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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FLNC
Full Name:
Filamin-C
Alias:
ABP-280; ABP-280-like; ABPL; ABP-L; Actin binding protein 280; Actin-binding-like; Filamin C, gamma; Filamin-2; Filamin-C; FLN2; Gamma-filamin
Type:
Cytoskeletal protein, actin binding
Mass (Da):
291022
Number AA:
2725
UniProt ID:
Q14315
International Prot ID:
IPI00178352
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030018
GO:0005856
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
M
N
N
S
G
Y
S
D
A
G
L
G
L
Site 2
S8
M
M
N
N
S
G
Y
S
D
A
G
L
G
L
G
Site 3
T18
G
L
G
L
G
D
E
T
D
E
M
P
S
T
E
Site 4
T24
E
T
D
E
M
P
S
T
E
K
D
L
A
E
D
Site 5
T58
K
C
V
G
K
R
L
T
D
L
Q
R
D
L
S
Site 6
S65
T
D
L
Q
R
D
L
S
D
G
L
R
L
I
A
Site 7
S78
I
A
L
L
E
V
L
S
Q
K
R
M
Y
R
K
Site 8
Y83
V
L
S
Q
K
R
M
Y
R
K
F
H
P
R
P
Site 9
T160
D
E
D
A
R
K
Q
T
P
K
Q
R
L
L
G
Site 10
S249
D
P
N
V
D
E
H
S
V
M
T
Y
L
S
Q
Site 11
Y253
D
E
H
S
V
M
T
Y
L
S
Q
F
P
K
A
Site 12
S255
H
S
V
M
T
Y
L
S
Q
F
P
K
A
K
L
Site 13
Y313
G
V
G
E
V
L
V
Y
I
E
D
P
E
G
H
Site 14
T335
P
N
N
D
K
D
R
T
Y
A
V
S
Y
V
P
Site 15
Y336
N
N
D
K
D
R
T
Y
A
V
S
Y
V
P
K
Site 16
S339
K
D
R
T
Y
A
V
S
Y
V
P
K
V
A
G
Site 17
S362
A
G
Q
N
I
E
R
S
P
F
E
V
N
V
G
Site 18
S379
L
G
D
A
N
K
V
S
A
R
G
P
G
L
E
Site 19
Y397
N
V
A
N
K
P
T
Y
F
D
I
Y
T
A
G
Site 20
Y401
K
P
T
Y
F
D
I
Y
T
A
G
A
G
T
G
Site 21
T402
P
T
Y
F
D
I
Y
T
A
G
A
G
T
G
D
Site 22
T423
D
P
Q
G
R
R
D
T
V
E
V
A
L
E
D
Site 23
T435
L
E
D
K
G
D
S
T
F
R
C
T
Y
R
P
Site 24
T439
G
D
S
T
F
R
C
T
Y
R
P
A
M
E
G
Site 25
Y440
D
S
T
F
R
C
T
Y
R
P
A
M
E
G
P
Site 26
S469
S
P
F
P
V
H
V
S
E
A
C
N
P
N
A
Site 27
S480
N
P
N
A
C
R
A
S
G
R
G
L
Q
P
K
Site 28
T512
G
S
G
E
L
K
V
T
V
K
G
P
K
G
T
Site 29
Y537
D
G
V
F
E
C
E
Y
Y
P
V
V
P
G
K
Site 30
Y538
G
V
F
E
C
E
Y
Y
P
V
V
P
G
K
Y
Site 31
Y545
Y
P
V
V
P
G
K
Y
V
V
T
I
T
W
G
Site 32
S559
G
G
Y
A
I
P
R
S
P
F
E
V
Q
V
S
Site 33
S566
S
P
F
E
V
Q
V
S
P
E
A
G
V
Q
K
Site 34
S589
E
T
G
Q
V
G
K
S
A
D
F
V
V
E
A
Site 35
S612
G
F
S
I
E
G
P
S
Q
A
K
I
E
C
D
Site 36
Y630
D
G
S
C
D
V
R
Y
W
P
T
E
P
G
E
Site 37
Y638
W
P
T
E
P
G
E
Y
A
V
H
V
I
C
D
Site 38
S652
D
D
E
D
I
R
D
S
P
F
I
A
H
I
L
Site 39
Y705
G
K
G
D
L
K
L
Y
A
Q
D
A
D
G
C
Site 40
T725
V
I
P
N
G
D
G
T
F
R
C
S
Y
V
P
Site 41
S729
G
D
G
T
F
R
C
S
Y
V
P
T
K
P
I
Site 42
Y730
N
G
T
F
R
C
S
Y
V
P
T
K
P
I
K
Site 43
T733
F
R
C
S
Y
V
P
T
K
P
I
K
H
T
I
Site 44
T739
P
T
K
P
I
K
H
T
I
I
I
S
W
G
G
Site 45
S752
G
G
V
N
V
P
K
S
P
F
R
V
N
V
G
Site 46
Y770
H
P
E
R
V
K
V
Y
G
P
G
V
E
K
T
Site 47
Y786
L
K
A
N
E
P
T
Y
F
T
V
D
C
S
E
Site 48
T788
A
N
E
P
T
Y
F
T
V
D
C
S
E
A
G
Site 49
S792
T
Y
F
T
V
D
C
S
E
A
G
Q
G
D
V
Site 50
S800
E
A
G
Q
G
D
V
S
I
G
I
K
C
A
P
Site 51
T828
I
I
K
N
D
N
D
T
F
T
V
K
Y
T
P
Site 52
T830
K
N
D
N
D
T
F
T
V
K
Y
T
P
P
G
Site 53
Y833
N
D
T
F
T
V
K
Y
T
P
P
G
A
G
R
Site 54
T834
D
T
F
T
V
K
Y
T
P
P
G
A
G
R
Y
Site 55
S855
A
N
Q
E
I
P
A
S
P
F
H
I
K
V
D
Site 56
S864
F
H
I
K
V
D
P
S
H
D
A
S
K
V
K
Site 57
S868
V
D
P
S
H
D
A
S
K
V
K
A
E
G
P
Site 58
T880
E
G
P
G
L
N
R
T
G
V
E
V
G
K
P
Site 59
Y926
E
I
I
D
N
H
D
Y
S
Y
T
V
K
Y
T
Site 60
Y928
I
D
N
H
D
Y
S
Y
T
V
K
Y
T
A
V
Site 61
Y932
D
Y
S
Y
T
V
K
Y
T
A
V
Q
Q
G
N
Site 62
T943
Q
Q
G
N
M
A
V
T
V
T
Y
G
G
D
P
Site 63
S987
V
G
Q
E
Q
A
F
S
V
N
T
R
G
A
G
Site 64
T1004
G
Q
L
D
V
R
M
T
S
P
S
R
R
P
I
Site 65
S1005
Q
L
D
V
R
M
T
S
P
S
R
R
P
I
P
Site 66
S1007
D
V
R
M
T
S
P
S
R
R
P
I
P
C
K
Site 67
Y1028
A
E
A
Q
A
V
R
Y
M
P
P
E
E
G
P
Site 68
Y1036
M
P
P
E
E
G
P
Y
K
V
D
I
T
Y
D
Site 69
T1041
G
P
Y
K
V
D
I
T
Y
D
G
H
P
V
P
Site 70
Y1042
P
Y
K
V
D
I
T
Y
D
G
H
P
V
P
G
Site 71
S1050
D
G
H
P
V
P
G
S
P
F
A
V
E
G
V
Site 72
S1063
G
V
L
P
P
D
P
S
K
V
C
A
Y
G
P
Site 73
Y1068
D
P
S
K
V
C
A
Y
G
P
G
L
K
G
G
Site 74
T1079
L
K
G
G
L
V
G
T
P
A
P
F
S
I
D
Site 75
S1084
V
G
T
P
A
P
F
S
I
D
T
K
G
A
G
Site 76
T1087
P
A
P
F
S
I
D
T
K
G
A
G
T
G
G
Site 77
S1116
C
Q
D
N
G
D
G
S
C
A
V
S
Y
L
P
Site 78
S1120
G
D
G
S
C
A
V
S
Y
L
P
T
E
P
G
Site 79
Y1121
D
G
S
C
A
V
S
Y
L
P
T
E
P
G
E
Site 80
S1143
A
E
A
H
I
P
G
S
P
F
K
A
T
I
R
Site 81
T1148
P
G
S
P
F
K
A
T
I
R
P
V
F
D
P
Site 82
S1156
I
R
P
V
F
D
P
S
K
V
R
A
S
G
P
Site 83
S1161
D
P
S
K
V
R
A
S
G
P
G
L
E
R
G
Site 84
T1175
G
K
V
G
E
A
A
T
F
T
V
D
C
S
E
Site 85
T1211
I
H
N
N
A
D
G
T
Y
H
I
T
Y
S
P
Site 86
Y1212
H
N
N
A
D
G
T
Y
H
I
T
Y
S
P
A
Site 87
T1215
A
D
G
T
Y
H
I
T
Y
S
P
A
F
P
G
Site 88
Y1216
D
G
T
Y
H
I
T
Y
S
P
A
F
P
G
T
Site 89
S1217
G
T
Y
H
I
T
Y
S
P
A
F
P
G
T
Y
Site 90
T1223
Y
S
P
A
F
P
G
T
Y
T
I
T
I
K
Y
Site 91
T1227
F
P
G
T
Y
T
I
T
I
K
Y
G
G
H
P
Site 92
S1256
D
T
S
G
V
K
V
S
G
P
G
V
E
P
H
Site 93
T1270
H
G
V
L
R
E
V
T
T
E
F
T
V
D
A
Site 94
T1274
R
E
V
T
T
E
F
T
V
D
A
R
S
L
T
Site 95
S1279
E
F
T
V
D
A
R
S
L
T
A
T
G
G
N
Site 96
T1281
T
V
D
A
R
S
L
T
A
T
G
G
N
H
V
Site 97
T1283
D
A
R
S
L
T
A
T
G
G
N
H
V
T
A
Site 98
T1289
A
T
G
G
N
H
V
T
A
R
V
L
N
P
S
Site 99
S1296
T
A
R
V
L
N
P
S
G
A
K
T
D
T
Y
Site 100
T1300
L
N
P
S
G
A
K
T
D
T
Y
V
T
D
N
Site 101
T1302
P
S
G
A
K
T
D
T
Y
V
T
D
N
G
D
Site 102
Y1303
S
G
A
K
T
D
T
Y
V
T
D
N
G
D
G
Site 103
T1311
V
T
D
N
G
D
G
T
Y
R
V
Q
Y
T
A
Site 104
Y1312
T
D
N
G
D
G
T
Y
R
V
Q
Y
T
A
Y
Site 105
Y1316
D
G
T
Y
R
V
Q
Y
T
A
Y
E
E
G
V
Site 106
Y1319
Y
R
V
Q
Y
T
A
Y
E
E
G
V
H
L
V
Site 107
S1338
D
E
V
A
V
P
K
S
P
F
R
V
G
V
T
Site 108
T1351
V
T
E
G
C
D
P
T
R
V
R
A
F
G
P
Site 109
T1372
V
N
K
A
N
R
F
T
V
E
T
R
G
A
G
Site 110
T1375
A
N
R
F
T
V
E
T
R
G
A
G
T
G
G
Site 111
T1406
D
N
K
D
G
S
C
T
V
E
Y
I
P
F
T
Site 112
Y1409
D
G
S
C
T
V
E
Y
I
P
F
T
P
G
D
Site 113
T1413
T
V
E
Y
I
P
F
T
P
G
D
Y
D
V
N
Site 114
T1422
G
D
Y
D
V
N
I
T
F
G
G
R
P
I
P
Site 115
S1431
G
G
R
P
I
P
G
S
P
F
R
V
P
V
K
Site 116
S1449
D
P
G
K
V
K
C
S
G
P
G
L
G
A
G
Site 117
T1464
V
R
A
R
V
P
Q
T
F
T
V
D
C
S
Q
Site 118
T1466
A
R
V
P
Q
T
F
T
V
D
C
S
Q
A
G
Site 119
S1470
Q
T
F
T
V
D
C
S
Q
A
G
R
A
P
L
Site 120
T1500
V
R
D
N
G
D
G
T
H
T
V
H
Y
T
P
Site 121
T1502
D
N
G
D
G
T
H
T
V
H
Y
T
P
A
T
Site 122
Y1505
D
G
T
H
T
V
H
Y
T
P
A
T
D
G
P
Site 123
T1506
G
T
H
T
V
H
Y
T
P
A
T
D
G
P
Y
Site 124
T1509
T
V
H
Y
T
P
A
T
D
G
P
Y
T
V
A
Site 125
Y1513
T
P
A
T
D
G
P
Y
T
V
A
V
K
Y
A
Site 126
T1514
P
A
T
D
G
P
Y
T
V
A
V
K
Y
A
D
Site 127
Y1519
P
Y
T
V
A
V
K
Y
A
D
Q
E
V
P
R
Site 128
S1527
A
D
Q
E
V
P
R
S
P
F
K
I
K
V
L
Site 129
S1540
V
L
P
A
H
D
A
S
K
V
R
A
S
G
P
Site 130
S1545
D
A
S
K
V
R
A
S
G
P
G
L
N
A
S
Site 131
S1552
S
G
P
G
L
N
A
S
G
I
P
A
S
L
P
Site 132
T1597
I
R
D
N
G
D
G
T
Y
T
V
S
Y
L
P
Site 133
Y1598
R
D
N
G
D
G
T
Y
A
V
S
Y
L
P
D
Site 134
T1599
D
N
G
D
G
T
Y
T
V
S
Y
L
P
D
M
Site 135
S1601
G
D
G
T
Y
T
V
S
Y
L
P
D
M
S
G
Site 136
Y1602
D
G
T
Y
T
V
S
Y
L
P
D
M
S
G
R
Site 137
T1611
P
D
M
S
G
R
Y
T
I
T
I
K
Y
G
G
Site 138
Y1616
R
Y
T
I
T
I
K
Y
G
G
D
E
I
P
Y
Site 139
Y1623
Y
G
G
D
E
I
P
Y
S
P
F
R
I
H
A
Site 140
S1624
G
G
D
E
I
P
Y
S
P
F
R
I
H
A
L
Site 141
T1679
A
A
G
E
G
K
V
T
C
T
V
S
T
P
D
Site 142
T1681
G
E
G
K
V
T
C
T
V
S
T
P
D
G
A
Site 143
S1683
G
K
V
T
C
T
V
S
T
P
D
G
A
E
L
Site 144
T1684
K
V
T
C
T
V
S
T
P
D
G
A
E
L
D
Site 145
T1701
V
V
E
N
H
D
G
T
F
D
I
Y
Y
T
A
Site 146
Y1705
H
D
G
T
F
D
I
Y
Y
T
A
P
E
P
G
Site 147
Y1706
D
G
T
F
D
I
Y
Y
T
A
P
E
P
G
K
Site 148
Y1714
T
A
P
E
P
G
K
Y
V
I
T
I
R
F
G
Site 149
T1717
E
P
G
K
Y
V
I
T
I
R
F
G
G
E
H
Site 150
S1745
L
P
H
E
E
E
P
S
E
V
P
Q
L
R
Q
Site 151
Y1754
V
P
Q
L
R
Q
P
Y
A
P
P
R
P
G
A
Site 152
T1764
P
R
P
G
A
R
P
T
H
W
A
T
E
E
P
Site 153
T1768
A
R
P
T
H
W
A
T
E
E
P
V
V
P
V
Site 154
S1806
T
G
E
V
R
M
P
S
G
K
T
A
R
P
N
Site 155
T1809
V
R
M
P
S
G
K
T
A
R
P
N
I
T
D
Site 156
T1821
I
T
D
N
K
D
G
T
I
T
V
R
Y
A
P
Site 157
T1823
D
N
K
D
G
T
I
T
V
R
Y
A
P
T
E
Site 158
Y1826
D
G
T
I
T
V
R
Y
A
P
T
E
K
G
L
Site 159
Y1840
L
H
Q
M
G
I
K
Y
D
G
N
H
I
P
G
Site 160
S1848
D
G
N
H
I
P
G
S
P
L
Q
F
Y
V
D
Site 161
Y1853
P
G
S
P
L
Q
F
Y
V
D
A
I
N
S
R
Site 162
S1863
A
I
N
S
R
H
V
S
A
Y
G
P
G
L
S
Site 163
Y1865
N
S
R
H
V
S
A
Y
G
P
G
L
S
H
G
Site 164
S1870
S
A
Y
G
P
G
L
S
H
G
M
V
N
K
P
Site 165
T1879
G
M
V
N
K
P
A
T
F
T
I
V
T
K
D
Site 166
S1893
D
A
G
E
G
G
L
S
L
A
V
E
G
P
S
Site 167
T1913
C
K
D
N
K
D
G
T
C
T
V
S
Y
L
P
Site 168
T1915
D
N
K
D
G
T
C
T
V
S
Y
L
P
T
A
Site 169
S1917
K
D
G
T
C
T
V
S
Y
L
P
T
A
P
G
Site 170
Y1918
D
G
T
C
T
V
S
Y
L
P
T
A
P
G
D
Site 171
S1927
P
T
A
P
G
D
Y
S
I
I
V
R
F
D
D
Site 172
S1940
D
D
K
H
I
P
G
S
P
F
T
A
K
I
T
Site 173
T1947
S
P
F
T
A
K
I
T
G
D
D
S
M
R
T
Site 174
S1951
A
K
I
T
G
D
D
S
M
R
T
S
Q
L
N
Site 175
S1955
G
D
D
S
M
R
T
S
Q
L
N
V
G
T
S
Site 176
S1962
S
Q
L
N
V
G
T
S
T
D
V
S
L
K
I
Site 177
S1966
V
G
T
S
T
D
V
S
L
K
I
T
E
S
D
Site 178
T1970
T
D
V
S
L
K
I
T
E
S
D
L
S
Q
L
Site 179
S1972
V
S
L
K
I
T
E
S
D
L
S
Q
L
T
A
Site 180
S1975
K
I
T
E
S
D
L
S
Q
L
T
A
S
I
R
Site 181
S1980
D
L
S
Q
L
T
A
S
I
R
A
P
S
G
N
Site 182
S1985
T
A
S
I
R
A
P
S
G
N
E
E
P
C
L
Site 183
S2004
P
N
R
H
I
G
I
S
F
T
P
K
E
V
G
Site 184
T2006
R
H
I
G
I
S
F
T
P
K
E
V
G
E
H
Site 185
S2016
E
V
G
E
H
V
V
S
V
R
K
S
G
K
H
Site 186
S2020
H
V
V
S
V
R
K
S
G
K
H
V
T
N
S
Site 187
T2025
R
K
S
G
K
H
V
T
N
S
P
F
K
I
L
Site 188
S2027
S
G
K
H
V
T
N
S
P
F
K
I
L
V
G
Site 189
S2042
P
S
E
I
G
D
A
S
K
V
R
V
W
G
K
Site 190
S2052
R
V
W
G
K
G
L
S
E
G
H
T
F
Q
V
Site 191
T2056
K
G
L
S
E
G
H
T
F
Q
V
A
E
F
I
Site 192
T2099
E
D
G
T
C
K
V
T
Y
C
P
T
E
P
G
Site 193
Y2100
D
G
T
C
K
V
T
Y
C
P
T
E
P
G
T
Site 194
S2122
A
D
K
H
V
P
G
S
P
F
T
V
K
V
T
Site 195
T2125
H
V
P
G
S
P
F
T
V
K
V
T
G
E
G
Site 196
S2137
G
E
G
R
M
K
E
S
I
T
R
R
R
Q
A
Site 197
T2139
G
R
M
K
E
S
I
T
R
R
R
Q
A
P
S
Site 198
S2146
T
R
R
R
Q
A
P
S
I
A
T
I
G
S
T
Site 199
S2152
P
S
I
A
T
I
G
S
T
C
D
L
N
L
K
Site 200
T2175
V
S
A
Q
E
R
L
T
R
T
F
T
R
S
S
Site 201
T2177
A
Q
E
R
L
T
R
T
F
T
R
S
S
H
T
Site 202
T2179
E
R
L
T
R
T
F
T
R
S
S
H
T
Y
T
Site 203
S2181
L
T
R
T
F
T
R
S
S
H
T
Y
T
R
T
Site 204
S2182
T
R
T
F
T
R
S
S
H
T
Y
T
R
T
E
Site 205
Y2185
F
T
R
S
S
H
T
Y
T
R
T
E
R
T
E
Site 206
T2186
T
R
S
S
H
T
Y
T
R
T
E
R
T
E
I
Site 207
T2188
S
S
H
T
Y
T
R
T
E
R
T
E
I
S
K
Site 208
S2194
R
T
E
R
T
E
I
S
K
T
R
G
G
E
T
Site 209
T2196
E
R
T
E
I
S
K
T
R
G
G
E
T
K
R
Site 210
S2210
R
E
V
R
V
E
E
S
T
Q
V
G
G
D
P
Site 211
T2211
E
V
R
V
E
E
S
T
Q
V
G
G
D
P
F
Site 212
S2233
L
G
R
E
R
L
G
S
F
G
S
I
T
R
Q
Site 213
S2236
E
R
L
G
S
F
G
S
I
T
R
Q
Q
E
G
Site 214
T2238
L
G
S
F
G
S
I
T
R
Q
Q
E
G
E
A
Site 215
S2246
R
Q
Q
E
G
E
A
S
S
Q
D
M
T
A
Q
Site 216
T2251
E
A
S
S
Q
D
M
T
A
Q
V
T
S
P
S
Site 217
S2256
D
M
T
A
Q
V
T
S
P
S
G
K
V
E
A
Site 218
S2272
E
I
V
E
G
E
D
S
A
Y
S
V
R
F
V
Site 219
Y2274
V
E
G
E
D
S
A
Y
S
V
R
F
V
P
Q
Site 220
S2275
E
G
E
D
S
A
Y
S
V
R
F
V
P
Q
E
Site 221
T2287
P
Q
E
M
G
P
H
T
V
A
V
K
Y
R
G
Site 222
S2300
R
G
Q
H
V
P
G
S
P
F
Q
F
T
V
G
Site 223
T2305
P
G
S
P
F
Q
F
T
V
G
P
L
G
E
G
Site 224
S2336
A
G
V
P
A
E
F
S
I
W
T
R
E
A
G
Site 225
S2368
F
E
D
R
K
D
G
S
C
G
V
S
Y
V
V
Site 226
S2372
K
D
G
S
C
G
V
S
Y
V
V
Q
E
P
G
Site 227
Y2373
D
G
S
C
G
V
S
Y
V
V
Q
E
P
G
D
Site 228
Y2381
V
V
Q
E
P
G
D
Y
E
V
S
I
K
F
N
Site 229
S2395
N
D
E
H
I
P
D
S
P
F
V
V
P
V
A
Site 230
S2403
P
F
V
V
P
V
A
S
L
S
D
D
A
R
R
Site 231
S2405
V
V
P
V
A
S
L
S
D
D
A
R
R
L
T
Site 232
T2412
S
D
D
A
R
R
L
T
V
T
S
L
Q
E
T
Site 233
T2414
D
A
R
R
L
T
V
T
S
L
Q
E
T
G
L
Site 234
S2415
A
R
R
L
T
V
T
S
L
Q
E
T
G
L
K
Site 235
T2446
V
I
D
A
R
V
H
T
P
S
G
A
V
E
E
Site 236
S2448
D
A
R
V
H
T
P
S
G
A
V
E
E
C
Y
Site 237
Y2455
S
G
A
V
E
E
C
Y
V
S
E
L
D
S
D
Site 238
S2457
A
V
E
E
C
Y
V
S
E
L
D
S
D
K
H
Site 239
S2461
C
Y
V
S
E
L
D
S
D
K
H
T
I
R
F
Site 240
T2465
E
L
D
S
D
K
H
T
I
R
F
I
P
H
E
Site 241
S2490
N
G
A
H
I
P
G
S
P
F
K
I
R
V
G
Site 242
S2500
K
I
R
V
G
E
Q
S
Q
A
G
D
P
G
L
Site 243
T2519
G
P
G
L
E
G
G
T
T
G
V
S
S
E
F
Site 244
T2520
P
G
L
E
G
G
T
T
G
V
S
S
E
F
I
Site 245
Y2563
P
E
G
H
V
V
T
Y
T
P
M
A
P
G
N
Site 246
T2564
E
G
H
V
V
T
Y
T
P
M
A
P
G
N
Y
Site 247
Y2577
N
Y
L
I
A
I
K
Y
G
G
P
Q
H
I
V
Site 248
S2586
G
P
Q
H
I
V
G
S
P
F
K
A
K
V
T
Site 249
T2593
S
P
F
K
A
K
V
T
G
P
R
L
S
G
G
Site 250
S2598
K
V
T
G
P
R
L
S
G
G
H
S
L
H
E
Site 251
S2602
P
R
L
S
G
G
H
S
L
H
E
T
S
T
V
Site 252
T2606
G
G
H
S
L
H
E
T
S
T
V
L
V
E
T
Site 253
T2613
T
S
T
V
L
V
E
T
V
T
K
S
S
S
S
Site 254
T2615
T
V
L
V
E
T
V
T
K
S
S
S
S
R
G
Site 255
S2617
L
V
E
T
V
T
K
S
S
S
S
R
G
S
S
Site 256
S2618
V
E
T
V
T
K
S
S
S
S
R
G
S
S
Y
Site 257
S2619
E
T
V
T
K
S
S
S
S
R
G
S
S
Y
S
Site 258
S2620
T
V
T
K
S
S
S
S
R
G
S
S
Y
S
S
Site 259
S2623
K
S
S
S
S
R
G
S
S
Y
S
S
I
P
K
Site 260
S2624
S
S
S
S
R
G
S
S
Y
S
S
I
P
K
F
Site 261
Y2625
S
S
S
R
G
S
S
Y
S
S
I
P
K
F
S
Site 262
S2626
S
S
R
G
S
S
Y
S
S
I
P
K
F
S
S
Site 263
S2627
S
R
G
S
S
Y
S
S
I
P
K
F
S
S
D
Site 264
S2632
Y
S
S
I
P
K
F
S
S
D
A
S
K
V
V
Site 265
S2633
S
S
I
P
K
F
S
S
D
A
S
K
V
V
T
Site 266
S2636
P
K
F
S
S
D
A
S
K
V
V
T
R
G
P
Site 267
T2640
S
D
A
S
K
V
V
T
R
G
P
G
L
S
Q
Site 268
S2646
V
T
R
G
P
G
L
S
Q
A
F
V
G
Q
K
Site 269
S2655
A
F
V
G
Q
K
N
S
F
T
V
D
C
S
K
Site 270
T2657
V
G
Q
K
N
S
F
T
V
D
C
S
K
A
G
Site 271
T2677
V
G
V
H
G
P
K
T
P
C
E
E
V
Y
V
Site 272
Y2683
K
T
P
C
E
E
V
Y
V
K
H
M
G
N
R
Site 273
Y2692
K
H
M
G
N
R
V
Y
N
V
T
Y
T
V
K
Site 274
T2695
G
N
R
V
Y
N
V
T
Y
T
V
K
E
K
G
Site 275
Y2696
N
R
V
Y
N
V
T
Y
T
V
K
E
K
G
D
Site 276
T2697
R
V
Y
N
V
T
Y
T
V
K
E
K
G
D
Y
Site 277
Y2704
T
V
K
E
K
G
D
Y
I
L
I
V
K
W
G
Site 278
S2714
I
V
K
W
G
D
E
S
V
P
G
S
P
F
K
Site 279
S2718
G
D
E
S
V
P
G
S
P
F
K
V
K
V
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation