PhosphoNET

           
Protein Info 
   
Short Name:  TARDBP
Full Name:  TAR DNA-binding protein 43
Alias:  TADBP; TAR DNA binding protein; TDP43; TDP-43
Type:  RNA binding protein
Mass (Da):  44740
Number AA:  414
UniProt ID:  Q13148
International Prot ID:  IPI00025815
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0003723  GO:0008017  GO:0000166 PhosphoSite+ KinaseNET
Biological Process:  GO:0008380  GO:0008219  GO:0006397 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S2______MSEYIRVTE
Site 2Y4____MSEYIRVTEDE
Site 3T8MSEYIRVTEDENDEP
Site 4S20DEPIEIPSEDDGTVL
Site 5T25IPSEDDGTVLLSTVT
Site 6Y43PGACGLRYRNPVSQC
Site 7S48LRYRNPVSQCMRGVR
Site 8Y73AGWGNLVYVVNYPKD
Site 9Y77NLVYVVNYPKDNKRK
Site 10T88NKRKMDETDASSAVK
Site 11S91KMDETDASSAVKVKR
Site 12S92MDETDASSAVKVKRA
Site 13T116LGLPWKTTEQDLKEY
Site 14Y123TEQDLKEYFSTFGEV
Site 15S125QDLKEYFSTFGEVLM
Site 16T141QVKKDLKTGHSKGFG
Site 17S144KDLKTGHSKGFGFVR
Site 18T153GFGFVRFTEYETQVK
Site 19Y155GFVRFTEYETQVKVM
Site 20S163ETQVKVMSQRHMIDG
Site 21S180CDCKLPNSKQSQDEP
Site 22S183KLPNSKQSQDEPLRS
Site 23S190SQDEPLRSRKVFVGR
Site 24T199KVFVGRCTEDMTEDE
Site 25T203GRCTEDMTEDELREF
Site 26S212DELREFFSQYGDVMD
Site 27S242ADDQIAQSLCGEDLI
Site 28S254DLIIKGISVHISNAE
Site 29S258KGISVHISNAEPKHN
Site 30S266NAEPKHNSNRQLERS
Site 31S273SNRQLERSGRFGGNP
Site 32S292NQGGFGNSRGGGAGL
Site 33S305GLGNNQGSNMGGGMN
Site 34S342GMMGMLASQQNQSGP
Site 35S347LASQQNQSGPSGNNQ
Site 36S350QQNQSGPSGNNQNQG
Site 37S369EPNQAFGSGNNSYSG
Site 38S373AFGSGNNSYSGSNSG
Site 39Y374FGSGNNSYSGSNSGA
Site 40S375GSGNNSYSGSNSGAA
Site 41S377GNNSYSGSNSGAAIG
Site 42S379NSYSGSNSGAAIGWG
Site 43S387GAAIGWGSASNAGSG
Site 44S389AIGWGSASNAGSGSG
Site 45S393GSASNAGSGSGFNGG
Site 46S395ASNAGSGSGFNGGFG
Site 47S403GFNGGFGSSMDSKSS
Site 48S404FNGGFGSSMDSKSSG
Site 49S407GFGSSMDSKSSGWGM
Site 50S409GSSMDSKSSGWGM__
Site 51S410SSMDSKSSGWGM___
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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