PhosphoNET

           
Protein Info 
   
Short Name:  PIN1
Full Name:  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Alias:  EC 5.2.1.8; PPIase Pin1; Rotamase Pin1
Type:  Enzyme - Isomerase, Nuclear receptor co-regulator
Mass (Da):  18243
Number AA:  163
UniProt ID:  Q13526
International Prot ID:  IPI00013723
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0003755  GO:0050815  GO:0050816 PhosphoSite+ KinaseNET
Biological Process:  GO:0007049  GO:0030512  GO:0051443 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S16PGWEKRMSRSSGRVY
Site 2S18WEKRMSRSSGRVYYF
Site 3S19EKRMSRSSGRVYYFN
Site 4Y23SRSSGRVYYFNHITN
Site 5Y24RSSGRVYYFNHITNA
Site 6S32FNHITNASQWERPSG
Site 7S38ASQWERPSGNSSSGG
Site 8S41WERPSGNSSSGGKNG
Site 9S42ERPSGNSSSGGKNGQ
Site 10S43RPSGNSSSGGKNGQG
Site 11S58EPARVRCSHLLVKHS
Site 12S65SHLLVKHSQSRRPSS
Site 13S67LLVKHSQSRRPSSWR
Site 14S71HSQSRRPSSWRQEKI
Site 15S72SQSRRPSSWRQEKIT
Site 16T79SWRQEKITRTKEEAL
Site 17S98GYIQKIKSGEEDFES
Site 18S105SGEEDFESLASQFSD
Site 19S108EDFESLASQFSDCSS
Site 20S111ESLASQFSDCSSAKA
Site 21S114ASQFSDCSSAKARGD
Site 22S115SQFSDCSSAKARGDL
Site 23S138QKPFEDASFALRTGE
Site 24T143DASFALRTGEMSGPV
Site 25S147ALRTGEMSGPVFTDS
Site 26T152EMSGPVFTDSGIHII
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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