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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
XRCC4
Full Name:
DNA repair protein XRCC4
Alias:
DNA-repair protein XRCC4; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross-complementing protein 4; X-ray repair, complementing defective, repair in Chinese hamster
Type:
DNA repair
Mass (Da):
38287
Number AA:
336
UniProt ID:
Q13426
International Prot ID:
IPI00007672
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032807
GO:0005958
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0051103
GO:0006303
GO:0019059
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
R
K
I
S
R
I
H
L
V
S
E
Site 2
T17
L
V
S
E
P
S
I
T
H
F
L
Q
V
S
W
Site 3
S23
I
T
H
F
L
Q
V
S
W
E
K
T
L
E
S
Site 4
S41
I
T
L
T
D
G
H
S
A
W
T
G
T
V
S
Site 5
T46
G
H
S
A
W
T
G
T
V
S
E
S
E
I
S
Site 6
S48
S
A
W
T
G
T
V
S
E
S
E
I
S
Q
E
Site 7
S53
T
V
S
E
S
E
I
S
Q
E
A
D
D
M
A
Site 8
Y66
M
A
M
E
K
G
K
Y
V
G
E
L
R
K
A
Site 9
Y84
G
A
G
P
A
D
V
Y
T
F
N
F
S
K
E
Site 10
T85
A
G
P
A
D
V
Y
T
F
N
F
S
K
E
S
Site 11
Y94
N
F
S
K
E
S
C
Y
F
F
F
E
K
N
L
Site 12
S105
E
K
N
L
K
D
V
S
F
R
L
G
S
F
N
Site 13
S110
D
V
S
F
R
L
G
S
F
N
L
E
K
V
E
Site 14
S167
G
R
F
E
K
C
V
S
A
K
E
A
L
E
T
Site 15
T174
S
A
K
E
A
L
E
T
D
L
Y
K
R
F
I
Site 16
T189
L
V
L
N
E
K
K
T
K
I
R
S
L
H
N
Site 17
S193
E
K
K
T
K
I
R
S
L
H
N
K
L
L
N
Site 18
Y229
T
A
D
R
D
P
V
Y
D
E
S
T
D
E
E
Site 19
S232
R
D
P
V
Y
D
E
S
T
D
E
E
S
E
N
Site 20
T233
D
P
V
Y
D
E
S
T
D
E
E
S
E
N
Q
Site 21
S237
D
E
S
T
D
E
E
S
E
N
Q
T
D
L
S
Site 22
T241
D
E
E
S
E
N
Q
T
D
L
S
G
L
A
S
Site 23
S244
S
E
N
Q
T
D
L
S
G
L
A
S
A
A
V
Site 24
S248
T
D
L
S
G
L
A
S
A
A
V
S
K
D
D
Site 25
S256
A
A
V
S
K
D
D
S
I
I
S
S
L
D
V
Site 26
S260
K
D
D
S
I
I
S
S
L
D
V
T
D
I
A
Site 27
S269
D
V
T
D
I
A
P
S
R
K
R
R
Q
R
M
Site 28
S299
Q
L
Q
E
K
E
N
S
R
P
D
S
S
L
P
Site 29
S303
K
E
N
S
R
P
D
S
S
L
P
E
T
S
K
Site 30
S304
E
N
S
R
P
D
S
S
L
P
E
T
S
K
K
Site 31
T308
P
D
S
S
L
P
E
T
S
K
K
E
H
I
S
Site 32
S315
T
S
K
K
E
H
I
S
A
E
N
M
S
L
E
Site 33
S320
H
I
S
A
E
N
M
S
L
E
T
L
R
N
S
Site 34
T323
A
E
N
M
S
L
E
T
L
R
N
S
S
P
E
Site 35
S327
S
L
E
T
L
R
N
S
S
P
E
D
L
F
D
Site 36
S328
L
E
T
L
R
N
S
S
P
E
D
L
F
D
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation