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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MST2
Full Name:
Serine/threonine-protein kinase 3
Alias:
EC 2.7.11.1; Krs-1; MESS1; Serine,threonine protein kinase 3; STK3
Type:
Protein-serine kinase, STE group, STE20 family, MST subfamily
Mass (Da):
56301
Number AA:
491
UniProt ID:
Q13188
International Prot ID:
IPI00411984
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0046983
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0043065
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
Q
P
P
A
P
K
S
K
L
K
K
L
S
E
Site 2
S15
K
S
K
L
K
K
L
S
E
D
S
L
T
K
Q
Site 3
S18
L
K
K
L
S
E
D
S
L
T
K
Q
P
E
E
Site 4
T20
K
L
S
E
D
S
L
T
K
Q
P
E
E
V
F
Site 5
Y38
E
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
Site 6
S40
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
Site 7
S62
I
K
Q
V
P
V
E
S
D
L
Q
E
I
I
K
Site 8
Y81
M
Q
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Site 9
Y85
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
Site 10
Y86
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
Site 11
Y89
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
Site 12
T117
I
I
R
L
R
N
K
T
L
I
E
D
E
I
A
Site 13
Y136
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
Site 14
T172
F
G
V
A
G
Q
L
T
D
T
M
A
K
R
N
Site 15
T174
V
A
G
Q
L
T
D
T
M
A
K
R
N
T
V
Site 16
T180
D
T
M
A
K
R
N
T
V
I
G
T
P
F
W
Site 17
T184
K
R
N
T
V
I
G
T
P
F
W
M
A
P
E
Site 18
Y221
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
Site 19
T235
R
A
I
F
M
I
P
T
N
P
P
P
T
F
R
Site 20
T240
I
P
T
N
P
P
P
T
F
R
K
P
E
L
W
Site 21
S248
F
R
K
P
E
L
W
S
D
D
F
T
D
F
V
Site 22
T268
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
Site 23
S316
L
E
E
E
E
E
N
S
D
E
D
E
L
D
S
Site 24
S323
S
D
E
D
E
L
D
S
H
T
M
V
K
T
S
Site 25
T325
E
D
E
L
D
S
H
T
M
V
K
T
S
V
E
Site 26
T329
D
S
H
T
M
V
K
T
S
V
E
S
V
G
T
Site 27
S330
S
H
T
M
V
K
T
S
V
E
S
V
G
T
M
Site 28
S333
M
V
K
T
S
V
E
S
V
G
T
M
R
A
T
Site 29
T336
T
S
V
E
S
V
G
T
M
R
A
T
S
T
M
Site 30
T340
S
V
G
T
M
R
A
T
S
T
M
S
E
G
A
Site 31
S341
V
G
T
M
R
A
T
S
T
M
S
E
G
A
Q
Site 32
T342
G
T
M
R
A
T
S
T
M
S
E
G
A
Q
T
Site 33
S344
M
R
A
T
S
T
M
S
E
G
A
Q
T
M
I
Site 34
T349
T
M
S
E
G
A
Q
T
M
I
E
H
N
S
T
Site 35
S355
Q
T
M
I
E
H
N
S
T
M
L
E
S
D
L
Site 36
T356
T
M
I
E
H
N
S
T
M
L
E
S
D
L
G
Site 37
S360
H
N
S
T
M
L
E
S
D
L
G
T
M
V
I
Site 38
T364
M
L
E
S
D
L
G
T
M
V
I
N
S
E
D
Site 39
S369
L
G
T
M
V
I
N
S
E
D
E
E
E
E
D
Site 40
T378
D
E
E
E
E
D
G
T
M
K
R
N
A
T
S
Site 41
T384
G
T
M
K
R
N
A
T
S
P
Q
V
Q
R
P
Site 42
S385
T
M
K
R
N
A
T
S
P
Q
V
Q
R
P
S
Site 43
S392
S
P
Q
V
Q
R
P
S
F
M
D
Y
F
D
K
Site 44
Y396
Q
R
P
S
F
M
D
Y
F
D
K
Q
D
F
K
Site 45
S444
F
D
F
L
K
N
L
S
L
E
E
L
Q
M
R
Site 46
Y470
I
E
E
L
R
Q
R
Y
T
A
K
R
Q
P
I
Site 47
T471
E
E
L
R
Q
R
Y
T
A
K
R
Q
P
I
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation