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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NNT
Full Name:
NAD(P) transhydrogenase, mitochondrial
Alias:
NAD; nicotinamide nucleotide transhydrogenase; NNTM; pyridine nucleotide transhydrogenase; transhydrogenase, mitochondrial
Type:
EC 1.6.1.2; Oxidoreductase; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide
Mass (Da):
113896
Number AA:
1086
UniProt ID:
Q13423
International Prot ID:
IPI00337541
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005746
Uniprot
OncoNet
Molecular Function:
GO:0051287
GO:0008750
GO:0003957
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0015992
GO:0006099
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
P
L
L
S
N
L
G
S
C
K
G
L
R
V
K
Site 2
T35
V
K
K
D
F
L
R
T
F
Y
T
H
Q
E
L
Site 3
T58
G
I
P
Y
K
Q
L
T
V
G
V
P
K
E
I
Site 4
S75
N
E
K
R
V
A
L
S
P
A
G
V
Q
N
L
Site 5
S93
G
F
N
V
V
V
E
S
G
A
G
E
A
S
K
Site 6
S99
E
S
G
A
G
E
A
S
K
F
S
D
D
H
Y
Site 7
Y106
S
K
F
S
D
D
H
Y
R
V
A
G
A
Q
I
Site 8
S153
K
T
S
G
T
L
I
S
F
I
Y
P
A
Q
N
Site 9
S168
P
E
L
L
N
K
L
S
Q
R
K
T
T
V
L
Site 10
T172
N
K
L
S
Q
R
K
T
T
V
L
A
M
D
Q
Site 11
T173
K
L
S
Q
R
K
T
T
V
L
A
M
D
Q
V
Site 12
T184
M
D
Q
V
P
R
V
T
I
A
Q
G
Y
D
A
Site 13
S194
Q
G
Y
D
A
L
S
S
M
A
N
I
A
G
Y
Site 14
T216
N
H
F
G
R
F
F
T
G
Q
I
T
A
A
G
Site 15
S268
A
A
L
E
Q
F
K
S
L
G
A
E
P
L
E
Site 16
S281
L
E
V
D
L
K
E
S
G
E
G
Q
G
G
Y
Site 17
Y288
S
G
E
G
Q
G
G
Y
A
K
E
M
S
K
E
Site 18
S293
G
G
Y
A
K
E
M
S
K
E
F
I
E
A
E
Site 19
S336
F
N
K
E
M
I
E
S
M
K
E
G
S
V
V
Site 20
T356
E
A
G
G
N
F
E
T
T
K
P
G
E
L
Y
Site 21
T357
A
G
G
N
F
E
T
T
K
P
G
E
L
Y
I
Site 22
Y363
T
T
K
P
G
E
L
Y
I
H
K
G
I
T
H
Site 23
T369
L
Y
I
H
K
G
I
T
H
I
G
Y
T
D
L
Site 24
Y373
K
G
I
T
H
I
G
Y
T
D
L
P
S
R
M
Site 25
T374
G
I
T
H
I
G
Y
T
D
L
P
S
R
M
A
Site 26
S378
I
G
Y
T
D
L
P
S
R
M
A
T
Q
A
S
Site 27
T382
D
L
P
S
R
M
A
T
Q
A
S
T
L
Y
S
Site 28
S385
S
R
M
A
T
Q
A
S
T
L
Y
S
N
N
I
Site 29
S389
T
Q
A
S
T
L
Y
S
N
N
I
T
K
L
L
Site 30
T393
T
L
Y
S
N
N
I
T
K
L
L
K
A
I
S
Site 31
S400
T
K
L
L
K
A
I
S
P
D
K
D
N
F
Y
Site 32
Y407
S
P
D
K
D
N
F
Y
F
D
V
K
D
D
F
Site 33
T426
M
G
H
V
I
R
G
T
V
V
M
K
D
G
K
Site 34
T440
K
V
I
F
P
A
P
T
P
K
N
I
P
Q
G
Site 35
T454
G
A
P
V
K
Q
K
T
V
A
E
L
E
A
E
Site 36
T465
L
E
A
E
K
A
A
T
I
T
P
F
R
K
T
Site 37
T467
A
E
K
A
A
T
I
T
P
F
R
K
T
M
S
Site 38
T472
T
I
T
P
F
R
K
T
M
S
T
A
S
A
Y
Site 39
T475
P
F
R
K
T
M
S
T
A
S
A
Y
T
A
G
Site 40
Y551
A
L
M
G
G
H
L
Y
P
S
T
T
S
Q
G
Site 41
S553
M
G
G
H
L
Y
P
S
T
T
S
Q
G
L
A
Site 42
T554
G
G
H
L
Y
P
S
T
T
S
Q
G
L
A
A
Site 43
T589
L
D
M
F
K
R
P
T
D
P
P
E
Y
N
Y
Site 44
Y594
R
P
T
D
P
P
E
Y
N
Y
L
Y
L
L
P
Site 45
Y596
T
D
P
P
E
Y
N
Y
L
Y
L
L
P
A
G
Site 46
Y598
P
P
E
Y
N
Y
L
Y
L
L
P
A
G
T
F
Site 47
Y614
G
G
Y
L
A
A
L
Y
S
G
Y
N
I
E
Q
Site 48
Y743
N
L
T
K
I
V
A
Y
L
G
T
Y
I
G
G
Site 49
Y747
I
V
A
Y
L
G
T
Y
I
G
G
V
T
F
S
Site 50
Y760
F
S
G
S
L
I
A
Y
G
K
L
Q
G
L
L
Site 51
S896
L
G
G
Y
G
T
T
S
T
A
G
G
K
P
M
Site 52
T897
G
G
Y
G
T
T
S
T
A
G
G
K
P
M
E
Site 53
T908
K
P
M
E
I
S
G
T
H
T
E
I
N
L
D
Site 54
T910
M
E
I
S
G
T
H
T
E
I
N
L
D
N
A
Site 55
Y942
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
Site 56
T952
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
Site 57
T1062
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation