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Updated November 2019
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Protein Info
Short Name:
NPAT
Full Name:
Protein NPAT
Alias:
E14; Nuclear protein, ataxia-telangiectasia locus; P220
Type:
Transcription regulation; Cell cycle regulation
Mass (Da):
154291
Number AA:
1427
UniProt ID:
Q14207
International Prot ID:
IPI00290547
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015030
Uniprot
OncoNet
Molecular Function:
GO:0008022
GO:0047485
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0000083
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
Q
T
F
I
L
E
S
S
D
L
K
E
Y
A
E
Site 2
Y66
L
T
T
I
L
N
E
Y
V
A
M
K
T
K
E
Site 3
T71
N
E
Y
V
A
M
K
T
K
E
T
S
N
N
V
Site 4
S84
N
V
P
A
I
M
S
S
L
W
K
K
L
D
H
Site 5
T92
L
W
K
K
L
D
H
T
L
S
Q
I
R
S
M
Site 6
S94
K
K
L
D
H
T
L
S
Q
I
R
S
M
Q
S
Site 7
S98
H
T
L
S
Q
I
R
S
M
Q
S
S
P
R
F
Site 8
S101
S
Q
I
R
S
M
Q
S
S
P
R
F
A
G
S
Site 9
S102
Q
I
R
S
M
Q
S
S
P
R
F
A
G
S
Q
Site 10
S108
S
S
P
R
F
A
G
S
Q
R
A
R
T
R
T
Site 11
T113
A
G
S
Q
R
A
R
T
R
T
G
I
A
E
I
Site 12
T115
S
Q
R
A
R
T
R
T
G
I
A
E
I
K
R
Site 13
S128
K
R
Q
R
K
L
A
S
Q
T
A
P
A
S
A
Site 14
T148
P
Y
L
S
G
Q
F
T
T
P
P
S
T
G
T
Site 15
T149
Y
L
S
G
Q
F
T
T
P
P
S
T
G
T
Q
Site 16
S152
G
Q
F
T
T
P
P
S
T
G
T
Q
V
T
R
Site 17
T155
T
T
P
P
S
T
G
T
Q
V
T
R
P
S
G
Site 18
S161
G
T
Q
V
T
R
P
S
G
Q
I
S
D
P
S
Site 19
S165
T
R
P
S
G
Q
I
S
D
P
S
R
S
Y
F
Site 20
S168
S
G
Q
I
S
D
P
S
R
S
Y
F
V
V
V
Site 21
S170
Q
I
S
D
P
S
R
S
Y
F
V
V
V
N
H
Site 22
Y171
I
S
D
P
S
R
S
Y
F
V
V
V
N
H
S
Site 23
S178
Y
F
V
V
V
N
H
S
Q
S
Q
D
T
V
T
Site 24
S180
V
V
V
N
H
S
Q
S
Q
D
T
V
T
T
G
Site 25
T183
N
H
S
Q
S
Q
D
T
V
T
T
G
E
A
L
Site 26
T185
S
Q
S
Q
D
T
V
T
T
G
E
A
L
N
V
Site 27
S204
Q
E
K
K
A
H
A
S
L
M
S
P
G
R
R
Site 28
S207
K
A
H
A
S
L
M
S
P
G
R
R
K
S
E
Site 29
S213
M
S
P
G
R
R
K
S
E
S
Q
R
K
S
T
Site 30
S215
P
G
R
R
K
S
E
S
Q
R
K
S
T
T
L
Site 31
S219
K
S
E
S
Q
R
K
S
T
T
L
S
G
P
H
Site 32
T220
S
E
S
Q
R
K
S
T
T
L
S
G
P
H
S
Site 33
T221
E
S
Q
R
K
S
T
T
L
S
G
P
H
S
T
Site 34
S223
Q
R
K
S
T
T
L
S
G
P
H
S
T
I
R
Site 35
S227
T
T
L
S
G
P
H
S
T
I
R
N
F
Q
D
Site 36
T228
T
L
S
G
P
H
S
T
I
R
N
F
Q
D
P
Site 37
S255
N
A
R
E
K
I
L
S
N
K
S
L
Q
E
K
Site 38
S258
E
K
I
L
S
N
K
S
L
Q
E
K
L
A
E
Site 39
S294
N
P
T
E
P
E
T
S
I
D
E
F
L
G
L
Site 40
S308
L
P
S
E
I
H
M
S
E
E
A
I
Q
D
I
Site 41
S321
D
I
L
E
Q
T
E
S
D
P
A
F
Q
A
L
Site 42
Y334
A
L
F
D
L
F
D
Y
G
K
T
K
N
N
K
Site 43
S344
T
K
N
N
K
N
I
S
Q
S
I
S
S
Q
P
Site 44
S346
N
N
K
N
I
S
Q
S
I
S
S
Q
P
M
E
Site 45
S348
K
N
I
S
Q
S
I
S
S
Q
P
M
E
S
N
Site 46
S349
N
I
S
Q
S
I
S
S
Q
P
M
E
S
N
P
Site 47
S357
Q
P
M
E
S
N
P
S
I
V
L
A
D
E
T
Site 48
S371
T
N
L
A
V
K
G
S
F
E
T
E
E
S
D
Site 49
S377
G
S
F
E
T
E
E
S
D
G
Q
S
G
Q
P
Site 50
S381
T
E
E
S
D
G
Q
S
G
Q
P
A
F
C
T
Site 51
Y390
Q
P
A
F
C
T
S
Y
Q
N
D
D
P
L
N
Site 52
S417
Q
E
D
Q
E
N
F
S
Q
I
S
T
S
I
Q
Site 53
T421
E
N
F
S
Q
I
S
T
S
I
Q
K
K
A
F
Site 54
S422
N
F
S
Q
I
S
T
S
I
Q
K
K
A
F
K
Site 55
T430
I
Q
K
K
A
F
K
T
A
V
P
T
E
Q
K
Site 56
T443
Q
K
C
D
I
D
I
T
F
E
S
V
P
N
L
Site 57
S446
D
I
D
I
T
F
E
S
V
P
N
L
N
D
F
Site 58
Y471
N
P
H
C
A
E
L
Y
T
N
Q
M
S
T
E
Site 59
S489
A
I
G
I
E
K
N
S
L
S
S
N
V
P
S
Site 60
S491
G
I
E
K
N
S
L
S
S
N
V
P
S
E
S
Site 61
S492
I
E
K
N
S
L
S
S
N
V
P
S
E
S
Q
Site 62
S496
S
L
S
S
N
V
P
S
E
S
Q
L
Q
P
D
Site 63
S498
S
S
N
V
P
S
E
S
Q
L
Q
P
D
Q
P
Site 64
S527
N
N
E
N
L
I
L
S
G
K
S
S
Q
L
L
Site 65
S530
N
L
I
L
S
G
K
S
S
Q
L
L
S
Q
D
Site 66
S531
L
I
L
S
G
K
S
S
Q
L
L
S
Q
D
T
Site 67
S535
G
K
S
S
Q
L
L
S
Q
D
T
S
L
T
G
Site 68
S539
Q
L
L
S
Q
D
T
S
L
T
G
K
P
S
K
Site 69
T541
L
S
Q
D
T
S
L
T
G
K
P
S
K
K
S
Site 70
S545
T
S
L
T
G
K
P
S
K
K
S
Q
F
C
E
Site 71
S548
T
G
K
P
S
K
K
S
Q
F
C
E
N
S
N
Site 72
T557
F
C
E
N
S
N
D
T
V
K
L
K
I
N
F
Site 73
S567
L
K
I
N
F
H
G
S
K
S
S
D
S
S
E
Site 74
S569
I
N
F
H
G
S
K
S
S
D
S
S
E
V
H
Site 75
S570
N
F
H
G
S
K
S
S
D
S
S
E
V
H
K
Site 76
S572
H
G
S
K
S
S
D
S
S
E
V
H
K
S
K
Site 77
S573
G
S
K
S
S
D
S
S
E
V
H
K
S
K
I
Site 78
S578
D
S
S
E
V
H
K
S
K
I
E
I
N
V
L
Site 79
S590
N
V
L
E
P
V
M
S
Q
L
S
N
C
Q
D
Site 80
S593
E
P
V
M
S
Q
L
S
N
C
Q
D
N
S
C
Site 81
S599
L
S
N
C
Q
D
N
S
C
L
Q
S
E
I
L
Site 82
S603
Q
D
N
S
C
L
Q
S
E
I
L
P
V
S
V
Site 83
S609
Q
S
E
I
L
P
V
S
V
E
S
S
H
L
N
Site 84
S613
L
P
V
S
V
E
S
S
H
L
N
V
S
G
Q
Site 85
S618
E
S
S
H
L
N
V
S
G
Q
V
E
I
H
L
Site 86
S628
V
E
I
H
L
G
D
S
L
S
S
T
K
Q
P
Site 87
S630
I
H
L
G
D
S
L
S
S
T
K
Q
P
S
N
Site 88
T632
L
G
D
S
L
S
S
T
K
Q
P
S
N
D
S
Site 89
S636
L
S
S
T
K
Q
P
S
N
D
S
A
S
V
E
Site 90
S639
T
K
Q
P
S
N
D
S
A
S
V
E
L
N
H
Site 91
S641
Q
P
S
N
D
S
A
S
V
E
L
N
H
T
E
Site 92
T647
A
S
V
E
L
N
H
T
E
N
E
A
Q
A
S
Site 93
S654
T
E
N
E
A
Q
A
S
K
S
E
N
S
Q
E
Site 94
S656
N
E
A
Q
A
S
K
S
E
N
S
Q
E
P
S
Site 95
S659
Q
A
S
K
S
E
N
S
Q
E
P
S
S
S
V
Site 96
S663
S
E
N
S
Q
E
P
S
S
S
V
K
E
E
N
Site 97
S664
E
N
S
Q
E
P
S
S
S
V
K
E
E
N
T
Site 98
S665
N
S
Q
E
P
S
S
S
V
K
E
E
N
T
I
Site 99
T671
S
S
V
K
E
E
N
T
I
F
L
S
L
G
G
Site 100
T688
N
C
E
K
V
A
L
T
P
P
E
G
T
P
V
Site 101
T693
A
L
T
P
P
E
G
T
P
V
E
N
S
H
S
Site 102
S698
E
G
T
P
V
E
N
S
H
S
L
P
P
E
S
Site 103
S700
T
P
V
E
N
S
H
S
L
P
P
E
S
V
C
Site 104
S705
S
H
S
L
P
P
E
S
V
C
S
S
V
G
D
Site 105
S708
L
P
P
E
S
V
C
S
S
V
G
D
S
H
P
Site 106
S709
P
P
E
S
V
C
S
S
V
G
D
S
H
P
E
Site 107
S713
V
C
S
S
V
G
D
S
H
P
E
S
Q
N
T
Site 108
S717
V
G
D
S
H
P
E
S
Q
N
T
D
D
K
P
Site 109
T720
S
H
P
E
S
Q
N
T
D
D
K
P
S
S
N
Site 110
S725
Q
N
T
D
D
K
P
S
S
N
N
S
A
E
I
Site 111
S726
N
T
D
D
K
P
S
S
N
N
S
A
E
I
D
Site 112
S729
D
K
P
S
S
N
N
S
A
E
I
D
A
S
N
Site 113
S751
I
S
D
D
P
F
V
S
S
D
T
E
L
T
S
Site 114
S752
S
D
D
P
F
V
S
S
D
T
E
L
T
S
A
Site 115
T754
D
P
F
V
S
S
D
T
E
L
T
S
A
V
S
Site 116
T757
V
S
S
D
T
E
L
T
S
A
V
S
S
I
N
Site 117
S758
S
S
D
T
E
L
T
S
A
V
S
S
I
N
G
Site 118
S762
E
L
T
S
A
V
S
S
I
N
G
E
N
L
P
Site 119
S774
N
L
P
T
I
I
L
S
S
P
T
K
S
P
T
Site 120
S775
L
P
T
I
I
L
S
S
P
T
K
S
P
T
K
Site 121
S779
I
L
S
S
P
T
K
S
P
T
K
N
A
E
L
Site 122
T781
S
S
P
T
K
S
P
T
K
N
A
E
L
V
K
Site 123
S807
V
Y
A
E
V
G
D
S
A
S
M
E
Q
S
L
Site 124
S809
A
E
V
G
D
S
A
S
M
E
Q
S
L
L
T
Site 125
S813
D
S
A
S
M
E
Q
S
L
L
T
F
K
S
E
Site 126
T816
S
M
E
Q
S
L
L
T
F
K
S
E
D
S
A
Site 127
S819
Q
S
L
L
T
F
K
S
E
D
S
A
V
N
N
Site 128
S881
D
P
T
A
L
G
T
S
V
S
Q
S
N
V
V
Site 129
T898
P
G
N
S
A
P
M
T
A
Q
P
L
P
P
Q
Site 130
T908
P
L
P
P
Q
L
Q
T
P
P
R
S
N
S
V
Site 131
S912
Q
L
Q
T
P
P
R
S
N
S
V
F
A
V
N
Site 132
S914
Q
T
P
P
R
S
N
S
V
F
A
V
N
Q
A
Site 133
S923
F
A
V
N
Q
A
V
S
P
N
F
S
Q
G
S
Site 134
S962
G
Q
N
G
N
N
F
S
T
P
P
R
E
V
L
Site 135
T963
Q
N
G
N
N
F
S
T
P
P
R
E
V
L
H
Site 136
S981
T
A
P
V
C
N
R
S
I
P
Q
F
P
V
P
Site 137
S991
Q
F
P
V
P
P
K
S
Q
K
A
Q
G
L
R
Site 138
S1013
Q
V
N
N
L
V
D
S
S
G
H
S
V
G
C
Site 139
S1017
L
V
D
S
S
G
H
S
V
G
C
H
A
Q
K
Site 140
S1028
H
A
Q
K
T
E
V
S
D
K
S
I
A
T
D
Site 141
S1031
K
T
E
V
S
D
K
S
I
A
T
D
L
G
K
Site 142
S1040
A
T
D
L
G
K
K
S
E
E
T
T
V
P
F
Site 143
T1043
L
G
K
K
S
E
E
T
T
V
P
F
P
E
E
Site 144
T1044
G
K
K
S
E
E
T
T
V
P
F
P
E
E
S
Site 145
S1051
T
V
P
F
P
E
E
S
I
V
P
A
A
K
P
Site 146
S1068
R
R
V
L
C
F
D
S
T
T
A
P
V
A
N
Site 147
S1085
G
P
N
H
K
M
V
S
Q
N
K
E
R
N
A
Site 148
S1094
N
K
E
R
N
A
V
S
F
P
N
L
D
S
P
Site 149
S1100
V
S
F
P
N
L
D
S
P
N
V
S
S
T
L
Site 150
S1104
N
L
D
S
P
N
V
S
S
T
L
K
P
P
S
Site 151
S1105
L
D
S
P
N
V
S
S
T
L
K
P
P
S
N
Site 152
T1106
D
S
P
N
V
S
S
T
L
K
P
P
S
N
N
Site 153
S1111
S
S
T
L
K
P
P
S
N
N
A
I
K
R
E
Site 154
S1129
P
P
L
P
K
I
L
S
K
S
E
S
A
I
S
Site 155
S1131
L
P
K
I
L
S
K
S
E
S
A
I
S
R
H
Site 156
S1133
K
I
L
S
K
S
E
S
A
I
S
R
H
T
T
Site 157
T1139
E
S
A
I
S
R
H
T
T
I
R
E
T
Q
S
Site 158
T1140
S
A
I
S
R
H
T
T
I
R
E
T
Q
S
E
Site 159
T1144
R
H
T
T
I
R
E
T
Q
S
E
K
K
V
S
Site 160
S1151
T
Q
S
E
K
K
V
S
P
T
E
I
V
L
E
Site 161
S1159
P
T
E
I
V
L
E
S
F
H
K
A
T
A
N
Site 162
S1173
N
K
E
N
E
L
C
S
D
V
E
R
Q
K
N
Site 163
S1187
N
P
E
N
S
K
L
S
I
G
Q
Q
N
G
G
Site 164
S1197
Q
Q
N
G
G
L
R
S
E
K
S
I
A
S
L
Site 165
S1200
G
G
L
R
S
E
K
S
I
A
S
L
Q
E
M
Site 166
S1203
R
S
E
K
S
I
A
S
L
Q
E
M
T
K
K
Site 167
S1214
M
T
K
K
Q
G
T
S
S
N
N
K
N
V
L
Site 168
S1215
T
K
K
Q
G
T
S
S
N
N
K
N
V
L
S
Site 169
S1222
S
N
N
K
N
V
L
S
V
G
T
A
V
K
D
Site 170
T1235
K
D
L
K
Q
E
Q
T
K
S
A
S
S
L
I
Site 171
S1237
L
K
Q
E
Q
T
K
S
A
S
S
L
I
T
T
Site 172
T1243
K
S
A
S
S
L
I
T
T
E
M
L
Q
D
I
Site 173
T1244
S
A
S
S
L
I
T
T
E
M
L
Q
D
I
Q
Site 174
S1254
L
Q
D
I
Q
R
H
S
S
V
S
R
L
A
D
Site 175
S1255
Q
D
I
Q
R
H
S
S
V
S
R
L
A
D
S
Site 176
S1257
I
Q
R
H
S
S
V
S
R
L
A
D
S
S
D
Site 177
S1263
V
S
R
L
A
D
S
S
D
L
P
V
P
R
T
Site 178
T1270
S
D
L
P
V
P
R
T
P
G
S
G
A
G
E
Site 179
S1273
P
V
P
R
T
P
G
S
G
A
G
E
K
H
K
Site 180
S1291
I
D
I
I
K
A
P
S
S
R
R
F
S
E
D
Site 181
S1292
D
I
I
K
A
P
S
S
R
R
F
S
E
D
S
Site 182
S1296
A
P
S
S
R
R
F
S
E
D
S
S
T
S
K
Site 183
S1299
S
R
R
F
S
E
D
S
S
T
S
K
V
M
V
Site 184
S1300
R
R
F
S
E
D
S
S
T
S
K
V
M
V
P
Site 185
T1301
R
F
S
E
D
S
S
T
S
K
V
M
V
P
P
Site 186
S1302
F
S
E
D
S
S
T
S
K
V
M
V
P
P
V
Site 187
S1317
T
P
D
L
P
A
C
S
P
A
S
E
T
G
S
Site 188
S1320
L
P
A
C
S
P
A
S
E
T
G
S
E
N
S
Site 189
S1324
S
P
A
S
E
T
G
S
E
N
S
V
N
M
A
Site 190
S1327
S
E
T
G
S
E
N
S
V
N
M
A
A
H
T
Site 191
T1346
S
R
A
A
I
S
R
T
T
S
A
T
P
L
K
Site 192
T1347
R
A
A
I
S
R
T
T
S
A
T
P
L
K
D
Site 193
S1348
A
A
I
S
R
T
T
S
A
T
P
L
K
D
N
Site 194
T1350
I
S
R
T
T
S
A
T
P
L
K
D
N
T
Q
Site 195
T1356
A
T
P
L
K
D
N
T
Q
Q
F
R
A
S
S
Site 196
S1362
N
T
Q
Q
F
R
A
S
S
R
S
T
T
K
K
Site 197
S1363
T
Q
Q
F
R
A
S
S
R
S
T
T
K
K
R
Site 198
S1365
Q
F
R
A
S
S
R
S
T
T
K
K
R
K
I
Site 199
T1366
F
R
A
S
S
R
S
T
T
K
K
R
K
I
E
Site 200
T1367
R
A
S
S
R
S
T
T
K
K
R
K
I
E
E
Site 201
S1382
L
D
E
R
E
R
N
S
R
P
S
S
K
N
L
Site 202
S1385
R
E
R
N
S
R
P
S
S
K
N
L
T
N
S
Site 203
S1386
E
R
N
S
R
P
S
S
K
N
L
T
N
S
S
Site 204
T1390
R
P
S
S
K
N
L
T
N
S
S
I
P
M
K
Site 205
S1392
S
S
K
N
L
T
N
S
S
I
P
M
K
K
K
Site 206
S1393
S
K
N
L
T
N
S
S
I
P
M
K
K
K
K
Site 207
S1408
I
K
K
K
K
L
P
S
S
F
P
A
G
M
D
Site 208
S1409
K
K
K
K
L
P
S
S
F
P
A
G
M
D
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation