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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HDAC1
Full Name:
Histone deacetylase 1
Alias:
GON-10; HD1; RPD3L1
Type:
EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator
Mass (Da):
55103
Number AA:
482
UniProt ID:
Q13547
International Prot ID:
IPI00013774
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016581
GO:0016580
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004407
GO:0042826
GO:0042802
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006338
GO:0016575
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
G
T
R
R
K
V
C
Y
Y
Y
D
G
D
V
G
Site 2
Y14
T
R
R
K
V
C
Y
Y
Y
D
G
D
V
G
N
Site 3
Y15
R
R
K
V
C
Y
Y
Y
D
G
D
V
G
N
Y
Site 4
Y22
Y
D
G
D
V
G
N
Y
Y
Y
G
Q
G
H
P
Site 5
Y23
D
G
D
V
G
N
Y
Y
Y
G
Q
G
H
P
M
Site 6
Y24
G
D
V
G
N
Y
Y
Y
G
Q
G
H
P
M
K
Site 7
T38
K
P
H
R
I
R
M
T
H
N
L
L
L
N
Y
Site 8
Y45
T
H
N
L
L
L
N
Y
G
L
Y
R
K
M
E
Site 9
Y48
L
L
L
N
Y
G
L
Y
R
K
M
E
I
Y
R
Site 10
Y54
L
Y
R
K
M
E
I
Y
R
P
H
K
A
N
A
Site 11
Y67
N
A
E
E
M
T
K
Y
H
S
D
D
Y
I
K
Site 12
Y72
T
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
Site 13
S78
D
Y
I
K
F
L
R
S
I
R
P
D
N
M
S
Site 14
S85
S
I
R
P
D
N
M
S
E
Y
S
K
Q
M
Q
Site 15
Y87
R
P
D
N
M
S
E
Y
S
K
Q
M
Q
R
F
Site 16
S145
G
L
H
H
A
K
K
S
E
A
S
G
F
C
Y
Site 17
Y172
K
Y
H
Q
R
V
L
Y
I
D
I
D
I
H
H
Site 18
Y188
D
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
Site 19
T189
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Site 20
T195
Y
T
T
D
R
V
M
T
V
S
F
H
K
Y
G
Site 21
Y201
M
T
V
S
F
H
K
Y
G
E
Y
F
P
G
T
Site 22
Y204
S
F
H
K
Y
G
E
Y
F
P
G
T
G
D
L
Site 23
T208
Y
G
E
Y
F
P
G
T
G
D
L
R
D
I
G
Site 24
Y221
I
G
A
G
K
G
K
Y
Y
A
V
N
Y
P
L
Site 25
Y222
G
A
G
K
G
K
Y
Y
A
V
N
Y
P
L
R
Site 26
Y226
G
K
Y
Y
A
V
N
Y
P
L
R
D
G
I
D
Site 27
S236
R
D
G
I
D
D
E
S
Y
E
A
I
F
K
P
Site 28
Y237
D
G
I
D
D
E
S
Y
E
A
I
F
K
P
V
Site 29
S263
A
V
V
L
Q
C
G
S
D
S
L
S
G
D
R
Site 30
S265
V
L
Q
C
G
S
D
S
L
S
G
D
R
L
G
Site 31
S267
Q
C
G
S
D
S
L
S
G
D
R
L
G
C
F
Site 32
T313
R
N
V
A
R
C
W
T
Y
E
T
A
V
A
L
Site 33
T322
E
T
A
V
A
L
D
T
E
I
P
N
E
L
P
Site 34
Y330
E
I
P
N
E
L
P
Y
N
D
Y
F
E
Y
F
Site 35
Y333
N
E
L
P
Y
N
D
Y
F
E
Y
F
G
P
D
Site 36
Y336
P
Y
N
D
Y
F
E
Y
F
G
P
D
F
K
L
Site 37
S346
P
D
F
K
L
H
I
S
P
S
N
M
T
N
Q
Site 38
Y358
T
N
Q
N
T
N
E
Y
L
E
K
I
K
Q
R
Site 39
S393
E
D
A
I
P
E
E
S
G
D
E
D
E
D
D
Site 40
S406
D
D
P
D
K
R
I
S
I
C
S
S
D
K
R
Site 41
S409
D
K
R
I
S
I
C
S
S
D
K
R
I
A
C
Site 42
S410
K
R
I
S
I
C
S
S
D
K
R
I
A
C
E
Site 43
S421
I
A
C
E
E
E
F
S
D
S
E
E
E
G
E
Site 44
S423
C
E
E
E
F
S
D
S
E
E
E
G
E
G
G
Site 45
S434
G
E
G
G
R
K
N
S
S
N
F
K
K
A
K
Site 46
S435
E
G
G
R
K
N
S
S
N
F
K
K
A
K
R
Site 47
T445
K
K
A
K
R
V
K
T
E
D
E
K
E
K
D
Site 48
T465
E
V
T
E
E
E
K
T
K
E
E
K
P
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation