PhosphoNET

           
Protein Info 
   
Short Name:  AML2
Full Name:  Runt-related transcription factor 3
Alias:  Acute myeloid leukemia 2 protein; CBFA3; CBF-alpha 3; Core-binding factor, alpha 3; Oncogene AML-2; PEA2-alpha C; PEBP2A3; PEBP2-alpha C; Polyomavirus enhancer binding protein 2 alpha C subunit; SL3/AKV core-binding factor alpha C; SL3-3 enhancer factor 1 alpha C
Type:  Transcription protein
Mass (Da):  44356
Number AA:  415
UniProt ID:  Q13761
International Prot ID:  IPI00004015
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005515  GO:0003700 PhosphoSite+ KinaseNET
Biological Process:  GO:0008283  GO:0006917  GO:0045786 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S8MRIPVDPSTSRRFTP
Site 2T9RIPVDPSTSRRFTPP
Site 3S10IPVDPSTSRRFTPPS
Site 4T14PSTSRRFTPPSPAFP
Site 5S17SRRFTPPSPAFPCGG
Site 6S33GGKMGENSGALSAQA
Site 7S37GENSGALSAQAAVGP
Site 8S54RARPEVRSMVDVLAD
Site 9T69HAGELVRTDSPNFLC
Site 10S71GELVRTDSPNFLCSV
Site 11S77DSPNFLCSVLPSHWR
Site 12Y117MAGNDENYSAELRNA
Site 13S125SAELRNASAVMKNQV
Site 14S144DLRFVGRSGRGKSFT
Site 15S149GRSGRGKSFTLTITV
Site 16T151SGRGKSFTLTITVFT
Site 17T153RGKSFTLTITVFTNP
Site 18T155KSFTLTITVFTNPTQ
Site 19T173YHRAIKVTVDGPREP
Site 20T209ERLRMRVTPSTPSPR
Site 21S211LRMRVTPSTPSPRGS
Site 22T212RMRVTPSTPSPRGSL
Site 23S214RVTPSTPSPRGSLST
Site 24S218STPSPRGSLSTTSHF
Site 25S220PSPRGSLSTTSHFSS
Site 26T221SPRGSLSTTSHFSSQ
Site 27T222PRGSLSTTSHFSSQP
Site 28S223RGSLSTTSHFSSQPQ
Site 29S226LSTTSHFSSQPQTPI
Site 30S227STTSHFSSQPQTPIQ
Site 31T231HFSSQPQTPIQGTSE
Site 32S237QTPIQGTSELNPFSD
Site 33S243TSELNPFSDPRQFDR
Site 34S251DPRQFDRSFPTLPTL
Site 35T254QFDRSFPTLPTLTES
Site 36T257RSFPTLPTLTESRFP
Site 37T259FPTLPTLTESRFPDP
Site 38S261TLPTLTESRFPDPRM
Site 39Y270FPDPRMHYPGAMSAA
Site 40Y280AMSAAFPYSATPSGT
Site 41S281MSAAFPYSATPSGTS
Site 42T283AAFPYSATPSGTSIS
Site 43S285FPYSATPSGTSISSL
Site 44T287YSATPSGTSISSLSV
Site 45T300SVAGMPATSRFHHTY
Site 46T306ATSRFHHTYLPPPYP
Site 47Y307TSRFHHTYLPPPYPG
Site 48Y312HTYLPPPYPGAPQNQ
Site 49S328GPFQANPSPYHLYYG
Site 50Y333NPSPYHLYYGTSSGS
Site 51Y334PSPYHLYYGTSSGSY
Site 52T336PYHLYYGTSSGSYQF
Site 53S337YHLYYGTSSGSYQFS
Site 54S338HLYYGTSSGSYQFSM
Site 55Y341YGTSSGSYQFSMVAG
Site 56S344SSGSYQFSMVAGSSS
Site 57S349QFSMVAGSSSGGDRS
Site 58S351SMVAGSSSGGDRSPT
Site 59S356SSSGGDRSPTRMLAS
Site 60T358SGGDRSPTRMLASCT
Site 61S363SPTRMLASCTSSAAS
Site 62S380AGNLMNPSLGGQSDG
Site 63S393DGVEADGSHSNSPTA
Site 64S395VEADGSHSNSPTALS
Site 65S397ADGSHSNSPTALSTP
Site 66T399GSHSNSPTALSTPGR
Site 67S402SNSPTALSTPGRMDE
Site 68T403NSPTALSTPGRMDEA
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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