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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IQGAP2
Full Name:
Stromal interaction molecule 1
Alias:
IQ motif containing GTPase activating protein 2; IQGA2
Type:
Intracellular, Actin cytoskeleton protein
Mass (Da):
180613
Number AA:
1575
UniProt ID:
Q13586
International Prot ID:
IPI00299048
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030176
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0032237
GO:0006816
GO:0005513
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
L
L
L
H
Q
G
Q
S
L
S
H
S
H
S
E
Site 2
T173
R
L
A
V
T
N
T
T
M
T
G
T
V
L
K
Site 3
Y236
F
A
Y
I
Q
N
R
Y
S
K
E
H
M
K
K
Site 4
S257
G
L
H
R
A
E
Q
S
L
H
D
L
Q
E
R
Site 5
T274
K
A
Q
E
E
H
R
T
V
E
V
E
K
V
H
Site 6
T307
L
K
E
L
R
E
G
T
E
N
E
R
S
R
Q
Site 7
S312
E
G
T
E
N
E
R
S
R
Q
K
Y
A
E
E
Site 8
Y316
N
E
R
S
R
Q
K
Y
A
E
E
E
L
E
Q
Site 9
S337
K
A
E
K
E
L
E
S
H
S
S
W
Y
A
P
Site 10
S339
E
K
E
L
E
S
H
S
S
W
Y
A
P
E
A
Site 11
S340
K
E
L
E
S
H
S
S
W
Y
A
P
E
A
L
Site 12
T354
L
Q
K
W
L
Q
L
T
H
E
V
E
V
Q
Y
Site 13
Y361
T
H
E
V
E
V
Q
Y
Y
N
I
K
K
Q
N
Site 14
Y362
H
E
V
E
V
Q
Y
Y
N
I
K
K
Q
N
A
Site 15
T389
K
I
K
K
K
R
N
T
L
F
G
T
F
H
V
Site 16
T393
K
R
N
T
L
F
G
T
F
H
V
A
H
S
S
Site 17
S401
F
H
V
A
H
S
S
S
L
D
D
V
D
H
K
Site 18
T420
K
Q
A
L
S
E
V
T
A
A
L
R
E
R
L
Site 19
S459
A
A
L
N
I
D
P
S
W
M
G
S
T
R
P
Site 20
S463
I
D
P
S
W
M
G
S
T
R
P
N
P
A
H
Site 21
S486
D
M
D
E
E
I
V
S
P
L
S
M
Q
S
P
Site 22
S489
E
E
I
V
S
P
L
S
M
Q
S
P
S
L
Q
Site 23
S492
V
S
P
L
S
M
Q
S
P
S
L
Q
S
S
V
Site 24
S494
P
L
S
M
Q
S
P
S
L
Q
S
S
V
R
Q
Site 25
S498
Q
S
P
S
L
Q
S
S
V
R
Q
R
L
T
E
Site 26
T504
S
S
V
R
Q
R
L
T
E
P
Q
H
G
L
G
Site 27
S512
E
P
Q
H
G
L
G
S
Q
R
D
L
T
H
S
Site 28
T517
L
G
S
Q
R
D
L
T
H
S
D
S
E
S
S
Site 29
S519
S
Q
R
D
L
T
H
S
D
S
E
S
S
L
H
Site 30
S521
R
D
L
T
H
S
D
S
E
S
S
L
H
M
S
Site 31
S523
L
T
H
S
D
S
E
S
S
L
H
M
S
D
R
Site 32
S524
T
H
S
D
S
E
S
S
L
H
M
S
D
R
Q
Site 33
S528
S
E
S
S
L
H
M
S
D
R
Q
R
V
A
P
Site 34
S553
E
A
L
N
A
M
T
S
N
G
S
H
R
L
I
Site 35
S556
N
A
M
T
S
N
G
S
H
R
L
I
E
G
V
Site 36
S567
I
E
G
V
H
P
G
S
L
V
E
K
L
P
D
Site 37
S575
L
V
E
K
L
P
D
S
P
A
L
A
K
K
A
Site 38
S595
H
G
L
D
K
A
H
S
L
M
E
L
S
P
S
Site 39
S600
A
H
S
L
M
E
L
S
P
S
A
P
P
G
G
Site 40
S602
S
L
M
E
L
S
P
S
A
P
P
G
G
S
P
Site 41
S608
P
S
A
P
P
G
G
S
P
H
L
D
S
S
R
Site 42
S613
G
G
S
P
H
L
D
S
S
R
S
H
S
P
S
Site 43
S614
G
S
P
H
L
D
S
S
R
S
H
S
P
S
S
Site 44
S616
P
H
L
D
S
S
R
S
H
S
P
S
S
P
D
Site 45
S618
L
D
S
S
R
S
H
S
P
S
S
P
D
P
D
Site 46
S620
S
S
R
S
H
S
P
S
S
P
D
P
D
T
P
Site 47
S621
S
R
S
H
S
P
S
S
P
D
P
D
T
P
S
Site 48
T626
P
S
S
P
D
P
D
T
P
S
P
V
G
D
S
Site 49
S628
S
P
D
P
D
T
P
S
P
V
G
D
S
R
A
Site 50
S639
D
S
R
A
L
Q
A
S
R
N
T
R
I
P
H
Site 51
T642
A
L
Q
A
S
R
N
T
R
I
P
H
L
A
G
Site 52
S660
V
A
E
E
D
N
G
S
I
G
E
E
T
D
S
Site 53
T665
N
G
S
I
G
E
E
T
D
S
S
P
G
R
K
Site 54
S667
S
I
G
E
E
T
D
S
S
P
G
R
K
K
F
Site 55
S668
I
G
E
E
T
D
S
S
P
G
R
K
K
F
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation