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Updated November 2019
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Protein Info
Short Name:
ITPR3
Full Name:
Inositol 1,4,5-trisphosphate receptor type 3
Alias:
Inositol 1,4,5-triphosphate receptor, type 3; IP3R3
Type:
Channel, calcium; Receptor, misc.
Mass (Da):
304106
Number AA:
2671
UniProt ID:
Q14573
International Prot ID:
IPI00291607
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0045177
GO:0005903
GO:0043025
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0043533
GO:0070679
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0006816
GO:0007204
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T106
M
E
Q
K
Q
N
D
T
E
N
K
K
V
H
G
Site 2
S120
G
D
V
V
K
Y
G
S
V
I
Q
L
L
H
M
Site 3
Y132
L
H
M
K
S
N
K
Y
L
T
V
N
K
R
L
Site 4
T134
M
K
S
N
K
Y
L
T
V
N
K
R
L
P
A
Site 5
T151
E
K
N
A
M
R
V
T
L
D
A
T
G
N
E
Site 6
T155
M
R
V
T
L
D
A
T
G
N
E
G
S
W
L
Site 7
S197
A
G
Q
P
L
H
A
S
N
Y
E
L
S
D
N
Site 8
Y199
Q
P
L
H
A
S
N
Y
E
L
S
D
N
A
G
Site 9
S202
H
A
S
N
Y
E
L
S
D
N
A
G
C
K
E
Site 10
T253
A
E
Q
E
K
F
L
T
C
D
E
Y
K
G
K
Site 11
Y257
K
F
L
T
C
D
E
Y
K
G
K
L
Q
V
F
Site 12
T268
L
Q
V
F
L
R
T
T
L
R
Q
S
A
T
S
Site 13
S272
L
R
T
T
L
R
Q
S
A
T
S
A
T
S
S
Site 14
T274
T
T
L
R
Q
S
A
T
S
A
T
S
S
N
A
Site 15
S275
T
L
R
Q
S
A
T
S
A
T
S
S
N
A
L
Site 16
S279
S
A
T
S
A
T
S
S
N
A
L
W
E
V
E
Site 17
Y304
A
G
H
W
N
G
L
Y
R
F
K
H
L
A
T
Site 18
Y314
K
H
L
A
T
G
N
Y
L
A
A
E
E
N
P
Site 19
Y323
A
A
E
E
N
P
S
Y
K
G
D
A
S
D
P
Site 20
S328
P
S
Y
K
G
D
A
S
D
P
K
A
A
G
M
Site 21
Y352
N
A
G
E
K
I
K
Y
C
L
V
A
V
P
H
Site 22
S365
P
H
G
N
D
I
A
S
L
F
E
L
D
P
T
Site 23
T372
S
L
F
E
L
D
P
T
T
L
Q
K
T
D
S
Site 24
T373
L
F
E
L
D
P
T
T
L
Q
K
T
D
S
F
Site 25
T377
D
P
T
T
L
Q
K
T
D
S
F
V
P
R
N
Site 26
S379
T
T
L
Q
K
T
D
S
F
V
P
R
N
S
Y
Site 27
S385
D
S
F
V
P
R
N
S
Y
V
R
L
R
H
L
Site 28
Y386
S
F
V
P
R
N
S
Y
V
R
L
R
H
L
C
Site 29
T394
V
R
L
R
H
L
C
T
N
T
W
I
Q
S
T
Site 30
T396
L
R
H
L
C
T
N
T
W
I
Q
S
T
N
V
Site 31
T419
P
I
R
L
M
L
G
T
C
P
T
K
E
D
K
Site 32
S454
D
A
S
S
M
L
A
S
A
V
E
K
L
N
E
Site 33
S465
K
L
N
E
G
F
I
S
Q
N
D
R
R
F
V
Site 34
S484
E
D
L
V
F
F
V
S
D
V
P
N
N
G
Q
Site 35
S542
L
V
R
L
E
E
L
S
D
Q
K
N
A
P
Y
Site 36
Y549
S
D
Q
K
N
A
P
Y
Q
H
M
F
R
L
C
Site 37
Y557
Q
H
M
F
R
L
C
Y
R
V
L
R
H
S
Q
Site 38
S563
C
Y
R
V
L
R
H
S
Q
E
D
Y
R
K
N
Site 39
Y567
L
R
H
S
Q
E
D
Y
R
K
N
Q
E
H
I
Site 40
T611
K
L
L
E
K
H
I
T
K
T
E
V
E
T
F
Site 41
T613
L
E
K
H
I
T
K
T
E
V
E
T
F
V
S
Site 42
S620
T
E
V
E
T
F
V
S
L
V
R
K
N
R
E
Site 43
Y633
R
E
P
R
F
L
D
Y
L
S
D
L
C
V
S
Site 44
S635
P
R
F
L
D
Y
L
S
D
L
C
V
S
N
H
Site 45
S679
P
V
K
E
M
A
Q
S
H
E
Y
L
S
I
E
Site 46
Y682
E
M
A
Q
S
H
E
Y
L
S
I
E
Y
S
E
Site 47
S684
A
Q
S
H
E
Y
L
S
I
E
Y
S
E
E
E
Site 48
S688
E
Y
L
S
I
E
Y
S
E
E
E
V
W
L
T
Site 49
T695
S
E
E
E
V
W
L
T
W
T
D
K
N
N
E
Site 50
S707
N
N
E
H
H
E
K
S
V
R
Q
L
A
Q
E
Site 51
Y728
H
D
E
N
V
L
S
Y
Y
R
Y
Q
L
K
L
Site 52
Y731
N
V
L
S
Y
Y
R
Y
Q
L
K
L
F
A
R
Site 53
Y745
R
M
C
L
D
R
Q
Y
L
A
I
D
E
I
S
Site 54
T795
R
D
P
Q
E
L
V
T
P
V
K
F
A
R
L
Site 55
Y815
T
A
I
T
I
K
D
Y
D
S
N
L
N
A
S
Site 56
S817
I
T
I
K
D
Y
D
S
N
L
N
A
S
R
D
Site 57
Y840
T
M
E
F
V
E
D
Y
L
N
N
V
V
S
E
Site 58
T860
N
E
E
K
N
K
L
T
F
E
V
V
S
L
A
Site 59
S879
Y
F
G
F
Y
S
F
S
E
L
L
R
L
T
R
Site 60
Y905
P
P
A
M
L
Q
A
Y
E
D
P
G
G
K
N
Site 61
S916
G
G
K
N
V
R
R
S
I
Q
G
V
G
H
M
Site 62
S925
Q
G
V
G
H
M
M
S
T
M
V
L
S
R
K
Site 63
T926
G
V
G
H
M
M
S
T
M
V
L
S
R
K
Q
Site 64
S934
M
V
L
S
R
K
Q
S
V
F
S
A
P
S
L
Site 65
S937
S
R
K
Q
S
V
F
S
A
P
S
L
S
A
G
Site 66
S940
Q
S
V
F
S
A
P
S
L
S
A
G
A
S
A
Site 67
S942
V
F
S
A
P
S
L
S
A
G
A
S
A
A
E
Site 68
S946
P
S
L
S
A
G
A
S
A
A
E
P
L
D
R
Site 69
S954
A
A
E
P
L
D
R
S
K
F
E
E
N
E
D
Site 70
Y989
R
L
D
Y
R
I
S
Y
L
L
S
V
F
K
K
Site 71
S1007
E
V
F
P
M
Q
D
S
G
A
D
G
T
A
P
Site 72
S1018
G
T
A
P
A
F
D
S
T
T
A
N
M
N
L
Site 73
T1020
A
P
A
F
D
S
T
T
A
N
M
N
L
D
R
Site 74
S1043
F
G
V
G
K
T
S
S
M
L
E
V
D
D
E
Site 75
S1083
Q
L
L
F
K
H
F
S
Q
R
Q
E
A
M
H
Site 76
T1091
Q
R
Q
E
A
M
H
T
F
K
Q
V
Q
L
L
Site 77
Y1107
S
A
Q
D
V
E
N
Y
K
V
I
K
S
E
L
Site 78
S1112
E
N
Y
K
V
I
K
S
E
L
D
R
L
R
T
Site 79
T1119
S
E
L
D
R
L
R
T
M
V
E
K
S
E
L
Site 80
T1152
K
D
K
K
E
R
P
T
D
E
E
G
F
L
H
Site 81
S1165
L
H
P
P
G
E
K
S
S
E
N
Y
Q
I
V
Site 82
Y1169
G
E
K
S
S
E
N
Y
Q
I
V
K
G
I
L
Site 83
Y1227
K
M
M
E
I
L
R
Y
T
H
Q
F
L
Q
K
Site 84
Y1272
Q
H
I
F
L
N
N
Y
Q
L
C
S
E
I
S
Site 85
S1279
Y
Q
L
C
S
E
I
S
E
P
V
L
Q
H
F
Site 86
Y1299
T
H
G
R
H
V
Q
Y
L
D
F
L
H
T
V
Site 87
T1305
Q
Y
L
D
F
L
H
T
V
I
K
A
E
G
K
Site 88
Y1313
V
I
K
A
E
G
K
Y
V
K
K
C
Q
D
M
Site 89
S1360
R
D
G
V
E
D
H
S
P
L
M
Y
H
I
S
Site 90
Y1364
E
D
H
S
P
L
M
Y
H
I
S
L
V
D
L
Site 91
Y1432
E
V
E
M
K
E
I
Y
T
S
N
H
I
W
T
Site 92
S1453
L
D
M
A
R
V
C
S
K
R
E
K
R
V
A
Site 93
T1463
E
K
R
V
A
D
P
T
L
E
K
Y
V
L
S
Site 94
S1481
D
T
I
N
A
F
F
S
S
P
F
S
E
N
S
Site 95
S1482
T
I
N
A
F
F
S
S
P
F
S
E
N
S
T
Site 96
S1485
A
F
F
S
S
P
F
S
E
N
S
T
S
L
Q
Site 97
S1488
S
S
P
F
S
E
N
S
T
S
L
Q
T
H
Q
Site 98
T1489
S
P
F
S
E
N
S
T
S
L
Q
T
H
Q
T
Site 99
S1490
P
F
S
E
N
S
T
S
L
Q
T
H
Q
T
I
Site 100
S1550
D
L
D
A
H
I
S
S
M
L
S
S
G
A
S
Site 101
S1567
A
A
A
Q
R
N
A
S
S
Y
K
A
T
T
R
Site 102
S1568
A
A
Q
R
N
A
S
S
Y
K
A
T
T
R
A
Site 103
Y1569
A
Q
R
N
A
S
S
Y
K
A
T
T
R
A
F
Site 104
T1572
N
A
S
S
Y
K
A
T
T
R
A
F
P
R
V
Site 105
T1580
T
R
A
F
P
R
V
T
P
T
A
N
Q
W
D
Site 106
Y1588
P
T
A
N
Q
W
D
Y
K
N
I
I
E
K
L
Site 107
T1600
E
K
L
Q
D
I
I
T
A
L
E
E
R
L
K
Site 108
S1632
E
L
L
F
L
E
G
S
E
A
Y
Q
R
C
E
Site 109
Y1635
F
L
E
G
S
E
A
Y
Q
R
C
E
S
G
G
Site 110
S1640
E
A
Y
Q
R
C
E
S
G
G
F
L
S
K
L
Site 111
S1645
C
E
S
G
G
F
L
S
K
L
I
Q
H
T
K
Site 112
Y1679
M
L
L
K
K
T
K
Y
G
D
R
G
N
Q
L
Site 113
Y1694
R
K
M
L
L
Q
N
Y
L
Q
N
R
K
S
T
Site 114
S1700
N
Y
L
Q
N
R
K
S
T
S
R
G
D
L
P
Site 115
T1701
Y
L
Q
N
R
K
S
T
S
R
G
D
L
P
D
Site 116
S1702
L
Q
N
R
K
S
T
S
R
G
D
L
P
D
P
Site 117
S1778
S
F
H
N
L
M
M
S
D
K
K
S
E
R
F
Site 118
S1782
L
M
M
S
D
K
K
S
E
R
F
F
K
V
L
Site 119
S1802
R
A
Q
Q
E
T
K
S
T
V
A
V
N
M
N
Site 120
T1803
A
Q
Q
E
T
K
S
T
V
A
V
N
M
N
D
Site 121
S1813
V
N
M
N
D
L
G
S
Q
P
H
E
D
R
E
Site 122
T1826
R
E
P
V
D
P
T
T
K
G
R
V
A
S
F
Site 123
S1832
T
T
K
G
R
V
A
S
F
S
I
P
G
S
S
Site 124
S1834
K
G
R
V
A
S
F
S
I
P
G
S
S
S
R
Site 125
S1838
A
S
F
S
I
P
G
S
S
S
R
Y
S
L
G
Site 126
S1839
S
F
S
I
P
G
S
S
S
R
Y
S
L
G
P
Site 127
S1840
F
S
I
P
G
S
S
S
R
Y
S
L
G
P
S
Site 128
Y1842
I
P
G
S
S
S
R
Y
S
L
G
P
S
L
R
Site 129
S1843
P
G
S
S
S
R
Y
S
L
G
P
S
L
R
R
Site 130
S1847
S
R
Y
S
L
G
P
S
L
R
R
G
H
E
V
Site 131
S1855
L
R
R
G
H
E
V
S
E
R
V
Q
S
S
E
Site 132
S1860
E
V
S
E
R
V
Q
S
S
E
M
G
T
S
V
Site 133
S1861
V
S
E
R
V
Q
S
S
E
M
G
T
S
V
L
Site 134
Y1947
T
L
E
T
L
T
E
Y
C
Q
G
P
C
H
E
Site 135
S2006
L
L
L
A
L
M
E
S
R
H
D
S
E
N
A
Site 136
S2010
L
M
E
S
R
H
D
S
E
N
A
E
R
I
L
Site 137
S2019
N
A
E
R
I
L
I
S
L
R
P
Q
E
L
V
Site 138
S2042
Q
E
E
E
R
E
N
S
E
V
S
P
R
E
V
Site 139
S2045
E
R
E
N
S
E
V
S
P
R
E
V
G
H
N
Site 140
Y2054
R
E
V
G
H
N
I
Y
I
L
A
L
Q
L
S
Site 141
S2061
Y
I
L
A
L
Q
L
S
R
H
N
K
Q
L
Q
Site 142
S2087
E
E
A
E
G
I
S
S
M
L
S
L
N
N
K
Site 143
S2090
E
G
I
S
S
M
L
S
L
N
N
K
Q
L
S
Site 144
S2097
S
L
N
N
K
Q
L
S
Q
M
L
K
S
S
A
Site 145
Y2116
E
E
E
D
P
L
A
Y
Y
E
N
H
T
S
Q
Site 146
Y2117
E
E
D
P
L
A
Y
Y
E
N
H
T
S
Q
I
Site 147
S2132
E
I
V
R
Q
D
R
S
M
E
Q
I
V
F
P
Site 148
T2148
P
G
I
C
Q
F
L
T
E
E
T
K
H
R
L
Site 149
T2157
E
T
K
H
R
L
F
T
T
T
E
Q
D
E
Q
Site 150
T2159
K
H
R
L
F
T
T
T
E
Q
D
E
Q
G
S
Site 151
S2176
S
D
F
F
D
Q
S
S
F
L
H
N
E
M
E
Site 152
S2190
E
W
Q
R
K
L
R
S
M
P
L
I
Y
W
F
Site 153
Y2195
L
R
S
M
P
L
I
Y
W
F
S
R
R
M
T
Site 154
T2231
P
Y
M
E
G
A
S
T
G
V
L
D
S
P
L
Site 155
T2306
S
F
V
G
N
R
G
T
F
I
R
G
Y
K
A
Site 156
Y2311
R
G
T
F
I
R
G
Y
K
A
M
V
M
D
M
Site 157
T2354
D
L
I
Y
R
E
E
T
L
F
N
V
I
K
S
Site 158
S2361
T
L
F
N
V
I
K
S
V
T
R
N
G
R
S
Site 159
S2407
D
R
L
P
N
N
H
S
T
A
S
P
L
G
M
Site 160
T2408
R
L
P
N
N
H
S
T
A
S
P
L
G
M
P
Site 161
S2410
P
N
N
H
S
T
A
S
P
L
G
M
P
H
G
Site 162
T2424
G
A
A
A
F
V
D
T
C
S
G
D
K
M
D
Site 163
S2450
E
E
D
R
E
L
D
S
T
E
R
A
C
D
T
Site 164
T2451
E
D
R
E
L
D
S
T
E
R
A
C
D
T
L
Site 165
S2484
G
D
I
L
R
K
P
S
K
D
E
S
L
F
P
Site 166
S2488
R
K
P
S
K
D
E
S
L
F
P
A
R
V
V
Site 167
T2552
R
D
K
F
D
N
K
T
V
S
F
E
E
H
I
Site 168
S2554
K
F
D
N
K
T
V
S
F
E
E
H
I
K
L
Site 169
T2581
L
V
R
V
K
N
K
T
D
Y
T
G
P
E
S
Site 170
Y2583
R
V
K
N
K
T
D
Y
T
G
P
E
S
Y
V
Site 171
T2584
V
K
N
K
T
D
Y
T
G
P
E
S
Y
V
A
Site 172
S2588
T
D
Y
T
G
P
E
S
Y
V
A
Q
M
I
K
Site 173
Y2589
D
Y
T
G
P
E
S
Y
V
A
Q
M
I
K
N
Site 174
S2609
F
P
R
M
R
A
M
S
L
V
S
N
E
G
E
Site 175
S2670
V
D
V
Q
N
C
I
S
R
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation