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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TUBB3
Full Name:
Tubulin beta-3 chain
Alias:
TBB3; TUBB4; Tubulin beta-4; Tubulin beta-III
Type:
Cytoskeletal protein - Microtubule dynamics
Mass (Da):
50433
Number AA:
450
UniProt ID:
Q13509
International Prot ID:
IPI00013683
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005874
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0007018
GO:0051258
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
Site 2
S33
D
E
H
G
I
D
P
S
G
N
Y
V
G
D
S
Site 3
Y36
G
I
D
P
S
G
N
Y
V
G
D
S
D
L
Q
Site 4
S40
S
G
N
Y
V
G
D
S
D
L
Q
L
E
R
I
Site 5
S48
D
L
Q
L
E
R
I
S
V
Y
Y
N
E
A
S
Site 6
Y50
Q
L
E
R
I
S
V
Y
Y
N
E
A
S
S
H
Site 7
Y51
L
E
R
I
S
V
Y
Y
N
E
A
S
S
H
K
Site 8
S55
S
V
Y
Y
N
E
A
S
S
H
K
Y
V
P
R
Site 9
Y59
N
E
A
S
S
H
K
Y
V
P
R
A
I
L
V
Site 10
T72
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
Site 11
S75
L
E
P
G
T
M
D
S
V
R
S
G
A
F
G
Site 12
Y106
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
Site 13
T107
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
Site 14
S115
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
Site 15
S138
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
Site 16
T149
G
T
G
S
G
M
G
T
L
L
I
S
K
V
R
Site 17
S153
G
M
G
T
L
L
I
S
K
V
R
E
E
Y
P
Site 18
Y159
I
S
K
V
R
E
E
Y
P
D
R
I
M
N
T
Site 19
T166
Y
P
D
R
I
M
N
T
F
S
V
V
P
S
P
Site 20
S168
D
R
I
M
N
T
F
S
V
V
P
S
P
K
V
Site 21
S172
N
T
F
S
V
V
P
S
P
K
V
S
D
T
V
Site 22
S176
V
V
P
S
P
K
V
S
D
T
V
V
E
P
Y
Site 23
T178
P
S
P
K
V
S
D
T
V
V
E
P
Y
N
A
Site 24
Y183
S
D
T
V
V
E
P
Y
N
A
T
L
S
I
H
Site 25
S188
E
P
Y
N
A
T
L
S
I
H
Q
L
V
E
N
Site 26
T196
I
H
Q
L
V
E
N
T
D
E
T
Y
C
I
D
Site 27
T199
L
V
E
N
T
D
E
T
Y
C
I
D
N
E
A
Site 28
Y200
V
E
N
T
D
E
T
Y
C
I
D
N
E
A
L
Site 29
Y208
C
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
Site 30
T219
F
R
T
L
K
L
A
T
P
T
Y
G
D
L
N
Site 31
T221
T
L
K
L
A
T
P
T
Y
G
D
L
N
H
L
Site 32
T238
A
T
M
S
G
V
T
T
S
L
R
F
P
G
Q
Site 33
T274
M
P
G
F
A
P
L
T
A
R
G
S
Q
Q
Y
Site 34
S278
A
P
L
T
A
R
G
S
Q
Q
Y
R
A
L
T
Site 35
T285
S
Q
Q
Y
R
A
L
T
V
P
E
L
T
Q
Q
Site 36
T290
A
L
T
V
P
E
L
T
Q
Q
M
F
D
A
K
Site 37
Y310
C
D
P
R
H
G
R
Y
L
T
V
A
T
V
F
Site 38
T312
P
R
H
G
R
Y
L
T
V
A
T
V
F
R
G
Site 39
T315
G
R
Y
L
T
V
A
T
V
F
R
G
R
M
S
Site 40
S322
T
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
Site 41
S335
E
Q
M
L
A
I
Q
S
K
N
S
S
Y
F
V
Site 42
S338
L
A
I
Q
S
K
N
S
S
Y
F
V
E
W
I
Site 43
S339
A
I
Q
S
K
N
S
S
Y
F
V
E
W
I
P
Site 44
Y340
I
Q
S
K
N
S
S
Y
F
V
E
W
I
P
N
Site 45
S364
P
P
R
G
L
K
M
S
S
T
F
I
G
N
S
Site 46
S365
P
R
G
L
K
M
S
S
T
F
I
G
N
S
T
Site 47
T366
R
G
L
K
M
S
S
T
F
I
G
N
S
T
A
Site 48
S382
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
Site 49
Y398
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
Site 50
T409
G
M
D
E
M
E
F
T
E
A
E
S
N
M
N
Site 51
S420
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
Site 52
Y422
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
Site 53
Y425
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
E
E
Site 54
T429
Y
Q
Q
Y
Q
D
A
T
A
E
E
E
G
E
M
Site 55
Y437
A
E
E
E
G
E
M
Y
E
D
D
E
E
E
S
Site 56
S444
Y
E
D
D
E
E
E
S
E
A
Q
G
P
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation