
S
R
T
N
R
S
S
V
K
T
Site 135
S1153
T
R
S
R
T
N
R
S
S
V
K
T
P
E
P
Site 136
S1154
R
S
R
T
N
R
S
S
V
K
T
P
E
P
V
Site 137
T1157
T
N
R
S
S
V
K
T
P
E
P
V
V
P
T
Site 138
S1171
T
A
P
E
L
Q
P
S
T
S
T
D
Q
P
V
Site 139
S1173
P
E
L
Q
P
S
T
S
T
D
Q
P
V
T
S
Site 140
T1179
T
S
T
D
Q
P
V
T
S
E
P
T
S
Q
V
Site 141
S1180
S
T
D
Q
P
V
T
S
E
P
T
S
Q
V
T
Site 142
S1184
P
V
T
S
E
P
T
S
Q
V
T
R
G
R
K
Site 143
S1192
Q
V
T
R
G
R
K
S
R
S
S
V
K
T
P
Site 144
S1194
T
R
G
R
K
S
R
S
S
V
K
T
P
E
T
Site 145
S1195
R
G
R
K
S
R
S
S
V
K
T
P
E
T
V
Site 146
T1198
K
S
R
S
S
V
K
T
P
E
T
V
V
P
T
Site 147
T1201
S
S
V
K
T
P
E
T
V
V
P
T
A
L
E
Site 148
S1212
T
A
L
E
L
Q
P
S
T
S
T
D
R
P
V
Site 149
S1214
L
E
L
Q
P
S
T
S
T
D
R
P
V
T
S
Site 150
T1215
E
L
Q
P
S
T
S
T
D
R
P
V
T
S
E
Site 151
T1220
T
S
T
D
R
P
V
T
S
E
P
T
S
Q
A
Site 152
S1221
S
T
D
R
P
V
T
S
E
P
T
S
Q
A
T
Site 153
T1224
R
P
V
T
S
E
P
T
S
Q
A
T
R
G
R
Site 154
S1225
P
V
T
S
E
P
T
S
Q
A
T
R
G
R
K
Site 155
S1235
T
R
G
R
K
N
R
S
S
V
K
T
P
E
P
Site 156
S1236
R
G
R
K
N
R
S
S
V
K
T
P
E
P
V
Site 157
T1239
K
N
R
S
S
V
K
T
P
E
P
V
V
P
T
Site 158
T1261
T
S
T
D
Q
P
V
T
S
E
P
T
Y
Q
A
Site 159
S1262
S
T
D
Q
P
V
T
S
E
P
T
Y
Q
A
T
Site 160
Y1266
P
V
T
S
E
P
T
Y
Q
A
T
R
G
R
K
Site 161
S1294
T
A
P
E
L
R
P
S
T
S
T
D
R
P
V
Site 162
T1295
A
P
E
L
R
P
S
T
S
T
D
R
P
V
T
Site 163
S1296
P
E
L
R
P
S
T
S
T
D
R
P
V
T
P
Site 164
T1297
E
L
R
P
S
T
S
T
D
R
P
V
T
P
K
Site 165
T1302
T
S
T
D
R
P
V
T
P
K
P
T
S
R
T
Site 166
S1307
P
V
T
P
K
P
T
S
R
T
T
R
S
R
T
Site 167
T1309
T
P
K
P
T
S
R
T
T
R
S
R
T
N
M
Site 168
T1310
P
K
P
T
S
R
T
T
R
S
R
T
N
M
S
Site 169
S1312
P
T
S
R
T
T
R
S
R
T
N
M
S
S
V
Site 170
T1314
S
R
T
T
R
S
R
T
N
M
S
S
V
K
T
Site 171
S1317
T
R
S
R
T
N
M
S
S
V
K
T
P
E
T
Site 172
S1318
R
S
R
T
N
M
S
S
V
K
T
P
E
T
V
Site 173
T1321
T
N
M
S
S
V
K
T
P
E
T
V
V
P
T
Site 174
T1324
S
S
V
K
T
P
E
T
V
V
P
T
A
P
E
Site 175
T1328
T
P
E
T
V
V
P
T
A
P
E
L
Q
I
S
Site 176
S1335
T
A
P
E
L
Q
I
S
T
S
T
D
Q
P
V
Site 177
S1337
P
E
L
Q
I
S
T
S
T
D
Q
P
V
T
P
Site 178
T1338
E
L
Q
I
S
T
S
T
D
Q
P
V
T
P
K
Site 179
T1343
T
S
T
D
Q
P
V
T
P
K
P
T
S
R
T
Site 180
T1355
S
R
T
T
R
S
R
T
N
M
S
S
V
K
N
Site 181
S1358
T
R
S
R
T
N
M
S
S
V
K
N
P
E
S
Site 182
S1359
R
S
R
T
N
M
S
S
V
K
N
P
E
S
T
Site 183
S1365
S
S
V
K
N
P
E
S
T
V
P
I
A
P
E
Site 184
T1366
S
V
K
N
P
E
S
T
V
P
I
A
P
E
L
Site 185
S1376
I
A
P
E
L
P
P
S
T
S
T
E
Q
P
V
Site 186
S1378
P
E
L
P
P
S
T
S
T
E
Q
P
V
T
P
Site 187
T1384
T
S
T
E
Q
P
V
T
P
E
P
T
S
R
A
Site 188
S1389
P
V
T
P
E
P
T
S
R
A
T
R
G
R
K
Site 189
T1392
P
E
P
T
S
R
A
T
R
G
R
K
N
R
S
Site 190
S1399
T
R
G
R
K
N
R
S
S
G
K
T
P
E
T
Site 191
S1400
R
G
R
K
N
R
S
S
G
K
T
P
E
T
L
Site 192
T1403
K
N
R
S
S
G
K
T
P
E
T
L
V
P
T
Site 193
T1406
S
S
G
K
T
P
E
T
L
V
P
T
A
P
K
Site 194
S1417
T
A
P
K
L
E
P
S
T
S
T
D
Q
P
V
Site 195
S1419
P
K
L
E
P
S
T
S
T
D
Q
P
V
T
P
Site 196
T1420
K
L
E
P
S
T
S
T
D
Q
P
V
T
P
E
Site 197
T1425
T
S
T
D
Q
P
V
T
P
E
P
T
S
Q
A
Site 198
T1429
Q
P
V
T
P
E
P
T
S
Q
A
T
R
G
R
Site 199
S1430
P
V
T
P
E
P
T
S
Q
A
T
R
G
R
T
Site 200
T1437
S
Q
A
T
R
G
R
T
N
R
S
S
V
K
T
Site 201
S1440
T
R
G
R
T
N
R
S
S
V
K
T
P
E
T
Site 202
S1441
R
G
R
T
N
R
S
S
V
K
T
P
E
T
V
Site 203
T1444
T
N
R
S
S
V
K
T
P
E
T
V
V
P
T
Site 204
S1460
P
E
L
Q
P
S
T
S
T
D
Q
P
V
T
P
Site 205
T1461
E
L
Q
P
S
T
S
T
D
Q
P
V
T
P
E
Site 206
T1478
S
Q
A
T
R
G
R
T
D
R
S
S
V
K
T
Site 207
S1481
T
R
G
R
T
D
R
S
S
V
K
T
P
E
T
Site 208
S1482
R
G
R
T
D
R
S
S
V
K
T
P
E
T
V
Site 209
T1485
T
D
R
S
S
V
K
T
P
E
T
V
V
P
T
Site 210
S1499
T
A
P
E
L
Q
A
S
A
S
T
D
Q
P
V
Site 211
S1501
P
E
L
Q
A
S
A
S
T
D
Q
P
V
T
S
Site 212
T1507
A
S
T
D
Q
P
V
T
S
E
P
T
S
R
T
Site 213
S1508
S
T
D
Q
P
V
T
S
E
P
T
S
R
T
T
Site 214
S1512
P
V
T
S
E
P
T
S
R
T
T
R
G
R
K
Site 215
T1514
T
S
E
P
T
S
R
T
T
R
G
R
K
N
R
Site 216
T1515
S
E
P
T
S
R
T
T
R
G
R
K
N
R
S
Site 217
S1522
T
R
G
R
K
N
R
S
S
V
K
T
P
E
T
Site 218
S1523
R
G
R
K
N
R
S
S
V
K
T
P
E
T
V
Site 219
T1526
K
N
R
S
S
V
K
T
P
E
T
V
V
P
A
Site 220
T1529
S
S
V
K
T
P
E
T
V
V
P
A
A
P
E
Site 221
S1540
A
A
P
E
L
Q
P
S
T
S
T
D
Q
P
V
Site 222
T1548
T
S
T
D
Q
P
V
T
P
E
P
T
S
R
A
Site 223
S1553
P
V
T
P
E
P
T
S
R
A
T
R
G
R
T
Site 224
T1556
P
E
P
T
S
R
A
T
R
G
R
T
N
R
S
Site 225
T1560
S
R
A
T
R
G
R
T
N
R
S
S
V
K
T
Site 226
S1563
T
R
G
R
T
N
R
S
S
V
K
T
P
E
S
Site 227
S1564
R
G
R
T
N
R
S
S
V
K
T
P
E
S
I
Site 228
T1567
T
N
R
S
S
V
K
T
P
E
S
I
V
P
I
Site 229
S1570
S
S
V
K
T
P
E
S
I
V
P
I
A
P
E
Site 230
S1581
I
A
P
E
L
Q
P
S
T
S
R
N
Q
L
V
Site 231
T1582
A
P
E
L
Q
P
S
T
S
R
N
Q
L
V
T
Site 232
S1583
P
E
L
Q
P
S
T
S
R
N
Q
L
V
T
P
Site 233
T1589
T
S
R
N
Q
L
V
T
P
E
P
T
S
R
A
Site 234
T1597
P
E
P
T
S
R
A
T
R
C
R
T
N
R
S
Site 235
T1601
S
R
A
T
R
C
R
T
N
R
S
S
V
K
T
Site 236
S1604
T
R
C
R
T
N
R
S
S
V
K
T
P
E
P
Site 237
S1605
R
C
R
T
N
R
S
S
V
K
T
P
E
P
V
Site 238
T1622
T
A
P
E
P
H
P
T
T
S
T
D
Q
P
V
Site 239
T1623
A
P
E
P
H
P
T
T
S
T
D
Q
P
V
T
Site 240
S1624
P
E
P
H
P
T
T
S
T
D
Q
P
V
T
P
Site 241
T1625
E
P
H
P
T
T
S
T
D
Q
P
V
T
P
K
Site 242
T1630
T
S
T
D
Q
P
V
T
P
K
L
T
S
R
A
Site 243
T1638
P
K
L
T
S
R
A
T
R
R
K
T
N
R
S
Site 244
T1642
S
R
A
T
R
R
K
T
N
R
S
S
V
K
T
Site 245
S1645
T
R
R
K
T
N
R
S
S
V
K
T
P
K
P
Site 246
S1646
R
R
K
T
N
R
S
S
V
K
T
P
K
P
V
Site 247
T1649
T
N
R
S
S
V
K
T
P
K
P
V
E
P
A
Site 248
S1658
K
P
V
E
P
A
A
S
D
L
E
P
F
T
P
Site 249
T1664
A
S
D
L
E
P
F
T
P
T
D
Q
S
V
T
Site 250
T1666
D
L
E
P
F
T
P
T
D
Q
S
V
T
P
E
Site 251
S1669
P
F
T
P
T
D
Q
S
V
T
P
E
A
I
A
Site 252
T1671
T
P
T
D
Q
S
V
T
P
E
A
I
A
Q
G
Site 253
S1681
A
I
A
Q
G
G
Q
S
K
T
L
R
S
S
T
Site 254
T1683
A
Q
G
G
Q
S
K
T
L
R
S
S
T
V
R
Site 255
S1686
G
Q
S
K
T
L
R
S
S
T
V
R
A
M
P
Site 256
S1687
Q
S
K
T
L
R
S
S
T
V
R
A
M
P
V
Site 257
T1688
S
K
T
L
R
S
S
T
V
R
A
M
P
V
P
Site 258
T1696
V
R
A
M
P
V
P
T
T
P
E
F
Q
S
P
Site 259
T1697
R
A
M
P
V
P
T
T
P
E
F
Q
S
P
V
Site 260
S1702
P
T
T
P
E
F
Q
S
P
V
T
T
D
Q
P
Site 261
T1705
P
E
F
Q
S
P
V
T
T
D
Q
P
I
S
P
Site 262
T1706
E
F
Q
S
P
V
T
T
D
Q
P
I
S
P
E
Site 263
S1711
V
T
T
D
Q
P
I
S
P
E
P
I
T
Q
P
Site 264
T1716
P
I
S
P
E
P
I
T
Q
P
S
C
I
K
R
Site 265
S1732
R
A
A
G
N
P
G
S
L
A
A
P
I
D
H
Site 266
S1743
P
I
D
H
K
P
C
S
A
P
L
E
P
K
S
Site 267
S1750
S
A
P
L
E
P
K
S
Q
A
S
R
N
Q
R
Site 268
S1775
T
A
I
P
E
P
A
S
P
Q
L
L
E
T
P
Site 269
T1781
A
S
P
Q
L
L
E
T
P
I
H
A
S
Q
I
Site 270
S1786
L
E
T
P
I
H
A
S
Q
I
Q
K
V
E
P
Site 271
S1797
K
V
E
P
A
G
R
S
R
F
T
P
E
L
Q
Site 272
T1800
P
A
G
R
S
R
F
T
P
E
L
Q
P
K
A
Site 273
S1808
P
E
L
Q
P
K
A
S
Q
S
R
K
R
S
L
Site 274
S1810
L
Q
P
K
A
S
Q
S
R
K
R
S
L
A
T
Site 275
S1814
A
S
Q
S
R
K
R
S
L
A
T
M
D
S
P
Site 276
T1817
S
R
K
R
S
L
A
T
M
D
S
P
P
H
Q
Site 277
S1820
R
S
L
A
T
M
D
S
P
P
H
Q
K
Q
P
Site 278
S1833
Q
P
Q
R
G
E
V
S
Q
K
T
V
I
I
K
Site 279
T1836
R
G
E
V
S
Q
K
T
V
I
I
K
E
E
E
Site 280
T1846
I
K
E
E
E
E
D
T
A
E
K
P
G
K
E
Site 281
T1858
G
K
E
E
D
V
V
T
P
K
P
G
K
R
K
Site 282
S1878
E
E
P
N
R
I
P
S
R
S
L
R
R
T
K
Site 283
S1880
P
N
R
I
P
S
R
S
L
R
R
T
K
L
N
Site 284
T1884
P
S
R
S
L
R
R
T
K
L
N
Q
E
S
T
Site 285
S1915
A
V
L
A
L
G
G
S
L
A
G
S
A
A
E
Site 286
T1928
A
E
A
S
H
L
V
T
D
R
I
R
R
T
V
Site 287
S1949
G
R
G
I
P
I
L
S
L
D
W
L
H
Q
S
Site 288
Y1968
F
F
L
P
P
D
E
Y
V
V
T
D
P
E
Q
Site 289
T1971
P
P
D
E
Y
V
V
T
D
P
E
Q
E
K
N
Site 290
S1982
Q
E
K
N
F
G
F
S
L
Q
D
A
L
S
R
Site 291
S1988
F
S
L
Q
D
A
L
S
R
A
R
E
R
R
L
Site 292
Y1999
E
R
R
L
L
E
G
Y
E
I
Y
V
T
P
G
Site 293
T2004
E
G
Y
E
I
Y
V
T
P
G
V
Q
P
P
P
Site 294
Y2025
I
S
C
C
G
G
T
Y
L
P
S
M
P
R
S
Site 295
S2028
C
G
G
T
Y
L
P
S
M
P
R
S
Y
K
P
Site 296
S2032
Y
L
P
S
M
P
R
S
Y
K
P
Q
R
V
V
Site 297
Y2033
L
P
S
M
P
R
S
Y
K
P
Q
R
V
V
I
Site 298
S2050
P
Q
D
F
P
H
C
S
I
P
L
R
V
G
L
Site 299
S2082
K
P
E
A
F
V
L
S
P
L
E
M
S
S
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation