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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCRIB
Full Name:
Protein scribble homolog
Alias:
CRIB1; KIAA0147; LAP4; Protein scribble homologue; SCRB1; VARTUL
Type:
Adhesion protein
Mass (Da):
174885
Number AA:
1630
UniProt ID:
Q14160
International Prot ID:
IPI00425560
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005913
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0032863
GO:0060561
GO:0016477
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
S
V
D
K
R
H
C
S
L
Q
A
V
P
E
E
Site 2
Y32
Q
A
V
P
E
E
I
Y
R
Y
S
R
S
L
E
Site 3
Y34
V
P
E
E
I
Y
R
Y
S
R
S
L
E
E
L
Site 4
S35
P
E
E
I
Y
R
Y
S
R
S
L
E
E
L
L
Site 5
S37
E
I
Y
R
Y
S
R
S
L
E
E
L
L
L
D
Site 6
S67
N
L
R
K
L
G
L
S
D
N
E
I
Q
R
L
Site 7
S90
Q
L
V
E
L
D
V
S
R
N
D
I
P
E
I
Site 8
S118
D
F
S
G
N
P
L
S
R
L
P
D
G
F
T
Site 9
T125
S
R
L
P
D
G
F
T
Q
L
R
S
L
A
H
Site 10
S210
W
L
D
R
N
Q
L
S
A
L
P
P
E
L
G
Site 11
S228
R
L
V
C
L
D
V
S
E
N
R
L
E
E
L
Site 12
T282
Q
N
R
L
C
E
V
T
E
A
I
G
D
C
E
Site 13
S292
I
G
D
C
E
N
L
S
E
L
I
L
T
E
N
Site 14
T357
L
P
P
E
L
A
H
T
T
E
L
H
V
L
D
Site 15
T400
Q
P
M
L
R
F
Q
T
E
D
D
A
R
T
G
Site 16
T412
R
T
G
E
K
V
L
T
C
Y
L
L
P
Q
Q
Site 17
Y414
G
E
K
V
L
T
C
Y
L
L
P
Q
Q
P
P
Site 18
S423
L
P
Q
Q
P
P
P
S
L
E
D
A
G
Q
Q
Site 19
S432
E
D
A
G
Q
Q
G
S
L
S
E
T
W
S
D
Site 20
S434
A
G
Q
Q
G
S
L
S
E
T
W
S
D
A
P
Site 21
T436
Q
Q
G
S
L
S
E
T
W
S
D
A
P
P
S
Site 22
S438
G
S
L
S
E
T
W
S
D
A
P
P
S
R
V
Site 23
S443
T
W
S
D
A
P
P
S
R
V
S
V
I
Q
F
Site 24
T475
R
G
L
Q
R
R
A
T
P
H
P
S
E
L
K
Site 25
S487
E
L
K
V
M
K
R
S
I
E
G
R
R
S
E
Site 26
S493
R
S
I
E
G
R
R
S
E
A
C
P
C
Q
P
Site 27
S502
A
C
P
C
Q
P
D
S
G
S
P
L
P
A
E
Site 28
S504
P
C
Q
P
D
S
G
S
P
L
P
A
E
E
E
Site 29
S515
A
E
E
E
K
R
L
S
A
E
S
G
L
S
E
Site 30
S518
E
K
R
L
S
A
E
S
G
L
S
E
D
S
R
Site 31
S521
L
S
A
E
S
G
L
S
E
D
S
R
P
S
A
Site 32
S524
E
S
G
L
S
E
D
S
R
P
S
A
S
T
V
Site 33
S527
L
S
E
D
S
R
P
S
A
S
T
V
S
E
A
Site 34
S529
E
D
S
R
P
S
A
S
T
V
S
E
A
E
P
Site 35
T530
D
S
R
P
S
A
S
T
V
S
E
A
E
P
E
Site 36
Y564
E
E
D
A
E
E
D
Y
Q
E
P
T
V
H
F
Site 37
T568
E
E
D
Y
Q
E
P
T
V
H
F
A
E
D
A
Site 38
T594
G
Q
P
E
A
P
W
T
L
P
G
G
R
Q
R
Site 39
T607
Q
R
L
I
R
K
D
T
P
H
Y
K
K
H
F
Site 40
Y610
I
R
K
D
T
P
H
Y
K
K
H
F
K
I
S
Site 41
S668
E
E
E
E
E
E
G
S
P
Q
E
E
E
V
E
Site 42
S688
R
A
E
E
E
E
A
S
T
E
E
E
D
K
E
Site 43
T689
A
E
E
E
E
A
S
T
E
E
E
D
K
E
G
Site 44
S700
D
K
E
G
A
V
V
S
A
P
S
V
K
G
V
Site 45
S703
G
A
V
V
S
A
P
S
V
K
G
V
S
F
D
Site 46
S708
A
P
S
V
K
G
V
S
F
D
Q
A
N
N
L
Site 47
T728
R
I
E
E
E
E
L
T
L
T
I
L
R
Q
T
Site 48
T730
E
E
E
E
L
T
L
T
I
L
R
Q
T
G
G
Site 49
T735
T
L
T
I
L
R
Q
T
G
G
L
G
I
S
I
Site 50
S741
Q
T
G
G
L
G
I
S
I
A
G
G
K
G
S
Site 51
S748
S
I
A
G
G
K
G
S
T
P
Y
K
G
D
D
Site 52
T749
I
A
G
G
K
G
S
T
P
Y
K
G
D
D
E
Site 53
Y751
G
G
K
G
S
T
P
Y
K
G
D
D
E
G
I
Site 54
S761
D
D
E
G
I
F
I
S
R
V
S
E
E
G
P
Site 55
S764
G
I
F
I
S
R
V
S
E
E
G
P
A
A
R
Site 56
T824
V
E
P
E
N
A
V
T
I
T
P
L
R
P
E
Site 57
T826
P
E
N
A
V
T
I
T
P
L
R
P
E
D
D
Site 58
Y834
P
L
R
P
E
D
D
Y
S
P
R
E
R
R
G
Site 59
S835
L
R
P
E
D
D
Y
S
P
R
E
R
R
G
G
Site 60
S853
L
P
L
L
P
P
E
S
P
G
P
L
R
Q
R
Site 61
S875
S
E
R
G
L
G
F
S
I
A
G
G
K
G
S
Site 62
S882
S
I
A
G
G
K
G
S
T
P
Y
R
A
G
D
Site 63
T883
I
A
G
G
K
G
S
T
P
Y
R
A
G
D
A
Site 64
Y885
G
G
K
G
S
T
P
Y
R
A
G
D
A
G
I
Site 65
T908
G
A
A
H
R
A
G
T
L
Q
V
G
D
R
V
Site 66
T924
S
I
N
G
V
D
V
T
E
A
R
H
D
H
A
Site 67
S933
A
R
H
D
H
A
V
S
L
L
T
A
A
S
P
Site 68
T936
D
H
A
V
S
L
L
T
A
A
S
P
T
I
A
Site 69
S939
V
S
L
L
T
A
A
S
P
T
I
A
L
L
L
Site 70
T941
L
L
T
A
A
S
P
T
I
A
L
L
L
E
R
Site 71
S957
A
G
G
P
L
P
P
S
P
L
P
H
S
S
P
Site 72
S962
P
P
S
P
L
P
H
S
S
P
P
T
A
A
V
Site 73
S963
P
S
P
L
P
H
S
S
P
P
T
A
A
V
A
Site 74
T966
L
P
H
S
S
P
P
T
A
A
V
A
T
T
S
Site 75
S973
T
A
A
V
A
T
T
S
I
T
T
A
T
P
G
Site 76
T976
V
A
T
T
S
I
T
T
A
T
P
G
V
P
G
Site 77
Y1000
A
A
A
L
E
G
P
Y
P
V
E
E
I
R
L
Site 78
S1022
G
L
S
I
V
G
G
S
D
H
S
S
H
P
F
Site 79
S1025
I
V
G
G
S
D
H
S
S
H
P
F
G
V
Q
Site 80
S1026
V
G
G
S
D
H
S
S
H
P
F
G
V
Q
E
Site 81
S1050
P
R
G
L
A
A
R
S
G
L
R
V
G
D
R
Site 82
T1070
G
Q
D
V
R
D
A
T
H
Q
E
A
V
S
A
Site 83
S1086
L
R
P
C
L
E
L
S
L
L
V
R
R
D
P
Site 84
S1114
P
G
E
R
L
G
I
S
I
R
G
G
A
R
G
Site 85
T1130
A
G
N
P
R
D
P
T
D
E
G
I
F
I
S
Site 86
S1137
T
D
E
G
I
F
I
S
K
V
S
P
T
G
A
Site 87
S1140
G
I
F
I
S
K
V
S
P
T
G
A
A
G
R
Site 88
T1142
F
I
S
K
V
S
P
T
G
A
A
G
R
D
G
Site 89
S1220
A
G
I
G
H
R
N
S
L
E
S
I
S
S
I
Site 90
S1223
G
H
R
N
S
L
E
S
I
S
S
I
D
R
E
Site 91
S1225
R
N
S
L
E
S
I
S
S
I
D
R
E
L
S
Site 92
S1226
N
S
L
E
S
I
S
S
I
D
R
E
L
S
P
Site 93
S1232
S
S
I
D
R
E
L
S
P
E
G
P
G
K
E
Site 94
Y1268
L
Q
P
L
K
L
D
Y
R
A
L
A
A
V
P
Site 95
S1276
R
A
L
A
A
V
P
S
A
G
S
V
Q
R
V
Site 96
S1279
A
A
V
P
S
A
G
S
V
Q
R
V
P
S
G
Site 97
S1285
G
S
V
Q
R
V
P
S
G
A
A
G
G
K
M
Site 98
S1295
A
G
G
K
M
A
E
S
P
C
S
P
S
G
Q
Site 99
S1298
K
M
A
E
S
P
C
S
P
S
G
Q
Q
P
P
Site 100
S1300
A
E
S
P
C
S
P
S
G
Q
Q
P
P
S
P
Site 101
S1306
P
S
G
Q
Q
P
P
S
P
P
S
P
D
E
L
Site 102
S1309
Q
Q
P
P
S
P
P
S
P
D
E
L
P
A
N
Site 103
S1330
A
F
A
A
V
P
T
S
H
P
P
E
D
A
P
Site 104
T1342
D
A
P
A
Q
P
P
T
P
G
P
A
A
S
P
Site 105
S1348
P
T
P
G
P
A
A
S
P
E
Q
L
S
F
R
Site 106
S1353
A
A
S
P
E
Q
L
S
F
R
E
R
Q
K
Y
Site 107
Y1360
S
F
R
E
R
Q
K
Y
F
E
L
E
V
R
V
Site 108
S1378
E
G
P
P
K
R
V
S
L
V
G
A
D
D
L
Site 109
S1437
D
E
Q
P
P
W
A
S
P
S
P
T
S
R
Q
Site 110
S1439
Q
P
P
W
A
S
P
S
P
T
S
R
Q
S
P
Site 111
T1441
P
W
A
S
P
S
P
T
S
R
Q
S
P
A
S
Site 112
S1442
W
A
S
P
S
P
T
S
R
Q
S
P
A
S
P
Site 113
S1445
P
S
P
T
S
R
Q
S
P
A
S
P
P
P
L
Site 114
S1448
T
S
R
Q
S
P
A
S
P
P
P
L
G
G
G
Site 115
S1475
Q
E
R
L
R
V
Q
S
P
E
P
P
A
P
E
Site 116
S1486
P
A
P
E
R
A
L
S
P
A
E
L
R
A
L
Site 117
S1508
W
R
A
A
R
M
K
S
L
E
Q
D
A
L
R
Site 118
S1521
L
R
A
Q
M
V
L
S
R
S
Q
E
G
R
G
Site 119
S1523
A
Q
M
V
L
S
R
S
Q
E
G
R
G
T
R
Site 120
T1529
R
S
Q
E
G
R
G
T
R
G
P
L
E
R
L
Site 121
S1541
E
R
L
A
E
A
P
S
P
A
P
T
P
S
P
Site 122
T1545
E
A
P
S
P
A
P
T
P
S
P
T
P
V
E
Site 123
S1547
P
S
P
A
P
T
P
S
P
T
P
V
E
D
L
Site 124
T1549
P
A
P
T
P
S
P
T
P
V
E
D
L
G
P
Site 125
T1558
V
E
D
L
G
P
Q
T
S
T
S
P
G
R
L
Site 126
S1559
E
D
L
G
P
Q
T
S
T
S
P
G
R
L
S
Site 127
T1560
D
L
G
P
Q
T
S
T
S
P
G
R
L
S
P
Site 128
S1561
L
G
P
Q
T
S
T
S
P
G
R
L
S
P
D
Site 129
S1566
S
T
S
P
G
R
L
S
P
D
F
A
E
E
L
Site 130
S1575
D
F
A
E
E
L
R
S
L
E
P
S
P
S
P
Site 131
S1579
E
L
R
S
L
E
P
S
P
S
P
G
P
Q
E
Site 132
S1581
R
S
L
E
P
S
P
S
P
G
P
Q
E
E
D
Site 133
S1613
P
E
D
V
A
L
C
S
S
R
R
P
V
R
P
Site 134
S1614
E
D
V
A
L
C
S
S
R
R
P
V
R
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation