PhosphoNET

           
Protein Info 
   
Short Name:  4E-BP1
Full Name:  Eukaryotic translation initiation factor 4E-binding protein 1
Alias:  4EBP1; EIF4EBP1; Eukaryotic translation initiation factor 4E binding protein 1; Insulin-stimulated EIF-4E binding protein PHAS-I; P,OKCL.6; P/OKCL.6; PHAS-1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1
Type:  Protein synthesis protein, inhibitor
Mass (Da):  12450
Number AA:  118
UniProt ID:  Q13541
International Prot ID:  IPI00002569
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829     Uniprot OncoNet
Molecular Function:  GO:0005515     PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S2______MSGGSSCSQ
Site 2S5___MSGGSSCSQTPS
Site 3S6__MSGGSSCSQTPSR
Site 4S8MSGGSSCSQTPSRAI
Site 5T10GGSSCSQTPSRAIPA
Site 6S12SSCSQTPSRAIPATR
Site 7T18PSRAIPATRRVVLGD
Site 8Y34VQLPPGDYSTTPGGT
Site 9S35QLPPGDYSTTPGGTL
Site 10T36LPPGDYSTTPGGTLF
Site 11T37PPGDYSTTPGGTLFS
Site 12T41YSTTPGGTLFSTTPG
Site 13S44TPGGTLFSTTPGGTR
Site 14T45PGGTLFSTTPGGTRI
Site 15T46GGTLFSTTPGGTRII
Site 16T50FSTTPGGTRIIYDRK
Site 17Y54PGGTRIIYDRKFLME
Site 18S65FLMECRNSPVTKTPP
Site 19T68ECRNSPVTKTPPRDL
Site 20T70RNSPVTKTPPRDLPT
Site 21T77TPPRDLPTIPGVTSP
Site 22T82LPTIPGVTSPSSDEP
Site 23S83PTIPGVTSPSSDEPP
Site 24S85PGVTSPSSDEPPMEA
Site 25S86PGVTSPSSDEPPMEA
Site 26S94DEPPMEASQSHLRNS
Site 27S96PPMEASQSHLRNSPE
Site 28S101SQSHLRNSPEDKRAG
Site 29S112KRAGGEESQFEMDI_
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


2019 Kinexus Bioinformatics Corporation