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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLD1
Full Name:
Phospholipase D1
Alias:
Choline phosphatase 1; Phosphatidylcholine-hydrolyzing phospholipase D1; phospholipase D1, phosphatidylcholine-specific
Type:
Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Phospholipase; EC 3.1.4.4
Mass (Da):
124184
Number AA:
1074
UniProt ID:
Q13393
International Prot ID:
IPI00012865
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0005768
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0070290
GO:0035091
GO:0004630
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0006935
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
L
K
N
E
P
R
V
Site 2
T11
K
N
E
P
R
V
N
T
S
A
L
Q
K
I
A
Site 3
S22
Q
K
I
A
A
D
M
S
N
I
I
E
N
L
D
Site 4
T30
N
I
I
E
N
L
D
T
R
E
L
H
F
E
G
Site 5
Y42
F
E
G
E
E
V
D
Y
D
V
S
P
S
D
P
Site 6
S45
E
E
V
D
Y
D
V
S
P
S
D
P
K
I
Q
Site 7
S47
V
D
Y
D
V
S
P
S
D
P
K
I
Q
E
V
Site 8
Y55
D
P
K
I
Q
E
V
Y
I
P
F
S
A
I
Y
Site 9
Y62
Y
I
P
F
S
A
I
Y
N
T
Q
G
F
K
E
Site 10
Y75
K
E
P
N
I
Q
T
Y
L
S
G
C
P
I
K
Site 11
S77
P
N
I
Q
T
Y
L
S
G
C
P
I
K
A
Q
Site 12
T92
V
L
E
V
E
R
F
T
S
T
T
R
V
P
S
Site 13
S93
L
E
V
E
R
F
T
S
T
T
R
V
P
S
I
Site 14
T94
E
V
E
R
F
T
S
T
T
R
V
P
S
I
N
Site 15
T95
V
E
R
F
T
S
T
T
R
V
P
S
I
N
L
Site 16
S99
T
S
T
T
R
V
P
S
I
N
L
Y
T
I
E
Site 17
Y103
R
V
P
S
I
N
L
Y
T
I
E
L
T
H
G
Site 18
Y133
F
H
R
E
L
L
K
Y
K
A
F
I
R
I
P
Site 19
T143
F
I
R
I
P
I
P
T
R
R
H
T
F
R
R
Site 20
T147
P
I
P
T
R
R
H
T
F
R
R
Q
N
V
R
Site 21
S162
E
E
P
R
E
M
P
S
L
P
R
S
S
E
N
Site 22
S166
E
M
P
S
L
P
R
S
S
E
N
M
I
R
E
Site 23
S167
M
P
S
L
P
R
S
S
E
N
M
I
R
E
E
Site 24
Y186
R
R
K
Q
L
E
D
Y
L
T
K
I
L
K
M
Site 25
T188
K
Q
L
E
D
Y
L
T
K
I
L
K
M
P
M
Site 26
Y196
K
I
L
K
M
P
M
Y
R
N
Y
H
A
T
T
Site 27
Y199
K
M
P
M
Y
R
N
Y
H
A
T
T
E
F
L
Site 28
S209
T
T
E
F
L
D
I
S
Q
L
S
F
I
H
D
Site 29
S230
E
G
M
I
M
K
R
S
G
G
H
R
I
P
G
Site 30
S260
R
W
L
I
V
K
D
S
F
L
L
Y
M
K
P
Site 31
Y264
V
K
D
S
F
L
L
Y
M
K
P
D
S
G
A
Site 32
S269
L
L
Y
M
K
P
D
S
G
A
I
A
F
V
L
Site 33
T291
I
K
V
G
K
K
E
T
E
T
K
Y
G
I
R
Site 34
Y295
K
K
E
T
E
T
K
Y
G
I
R
I
D
N
L
Site 35
T305
R
I
D
N
L
S
R
T
L
I
L
K
C
N
S
Site 36
S342
L
K
D
H
R
F
G
S
Y
A
A
I
Q
E
N
Site 37
Y355
E
N
A
L
A
K
W
Y
V
N
A
K
G
Y
F
Site 38
Y361
W
Y
V
N
A
K
G
Y
F
E
D
V
A
N
A
Site 39
Y420
V
R
I
F
I
M
L
Y
K
E
V
E
L
A
L
Site 40
Y433
A
L
G
I
N
S
E
Y
T
K
R
T
L
M
R
Site 41
T434
L
G
I
N
S
E
Y
T
K
R
T
L
M
R
L
Site 42
Y459
D
H
V
S
S
T
V
Y
L
W
A
H
H
E
K
Site 43
Y484
V
G
G
I
D
L
A
Y
G
R
W
D
D
N
E
Site 44
T495
D
D
N
E
H
R
L
T
D
V
G
S
V
K
R
Site 45
S499
H
R
L
T
D
V
G
S
V
K
R
V
T
S
G
Site 46
T504
V
G
S
V
K
R
V
T
S
G
P
S
L
G
S
Site 47
S505
G
S
V
K
R
V
T
S
G
P
S
L
G
S
L
Site 48
S508
K
R
V
T
S
G
P
S
L
G
S
L
P
P
A
Site 49
S511
T
S
G
P
S
L
G
S
L
P
P
A
A
M
E
Site 50
S519
L
P
P
A
A
M
E
S
M
E
S
L
R
L
K
Site 51
S522
A
A
M
E
S
M
E
S
L
R
L
K
D
K
N
Site 52
S540
Q
N
L
P
I
Q
K
S
I
D
D
V
D
S
K
Site 53
S546
K
S
I
D
D
V
D
S
K
L
K
G
I
G
K
Site 54
S558
I
G
K
P
R
K
F
S
K
F
S
L
Y
K
Q
Site 55
S561
P
R
K
F
S
K
F
S
L
Y
K
Q
L
H
R
Site 56
Y563
K
F
S
K
F
S
L
Y
K
Q
L
H
R
H
H
Site 57
S576
H
H
L
H
D
A
D
S
I
S
S
I
D
S
T
Site 58
S578
L
H
D
A
D
S
I
S
S
I
D
S
T
S
S
Site 59
S579
H
D
A
D
S
I
S
S
I
D
S
T
S
S
Y
Site 60
S582
D
S
I
S
S
I
D
S
T
S
S
Y
F
N
H
Site 61
T583
S
I
S
S
I
D
S
T
S
S
Y
F
N
H
Y
Site 62
S584
I
S
S
I
D
S
T
S
S
Y
F
N
H
Y
R
Site 63
S585
S
S
I
D
S
T
S
S
Y
F
N
H
Y
R
S
Site 64
Y586
S
I
D
S
T
S
S
Y
F
N
H
Y
R
S
H
Site 65
Y590
T
S
S
Y
F
N
H
Y
R
S
H
H
N
L
I
Site 66
S610
H
F
K
L
F
H
P
S
S
E
S
E
Q
G
L
Site 67
S611
F
K
L
F
H
P
S
S
E
S
E
Q
G
L
T
Site 68
S613
L
F
H
P
S
S
E
S
E
Q
G
L
T
R
P
Site 69
T618
S
E
S
E
Q
G
L
T
R
P
H
A
D
T
G
Site 70
T624
L
T
R
P
H
A
D
T
G
S
I
R
S
L
Q
Site 71
S626
R
P
H
A
D
T
G
S
I
R
S
L
Q
T
G
Site 72
S629
A
D
T
G
S
I
R
S
L
Q
T
G
V
G
E
Site 73
T632
G
S
I
R
S
L
Q
T
G
V
G
E
L
H
G
Site 74
Y671
F
A
D
F
I
D
R
Y
S
T
P
R
M
P
W
Site 75
T673
D
F
I
D
R
Y
S
T
P
R
M
P
W
H
D
Site 76
S709
N
F
T
K
I
M
K
S
K
Y
R
S
L
S
Y
Site 77
Y711
T
K
I
M
K
S
K
Y
R
S
L
S
Y
P
F
Site 78
S713
I
M
K
S
K
Y
R
S
L
S
Y
P
F
L
L
Site 79
S715
K
S
K
Y
R
S
L
S
Y
P
F
L
L
P
K
Site 80
Y716
S
K
Y
R
S
L
S
Y
P
F
L
L
P
K
S
Site 81
S723
Y
P
F
L
L
P
K
S
Q
T
T
A
H
E
L
Site 82
T725
F
L
L
P
K
S
Q
T
T
A
H
E
L
R
Y
Site 83
Y732
T
T
A
H
E
L
R
Y
Q
V
P
G
S
V
H
Site 84
S737
L
R
Y
Q
V
P
G
S
V
H
A
N
V
Q
L
Site 85
S747
A
N
V
Q
L
L
R
S
A
A
D
W
S
A
G
Site 86
S752
L
R
S
A
A
D
W
S
A
G
I
K
Y
H
E
Site 87
Y757
D
W
S
A
G
I
K
Y
H
E
E
S
I
H
A
Site 88
Y766
E
E
S
I
H
A
A
Y
V
H
V
I
E
N
S
Site 89
Y776
V
I
E
N
S
R
H
Y
I
Y
I
E
N
Q
F
Site 90
Y778
E
N
S
R
H
Y
I
Y
I
E
N
Q
F
F
I
Site 91
Y815
A
H
R
E
N
Q
K
Y
R
V
Y
V
V
I
P
Site 92
Y818
E
N
Q
K
Y
R
V
Y
V
V
I
P
L
L
P
Site 93
S832
P
G
F
E
G
D
I
S
T
G
G
G
N
A
L
Site 94
S918
S
A
N
I
N
D
R
S
M
L
G
K
R
D
S
Site 95
S925
S
M
L
G
K
R
D
S
E
M
A
V
I
V
Q
Site 96
S939
Q
D
T
E
T
V
P
S
V
M
D
G
K
E
Y
Site 97
Y946
S
V
M
D
G
K
E
Y
Q
A
G
R
F
A
R
Site 98
Y966
C
F
R
V
V
L
G
Y
L
D
D
P
S
E
D
Site 99
S971
L
G
Y
L
D
D
P
S
E
D
I
Q
D
P
V
Site 100
S979
E
D
I
Q
D
P
V
S
D
K
F
F
K
E
V
Site 101
T996
S
T
A
A
R
N
A
T
I
Y
D
K
V
F
R
Site 102
S1053
Q
F
P
F
Y
F
L
S
E
E
S
L
L
P
S
Site 103
S1060
S
E
E
S
L
L
P
S
V
G
T
K
E
A
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation