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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IKKe
Full Name:
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Alias:
EC 2.7.11.10; I kappa-B kinase epsilon; IkBKE; IKKE; IKKI; KIAA0151
Type:
Protein-serine kinase, Other group, IKK family
Mass (Da):
80462
Number AA:
716
UniProt ID:
Q14164
International Prot ID:
IPI00029045
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008384
GO:0004704
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0043123
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Inhibitor of nuclear factor kappa-B kinase subunit epsilon S172 phosphosite-specific antibody AB-PK660#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK660#Inhibitor of nuclear factor kappa-B kinase subunit epsilon (K169-G175, human) pS172 phosphopeptide - Powder PE-04AMW99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AMW99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
L
G
Q
G
A
T
A
S
V
Y
K
A
R
N
K
Site 2
Y24
Q
G
A
T
A
S
V
Y
K
A
R
N
K
K
S
Site 3
S31
Y
K
A
R
N
K
K
S
G
E
L
V
A
V
K
Site 4
S44
V
K
V
F
N
T
T
S
Y
L
R
P
R
E
V
Site 5
Y45
K
V
F
N
T
T
S
Y
L
R
P
R
E
V
Q
Site 6
S96
C
S
S
G
S
L
L
S
V
L
E
S
P
E
N
Site 7
S151
L
V
G
E
E
G
Q
S
I
Y
K
L
T
D
F
Site 8
S172
D
D
D
E
K
F
V
S
V
Y
G
T
E
E
Y
Inhibitor of nuclear factor kappa-B kinase subunit epsilon S172 phosphosite-specific antibody AB-PK660#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK660#Inhibitor of nuclear factor kappa-B kinase subunit epsilon (K169-G175, human) pS172 phosphopeptide - Powder PE-04AMW99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AMW99
Site 9
T176
K
F
V
S
V
Y
G
T
E
E
Y
L
H
P
D
Site 10
Y179
S
V
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
Site 11
Y185
E
Y
L
H
P
D
M
Y
E
R
A
V
L
R
K
Site 12
T238
K
E
I
M
Y
R
I
T
T
E
K
P
A
G
A
Site 13
T239
E
I
M
Y
R
I
T
T
E
K
P
A
G
A
I
Site 14
Y261
N
G
P
L
E
W
S
Y
T
L
P
I
T
C
Q
Site 15
Y352
V
A
P
R
H
Q
E
Y
L
F
E
G
H
L
C
Site 16
T373
S
A
Q
H
I
A
H
T
T
A
S
S
P
L
T
Site 17
Y412
K
V
D
L
Q
A
D
Y
N
T
A
K
G
V
L
Site 18
T457
L
Q
A
T
C
R
R
T
L
E
V
A
R
T
S
Site 19
S469
R
T
S
L
L
Y
L
S
S
S
L
G
T
E
R
Site 20
S470
T
S
L
L
Y
L
S
S
S
L
G
T
E
R
F
Site 21
S471
S
L
L
Y
L
S
S
S
L
G
T
E
R
F
S
Site 22
T474
Y
L
S
S
S
L
G
T
E
R
F
S
S
V
A
Site 23
S478
S
L
G
T
E
R
F
S
S
V
A
G
T
P
E
Site 24
S479
L
G
T
E
R
F
S
S
V
A
G
T
P
E
I
Site 25
T483
R
F
S
S
V
A
G
T
P
E
I
Q
E
L
K
Site 26
T501
E
L
R
S
R
L
R
T
L
A
E
V
L
S
R
Site 27
S507
R
T
L
A
E
V
L
S
R
C
S
Q
N
I
T
Site 28
S510
A
E
V
L
S
R
C
S
Q
N
I
T
E
T
Q
Site 29
T514
S
R
C
S
Q
N
I
T
E
T
Q
E
S
L
S
Site 30
T516
C
S
Q
N
I
T
E
T
Q
E
S
L
S
S
L
Site 31
S519
N
I
T
E
T
Q
E
S
L
S
S
L
N
R
E
Site 32
S522
E
T
Q
E
S
L
S
S
L
N
R
E
L
V
K
Site 33
S530
L
N
R
E
L
V
K
S
R
D
Q
V
H
E
D
Site 34
Y554
L
D
K
M
N
F
I
Y
K
Q
F
K
K
S
R
Site 35
S560
I
Y
K
Q
F
K
K
S
R
M
R
P
G
L
G
Site 36
Y568
R
M
R
P
G
L
G
Y
N
E
E
Q
I
H
K
Site 37
Y600
Q
E
E
C
V
Q
K
Y
Q
A
S
L
V
T
H
Site 38
T617
R
M
R
V
V
H
E
T
R
N
H
L
R
L
V
Site 39
S641
E
A
Q
G
V
Q
E
S
L
S
K
L
L
E
E
Site 40
S650
S
K
L
L
E
E
L
S
H
Q
L
L
Q
D
R
Site 41
S664
R
A
K
G
A
Q
A
S
P
P
P
I
A
P
Y
Site 42
Y671
S
P
P
P
I
A
P
Y
P
S
P
T
R
K
D
Site 43
S673
P
P
I
A
P
Y
P
S
P
T
R
K
D
L
L
Site 44
T675
I
A
P
Y
P
S
P
T
R
K
D
L
L
L
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation